Hepatitis Monthly

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Differentially Expressed Proteins in Chronic Active Hepatitis, Cirrhosis, and HCC Related to HCV Infection in Comparison With HBV Infection: A proteomics study

Jamal Sarvari 1 , 2 , 5 , Zahra Mojtahedi 1 , Seyed Ali Reza Taghavi 3 , Yasuhiro Kuramitsu 5 , Mahmoud Shamsi Shahrabadi 4 , Abbas Ghaderi 1 , * and Kazuyuki Nakamura 5
Authors Information
1 Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, IR Iran
2 Department of Bacteriology and Virology, Shiraz University of Medical Sciences, Shiraz, IR Iran
3 Department of Internal Medicine, Shiraz University of Medical Sciences, Shiraz, IR Iran
4 Department of Virology, Tehran University of Medical Sciences, Tehran, IR Iran
5 Department of Biochemistry and Functional Proteomics, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
Article information
  • Hepatitis Monthly: July 01, 2013, 13 (7); e8351
  • Published Online: July 3, 2013
  • Article Type: Research Article
  • Received: September 30, 2012
  • Revised: December 25, 2012
  • Accepted: April 19, 2013
  • DOI: 10.5812/hepatmon.8351

To Cite: Sarvari J, Mojtahedi Z, Taghavi S A R, Kuramitsu Y, Shamsi Shahrabadi M, et al. Differentially Expressed Proteins in Chronic Active Hepatitis, Cirrhosis, and HCC Related to HCV Infection in Comparison With HBV Infection: A proteomics study, Hepat Mon. 2013 ; 13(7):e8351. doi: 10.5812/hepatmon.8351.

Copyright © 2013, Kowsar Corp. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Yang JD, Roberts LR. Hepatocellular carcinoma: A global view. Nat Rev Gastroenterol Hepatol. 2010; 7(8): 448-58[DOI][PubMed]
  • 2. Kuramitsu Y, Nakamura K. Proteomic analysis of cancer tissues: shedding light on carcinogenesis and possible biomarkers. Proteomics. 2006; 6(20): 5650-61[DOI][PubMed]
  • 3. Lavanchy D. The global burden of hepatitis C. Liver Int. 2009; 29 Suppl 1: 74-81[DOI][PubMed]
  • 4. McMahon BJ. The natural history of chronic hepatitis B virus infection. Hepatology. 2009; 49(5 Suppl)-55[DOI][PubMed]
  • 5. El-Serag HB, Rudolph KL. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology. 2007; 132(7): 2557-76[DOI][PubMed]
  • 6. Fattovich G. Natural history and prognosis of hepatitis B. Semin Liver Dis. 2003; 23(1): 47-58[DOI][PubMed]
  • 7. Fattovich G, Stroffolini T, Zagni I, Donato F. Hepatocellular carcinoma in cirrhosis: incidence and risk factors. Gastroenterology. 2004; 127(5 Suppl 1)-50[PubMed]
  • 8. Takashima M, Kuramitsu Y, Yokoyama Y, Iizuka N, Harada T, Fujimoto M, et al. Proteomic analysis of autoantibodies in patients with hepatocellular carcinoma. Proteomics. 2006; 6(13): 3894-900[DOI][PubMed]
  • 9. Pateron D, Ganne N, Trinchet JC, Aurousseau MH, Mal F, Meicler C, et al. Prospective study of screening for hepatocellular carcinoma in Caucasian patients with cirrhosis. J Hepatol. 1994; 20(1): 65-71[PubMed]
  • 10. Tsai WL, Chung RT. Viral hepatocarcinogenesis. Oncogene. 2010; 29(16): 2309-24[DOI][PubMed]
  • 11. Kuramitsu Y, Nakamura K. Current progress in proteomic study of hepatitis C virus-related human hepatocellular carcinoma. Expert Rev Proteomics. 2005; 2(4): 589-601[DOI][PubMed]
