Hepatitis Monthly

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Prevalence of Hepatitis D in the Eastern Mediterranean Region: Systematic Review and Meta Analysis

Neda Amini 1 , Seyed Moayed Alavian 2 , * , Ali Kabir 3 , 4 , Seyed Hossein Aalaei-Andabili 2 , Seyed Yasser Saiedi Hosseini 2 and Mario Rizzetto 5
Authors Information
1 Tehran University of Medical Sciences, Students' Scientific Research Centre, Tehran, IR Iran
2 Baqiyatallah Research Center for Gastroenterology and Liver Diseases, Baqiyatallah University of Medical Sciences, Tehran, IR Iran
3 Department of Epidemiology, School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran
4 Center for Educational Research in Medical Sciences, Tehran University of Medical Sciences, Tehran, IR Iran
5 Division of Gastroenterology, Molinette – University of Turin, Corso Bramante, Turin, Italy
Article information
  • Hepatitis Monthly: January 01, 2013, 13 (1); e8210
  • Published Online: January 6, 2013
  • Article Type: Research Article
  • Received: August 15, 2012
  • Revised: September 1, 2012
  • Accepted: September 22, 2012
  • DOI: 10.5812/hepatmon.8210

To Cite: Amini N, Alavian S M, Kabir A, Aalaei-Andabili S H, Saiedi Hosseini S Y, et al. Prevalence of Hepatitis D in the Eastern Mediterranean Region: Systematic Review and Meta Analysis, Hepat Mon. 2013 ; 13(1):e8210. doi: 10.5812/hepatmon.8210.

Copyright © 2013, Kowsar Corp. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Rizzetto M, Canese MG, Arico S, Crivelli O, Trepo C, Bonino F, et al. Immunofluorescence detection of new antigen-antibody system (delta/anti-delta) associated to hepatitis B virus in liver and in serum of HBsAg carriers. Gut. 1977; 18(12): 997-1003[PubMed]
  • 2. Hajiani E, Hashemi S, Jalali F. Seroprevalence of Delta Hepatitis in Patients with Chronic Hepatitis B and its Clinical Impact in Khuzestan Province, Southwest Iran. Hepat Mon. 2009; 9(4): 287-92
  • 3. Yamaguchi Y, Delehouzee S, Handa H. HIV and hepatitis delta virus: evolution takes different paths to relieve blocks in transcriptional elongation. Microbes Infect. 2002; 4(11): 1169-75[PubMed]
  • 4. Taghavi SA, Sedighi S, Mehrabani D, Khademolhosseini F. Hepatitis D in Chronic Active Hepatitis B: Prevalence, Liver Enzyme Levels and Histopathology- an Epidemiological Study in Shiraz, Southern Iran, 2003-2004. Hepat Mon. 2008; 8(4): 248-51
  • 5. Mumtaz K, Hamid SS, Adil S, Afaq A, Islam M, Abid S, et al. Epidemiology and clinical pattern of hepatitis delta virus infection in Pakistan. J Gastroenterol Hepatol. 2005; 20(10): 1503-7[DOI][PubMed]
  • 6. Gaeta GB, Stroffolini T, Chiaramonte M, Ascione T, Stornaiuolo G, Lobello S, et al. Chronic hepatitis D: a vanishing Disease? An Italian multicenter study. Hepatology. 2000; 32(4 Pt 1): 824-7[DOI][PubMed]
  • 7. Husa P, Linhartova A, Nemecek V, Husova L. Hepatitis D. Acta Virol. 2005; 49(4): 219-25[PubMed]
  • 8. Glynn L. EBLIP Critical Appraisal Checklist.
  • 9. Abbas Z, Jafri W, Raza S. Hepatitis D: Scenario in the Asia-Pacific region. World J Gastroenterol. 2010; 16(5): 554-62[PubMed]
  • 10. Alavian SM. We Have More Data Regarding Epidemiology of Hepatitis D in Iran but There are Defects to be Filled Yet! Hepat Mon. 2008; 8(4): 245-7
  • 11. Alavian SM. Hepatitis D Is a Forgotten Problem in Hemodialysis Patients in the World. Hepat Mon. 2008; 8(1): 9-10
  • 12. Alavian SM. Hepatitis D in hemodialysis setting: A short Review. Acta Med Sal. 2009; 38(2): 59-62
  • 13. Alavian SM. Unthought of Problems Regarding Hepatitis D Virus Infection. Hepat Mon. 2010; 10(2): 77-9
  • 14. Alavian SM, Alavian SH. Hepatitis D virus Infection; Iran, Middle East and Central Asia. Hepat Mon. 2005; 5(4): 137-43
  • 15. Aly MA, Mangood AM, Essa MH, Refaat MA, Helmy E, Makarem SS. The pattern of bilharzial infection with hepatitis B virus associated with delta agent. J Egypt Soc Parasitol. 1989; 19(2 Suppl): 869-78[PubMed]
