Hepatitis Monthly

Published by: Kowsar

Normal Limit for Serum Alanine Aminotransferase Level and Distribution of Metabolic Factors in Old Population of Kalaleh, Iran

Ali Kabir 1 , 2 , Akram Pourshams 3 , * , Masoud Khoshnia 4 and Fatemeh Malekzadeh 3
Authors Information
1 Department of Epidemiology, Faculty of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran
2 Center for Educational Research in Medical Sciences, Tehran University of Medical Sciences, Tehran, IR Iran
3 Digestive Disease Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, IR Iran
4 Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, IR Iran
Article information
  • Hepatitis Monthly: October 01, 2013, 13 (10); e10640
  • Published Online: October 20, 2013
  • Article Type: Research Article
  • Received: February 9, 2013
  • Accepted: April 15, 2013
  • DOI: 10.5812/hepatmon.10640

To Cite: Kabir A, Pourshams A, Khoshnia M, Malekzadeh F. Normal Limit for Serum Alanine Aminotransferase Level and Distribution of Metabolic Factors in Old Population of Kalaleh, Iran, Hepat Mon. 2013 ; 13(10):e10640. doi: 10.5812/hepatmon.10640.

Copyright © 2013, Kowsar Corp. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Kim HC, Nam CM, Jee SH, Han KH, Oh DK, Suh I. Normal serum aminotransferase concentration and risk of mortality from liver diseases: prospective cohort study. BMJ. 2004; 328(7446): 983[DOI][PubMed]
  • 2. Pratt DS, Kaplan MM. Evaluation of abnormal liver-enzyme results in asymptomatic patients. N Engl J Med. 2000; 342(17): 1266-71[DOI][PubMed]
  • 3. Karmen A, Wroblewski F, Ladue JS. Transaminase activity in human blood. J Clin Invest. 1955; 34(1): 126-31[DOI][PubMed]
  • 4. Pourshams A, Malekzadeh R, Monavvari A, Akbari MR, Mohamadkhani A, Yarahmadi S, et al. Prevalence and etiology of persistently elevated alanine aminotransferase levels in healthy Iranian blood donors. J Gastroenterol Hepatol. 2005; 20(2): 229-33[DOI][PubMed]
  • 5. Pagano G, Pacini G, Musso G, Gambino R, Mecca F, Depetris N, et al. Nonalcoholic steatohepatitis, insulin resistance, and metabolic syndrome: further evidence for an etiologic association. Hepatology. 2002; 35(2): 367-72[DOI][PubMed]
  • 6. Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults. 1998;
  • 7. Alberti KG, Zimmet P, Shaw J. Metabolic syndrome--a new world-wide definition. A Consensus Statement from the International Diabetes Federation. Diabet Med. 2006; 23(5): 469-80[DOI][PubMed]
  • 8. Delavari A, Forouzanfar MH, Alikhani S, Sharifian A, Kelishadi R. First nationwide study of the prevalence of the metabolic syndrome and optimal cutoff points of waist circumference in the Middle East: the national survey of risk factors for noncommunicable diseases of Iran. Diabetes Care. 2009; 32(6): 1092-7[DOI][PubMed]
  • 9. Azizi F, Hadaegh F, Khalili D, Esteghamati A, Hosseinpanah F, Delavari A, et al. Appropriate definition of metabolic syndrome among Iranian adults: report of the Iranian National Committee of Obesity. Arch Iran Med. 2010; 13(5): 426-8[PubMed]
  • 10. Gharipour M, Sarrafzadegan N, Sadeghi M, Andalib E, Talaie M, Shafie D, et al. Predictors of metabolic syndrome in the Iranian population: waist circumference, body mass index, or waist to hip ratio? Cholesterol. 2013; 2013: 198384[DOI][PubMed]
  • 11. Piton A, Poynard T, Imbert-Bismut F, Khalil L, Delattre J, Pelissier E, et al. Factors associated with serum alanine transaminase activity in healthy subjects: consequences for the definition of normal values, for selection of blood donors, and for patients with chronic hepatitis C. MULTIVIRC Group. Hepatology. 1998; 27(5): 1213-9[DOI][PubMed]
