Hepatitis Monthly

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The effects of Leptin and Adiponectin on Pdx1, Foxm1, and PPARγ Transcription in Rat Islets of Langerhans

Mandana Mahmoodzadeh Sagheb 1 , Negar Azarpira 2 , * , Mokhtar Mokhtary 3 , Sayyed Ebrahim Hosseini 1 and Ramin Yaghobi 2
Authors Information
1 Department of Biology, Science and Research Branch, Islamic Azad University, Shiraz, IR Iran
2 Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran
3 Department of Biology, Kazeroon Branch, Islamic Azad University, Kazeroon, IR Iran
Article information
  • Hepatitis Monthly: June 01, 2013, 13 (6); e9055
  • Published Online: June 22, 2013
  • Article Type: Research Article
  • Received: November 9, 2012
  • Revised: March 5, 2013
  • Accepted: April 6, 2013
  • DOI: 10.5812/hepatmon.9055

To Cite: Mahmoodzadeh Sagheb M, Azarpira N, Mokhtary M, Hosseini S E, Yaghobi R. The effects of Leptin and Adiponectin on Pdx1, Foxm1, and PPARγ Transcription in Rat Islets of Langerhans, Hepat Mon. 2013 ; 13(6):e9055. doi: 10.5812/hepatmon.9055.