  • 12. Miyagawa S, Kawasaki S, Makuuchi M. Comparison of the characteristics of hepatocellular carcinoma between hepatitis B and C viral infection: tumor multicentricity in cirrhotic liver with hepatitis C. Hepatology. 1996; 24(2): 307-10[DOI][PubMed]
  • 13. Kim W, Oe Lim S, Kim JS, Ryu YH, Byeon JY, Kim HJ, et al. Comparison of proteome between hepatitis B virus- and hepatitis C virus-associated hepatocellular carcinoma. Clin Cancer Res. 2003; 9(15): 5493-500[PubMed]
  • 14. Sarvari J, Mojtahedi Z, Kuramitsu Y, Malek-Hosseini SA, Shamsi Shahrabadi M, Ghaderi A, et al. Differential expression of haptoglobin isoforms in chronic active hepatitis, cirrhosis and HCC related to HBV infection. Oncol Lett. 2011; 2(5): 871-77[DOI][PubMed]
  • 15. Keyvani H, Alizadeh AH, Alavian SM, Ranjbar M, Hatami S. Distribution frequency of hepatitis C virus genotypes in 2231 patients in Iran. Hepatol Res. 2007; 37(2): 101-3[DOI][PubMed]
  • 16. Mojiri A, Behzad-Behbahani A, Saberifirozi M, Ardabili M, Beheshti M, Rahsaz M, et al. Hepatitis B virus genotypes in southwest Iran: molecular, serological and clinical outcomes. World J Gastroenterol. 2008; 14(10): 1510-3[PubMed]
  • 17. Yan JX, Wait R, Berkelman T, Harry RA, Westbrook JA, Wheeler CH, et al. A modified silver staining protocol for visualization of proteins compatible with matrix-assisted laser desorption/ionization and electrospray ionization-mass spectrometry. Electrophoresis. 2000; 21(17): 3666-72[PubMed]
  • 18. Yousefi Z, Sarvari J, Nakamura K, Kuramitsu Y, Ghaderi A, Mojtahedi Z. Secretomic analysis of large cell lung cancer cell lines using two-dimensional gel electrophoresis coupled to mass spectrometry. Folia Histochem Cytobiol. 2012; 50(3): 368-74[DOI][PubMed]
  • 19. Gangadharan B, Antrobus R, Dwek RA, Zitzmann N. Novel serum biomarker candidates for liver fibrosis in hepatitis C patients. Clin Chem. 2007; 53(10): 1792-9[DOI][PubMed]
  • 20. Gray J, Chattopadhyay D, Beale GS, Patman GL, Miele L, King BP, et al. A proteomic strategy to identify novel serum biomarkers for liver cirrhosis and hepatocellular cancer in individuals with fatty liver disease. BMC Cancer. 2009; 9: 271[DOI][PubMed]
  • 21. Kim WK, Hwang HR, Kim do H, Lee PY, In YJ, Ryu HY, et al. Glycoproteomic analysis of plasma from patients with atopic dermatitis: CD5L and ApoE as potential biomarkers. Exp Mol Med. 2008; 40(6): 677-85[DOI][PubMed]
  • 22. Yu HR, Kuo HC, Sheen JM, Wang L, Lin IC, Wang CL, et al. A unique plasma proteomic profiling with imbalanced fibrinogen cascade in patients with Kawasaki disease. Pediatr Allergy Immunol. 2009; 20(7): 699-707[DOI][PubMed]
  • 23. Sarrias MR, Rosello S, Sanchez-Barbero F, Sierra JM, Vila J, Yelamos J, et al. A role for human Sp alpha as a pattern recognition receptor. J Biol Chem. 2005; 280(42): 35391-8[DOI][PubMed]
  • 24. Sarrias MR, Padilla O, Monreal Y, Carrascal M, Abian J, Vives J, et al. Biochemical characterization of recombinant and circulating human Spalpha. Tissue Antigens. 2004; 63(4): 335-44[PubMed]
  • 25. Tabone M, Secreto P, Marini C, Bonardi R, Boero M, Taraglio S, et al. Pre-treatment levels of anti-HCV core IgM antibodies are closely associated with response to alpha interferon therapy in chronic hepatitis C patients. Eur J Gastroenterol Hepatol. 1997; 9(3): 287-91[PubMed]
