Hepatitis Monthly

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How Does Addition of Regular Aerobic Exercises, Influence the Efficacy of Calorie-Restricted Diet in Patients with Non-Alcoholic Steatohepatatis (NASH)?

Hossein Nikroo 1 , Mohsen Nematy 2 , Seyyed Reza Attarzadeh Hosseini 1 , Hamid Reza Sima 3 and Farkhonde Razmpour 4 , *
Authors Information
1 Department of Sport Physiology, School of Physical Education and Sport Sciences, Ferdowsi University of Mashhad, Mashhad, Iran
2 Biochemistry and Nutrition, Endoscopic and Minimally Invasive Surgery and Cancer Research Centers, Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
3 Department of Medicine, James J. Peters VA Medical Center, Mount Sinai School of Medicine, New York, NY, USA
4 Departments of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Article information
  • Hepatitis Monthly: May 2017, 17 (5); e45339
  • Published Online: May 9, 2017
  • Article Type: Research Article
  • Received: January 23, 2017
  • Revised: March 5, 2017
  • Accepted: April 4, 2017
  • DOI: 10.5812/hepatmon.45339

To Cite: Nikroo H, Nematy M, Attarzadeh Hosseini S R, Sima H R, Razmpour F. et al. How Does Addition of Regular Aerobic Exercises, Influence the Efficacy of Calorie-Restricted Diet in Patients with Non-Alcoholic Steatohepatatis (NASH)?, Hepat Mon. 2017 ;17(5):e45339. doi: 10.5812/hepatmon.45339.