  • 16. Behzadian F, Sabahi F, Karimi M, Sadeghizadeh M, Maghsoudi N, Forooshani RS, et al. Molecular phylogenetic analysis of Iranian HDV complete genome. Virus Genes. 2005; 30(3): 383-93[PubMed]
  • 17. Behzadian F, Sabahia F, Sadeghizadeh M, Maghsoudi N, Fotouhi Chahooki F, Karimi M. In vitro Replication of Hepatitis D Virus Using a New Construct Containing a cDNA Dimer of HDV Genome. Intervirology. 2007; 50(6): 387-393
  • 18. Bhat SK, Sachdeva VN, Saleem HI. Profile of viral hepatitis patients in Dakhliya, Oman. Saudi Med J. 2005; 26(5): 819-23
  • 19. Chao YC, Tang HS, Hsu CT. Evolution rate of hepatitis delta virus RNA isolated in Taiwan. J Med Virol. 1994; 43(4): 397-403[PubMed]
  • 20. el-Dep HA, Hashim E, el-Tabakh S. Epidemiology of non A non B hepatitis in Jeddah, KSA with special reference to aminotransferases as a prognostic criterion. J Egypt Public Health Assoc. 1989; 64(1-2): 155-68[PubMed]
  • 21. el-Zimaity DM, Hyams KC, Imam IZ, Watts DM, Bassily S, Naffea EK, et al. Acute sporadic hepatitis E in an Egyptian pediatric population. Am J Trop Med Hyg. 1993; 48(3): 372-6[PubMed]
  • 22. Elzouki ANY. Hepatitis D virus. Annals of Saudi Medicine. 1996; 16(2): 184-192
  • 23. Esmaeili R, Alavian SM, Hajibeigi B, Sabouri E, Edalat R, Adeli A, et al. Phylogenetic analysis of twenty-six cases of hepatitis delta virus isolates in Tehran, Iran. Hepat Mon. 2009; 9(3): 196-200
  • 24. Faustini A, Franco E, Saitto C, Cauletti M, Zaratti L, Papini P, et al. Hepatitis A, B, C and D in a community in Italy of immigrants from NE Africa. J Public Health Med. 1994; 16(1): 71-8[PubMed]
  • 25. Fong TL, DeCock KM, Govindarajan S, Yamada S, Morgan TR, Redeker AG. Clustering of delta hepatitis in a family from Lebanon. J Infect Dis. 1986; 154(5): 912-3[PubMed]
  • 26. Gomatos PJ, Monier MK, Arthur RR, Rodier GR, el-Zimaity D, Hassan NF, et al. Sporadic acute hepatitis caused by hepatitis E virus in Egyptian adults. Clin Infect Dis. 1996; 23(1): 195-6[PubMed]
  • 27. Hannachi N, Bahri O, Boukatef B, Triki H, Boukadida J. Isolated anti-HBc profile should be investigated in a country of intermediate endemicity for hepatitis B. Clin Microbiol Infect. 2010; 16
  • 28. Huo TI, Wu JC, Lai CR, Lu CL, Sheng WY, Lee SD. Comparison of clinico-pathological features in hepatitis B virus-associated hepatocellular carcinoma with or without hepatitis D virus superinfection. J Hepatol. 1996; 25(4): 439-44[PubMed]
  • 29. Hyams KC, al-Arabi MA, al-Tagani AA, Messiter JF, al-Gaali AA, George JF. Epidemiology of hepatitis B in the Gezira region of Sudan. Am J Trop Med Hyg. 1989; 40(2): 200-6[PubMed]
  • 30. Khuroo MS. Viral hepatitis in international travellers: risks and prevention. Int J Antimicrob Agents. 2003; 21(2): 143-52[PubMed]
  • 31. Mirshafiee H, Mahmoodian-Shooshtari M, Sharifi Z, Hosseini SM. Genotype Analysis of Hepatitis Delta Virus from Hepatitis B Surface Antigen-Positive Patients Using PCR-RFLP in Tehran, Iran. Arch Iran Med. 2009; 12(3): 238-43[PubMed]
  • 32. Mahoney FJ. Update on Diagnosis, Management, and Prevention of Hepatitis B Virus Infection. Clin. Microbiol. Rev. 1999; 12(2): 351-66
  • 33. Moatter T, Abbas Z, Shabir S, Jafri W. Clinical presentation and genotype of hepatitis delta in Karachi. World J Gastroenterol. 2007; 13(18): 2604-7[PubMed]
  • 34. Mohebbi SR, Zali N, Derakhshan F, Tahami A, Mashayekhi R, Amini-Bavil-Olyaee S, et al. Molecular epidemiology of hepatitis delta virus (HDV) in Iran: A preliminary report. J Med Virol. 2008; 80(12): 2092-9[DOI][PubMed]
  • 35. Qureshi H, Arif A, Alam E. Treatment of HBV and HDV co-infection using lamivudine. J Ayub Med Coll Abbottabad. 2009; 21(2): 1-3[PubMed]
  • 36. Riaz A, Zuberi SJ, Qureshi H, Alam SE. Delta hepatitis in Pakistan. Trop Doct. 2005; 35(2): 121[DOI][PubMed]
  • 37. Saudy N, Sugauchi F, Tanaka Y, Suzuki S, Aal AA, Zaid MA, et al. Genotypes and phylogenetic characterization of hepatitis B and delta viruses in Egypt. J Med Virol. 2003; 70(4): 529-36[DOI][PubMed]
