Hepatitis Monthly

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Mitoptosis, a Novel Mitochondrial Death Mechanism Leading Predominantly to Activation of Autophagy

Jaganmohan Jangamreddy 1 and Marek Los 1 , *
Authors Information
1 Deptartment of Clinical and Experimental Medicine, Integrative Regenerative Medicine Center (IGEN), Division of Cell Biology, Linköping University, Linkoping, Sweden
Article information
  • Hepatitis Monthly: August 01, 2012, 12 (8); e6159
  • Published Online: August 20, 2012
  • Article Type: Editorial
  • Received: February 28, 2012
  • Revised: March 10, 2012
  • Accepted: March 23, 2012
  • DOI: 10.5812/hepatmon.6159

To Cite: Jangamreddy J, Los M. Mitoptosis, a Novel Mitochondrial Death Mechanism Leading Predominantly to Activation of Autophagy, Hepat Mon. 2012 ; 12(8):e6159. doi: 10.5812/hepatmon.6159.

Copyright © 2012, Kowsar Corp. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
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  • 2. Los M, Wesselborg S, Schulze-Osthoff K. The role of caspases in development, immunity, and apoptotic signal transduction: lessons from knockout mice. Immunity. 1999; 10: 629-39[DOI]
  • 3. Ghavami S, Mutawe MM, Hauff K, Stelmack GL, Schaafsma D, Sharma P, et al. Statin-triggered cell death in primary human lung mesenchymal cells involves p53-PUMA and release of Smac and Omi but not cytochrome c. Biochim Biophys Acta. 2010; 1803(4): 452-67[DOI][PubMed]
  • 4. Ghavami S, Mutawe MM, Sharma P, Yeganeh B, McNeill KD, Klonisch T, et al. Mevalonate Cascade Regulation of Airway Mesenchymal Cell Autophagy and Apoptosis: A Dual Role for p53. PLoS One. 2011; 6(1)[DOI][PubMed]
  • 5. Vincent FC, Los MJ. New potential instrument to fight hepatocellular cancer by restoring p53. Hepat Mon. 2011; 11(5): 331-2[PubMed]
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  • 10. Ghavami S, Asoodeh A, Klonisch T, Halayko AJ, Kadkhoda K, Kroczak TJ, et al. Brevinin-2R(1) semi-selectively kills cancer cells by a distinct mechanism, which involves the lysosomal-mitochondrial death pathway. J Cell Mol Med. 2008; 12(3): 1005-22[DOI][PubMed]
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  • 13. Alavian SM, Ande SR, Coombs KM, Yeganeh B, Davoodpour P, Hashemi M, et al. Virus-triggered autophagy in viral hepatitis- possible novel strategies for drug development. J Viral Hepat. 2011; 18(12): 821-30[DOI][PubMed]
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  • 20. Izyumov DS, Avetisyan AV, Pletjushkina OY, Sakharov DV, Wirtz KW, Chernyak BV, et al. “Wages of fear”: transient threefold decrease in intracellular ATP level imposes apoptosis. Biochim Biophys Acta. 2004; 1658(1-2): 141-7[DOI][PubMed]
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