Hepatitis Monthly

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Fibrosis Evaluation by Transient Elastography in Patients With Long-Term Sustained HCV Clearance

Vincenza Calvaruso 1 , * , Vito Di Marco 1 , Donatella Ferraro 2 , Salvatore Petta 1 , Anna Calì 1 , Maria Grazia Bavetta 1 , Elisabetta Conte 1 and Piero Luigi Almasio 1
Authors Information
1 Gastroenterologia and Epatologia, Di.Bi.M.I.S., University of Palermo, Palermo, Italy
2 Dipartimento di Igiene G.D’Alessandro, University of Palermo, Palermo, Italy
Article information
  • Hepatitis Monthly: May 01, 2013, 13 (5); e7176
  • Published Online: May 11, 2013
  • Article Type: Research Article
  • Received: July 9, 2012
  • Accepted: January 19, 2013
  • DOI: 10.5812/hepatmon.7176

To Cite: Calvaruso V, Di Marco V, Ferraro D, Petta S, Calì A, et al. Fibrosis Evaluation by Transient Elastography in Patients With Long-Term Sustained HCV Clearance, Hepat Mon. 2013 ; 13(5):e7176. doi: 10.5812/hepatmon.7176.

Copyright © 2013, Kowsar Corp. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Dufour JF, DeLellis R, Kaplan MM. Reversibility of hepatic fibrosis in autoimmune hepatitis. Ann Intern Med. 1997; 127(11): 981-5[PubMed]
  • 2. Hammel P, Couvelard A, O'Toole D, Ratouis A, Sauvanet A, Flejou JF, et al. Regression of liver fibrosis after biliary drainage in patients with chronic pancreatitis and stenosis of the common bile duct. N Engl J Med. 2001; 344(6): 418-23[DOI][PubMed]
  • 3. Muretto P, Angelucci E, Lucarelli G. Reversibility of cirrhosis in patients cured of thalassemia by bone marrow transplantation. Ann Intern Med. 2002; 136(9): 667-72[PubMed]
  • 4. Dixon JB, Bhathal PS, Hughes NR, O'Brien PE. Nonalcoholic fatty liver disease: Improvement in liver histological analysis with weight loss. Hepatology. 2004; 39(6): 1647-54[DOI][PubMed]
  • 5. Kral JG, Thung SN, Biron S, Hould FS, Lebel S, Marceau S, et al. Effects of surgical treatment of the metabolic syndrome on liver fibrosis and cirrhosis. Surgery. 2004; 135(1): 48-58[DOI][PubMed]
  • 6. Dienstag JL, Goldin RD, Heathcote EJ, Hann HW, Woessner M, Stephenson SL, et al. Histological outcome during long-term lamivudine therapy. Gastroenterology. 2003; 124(1): 105-17[DOI][PubMed]
  • 7. Farci P, Roskams T, Chessa L, Peddis G, Mazzoleni AP, Scioscia R, et al. Long-term benefit of interferon alpha therapy of chronic hepatitis D: regression of advanced hepatic fibrosis. Gastroenterology. 2004; 126(7): 1740-9[PubMed]
  • 8. Kweon YO, Goodman ZD, Dienstag JL, Schiff ER, Brown NA, Burchardt E, et al. Decreasing fibrogenesis: an immunohistochemical study of paired liver biopsies following lamivudine therapy for chronic hepatitis B. J Hepatol. 2001; 35(6): 749-55[PubMed]
  • 9. Poynard T, McHutchison J, Manns M, Trepo C, Lindsay K, Goodman Z, et al. Impact of pegylated interferon alfa-2b and ribavirin on liver fibrosis in patients with chronic hepatitis C. Gastroenterology. 2002; 122(5): 1303-13[PubMed]
  • 10. Shiratori Y, Imazeki F, Moriyama M, Yano M, Arakawa Y, Yokosuka O, et al. Histologic improvement of fibrosis in patients with hepatitis C who have sustained response to interferon therapy. Ann Intern Med. 2000; 132(7): 517-24[PubMed]
  • 11. Furusyo N, Hayashi J, Ueno K, Sawayama Y, Kawakami Y, Kishihara Y, et al. Human lymphoblastoid interferon treatment for patients with hepatitis C virus-related cirrhosis. Clin Ther. 1997; 19(6): 1352-67[PubMed]
  • 12. Manning DS, Afdhal NH. Diagnosis and quantitation of fibrosis. Gastroenterology. 2008; 134(6): 1670-81[DOI][PubMed]
  • 13. Regev A, Berho M, Jeffers LJ, Milikowski C, Molina EG, Pyrsopoulos NT, et al. Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection. Am J Gastroenterol. 2002; 97(10): 2614-8[DOI][PubMed]
  • 14. Foucher J, Chanteloup E, Vergniol J, Castera L, Le Bail B, Adhoute X, et al. Diagnosis of cirrhosis by transient elastography (FibroScan): a prospective study. Gut. 2006; 55(3): 403-8[DOI][PubMed]
  • 15. Ganne-Carrie N, Ziol M, de Ledinghen V, Douvin C, Marcellin P, Castera L, et al. Accuracy of liver stiffness measurement for the diagnosis of cirrhosis in patients with chronic liver diseases. Hepatology. 2006; 44(6): 1511-7[DOI][PubMed]
  • 16. Fraquelli M, Rigamonti C, Casazza G, Conte D, Donato MF, Ronchi G, et al. Reproducibility of transient elastography in the evaluation of liver fibrosis in patients with chronic liver disease. Gut. 2007; 56(7): 968-73[DOI][PubMed]