  • 38. Shahinsaz L, Sabahi F, Karami M, Behzadian F, Alavian S.M, Zand V. Detection and genotyping of hepatitis D virus from HBsAg positive patients in Iran using RT-PCR. Iran J Biotech. 2006; 4(3): 174-9
  • 39. Toukan AU, al-Kandari S. The role of hepatitis D virus in liver disease in the Middle East. Prog Clin Biol Res. 1991; 364: 63-8[PubMed]
  • 40. Wallace MR, Hale BR, Utz GC, Olson PE, Earhart KC, Thornton SA, et al. Endemic Infectious Diseases of Afghanistan. Clin Infect Dis. 2002; 34[DOI][PubMed]
  • 41. Zaki Mel S, Salama OS, Mansour FA, Hossein S. Hepatitis E virus coinfection with hepatotropic viruses in Egyptian children. J Microbiol Immunol Infect. 2008; 41(3): 254-8[PubMed]
  • 42. Zhang YY, Tsega E, Hansson BG. Phylogenetic analysis of hepatitis D viruses indicating a new genotype I subgroup among African isolates. J Clin Microbiol. 1996; 34(12): 3023-30[PubMed]
  • 43. Zuberi BF, Quraishy MS, Afsar S, Akhtar N, Kumar A, Dodani SK. Treatment outcome in patients of hepatitis B with hepatitis D: experience of 4 years at a tertiary care centre in Pakistan. J Coll Physicians Surg Pak. 2007; 17(6): 320-2[PubMed]
  • 44. Gholamreza R, Shahryar S, Abbasali K, Hamidreza J, Abdolvahab M, Khodaberdi K, et al. Seroprevalence of hepatitis B virus and its co-infection with hepatitis D virus and hepatitis C virus in Iranian adult population. Indian J Med Sci. 2007; 61(5): 263-8[PubMed]
  • 45. Rezvan H, Forouzandeh B, Taroyan S, Fadaei S, Azordegan F. Epidemiology of Delta virus infection and its clinical impact in Iran. J Iran Med Council. 1991; 3(10): 171-8
  • 46. Roshandel G, Semnani S, Abdolahi N, Besharat S, Keshtkar AA, Joshaqani H, et al. Prevalence of hepatitis D virus infection in hepatitis B surface antigen-positive subjects in Golestan province, northeast Iran. J Microbiol Immunol Infect. 2008; 41(3): 227-30[PubMed]
  • 47. Ali HYM, Yassen SA. Qatar Med J. 2001; 10(2): 51-3
  • 48. Arya SC, Ashraf SJ, Pathak VP, Nanda V, Parande CM, Tajuddin S. Serological profiles for HBV, HDV, HIV-1 and HTLV-1 in Saudi patients with a malignancy. J Commun Dis. 1991; 23(4): 270-5[PubMed]
  • 49. Ashraf SJ, Arya SC, Arendrup M, Krogsgaard K, Parande CM, Orskov B, et al. Frequencies of hepatitis B, delta and HTLV-III virus markers in Saudi Arabia. Liver. 1986; 6(2): 73-7[PubMed]
  • 50. Eleftheriou A, Teloni F, Ioannou P. HDV infection in Cyprus. Prog Clin Biol Res. 1993; 382: 277-85[PubMed]
  • 51. el-Hawey AM, Abdel-Rahman MM, Ibrahim MS, Abdel-Rahman AH, Salama MM. Delta virus versus HBsAg in chronic active hepatitis and their relation to clinical, laboratory, and morbidity findings in bilharzial and non-bilharzial patients. J Egypt Soc Parasitol. 1993; 23(1): 151-60[PubMed]
  • 52. el-Hazmi MA, Ramia S. Frequencies of hepatitis B, delta and human immune deficiency virus markers in multitransfused Saudi patients with thalassaemia and sickle-cell disease. J Trop Med Hyg. 1989; 92(1): 1-5[PubMed]
  • 53. el-Hazmi MA, Ramia S. Epidemiology of delta agent infection in Arabia: geographical distribution and prevalence of anti-delta. Vox Sang. 1986; 50(4): 216-9[PubMed]
  • 54. Malik IA, Ahmed A, Iqbal M, Legters LJ, Luqman M, Akhtar MA. Infection with delta agent in Pakistan. Introduction of a new hepatitis agent. J Pak Med Assoc. 1988; 38(5): 126-8[PubMed]
  • 55. Massoud M, Helmy O, Saleh WA. Hepatitis D anti-bodies in some HBs Ag positive in Saudis at Riyadh. J Egypt Soc Parasitol. 1991; 21(2): 561-5[PubMed]
  • 56. Safer L, Ben Chaabene N, Melki W, Saffar H. Epidemiology of viral hepatitis in Tunisia. Rev Epidemiol Sante Publique. 2006; 54(4): 377-80[PubMed]
  • 57. Shobokshi OA, Serebour FE. Prevalence of delta antigen/antibody in various HBsAg positive patients in Saudi Arabia. Prog Clin Biol Res. 1987; 234: 471-5[PubMed]
  • 58. Torabi S, Ebrahimpoor S, Maljaei S, Naghili B. Seroepidemiological studies of Hepatitis Delta (HDV) in HBsAg positive individuals in Tabriz. J Urmia Univ Med Sci. 2003; 13(4): 290-7
  • 59. Triki H. Epidemiology of hepatitis B virus, hepatitis C virus and Delta virus in the general population and in liver cirrhosis in Tunisia. Arch Inst Pasteur Tunis. 1994; 71(3-4): 403-6[PubMed]
