Hepatitis Monthly

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A Survey of Correlation Between Insulin-Like Growth Factor-I (IGF-I) Levels and Severity of Liver Cirrhosis

Asghar Khoshnood 1 , * , Mohsen Nasiri Toosi 2 , Mohammad Jafar Faravash 2 , Alireza Esteghamati 3 , Hosein Froutan 2 , Hadi Ghofrani 2 , Mohammad Kalani 2 , Arash Miroliaee 2 , Ahmad Abdollahi 4 and Andrabi Yasir 2
Authors Information
1 Department of Internal Medicine, Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, IR Iran
2 Department of Gastroenterology, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, IR Iran
3 Department of Endocrinology, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, IR Iran
4 Department of Pathology, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, IR Iran
Article information
  • Hepatitis Monthly: February 01, 2013, 13 (2); e6181
  • Published Online: February 23, 2013
  • Article Type: Research Article
  • Received: May 9, 2012
  • Revised: June 13, 2012
  • Accepted: July 28, 2012
  • DOI: 10.5812/hepatmon.6181

To Cite: Khoshnood A, Nasiri Toosi M, Faravash M J, Esteghamati A, Froutan H, et al. A Survey of Correlation Between Insulin-Like Growth Factor-I (IGF-I) Levels and Severity of Liver Cirrhosis, Hepat Mon. 2013 ;13(2):e6181. doi: 10.5812/hepatmon.6181.