  • 17. Sandrin L, Tanter M, Gennisson JL, Catheline S, Fink M. Shear elasticity probe for soft tissues with 1-D transient elastography. IEEE Trans Ultrason Ferroelectr Freq Control. 2002; 49(4): 436-46[PubMed]
  • 18. Ogawa E, Furusyo N, Toyoda K, Takeoka H, Maeda S, Hayashi J. The longitudinal quantitative assessment by transient elastography of chronic hepatitis C patients treated with pegylated interferon alpha-2b and ribavirin. Antiviral Res. 2009; 83(2): 127-34[DOI][PubMed]
  • 19. Arena U, Vizzutti F, Corti G, Ambu S, Stasi C, Bresci S, et al. Acute viral hepatitis increases liver stiffness values measured by transient elastography. Hepatology. 2008; 47(2): 380-4[DOI][PubMed]
  • 20. Coco B, Oliveri F, Maina AM, Ciccorossi P, Sacco R, Colombatto P, et al. Transient elastography: a new surrogate marker of liver fibrosis influenced by major changes of transaminases. J Viral Hepat. 2007; 14(5): 360-9[DOI][PubMed]
  • 21. Sagir A, Erhardt A, Schmitt M, Haussinger D. Transient elastography is unreliable for detection of cirrhosis in patients with acute liver damage. Hepatology. 2008; 47(2): 592-5[DOI][PubMed]
  • 22. Bruno S, Stroffolini T, Colombo M, Bollani S, Benvegnu L, Mazzella G, et al. Sustained virological response to interferon-alpha is associated with improved outcome in HCV-related cirrhosis: a retrospective study. Hepatology. 2007; 45(3): 579-87[DOI][PubMed]
  • 23. Camma C, Di Marco V, Lo Iacono O, Almasio P, Giunta M, Fuschi P, et al. Long-term course of interferon-treated chronic hepatitis C. J Hepatol. 1998; 28(4): 531-7[PubMed]
  • 24. Furusyo N, Kajiwara E, Takahashi K, Nomura H, Tanabe Y, Masumoto A, et al. Association between the treatment length and cumulative dose of pegylated interferon alpha-2b plus ribavirin and their effectiveness as a combination treatment for Japanese chronic hepatitis C patients: project of the Kyushu University Liver Disease Study Group. J Gastroenterol Hepatol. 2008; 23(7 Pt 1): 1094-104[DOI][PubMed]
  • 25. Camma C, Bruno S, Di Marco V, Di Bona D, Rumi M, Vinci M, et al. Insulin resistance is associated with steatosis in nondiabetic patients with genotype 1 chronic hepatitis C. Hepatology. 2006; 43(1): 64-71[DOI][PubMed]
  • 26. Moucari R, Asselah T, Cazals-Hatem D, Voitot H, Boyer N, Ripault MP, et al. Insulin resistance in chronic hepatitis C: association with genotypes 1 and 4, serum HCV RNA level, and liver fibrosis. Gastroenterology. 2008; 134(2): 416-23[DOI][PubMed]
  • 27. Petta S, Camma C, Di Marco V, Alessi N, Cabibi D, Caldarella R, et al. Insulin resistance and diabetes increase fibrosis in the liver of patients with genotype 1 HCV infection. Am J Gastroenterol. 2008; 103(5): 1136-44[DOI][PubMed]
  • 28. Petta S, Camma C, Di Marco V, Alessi N, Barbaria F, Cabibi D, et al. Retinol-binding protein 4: a new marker of virus-induced steatosis in patients infected with hepatitis c virus genotype 1. Hepatology. 2008; 48(1): 28-37[DOI][PubMed]
  • 29. Camma C, Petta S, Di Marco V, Bronte F, Ciminnisi S, Licata G, et al. Insulin resistance is a risk factor for esophageal varices in hepatitis C virus cirrhosis. Hepatology. 2009; 49(1): 195-203[DOI][PubMed]
  • 30. Javer M, Rincon D, Camacho I, et al. Insulin resistance correlates with HVPG and predicts the risk for the development of variceal bleeding in cirrhotics. Hepatology. 2008; 48: 324A
  • 31. Iwakiri Y, Groszmann RJ. Vascular endothelial dysfunction in cirrhosis. J Hepatol. 2007; 46(5): 927-34[DOI][PubMed]
  • 32. Paradis V, Perlemuter G, Bonvoust F, Dargere D, Parfait B, Vidaud M, et al. High glucose and hyperinsulinemia stimulate connective tissue growth factor expression: a potential mechanism involved in progression to fibrosis in nonalcoholic steatohepatitis. Hepatology. 2001; 34(4 Pt 1): 738-44[DOI][PubMed]
  • 33. Svegliati-Baroni G, Ridolfi F, Di Sario A, Casini A, Marucci L, Gaggiotti G, et al. Insulin and insulin-like growth factor-1 stimulate proliferation and type I collagen accumulation by human hepatic stellate cells: differential effects on signal transduction pathways. Hepatology. 1999; 29(6): 1743-51[DOI][PubMed]
  • 34. Vincent MA, Montagnani M, Quon MJ. Molecular and physiologic actions of insulin related to production of nitric oxide in vascular endothelium. Curr Diab Rep. 2003; 3(4): 279-88[PubMed]
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