  • 60. Zahedi M. Serologic prevalence of hepatitis D in HBsAg positive patients in Kerman, south of Iran, 2002-2003. Kerman Univ Med Sci Health Serv. 2003;
  • 61. Abdel-Wahab KS, Abu-Shady EA. Evidence of a 1985-1987 outbreak of acute and chronic hepatitis in Egypt caused by a mutant hepatitis-B virus detected by spot-DNA hybridization test. J Egypt Public Health Assoc. 1992; 67(1-2): 181-93[PubMed]
  • 62. Zuberi SJ. The delta agent and hepatitis-D. J Pak Med Assoc. 1988; 38(11): 283[PubMed]
  • 63. Al-Kandari S, Nordenfelt E, Al-Nakib B, Radakrishnan S, Al-Nakib W. Acute non-A, non-B hepatitis in Kuwait. Scand J Infect Dis. 1987; 19(6): 611-6[PubMed]
  • 64. Al-Kandari S, Nordenfelt E, Al-Nakib B, Hansson BG, Ljunggren K, Al-Nakib W. Hepatitis delta virus infection in acute hepatitis in Kuwait. Scand J Infect Dis. 1988; 20(1): 15-9[PubMed]
  • 65. Ayed K, Gorgi Y, Pichoud C, Trepo C. Prevalence of HD Ag and anti HD by radioimmunoassay in acute and chronic HBV infections in Tunisia. Prog Clin Biol Res. 1987; 234: 441-2[PubMed]
  • 66. Bassily S, Hyams KC, el Ghorab NM, Ansari AA, Fanous AS. Acute sporadic hepatitis in adults living in Cairo, Egypt. Am J Trop Med Hyg. 1986; 35(5): 1040-4[PubMed]
  • 67. Ghabrah TM, Strickland GT, Tsarev S, Yarbough P, Farci P, Engle R, et al. Acute viral hepatitis in Saudi Arabia: Seroepidemiological analysis, risk factors, clinical manifestations, and evidence for a sixth hepatitis agent. Clin Infect Dis. 1995; 21(3): 621-7[PubMed]
  • 68. Glynn MJ, Rashid A, Antao AJO. Imported epidemic non-A, non-B hepatitis in Qatar. J Med Virol. 1985; 17(4): 371-5[PubMed]
  • 69. Gunaid AA, Nasher TM, el-Guneid AM, Hill M, Dayton R, Pal A, et al. Acute sporadic hepatitis in the Republic of Yemen. J Med Virol. 1997; 51(1): 64-6[PubMed]
  • 70. Haider Z, Khan AA, Rehman K, Janjua MI, Iqbal J, Chishti MA, et al. Sero-diagnosis for viral hepatitis in 93 patients admitted with acute hepatitis in three different teaching hospitals in Lahore. J Pak Med Assoc. 1994; 44(8): 182-4[PubMed]
  • 71. Marcus S, Al-Moslih M, Al-Tawil NG, Kassir ZA. Virological and immunological studies in patients with acute viral hepatitis. Scand J Immunol. 1993; 37(2): 265-70[PubMed]
  • 72. Meky FA, Stoszek SK, Abdel-Hamid M, Selim S, Abdel-Wahab A, Mikhail N, et al. Active surveillance for acute viral hepatitis in rural villages in the Nile Delta. Clin Infect Dis. 2006; 42(5): 628-33[DOI][PubMed]
  • 73. Rassam SW, Goudeau AM, Dubois F, Al-Khoury BN, Muhyee Al-Deen JA, Sadik AM. Acute viral hepatitis: An aetiological study of 253 patients. J Gastroenterol Hepatol. 1989; 4(2): 151-4[PubMed]
  • 74. Abdel-Fattah S, el-Kholy MS, Abdel-Fattah SM, el-Shimi S, el-Rasad MM, Mikhail TH, et al. Delta virus and hepatitis B surface antigen in chronic liver diseases. J Egypt Public Health Assoc. 1991; 66(3-4): 427-39[PubMed]
  • 75. Bahakim H, Ramia S, Kurbaan K. Combined immunoprophylaxis in the prevention of perinatal transmission of hepatitis B and hepatitis D virus infections in Saudi children. Ann Trop Paediatr. 1990; 10(2): 139-43[PubMed]
  • 76. Morcos MM, Mikhail TH, Hanna WM, Abdel-Fattah S, el-Rasad MM, Wassef EL. The prevalence of delta virus infection in chronic liver disease in Egyptian children in comparison with some other countries. Panminerva Med. 2000; 42(2): 97-100[PubMed]
  • 77. al Adnani MS. Hepatitis B core and surface antigens and delta agent in chronic liver disease in Kuwait. Histol Histopathol. 1988; 3(1): 57-62[PubMed]
  • 78. Al-Moslih MI, Al-Huraibi MA. Prevalence of hepatitis C virus among patients with liver disease in the Republic of Yemen. East Mediterr Health J. 2001; 7(4-5): 771-8[PubMed]
  • 79. Arya SC, Ashraf SJ, Parande CM, Tobeiqi MS, Ageel AR. Hepatitis B and delta markers in primary hepatocellular carcinoma patients in the Gizan area of Saudi Arabia. APMIS Suppl. 1988; 3: 30-4[PubMed]
