Hepatitis Monthly

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The Relationship between Intestinal Motility and Interstitial Cells of Cajal in Nonalcoholic Fatty Liver Mice

Ming-Liang Lu 1 , Hua Huang 1 , * , Li-Ming Liu 1 and Jiang Chang 1
Authors Information
1 Department of Gastroenterology, The Second Affiliated Hospital of Kunming Medical University, Kunming, China
Article information
  • Hepatitis Monthly: October 01, 2013, 13 (10); e13674
  • Published Online: October 1, 2013
  • Article Type: Research Article
  • Received: July 18, 2013
  • Revised: September 14, 2013
  • Accepted: September 21, 2013
  • DOI: 10.5812/hepatmon.13674

To Cite: Lu M, Huang H, Liu L, Chang J. The Relationship between Intestinal Motility and Interstitial Cells of Cajal in Nonalcoholic Fatty Liver Mice, Hepat Mon. 2013 ; 13(10):e13674. doi: 10.5812/hepatmon.13674.

Copyright © 2013, Kowsar Corp. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
  • 1. Lomonaco R, Sunny NE, Bril F, Cusi K. Nonalcoholic fatty liver disease: current issues and novel treatment approaches. Drugs. 2013; 73(1): 1-14[DOI][PubMed]
  • 2. Houghton-Rahrig LD, Schutte DL, von Eye A, Fenton JI, Given BA, Hord NG. Exploration of a symptoms experience in people with obesity-related nonalcoholic fatty liver disease. Nurs Outlook. 2013; 61(4): 242-251 e2[DOI][PubMed]
  • 3. Haycock JW, Bro S. Corpus striatum (Translation of S. Ramon y Cajal). translated from Corps Strie, chapter 23, in "Histologie du systeme nerveux de l'homme et des vertebres" 1911. Behav Biol. 1975; 14(3): 387-402[PubMed]
  • 4. Klein S, Seidler B, Kettenberger A, Sibaev A, Rohn M, Feil R, et al. Interstitial cells of Cajal integrate excitatory and inhibitory neurotransmission with intestinal slow-wave activity. Nat Commun. 2013; 4: 1630[DOI][PubMed]
  • 5. Soza A, Riquelme A, Gonzalez R, Alvarez M, Perez-Ayuso RM, Glasinovic JC, et al. Increased orocecal transit time in patients with nonalcoholic fatty liver disease. Dig Dis Sci. 2005; 50(6): 1136-40[PubMed]
  • 6. Wu WC, Zhao W, Li S. Small intestinal bacteria overgrowth decreases small intestinal motility in the NASH rats. World J Gastroenterol. 2008; 14(2): 313-7[PubMed]
  • 7. Fan JG, Zhong L, Wang GL, Xu XN, Jing DD, Zhang PL. The role of Kupffer cells in the pathogenesis of nonalcoholic steatohepatitis. ZhonghuaGanzangbing Zazhi. 2001; 9: 16-8
  • 8. Zhonglan , Fanjiangao , Wangguoliang , Wuweiqing , Shiqi . The establishment of obesity, hyperlipidemia steatohepatitis mode. Shiyan dongwu kexue yu luanli. 2000; 17(2): 16-20
  • 9. Wilkins T, Tadkod A, Hepburn I, Schade RR. Nonalcoholic Fatty liver disease: diagnosis and management. Am Fam Physician. 2013; 88(1): 35-42[PubMed]
  • 10. Zhu J-Z, Ji T-H, Liu Q-H. Study of Cajal interstitial cells in intestine of rats with liver cirrhosis. Acad J Sec Mil Med Univ. 2006; 27: 65-7
  • 11. Browning JD, Szczepaniak LS, Dobbins R, Nuremberg P, Horton JD, Cohen JC, et al. Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology. 2004; 40(6): 1387-95[DOI][PubMed]
  • 12. Musso G, Gambino R, Cassader M, Pagano G. Meta-analysis: natural history of non-alcoholic fatty liver disease (NAFLD) and diagnostic accuracy of non-invasive tests for liver disease severity. Ann Med. 2011; 43(8): 617-49[DOI][PubMed]
  • 13. Vernon G, Baranova A, Younossi ZM. Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults. Aliment Pharmacol Ther. 2011; 34(3): 274-85[DOI][PubMed]
  • 14. Lieverse RJ, Jansen JB, Masclee AA, Lamers CB. Gastrointestinal disturbances with obesity. Scand J Gastroenterol Suppl. 1993; 200: 53-8[PubMed]
  • 15. Daniel EE. Communication between interstitial cells of Cajal and gastrointestinal muscle. Neurogastroenterol Motil. 2004; 16 Suppl 1: 118-22[DOI][PubMed]
  • 16. Takaki M. Gut pacemaker cells: the interstitial cells of Cajal (ICC). J Smooth Muscle Res. 2003; 39(5): 137-61[PubMed]
  • 17. Kim BJ, Chang IY, Choi S, Jun JY, Jeon JH, Xu WX, et al. Involvement of Na(+)-leak channel in substance P-induced depolarization of pacemaking activity in interstitial cells of Cajal. Cell Physiol Biochem. 2012; 29(3-4): 501-10[DOI][PubMed]
  • 18. Kim BJ, Chang IY, So I. Pharmacological differences of endothelin receptors-mediated modulation in cultured interstitial cells of Cajal from the murine small and large intestine. Cell Physiol Biochem. 2012; 30(2): 359-71[DOI][PubMed]
  • 19. Kim BJ, Lim HH, Yang DK, Jun JY, Chang IY, Park CS, et al. Melastatin-type transient receptor potential channel 7 is required for intestinal pacemaking activity. Gastroenterology. 2005; 129(5): 1504-17[DOI][PubMed]
  • 20. Koh SD, Jun JY, Kim TW, Sanders KM. A Ca(2+)-inhibited non-selective cation conductance contributes to pacemaker currents in mouse interstitial cell of Cajal. J Physiol. 2002; 540: 803-14[PubMed]
  • 21. Sanders KM. A case for interstitial cells of Cajal as pacemakers and mediators of neurotransmission in the gastrointestinal tract. Gastroenterology. 1996; 111(2): 492-515[PubMed]
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