Copyright © 2013, Kowsar Corp. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
  • 1. Sachdeva MM, Stoffers DA. Minireview: Meeting the demand for insulin: molecular mechanisms of adaptive postnatal beta-cell mass expansion. Mol Endocrinol. 2009; 23(6): 747-58[DOI][PubMed]
  • 2. Klaus S. Adipose tissue as a regulator of energy balance. Curr Drug Targets. 2004; 5(3): 241-50[PubMed]
  • 3. Ahima RS, Lazar MA. Adipokines and the peripheral and neural control of energy balance. Mol Endocrinol. 2008; 22(5): 1023-31[DOI][PubMed]
  • 4. Bandaru P, Shankar A. Association between plasma leptin levels and diabetes mellitus. Metab Syndr Relat Disord. 2011; 9(1): 19-23[DOI][PubMed]
  • 5. Kiess W, Anil M, Blum WF, Englaro P, Juul A, Attanasio A, et al. Serum leptin levels in children and adolescents with insulin-dependent diabetes mellitus in relation to metabolic control and body mass index. Eur J Endocrinol. 1998; 138(5): 501-9[PubMed]
  • 6. Swarbrick MM, Havel PJ. Physiological, pharmacological, and nutritional regulation of circulating adiponectin concentrations in humans. Metab Syndr Relat Disord. 2008; 6(2): 87-102[DOI][PubMed]
  • 7. Seufert J. Leptin effects on pancreatic beta-cell gene expression and function. diabetes. 2004; 53 Suppl 1: 152-8[PubMed]
  • 8. Seufert J, Kieffer TJ, Leech CA, Holz GG, Moritz W, Ricordi C, et al. Leptin suppression of insulin secretion and gene expression in human pancreatic islets: implications for the development of adipogenic diabetes mellitus. J Clin Endocrinol Metab. 1999; 84(2): 670-6[PubMed]
  • 9. Pallett AL, Morton NM, Cawthorne MA, Emilsson V. Leptin inhibits insulin secretion and reduces insulin mRNA levels in rat isolated pancreatic islets. Biochem Biophys Res Commun. 1997; 238(1): 267-70[DOI][PubMed]
  • 10. Marroqui L, Gonzalez A, Neco P, Caballero-Garrido E, Vieira E, Ripoll C, et al. Role of leptin in the pancreatic beta-cell: effects and signaling pathways. J Mol Endocrinol. 2012; 49(1)-17[DOI][PubMed]
  • 11. Winzell MS, Nogueiras R, Dieguez C, Ahren B. Dual action of adiponectin on insulin secretion in insulin-resistant mice. Biochem Biophys Res Commun. 2004; 321(1): 154-60[DOI][PubMed]
  • 12. Dai C, Brissova M, Hang Y, Thompson C, Poffenberger G, Shostak A, et al. Islet-enriched gene expression and glucose-induced insulin secretion in human and mouse islets. Diabetologia. 2012; 55(3): 707-18[DOI][PubMed]
  • 13. Sachdeva MM, Claiborn KC, Khoo C, Yang J, Groff DN, Mirmira RG, et al. Pdx1 (MODY4) regulates pancreatic beta cell susceptibility to ER stress. Proc Natl Acad Sci U S A. 2009; 106(45): 19090-5[DOI][PubMed]
  • 14. Masuda K, Okamoto Y, Tsuura Y, Kato S, Miura T, Tsuda K, et al. Effects of Troglitazone (CS-045) on insulin secretion in isolated rat pancreatic islets and HIT cells: an insulinotropic mechanism distinct from glibenclamide. Diabetologia. 1995; 38(1): 24-30[PubMed]
  • 15. Brown JE, Conner AC, Digby JE, Ward KL, Ramanjaneya M, Randeva HS, et al. Regulation of beta-cell viability and gene expression by distinct agonist fragments of adiponectin. Peptides. 2010; 31(5): 944-9[DOI][PubMed]
  • 16. Kaneto H, Miyatsuka T, Kawamori D, Yamamoto K, Kato K, Shiraiwa T, et al. PDX-1 and MafA play a crucial role in pancreatic beta-cell differentiation and maintenance of mature beta-cell function. Endocr J. 2008; 55(2): 235-52[PubMed]
  • 17. Davis DB, Lavine JA, Suhonen JI, Krautkramer KA, Rabaglia ME, Sperger JM, et al. FoxM1 is up-regulated by obesity and stimulates beta-cell proliferation. Mol Endocrinol. 2010; 24(9): 1822-34[DOI][PubMed]
  • 18. Zhang H, Ackermann AM, Gusarova GA, Lowe D, Feng X, Kopsombut UG, et al. The FoxM1 transcription factor is required to maintain pancreatic beta-cell mass. Mol Endocrinol. 2006; 20(8): 1853-66[DOI][PubMed]
  • 19. Havel PJ. Role of adipose tissue in body-weight regulation: mechanisms regulating leptin production and energy balance. Proc Nutr Soc. 2000; 59(3): 359-71[PubMed]
  • 20. Kharroubi I, Rasschaert J, Eizirik DL, Cnop M. Expression of adiponectin receptors in pancreatic beta cells. Biochem Biophys Res Commun. 2003; 312(4): 1118-22[PubMed]
  • 21. Melloul D, Marshak S, Cerasi E. Regulation of insulin gene transcription. Diabetologia. 2002; 45(3): 309-26[DOI][PubMed]
  • 22. Bernardo AS, Hay CW, Docherty K. Pancreatic transcription factors and their role in the birth, life and survival of the pancreatic beta cell. Mol Cell Endocrinol. 2008; 294(1-2): 1-9[DOI][PubMed]
  • 23. Mehrabian M, Schulthess FT, Nebohacova M, Castellani LW, Zhou Z, Hartiala J, et al. Identification of ALOX5 as a gene regulating adiposity and pancreatic function. Diabetologia. 2008; 51(6): 978-88[DOI][PubMed]
  • 24. Welters HJ, McBain SC, Tadayyon M, Scarpello JH, Smith SA, Morgan NG. Expression and functional activity of PPARgamma in pancreatic beta cells. Br J Pharmacol. 2004; 142(7): 1162-70[DOI][PubMed]
  • 25. Zhou Y, Jia X, Qin J, Lu C, Zhu H, Li X, et al. Leptin inhibits PPARgamma gene expression in hepatic stellate cells in the mouse model of liver damage. Mol Cell Endocrinol. 2010; 323(2): 193-200[DOI][PubMed]
  • 26. Banga A, Unal R, Tripathi P, Pokrovskaya I, Owens RJ, Kern PA, et al. Adiponectin translation is increased by the PPARgamma agonists pioglitazone and omega-3 fatty acids. Am J Physiol Endocrinol Metab. 2009; 296(3)-9[DOI][PubMed]
  • 27. Zhao AZ, Bornfeldt KE, Beavo JA. Leptin inhibits insulin secretion by activation of phosphodiesterase 3B. J Clin Invest. 1998; 102(5): 869-73[DOI][PubMed]
  • 28. Staiger K, Stefan N, Staiger H, Brendel MD, Brandhorst D, Bretzel RG, et al. Adiponectin is functionally active in human islets but does not affect insulin secretory function or beta-cell lipoapoptosis. J Clin Endocrinol Metab. 2005; 90(12): 6707-13[DOI][PubMed]
  • 29. Gu W, Li X, Liu C, Yang J, Ye L, Tang J, et al. Globular adiponectin augments insulin secretion from pancreatic islet beta cells at high glucose concentrations. Endocrine. 2006; 30(2): 217-21[DOI][PubMed]
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