  • 80. Bashardust n. seroprevalance of HDV in high risk group. Med J Shahid Sadughi Yazd. 1999; 3: 51
  • 81. Farci P, Burroughs AK, Thomas HC, Shamma'a M. Delta hepatitis in Lebanon. Prevalence studies and a report on six siblings with chronic delta-positive active hepatitis. J Hepatol. 1987; 4(2): 224-8[PubMed]
  • 82. Nordenfelt E, Hansson BG, Al-Nakib B. Frequency of delta agent infections in Kuwait. J Infect Dis. 1983; 148(4): 768[PubMed]
  • 83. Ramia S, el-Hazmi MA, Vivian PA, Waller DK, Mushahwar IK, Frosner GG. Delta agent infection in Riyadh, Saudi Arabia. Trans R Soc Trop Med Hyg. 1987; 81(2): 317-8[PubMed]
  • 84. Vosoughinia H, Esmailzadeh A, Mokhtarifard A, Sima HR, Saadatnia H, Khosravi A. Seroepidemiology and co infetion of hepatitis D virus infection in the north-east of Iran. Med J Mashhad Unive Med Sci. 2010; 53(2): 69-72
  • 85. Zaidi G, Idrees M, Malik FA, Amin I, Shahid M, Younas S, et al. Prevalence of Hepatitis Delta Virus infection among Hepatitis B Virus surface antigen positive patients circulating in the largest province of Pakistan. Virol J. 2010; 7(1): 283[DOI][PubMed]
  • 86. Zuberi BF, Quraishy MS, Afsar S, Kazi LA, Memon AR, Qadeer R, et al. Frequency and comparative analysis of hapatitis D in petients seeking treatment for hepatitis B. J Coll Physicians Surg Pak. 2006; 16(9): 581-4[PubMed]
  • 87. Jacobson IM, Dienstag JL, Werner BaG, Brettler DB, Levine PH, Mushahwar IK. Epidemiology and clinical impact of hepatitis D virus (delta) infection. Hepatology. 1985; 5(2): 188-91
  • 88. Abbatte EA, Fox E, Salah S, Constantine NT, Wassef HH. Ethnic differences in the prevalence of hepatitis delta agent in Djibouti. Trans R Soc Trop Med Hyg. 1989; 83(1): 107-8
  • 89. Angelico M, Renganathan E, Gandin C, Fathy M, Profili MC, Refai W, et al. Chronic liver disease in the Alexandria governorate, Egypt: contribution of schistosomiasis and hepatitis virus infections. J Hepatol. 1997; 26(2): 236-43[PubMed]
  • 90. Darwish MA, Shaker M, Raslan O, Raouf TA. J Egypt Public Health Assoc. 1992; 67(5-6): 549-63[PubMed]
  • 91. Darwish MA, Shaker M, Raslan OS, Abdel-Raouf T. Delta virus infection in Egypt. J Egypt Public Health Assoc. 1992; 67(1-2): 147-61[PubMed]
  • 92. el Zayadi A, Ponzetto A, Selim O, Forzani B, Lavarini C, Rizzetto M. Prevalence of delta antibodies among urban HBsAg-positive chronic liver disease patients in Egypt. Hepatogastroenterology. 1988; 35(6): 313-5[PubMed]
  • 93. Youssef A, Yano Y, Utsumi T, abd El-alah EM, abd El-Hameed Ael E, Serwah Ael H, et al. Molecular epidemiological study of hepatitis viruses in Ismailia, Egypt. Intervirology. 2009; 52(3): 123-31[DOI][PubMed]
  • 94. Zaki S, Khatwa MA, Mikhail H. Prevalence of infection with delta virus in patients positive for hepatitis B surface antigen. Int J Infect Dis. 2010; 14
  • 95. Alavian SM, Asari SH, Manzoori-Joybari H, Moghani Lankarani M, Doroudi T, HajiBeigi B, et al. [Frequency and risk factors of hepatitis D virus in hepatitis B patients]. Govaresh. 2004; 3(9): 169-75
  • 96. Alizadeh AH, Ranjbar M, Tehrani AS, Keramat F, Mamani M, Rezazadeh M, et al. Seroprevalence of hepatitis D virus and its risk factors in the west of Iran. J Microbiol Immunol Infect. 2010; 43(6): 519-23[DOI][PubMed]
  • 97. Amini S, Mahmoodi MF, Andalibi S, Solati A. Seroepidemiology of hepatitis B, Delta and HIV infections in Hamadan province of Iran. J. Trop. Med. Hyg. 1993; 96: 277-87
  • 98. Amini S, Taghinia A, Khanbaba F, Talebian A. Prevalence of Delta agent super-infection and co-infection among HBsAg-positive patients referring to reference IBTO Lab [In Persian]. Hakim Res J. 2007; 9(4): 7-11
  • 99. Ataei B, Yazdani MR, Kalantari H, Yaran M, Nokhodian Z, Javadi AA, et al. Delta hepatitis infection in patients with chronic hepatitis B infection in Isfahan, Iran. Clin Microbiol Infect. 144: 41.6
  • 100. Doosti A, Amini-Bavil-Olyaee S, Tajbakhsh E, Adeli A, Mahboudi F. Prevalence of viral hepatitis and molecular analysis of HBV among voluntary blood donors in west Iran. New Microbiol. 2009; 32(2): 193-8[PubMed]