  • 12. Prati D, Taioli E, Zanella A, Della Torre E, Butelli S, Del Vecchio E, et al. Updated definitions of healthy ranges for serum alanine aminotransferase levels. Ann Intern Med. 2002; 137(1): 1-10[PubMed]
  • 13. Mohamadnejad M, Pourshams A, Malekzadeh R, Mohamadkhani A, Rajabiani A, Asgari AA, et al. Healthy ranges of serum alanine aminotransferase levels in Iranian blood donors. World J Gastroenterol. 2003; 9(10): 2322-4[PubMed]
  • 14. Jamali R, Pourshams A, Amini S, Deyhim MR, Rezvan H, Malekzadeh R. The upper normal limit of serum alanine aminotransferase in Golestan Province, northeast Iran. Arch Iran Med. 2008; 11(6): 602-7[PubMed]
  • 15. Malekzadeh F, Marshall T, Pourshams A, Gharravi M, Aslani A, Nateghi A, et al. A pilot double-blind randomised placebo-controlled trial of the effects of fixed-dose combination therapy ('polypill') on cardiovascular risk factors. Int J Clin Pract. 2010; 64(9): 1220-7[DOI][PubMed]
  • 16. Elinav E, Ben-Dov IZ, Ackerman E, Kiderman A, Glikberg F, Shapira Y, et al. Correlation between serum alanine aminotransferase activity and age: an inverted U curve pattern. Am J Gastroenterol. 2005; 100(10): 2201-4[DOI][PubMed]
  • 17. Leclercq I, Horsmans Y, De Bruyere M, Geubel AP. Influence of body mass index, sex and age on serum alanine aminotransferase (ALT) level in healthy blood donors. Acta Gastroenterol Belg. 1999; 62(1): 16-20[PubMed]
  • 18. Hsieh MH, Lin WY, Chien HH, Chien LH, Huang CK, Yang JF, et al. Waist circumference, body mass index, serum uric acid, blood sugar, and triglyceride levels are important risk factors for abnormal liver function tests in the Taiwanese population. Kaohsiung J Med Sci. 2012; 28(9): 470-6[DOI][PubMed]
  • 19. Saligram S, Williams EJ, Masding MG. Raised liver enzymes in newly diagnosed Type 2 diabetes are associated with weight and lipids, but not glycaemic control. Indian J Endocrinol Metab. 2012; 16(6): 1012-4[DOI][PubMed]
  • 20. Jeong SK, Nam HS, Rhee JA, Shin JH, Kim JM, Cho KH. Metabolic syndrome and ALT: a community study in adult Koreans. Int J Obes Relat Metab Disord. 2004; 28(8): 1033-8[DOI][PubMed]
  • 21. Liangpunsakul S, Chalasani N. Unexplained elevations in alanine aminotransferase in individuals with the metabolic syndrome: results from the third National Health and Nutrition Survey (NHANES III). Am J Med Sci. 2005; 329(3): 111-6[PubMed]
  • 22. Wannamethee SG, Shaper AG, Lennon L, Whincup PH. Hepatic enzymes, the metabolic syndrome, and the risk of type 2 diabetes in older men. Diabetes Care. 2005; 28(12): 2913-8[PubMed]
  • 23. Hadaegh F, Zabetian A, Khalili D, Safarkhani M, Philip TJW, Azizi F. A new approach to compare the predictive power of metabolic syndrome defined by a joint interim statement versus its components for incident cardiovascular disease in Middle East Caucasian residents in Tehran. J Epidemiol Community Health. 2012; 66(5): 427-32[DOI][PubMed]
  • 24. Schwimmer JB, McGreal N, Deutsch R, Finegold MJ, Lavine JE. Influence of gender, race, and ethnicity on suspected fatty liver in obese adolescents. Pediatrics. 2005; 115(5)-5[DOI][PubMed]
  • 25. Bilal M, Tariq A, Khan S, Quratulain , Shahid MF, Khan MW, et al. Influence of gender, BMI, and ethnicity on serum ALT levels of healthy students of a medical school. J Ayub Med Coll Abbottabad. 2011; 23(1): 70-2[PubMed]
  • 26. Abnet CC, Saadatian-Elahi M, Pourshams A, Boffetta P, Feizzadeh A, Brennan P, et al. Reliability and validity of opiate use self-report in a population at high risk for esophageal cancer in Golestan, Iran. Cancer Epidemiol Biomarkers Prev. 2004; 13(6): 1068-70[PubMed]
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