  • 26. Cheung KJ, Tilleman K, Deforce D, Colle I, Van Vlierberghe H. The HCV serum proteome: a search for fibrosis protein markers. J Viral Hepat. 2009; 16(6): 418-29[DOI][PubMed]
  • 27. Andersen JD, Boylan KL, Xue FS, Anderson LB, Witthuhn BA, Markowski TW, et al. Identification of candidate biomarkers in ovarian cancer serum by depletion of highly abundant proteins and differential in-gel electrophoresis. Electrophoresis. 2010; 31(4): 599-610[DOI][PubMed]
  • 28. Haupt H, Baudner S. [Isolation and characterization of an unknown, leucine-rich 3.1-S-alpha2-glycoprotein from human serum (author's transl)]. Hoppe Seylers Z Physiol Chem. 1977; 358(6): 639-46[PubMed]
  • 29. Tanizaki H, Ryu M, Kinoshita T, Kawano N, Konishi M, Cho A, et al. Comparison of clinical features and survival in patients with hepatitis B and C virus-related hepatocellular carcinoma. Jpn J Clin Oncol. 1997; 27(2): 67-70[PubMed]
  • 30. Lee J, Wu CC, Lee KJ, Chuang TH, Katakura K, Liu YT, et al. Activation of anti-hepatitis C virus responses via Toll-like receptor 7. Proc Natl Acad Sci U S A. 2006; 103(6): 1828-33[DOI][PubMed]
  • 31. Ahmed N, Barker G, Oliva KT, Hoffmann P, Riley C, Reeve S, et al. Proteomic-based identification of haptoglobin-1 precursor as a novel circulating biomarker of ovarian cancer. Br J Cancer. 2004; 91(1): 129-40[DOI][PubMed]
  • 32. Chen CB, Su YC, Huang TT, Ho HC, Chang YT, Tung YT, et al. Differentially expressed serum haptoglobin alpha chain isoforms with potential application for diagnosis of head and neck cancer. Clin Chim Acta. 2008; 398(1-2): 48-52[DOI][PubMed]
  • 33. Fleming CE, Nunes AF, Sousa MM. Transthyretin: more than meets the eye. Prog Neurobiol. 2009; 89(3): 266-76[DOI][PubMed]
  • 34. Albuquerque LM, Trugilho MR, Chapeaurouge A, Jurgilas PB, Bozza PT, Bozza FA, et al. Two-dimensional difference gel electrophoresis (DiGE) analysis of plasmas from dengue fever patients. J Proteome Res. 2009; 8(12): 5431-41[DOI][PubMed]
  • 35. Borish L, King MS, Mascali JJ, Johnson S, Coll B, Rosenwasser LJ. Transthyretin is an inhibitor of monocyte and endothelial cell interleukin-1 production. Inflammation. 1992; 16(5): 471-84[PubMed]
  • 36. Quaye IK. Haptoglobin, inflammation and disease. Trans R Soc Trop Med Hyg. 2008; 102(8): 735-42[DOI][PubMed]
  • 37. Zhang Z, Bast RC, Jr, Yu Y, Li J, Sokoll LJ, Rai AJ, et al. Three biomarkers identified from serum proteomic analysis for the detection of early stage ovarian cancer. Cancer Res. 2004; 64(16): 5882-90[DOI][PubMed]
  • 38. Ren F, Chen Y, Wang Y, Yan Y, Zhao J, Ding M, et al. Comparative serum proteomic analysis of patients with acute-on-chronic liver failure: alpha-1-acid glycoprotein maybe a candidate marker for prognosis of hepatitis B virus infection. J Viral Hepat. 2010; 17(11): 816-24[DOI][PubMed]
  • 39. Mondal G, Chatterjee U, Das HR, Chatterjee BP. Enhanced expression of alpha1-acid glycoprotein and fucosylation in hepatitis B patients provides an insight into pathogenesis. Glycoconj J. 2009; 26(9): 1225-34[DOI][PubMed]
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