  • 101. Habibi F, Mokhtari H, Gazerani M, Roshani Zaferanloo N. The Frequency of Hepatitis Delta in Hepatitis B surfuce antigen positive patients. Med Sci J Islamic Azad Univ Mashhad Branch. 2000; 5(3): 61-7
  • 102. Hajiani E, Hashemi S, Masjedizadeh A. Seroepidemiology of Hepatitis B Virus Infection in Khuzestan Province, Southwest of Iran. Hepat Mon. 2009; 9(1): 34-8
  • 103. Hassanjani Roshan MR, Beigi AA, Soleimani MJ. [Prevalence of anti-HDV in chronic carrier of HBV in Babol]. Babol Med J. 2004; 6(21): 50-4
  • 104. Jedary Seifi S, Sabouri Ghannad M. A Study of HDV in HBsAg Positive Patients in Tabriz, Northwestern Iran. Hepat Mon. 2010; 10(2): 110-5
  • 105. Karimi A, Amini S, Amirkhani A. [Investigation and Comparison of hepatitis D prevalence in dialysis patients and the donors of HBsAg carrier]. Teb va Tazkieh. 2000; 36: 30-5
  • 106. Makvandi M, Samrbafzadeh AR, Malekan E. Determination of HBV, HCV and HDV markers among the cirrhotic patients. J Gastroenterol Hepatol. 2004; 19
  • 107. Malekzadeh R, Borhanmanesh F. Prevalence of HDV in asymptomatic healthy carrier of HBV in Iran. Iran J Med Sci. 1989; 14(2): 33-8
  • 108. Rezvan H, Taroyan S, Forouzandeh B, Fadaiee S, Azordegan F. A study on delta virus infection and its clinical impact in Iran. Infection. 1990; 18(1): 26-28
  • 109. Roshandel G, Semnani SH, Abdolahi N, Keshtkar A, Besharat S, Joshaghni H, et al. Prevalence of Hepatitis D Virus Infection in HBsAg Positive Subjects in Iran. Pak J Biol Sci. 2007; 10(10): 1751-1754[PubMed]
  • 110. Somi MH, Farhang S, Miri SM, Pouri AA, Mjidi G, Alavian SM. The frequency of hepatitis D virus in patients with hepatitis B in Iran: an increasing rate? Trop Doct. 2009; 39(3): 154-6[DOI][PubMed]
  • 111. Taghavi SA, Sedighi SH, Mehrabani D, Khademolhosseini F. Hepatitis D in chronic active hepatitis B: prevalence, liver enzymes and histopathology- an epidemiological study in Shiraz, southern Iran, 2003-2004. Hepat Mon. 2008; 4(8): 248-51
  • 112. Taghvaei T, Khanlarpor M, Mahdavi Mohammad R, Tirgar Fakher H, Maleki I, Khalilian AR. Prevalence of positive Hepatitis Delta Virus in patients with positive Hepatitis B surface Antigen and its correlative factors in Sari. J Mazandaran Univ Med Sci. 2008;
  • 113. Zahedi M, Darvish-Moghaddam S, Zareei H. Clinical Impact and Frequency of Hepatitis D Virus Infection in HBsAg Positive Patients in a Southern Province of Iran (Kerman). Iran J Virol. 2010; 3(2): 1-6
  • 114. Toukan AU, Abu-El-Rub OA, Abu-Laban SA, Tarawneh MS, Kamal MF, Hadler SC, et al. The epidemiology and clinical outcome of hepatitis D virus (Delta) infection in Jordan. Hepatology. 1987; 7(6): 1340-5
  • 115. Alkandari S, Mahbut S, Nordenfelt E, al-Nakib B, al-Nakib W. Fulminant viral hepatitis in Kuwait. Ann Trop Med Parasitol. 1988; 82(6): 555-9[PubMed]
  • 116. Ramia S, El-Zaatari M, Sharara AI, Ramlawi F, Farhat B. Current prevalence of hepatitis delta virus (HDV) infection and the range of HDV genotypes in Lebanon. Epidemiol Infect. 2007; 135(6): 959-62[DOI][PubMed]
  • 117. Rioche M, Himmich H, Hansson BG, Nordenfelt E. [Low occurrence of delta agent infections in Morocco]. Bull Soc Pathol Exot Filiales. 1987; 80(5): 741-4[PubMed]
  • 118. Aghanashinikar PN, al-Dhahry SH, al-Marhuby HA, Buhl MR, Daar AS, Al-Hasani MK. Prevalence of hepatitis B, hepatitis delta, and human immunodeficiency virus infections in Omani patients with renal diseases. Transplant Proc. 1992; 24(5): 1913-4[PubMed]
  • 119. Baig S, Siddiqui AA, Ahmed WU, Qureshi H, Arif A. Frequency of hepatitis C and D super infection in patients with hepatitis B related complex liver disorders. J Coll Physicians Surg Pak. 2009; 19(11): 699-703[PubMed]
  • 120. Das K, Ali H, Mahmood T, Munir SM, Ahmed T, Farooq MU. Comparative analysis of disease activity in patients of chronic hepatitis B virus, with and without superinfection with hepatitis D virus; an experience at tertiary care centre. J Ayub Med Coll Abbottabad. 2008; 20(2): 39-42[PubMed]