Abstract
Copyright © 2013, Kowsar Corp. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
Acknowledgements
Footnotes
References
  • 1. Le Roith D. Seminars in medicine of the Beth Israel Deaconess Medical Center. Insulin-like growth factors. N Engl J Med. 1997; 336(9): 633-40[DOI][PubMed]
  • 2. Friedrich N, Alte D, Volzke H, Spilcke-Liss E, Ludemann J, Lerch MM, et al. Reference ranges of serum IGF-1 and IGFBP-3 levels in a general adult population: results of the Study of Health in Pomerania (SHIP). Growth Horm IGF Res. 2008; 18(3): 228-37[DOI][PubMed]
  • 3. Life JS, Kipgen WW. Guidelines for the Diagnosis and Treatment of Adult Growth Hormone Deficiency 2011;
  • 4. Daughaday WH, Rotwein P. Insulin-like growth factors I and II. Peptide, messenger ribonucleic acid and gene structures, serum, and tissue concentrations. Endocr Rev. 1989; 10(1): 68-91[PubMed]
  • 5. Baxter RC. The somatomedins: insulin-like growth factors. Adv Clin Chem. 1986; 25: 49-115[PubMed]
  • 6. Jones JI, Clemmons DR. Insulin-like growth factors and their binding proteins: biological actions. Endocr Rev. 1995; 16(1): 3-34[PubMed]
  • 7. Chen YH, Hung PF, Kao YH. IGF-I downregulates resistin gene expression and protein secretion. Am J Physiol Endocrinol Metab. 2005; 288(5)-27[DOI][PubMed]
  • 8. Thoren MC, Wivall-Helleryd IL, Blum WF, Hall KE. Effects of repeated subcutaneous administration of recombinant human insulin-like growth factor I in adults with growth hormone deficiency. Eur J Endocrinol. 1994; 131(1): 33-40[PubMed]
  • 9. Assy N, Hochberg Z, Amit T, Shen-Orr Z, Enat R, Baruch Y. Growth hormone-stimulated insulin-like growth factor (IGF) I and IGF-binding protein-3 in liver cirrhosis. J Hepatol. 1997; 27(5): 796-802[PubMed]
  • 10. Caufriez A, Reding P, Urbain D, Golstein J, Copinschi G. Insulin-like growth factor I: a good indicator of functional hepatocellular capacity in alcoholic liver cirrhosis. J Endocrinol Invest. 1991; 14(4): 317-21[PubMed]
  • 11. Cuneo RC, Hickman PE, Wallace JD, Teh BT, Ward G, Veldhuis JD, et al. Altered endogenous growth hormone secretory kinetics and diurnal GH-binding protein profiles in adults with chronic liver disease. Clin Endocrinol (Oxf). 1995; 43(3): 265-75[PubMed]
  • 12. Donaghy A, Ross R, Wicks C, Hughes SC, Holly J, Gimson A, et al. Growth hormone therapy in patients with cirrhosis: a pilot study of efficacy and safety. Gastroenterology. 1997; 113(5): 1617-22[PubMed]
  • 13. Scharf JG, Schmitz F, Frystyk J, Skjaerbaek C, Moesus H, Blum WF, et al. Insulin-like growth factor-I serum concentrations and patterns of insulin-like growth factor binding proteins in patients with chronic liver disease. J Hepatol. 1996; 25(5): 689-99[PubMed]
  • 14. Shmueli E, Stewart M, Alberti KG, Record CO. Growth hormone, insulin-like growth factor-1 and insulin resistance in cirrhosis. Hepatology. 1994; 19(2): 322-8[PubMed]
  • 15. Chang TC, Lin JJ, Yu SC, Chang TJ. Absence of growth-hormone receptor in hepatocellular carcinoma and cirrhotic liver. Hepatology. 1990; 11(1): 123-6[PubMed]
  • 16. Donaghy AJ, Delhanty PJ, Ho KK, Williams R, Baxter RC. Regulation of the growth hormone receptor/binding protein, insulin-like growth factor ternary complex system in human cirrhosis. J Hepatol. 2002; 36(6): 751-8[PubMed]
  • 17. Shen XY, Holt RI, Miell JP, Justice S, Portmann B, Postel-Vinay MC, et al. Cirrhotic liver expresses low levels of the full-length and truncated growth hormone receptors. J Clin Endocrinol Metab. 1998; 83(7): 2532-8[PubMed]
  • 18. Donaghy A, Ross R, Gimson A, Hughes SC, Holly J, Williams R. Growth hormone, insulinlike growth factor-1, and insulinlike growth factor binding proteins 1 and 3 in chronic liver disease. Hepatology. 1995; 21(3): 680-8[PubMed]
  • 19. Petersen KF, Jacob R, West AB, Sherwin RS, Shulman GI. Effects of insulin-like growth factor I on glucose metabolism in rats with liver cirrhosis. Am J Physiol. 1997; 273(6 Pt 1)-93[PubMed]
  • 20. Shmueli E, Miell JP, Stewart M, Alberti KG, Record CO. High insulin-like growth factor binding protein 1 levels in cirrhosis: link with insulin resistance. Hepatology. 1996; 24(1): 127-33[DOI][PubMed]
  • 21. Pugh RN, Murray-Lyon IM, Dawson JL, Pietroni MC, Williams R. Transection of the oesophagus for bleeding oesophageal varices. Br J Surg. 1973; 60(8): 646-9[PubMed]
  • 22. Kamath PS, Kim WR. The model for end-stage liver disease (MELD). Hepatology. 2007; 45(3): 797-805[DOI][PubMed]
  • 23. Wiesner R, Edwards E, Freeman R, Harper A, Kim R, Kamath P, et al. Model for end-stage liver disease (MELD) and allocation of donor livers. Gastroenterology. 2003; 124(1): 91-6[DOI][PubMed]
  • 24. Vyzantiadis T, Theodoridou S, Giouleme O, Harsoulis P, Evgenidis N, Vyzantiadis A. Serum concentrations of insulin-like growth factor-I (IGF-I) in patients with liver cirrhosis. Hepatogastroenterol. 2003; 50(51): 814-6[PubMed]
  • 25. Wu YL, Ye J, Zhang S, Zhong J, Xi RP. Clinical significance of serum IGF-I, IGF-II and IGFBP-3 in liver cirrhosis. World J Gastroenterol. 2004; 10(18): 2740-3[PubMed]
  • 26. Lou M, Song N, Jin X, Luo SQ, Wang JJ. [Detection of serum free insulin-like growth factor 1 in patients with chronic viral hepatitis]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2001; 15(3): 291-2[PubMed]
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