Copyright: Copyright © 2017, Hepatitis Monthly. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited..
1. Background
2. Methods
3. Results
4. Discussion
  • 1. Younossi ZM. Review article: current management of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis. Aliment Pharmacol Ther. 2008; 28(1): 2-12[DOI][PubMed]
  • 2. Sreenivasa Baba C, Alexander G, Kalyani B, Pandey R, Rastogi S, Pandey A, et al. Effect of exercise and dietary modification on serum aminotransferase levels in patients with nonalcoholic steatohepatitis. J Gastroenterol Hepatol. 2006; 21(1 Pt 1): 191-8[DOI][PubMed]
  • 3. Petta S, Muratore C, Craxi A. Non-alcoholic fatty liver disease pathogenesis: the present and the future. Dig Liver Dis. 2009; 41(9): 615-25[DOI][PubMed]
  • 4. Ludwig J, Viggiano TR, McGill DB, Oh BJ. Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease. Mayo Clin Proc. 1980; 55(7): 434-8[PubMed]
  • 5. Dowman JK, Tomlinson JW, Newsome PN. Pathogenesis of non-alcoholic fatty liver disease. QJM. 2010; 103(2): 71-83[DOI][PubMed]
  • 6. Di Rosa M, Mangano K, De Gregorio C, Nicoletti F, Malaguarnera L. Association of chitotriosidase genotype with the development of non-alcoholic fatty liver disease. Hepatol Res. 2013; 43(3): 267-75[DOI][PubMed]
  • 7. Caldwell S, Lazo M. Is exercise an effective treatment for NASH? Knowns and unknowns. Ann Hepatol. 2009; 8 Suppl 1-6[PubMed]
  • 8. Shifflet A, Wu GY. Non-alcoholic steatohepatitis: an overview. J Formos Med Assoc. 2009; 108(1): 4-12[DOI][PubMed]
  • 9. Spassiani NA, Kuk JL. Exercise and the fatty liver. Appl Physiol Nutr Metab. 2008; 33(4): 802-7[DOI][PubMed]
  • 10. Jamali R, Mofid A, Vahedi H, Farzaneh R, Dowlatshahi S. The effect of helicobacter pylori eradication on liver fat content in subjects with non-alcoholic Fatty liver disease: a randomized open-label clinical trial. Hepat Mon. 2013; 13(12)[DOI][PubMed]
  • 11. Razavizade M, Jamali R, Arj A, Matini SM, Moraveji A, Taherkhani E. The effect of pioglitazone and metformin on liver function tests, insulin resistance, and liver fat content in nonalcoholic Fatty liver disease: a randomized double blinded clinical trial. Hepat Mon. 2013; 13(5)[DOI][PubMed]
  • 12. Day CP, James OF. Steatohepatitis: a tale of two "hits"? Gastroenterology. 1998; 114(4): 842-5[DOI][PubMed]
  • 13. Chen ZW, Chen LY, Dai HL, Chen JH, Fang LZ. Relationship between alanine aminotransferase levels and metabolic syndrome in nonalcoholic fatty liver disease. J Zhejiang Univ Sci B. 2008; 9(8): 616-22[DOI][PubMed]
  • 14. Wang CC, Wu WW, Hsu CS, Wang PC, Lin HH, Kao JH. Association of insulin resistance with alanine aminotransferase activity in patients with nonalcoholic fatty liver disease. Tzu Chi Med J. 2008; 20(4): 275-9[DOI]
  • 15. Nikroo H, Mohammadian M, Nematy M, Sima HR, Attarzadeh Hosseini SR. The effect of diet and exercise on improvement of quality of life in patients with nonalcoholic steatohepatitis [In Persian]. J Kerman Univ Med Sci. 2014; 21(1): 61-72
  • 16. Yun KE, Shin CY, Yoon YS, Park HS. Elevated alanine aminotransferase levels predict mortality from cardiovascular disease and diabetes in Koreans. Atherosclerosis. 2009; 205(2): 533-7[DOI][PubMed]
  • 17. Vos MB. Is it time to advance pediatric NAFLD diagnosis to the magnetic resonance imaging era? Hepatology. 2015; 61(6): 1779-80[DOI][PubMed]
  • 18. Saadeh S, Younossi ZM, Remer EM, Gramlich T, Ong JP, Hurley M, et al. The utility of radiological imaging in nonalcoholic fatty liver disease. Gastroenterology. 2002; 123(3): 745-50[DOI][PubMed]
  • 19. Brazier JE, Roberts J. The estimation of a preference-based measure of health from the SF-12. Med Care. 2004; 42(9): 851-9[DOI][PubMed]
  • 20. Brazier JE, Harper R, Jones NM, O'Cathain A, Thomas KJ, Usherwood T, et al. Validating the SF-36 health survey questionnaire: new outcome measure for primary care. BMJ. 1992; 305(6846): 160-4[DOI][PubMed]
  • 21. Church TS, Kuk JL, Ross R, Priest EL, Biltoft E, Blair SN. Association of cardiorespiratory fitness, body mass index, and waist circumference to nonalcoholic fatty liver disease. Gastroenterology. 2006; 130(7): 2023-30[DOI][PubMed]
  • 22. Benjaminov O, Beglaibter N, Gindy L, Spivak H, Singer P, Wienberg M, et al. The effect of a low-carbohydrate diet on the nonalcoholic fatty liver in morbidly obese patients before bariatric surgery. Surg Endosc. 2007; 21(8): 1423-7[DOI][PubMed]
  • 23. Okita M, Hayashi M, Sasagawa T, Takagi K, Suzuki K, Kinoyama S, et al. Effect of a moderately energy-restricted diet on obese patients with fatty liver. Nutrition. 2001; 17(7-8): 542-7[DOI][PubMed]
  • 24. Tendler D, Lin S, Yancy WJ, Mavropoulos J, Sylvestre P, Rockey DC, et al. The effect of a low-carbohydrate, ketogenic diet on nonalcoholic fatty liver disease: a pilot study. Dig Dis Sci. 2007; 52(2): 589-93[DOI][PubMed]
  • 25. Ueno T, Sugawara H, Sujaku K, Hashimoto O, Tsuji R, Tamaki S, et al. Therapeutic effects of restricted diet and exercise in obese patients with fatty liver. J Hepatol. 1997; 27(1): 103-7[DOI][PubMed]
  • 26. Hickman IJ, Jonsson JR, Prins JB, Ash S, Purdie DM, Clouston AD, et al. Modest weight loss and physical activity in overweight patients with chronic liver disease results in sustained improvements in alanine aminotransferase, fasting insulin, and quality of life. Gut. 2004; 53(3): 413-9[PubMed]
  • 27. Suzuki A, Lindor K, St Saver J, Lymp J, Mendes F, Muto A, et al. Effect of changes on body weight and lifestyle in nonalcoholic fatty liver disease. J Hepatol. 2005; 43(6): 1060-6[DOI][PubMed]
  • 28. Cinar K, Coban S, Idilman R, Tuzun A, Sarioglu M, Bektas M, et al. Long-term prognosis of nonalcoholic fatty liver disease: is pharmacological therapy actually necessary? J Gastroenterol Hepatol. 2006; 21(1 Pt 1): 169-73[DOI][PubMed]
  • 29. Akyuz F, Demir K, Ozdil S, Aksoy N, Poturoglu S, Ibrisim D, et al. The effects of rosiglitazone, metformin, and diet with exercise in nonalcoholic fatty liver disease. Dig Dis Sci. 2007; 52(9): 2359-67[DOI][PubMed]
  • 30. Wang CL, Liang L, Fu JF, Zou CC, Hong F, Xue JZ, et al. Effect of lifestyle intervention on non-alcoholic fatty liver disease in Chinese obese children. World J Gastroenterol. 2008; 14(10): 1598-602[DOI][PubMed]
  • 31. Promrat K, Kleiner DE, Niemeier HM, Jackvony E, Kearns M, Wands JR, et al. Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis. Hepatology. 2010; 51(1): 121-9[DOI][PubMed]
  • 32. Hargreaves M, Spriet LL. Exercise metabolism: Human Kinetics. 2006;
  • 33. Lavoie JM, Gauthier MS. Regulation of fat metabolism in the liver: link to non-alcoholic hepatic steatosis and impact of physical exercise. Cell Mol Life Sci. 2006; 63(12): 1393-409[DOI][PubMed]
  • 34. Van Wagner LB, Rinella ME. The role of insulin-sensitizing agents in the treatment of nonalcoholic steatohepatitis. Therap Adv Gastroenterol. 2011; 4(4): 249-63[DOI][PubMed]
  • 35. Perseghin G, Lattuada G, De Cobelli F, Ragogna F, Ntali G, Esposito A, et al. Habitual physical activity is associated with intrahepatic fat content in humans. Diabetes Care. 2007; 30(3): 683-8[DOI][PubMed]
  • 36. Larson-Meyer DE, Heilbronn LK, Redman LM, Newcomer BR, Frisard MI, Anton S, et al. Effect of calorie restriction with or without exercise on insulin sensitivity, beta-cell function, fat cell size, and ectopic lipid in overweight subjects. Diabetes Care. 2006; 29(6): 1337-44[DOI][PubMed]
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