  • 121. Qureshi H, Zuberi SJ, Lodi TZ, Alam E. Clinical features, course, viral markers and follow-up in young versus adult nonalcoholic cirrhotics--a retrospective study. Digestion. 1989; 42(2): 110-5[PubMed]
  • 122. Saeed Ur R, Hafiz A. Seroprevalence of HDV in hemodialysis and drug addicts in Karachi. J Coll Physicians Surg Pak. 2000; 10(12): 470-2
  • 123. Seetlani NK, Abbas Z, Raza S, Yakoob J, Jafris W. Prevalence of hepatitis D in HBsAg positive patients visiting liver clinics. J Pak Med Assoc. 2009; 59(7): 434-7[PubMed]
  • 124. Ur Rahman S, Hafiz A. Study of hepatitis D in high risk population of hepatitis B. J Coll Physicians Surg Pak. 2000; 10(1): 29-32
  • 125. Aceti A, Mohamed OM, Paparo BS, Mohamud OM, Quaranta G, Maalin KA, et al. High prevalence of anti-hepatitis delta virus antibody in chronic liver disease in Somalia. Trans R Soc Trop Med Hyg. 1991; 85(4): 541-2[PubMed]
  • 126. Aceti A, Paparo BS, Celestino D, Pennica A, Caferro M, Grilli A, et al. Sero-epidemiology of hepatitis delta virus infection in Somalia. Trans R Soc Trop Med Hyg. 1989; 83(3): 399-400[PubMed]
  • 127. Bile K, Aden C, Norder H, Magnius L, Lindberg G, Nilsson L. Important role of hepatitis C virus infection as a cause of chronic liver disease in Somalia. Scand J Infect Dis. 1993; 25(5): 559-64[PubMed]
  • 128. Bile KM, Abdirahman M, Aden C, Norder H, Magnius L, Lindberg G, et al. Minor role of hepatitis B virus in the causation of chronic liver disease in Somalia indicated by a case-control study. Trans R Soc Trop Med Hyg. 1991; 85(1): 104-8[PubMed]
  • 129. al Nasser MN, al Mugeiren MA, Assuhaimi SA, Obineche E, Onwabalili J, Ramia S. Seropositivity to hepatitis C virus in Saudi haemodialysis patients. Vox Sang. 1992; 62(2): 94-7[PubMed]
  • 130. Al Traif I, Ali A, Dafalla M, Al Tamimi W, Qassem L. Prevalence of hepatitis delta antibody among HBsAg carriers in Saudi Arabia. Ann Saudi Med. 2004; 24(5): 343-4
  • 131. Alzahrani AJ, Dela Cruz DM, Obeid OE, Bukhari HA, Al-Qahtani AA, Al-Ahdal MN. Molecular detection of hepatitis B, hepatitis C, and torque teno viruses in drug users in Saudi Arabia. J Med Virol. 2009; 81(8): 1343-7[DOI][PubMed]
  • 132. Ashraf SJ, Arya SC, Parande CM. Viral hepatitis markers in patients on haemodialysis in a hyperendemic area. J Med Virol. 1986; 19(1): 41-6[PubMed]
  • 133. Ashraf SJ, Arya SC, Parande CM, Sahay R, Ageel AR. Anti-delta antibody in primary hepatocellular carcinoma patients in the Gizan area of Saudi Arabia. Infection. 1986; 14(5): 250-1[PubMed]
  • 134. Fathalla SE, Abdulazziz FM, Sabri HS, Abdulhameed O. Seroepidemiological prevalence of hepatitis delta virus in Eastern Saudi Arabia. Annals of Saudi Medicine. 1994; 14(6): 503-6
  • 135. Njoh J, Zimmo S. Prevalence of antibody to hepatitis D virus among HBsAg-positive drug-dependent patients in Jeddah, Saudi Arabia. East Afr Med J. 1998; 75(6): 327-8[PubMed]
  • 136. Ramia S, Bahakim H. Perinatal transmission of hepatitis B virus-associated hepatitis D virus. Ann Inst Pasteur Virol. 1988; 139(3): 285-90[PubMed]
  • 137. Sheth KV, Schifano J, Carr A. Anti-delta-virus antibody in sera positive for hepatitis B surface antigen in male Saudi blood donors. Ann Saudi Med. 1989; 9(5): 463-5
  • 138. Djebbi A, Rebai WK, Bahri O, Hogga N, Sadraoui A, Triki H. [Serological markers, viral RNA and genotype of hepatitis delta virus in HBs antigen positive Tunisian patients]. Pathol Biol (Paris). 2009; 57(7-8): 518-23[DOI][PubMed]
  • 139. Jenhani F, Ayed K, Gorgi Y, Zoulim F, Pichoud C, Trepo C. Delta infection in chronic HBs Ag carriers in Tunisia: high prevalence in chronic asymptomatic HBs Ag carriers and in HBs Ag positive cirrhosis. Ann Trop Med Parasitol. 1990; 84(4): 349-53[PubMed]
  • 140. Skouri H, Gandouz R, Hammami N, Kraiem I, El Omri H. [HBeAg/Anti-HBe status, anti-HD and ALT levels in blood donors found to be chronic AgHBs carriers]. Med Mal Infect. 2004; 34(4): 181-2[PubMed]
  • 141. Triki H, Said N, Ben Salah A, Arrouji A, Ben Ahmed F, Bouguerra A, et al. Seroepidemiology of hepatitis B, C and delta viruses in Tunisia. Trans R Soc Trop Med Hyg. 1997; 91(1): 11-4[PubMed]
  • 142. el Guneid AM, Gunaid AA, O'Neill AM, Zureikat NI, Coleman JC, Murray-Lyon IM. Prevalence of hepatitis B, C, and D virus markers in Yemeni patients with chronic liver disease. J Med Virol. 1993; 40(4): 330-3[PubMed]
  • 143. Scott DA, Burans JP, al-Ouzeib HD, Arunkumar BK, al-Fadeel M, Nigad YR, et al. A seroepidemiological survey of viral hepatitis in the Yemen Arab Republic. Trans R Soc Trop Med Hyg. 1990; 84(2): 288-91[PubMed]
  • 144. Al-Arabi MA, Hyams KC, Mahgoub M. Non-A, non-B hepatitis in Omdurman, Sudan. J Med Virol. 1987; 21(3): 217-222
  • 145. Woodruff PW, Morrill JC, Burans JP, Hyams KC, Woody JN. A study of viral and rickettsial exposure and causes of fever in Juba, southern Sudan. Trans R Soc Trop Med Hyg. 1988; 82(5): 761-6[PubMed]
  • 146. Pascarella S, Negro F. Hepatitis D virus: an update. Liver Int. 2011; 31(1): 7-21[DOI][PubMed]
  • 147. Fonseca JCF, Simonetti SRR, Schatzmayr HG, Castejón MJ, Cesário ALO, Simonetti JP. Prevalence of infection with hepatitis delta virus (HDV) among carriers of hepatitis B surface antigen in Amazonas State, Brazil. Trans R Soc Trop Med Hyg. 1988; 82(3): 469-471[DOI][PubMed]
  • 148. Hadler SC, Alcala de Monzon M, Rivero D, Perez M, Bracho A, Fields H. Epidemiology and long-term consequences of hepatitis delta virus infection in the Yucpa Indians of Venezuela. Am J Epidemiol. 1992; 136(12): 1507-16[PubMed]
  • 149. Degertekin H, Yalcin K, Yakut M, Yurdaydin C. Seropositivity for delta hepatitis in patients with chronic hepatitis B and liver cirrhosis in Turkey: a meta-analysis. Liver Int. 2008; 28(4): 494-8[DOI][PubMed]
  • 150. Tsatsralt-Od B, Takahashi M, Nishizawa T, Endo K, Inoue J, Okamoto H. High prevalence of dual or triple infection of hepatitis B, C, and delta viruses among patients with chronic liver disease in Mongolia. J Med Virol. 2005; 77(4): 491-9[DOI][PubMed]
  • 151. Fattovich G, Giustina G, Christensen E, Pantalena M, Zagni I, Realdi G, et al. Influence of hepatitis delta virus infection on morbidity and mortality in compensated cirrhosis type B. The European Concerted Action on Viral Hepatitis (Eurohep). Gut. 2000; 46(3): 420-6[PubMed]
  • 152. Saracco G, Rosina F, Brunetto MR, Amoroso P, Caredda F, Farci P, et al. Rapidly progressive HBsAg-positive hepatitis in Italy: The role of hepatitis delta virus infection. J Hepatol. 1987; 5(3): 274-281[DOI][PubMed]
  • 153. Chang SY, Yang CL, Ko WS, Liu WC, Lin CY, Wu CH, et al. Molecular epidemiology of hepatitis D virus infection among injecting drug users with and without human immunodeficiency virus infection in Taiwan. J Clin Microbiol. 2011; 49(3): 1083-9[DOI][PubMed]
  • 154. Nwokediuko SC, Ijeoma U. Seroprevalence of antibody to HDV in Nigerians with hepatitis B virus-related liver diseases. Niger J Clin Pract. 2009; 12(4): 439-42[PubMed]
  • 155. Rapicetta M, Hailu K, Ponzetto A, Hele C, Morace G, Bekura D, et al. Delta hepatitis virus infection in ethiopia. Eur J Epidemiol. 1988; 4(2): 185-188[DOI][PubMed]
  • 156. Foupouapouognigni Y, Noah DN, Sartre MT, Njouom R. High prevalence and predominance of hepatitis delta virus genotype 1 infection in Cameroon. J Clin Microbiol. 2011; 49(3): 1162-4[DOI][PubMed]
  • 157. Kim HS, Kim SJ, Park HW, Shin WG, Kim KH, Lee JH, et al. Prevalence and clinical significance of hepatitis D virus co-infection in patients with chronic hepatitis B in Korea. J Med Virol. 2011; 83(7): 1172-7[DOI][PubMed]
  • 158. Chakraborty P, Kailash U, Jain A, Goyal R, Gupta RK, Das BC, et al. Seroprevalence of hepatitis D virus in patients with hepatitis B virus-related liver diseases. Indian J Med Res. 2005; 122(3): 254-7[PubMed]
  • 159. Chen X, Xuan M, Yin Y. [Study of HDV infection in Shandong province]. Zhonghua Liu Xing Bing Xue Za Zhi. 1998; 19(3): 138-40[PubMed]
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