Hepatitis Monthly

Published by: Kowsar

Hyaluronic Acid: From Biochemical Characteristics to its Clinical Translation in Assessment of Liver Fibrosis

Sahar Rostami 1 , 2 and Hadi Parsian 3 , 4 , *
Authors Information
1 Student Research Committee, Babol University of Medical Sciences, Babol, IR Iran
2 Department of Biochemistry, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, IR Iran
3 Cellular and Molecular Biology Research Center, Babol University of Medical Sciences, Babol, IR Iran
4 Department of Biochemistry and Biophysics, Babol University of Medical Sciences, Babol, IR Iran
Article information
  • Hepatitis Monthly: December 01, 2013, 13 (12); e13787
  • Published Online: December 14, 2013
  • Article Type: Review Article
  • Received: July 24, 2013
  • Revised: August 24, 2013
  • Accepted: November 21, 2013
  • DOI: 10.5812/hepatmon.13787

To Cite: Rostami S, Parsian H. Hyaluronic Acid: From Biochemical Characteristics to its Clinical Translation in Assessment of Liver Fibrosis, Hepat Mon. 2013 ; 13(12):e13787. doi: 10.5812/hepatmon.13787.

Copyright © 2013, Kowsar Corp. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Context
2. Evidence Acquisition
3. Results
4. Conclusions
  • 1. Boyer TD, Manns MP, Sanyal AJ. Zakim and boyerʼs hepatology. 2006; : 87-109
  • 2. Rossi E, Adams LA, Bulsara M, Jeffrey GP. Assessing liver fibrosis with serum marker models. Clin Biochem Rev. 2007; 28(1): 3-10[PubMed]
  • 3. Kershenobich Stalnikowitz D, Weissbrod AB. Liver fibrosis and inflammation. A review. Ann Hepatol. 2003; 2(4): 159-63[PubMed]
  • 4. Guechot J, Laudat A, Loria A, Serfaty L, Poupon R, Giboudeau J. Diagnostic accuracy of hyaluronan and type III procollagen amino-terminal peptide serum assays as markers of liver fibrosis in chronic viral hepatitis C evaluated by ROC curve analysis. Clin Chem. 1996; 42(4): 558-63[PubMed]
  • 5. Resino S, Bellon JM, Asensio C, Micheloud D, Miralles P, Vargas A, et al. Can serum hyaluronic acid replace simple non-invasive indexes to predict liver fibrosis in HIV/Hepatitis C coinfected patients? BMC Infect Dis. 2010; 10: 244[DOI][PubMed]
  • 6. McHutchison JG, Blatt LM, de Medina M, Craig JR, Conrad A, Schiff ER, et al. Measurement of serum hyaluronic acid in patients with chronic hepatitis C and its relationship to liver histology. J Gastroenterol Hepatol. 2000; 15(8): 945-51[PubMed]
  • 7. Wong GLH. Update of liver fibrosis and steatosis with transient elastography (Fibroscan). Gastroenterol Rep. 2013; [DOI]
  • 8. Halfon P, Bourliere M, Penaranda G, Deydier R, Renou C, Botta-Fridlund D, et al. Accuracy of hyaluronic acid level for predicting liver fibrosis stages in patients with hepatitis C virus. Comp Hepatol. 2005; 4: 6[DOI][PubMed]
  • 9. Mardini H, Record C. Detection assessment and monitoring of hepatic fibrosis: biochemistry or biopsy? Ann Clin Biochem. 2005; 42: 441-7[DOI][PubMed]
  • 10. Seven G, Karatayli SC, Kose SK, Yakut M, Kabacam G, Toruner M, et al. Serum connective tissue markers as predictors of advanced fibrosis in patients with chronic hepatitis B and D. Turk J Gastroenterol. 2011; 22(3): 305-14[PubMed]
  • 11. Serviddio G. Practical management of chronic viral hepatitis. 2013; : 91-110
  • 12. Attallah AM, Toson el SA, El-Waseef AM, Abo-Seif MA, Omran MM, Shiha GE. Discriminant function based on hyaluronic acid and its degrading enzymes and degradation products for differentiating cirrhotic from non-cirrhotic liver diseased patients in chronic HCV infection. Clin Chim Acta. 2006; 369(1): 66-72[DOI][PubMed]
  • 13. Necas J, Bartosikova L, Brauner P, Kolar J. Hyaluronic acid (hyaluronan): a review. Vet Med. 2008; 53(8): 397-411
  • 14. Kopke-Aguiar LA, Martins JR, Passerotti CC, Toledo CF, Nader HB, Borges DR. Serum hyaluronic acid as a comprehensive marker to assess severity of liver disease in schistosomiasis. Acta Trop. 2002; 84(2): 117-26[PubMed]
  • 15. Wong CS, Gibson PR. Effects of eating on plasma hyaluronan in patients with cirrhosis: its mechanism and influence on clinical interpretation. J Gastroenterol Hepatol. 1998; 13(12): 1218-24[PubMed]
  • 16. Toole BP. Hyaluronan promotes the malignant phenotype. Glycobiology. 2002; 12(3): 37R-42R[PubMed]
  • 17. Cowman MK, Matsuoka S. Experimental approaches to hyaluronan structure. Carbohydr Res. 2005; 340(5): 791-809[DOI][PubMed]
  • 18. Fraser JR, Laurent TC, Laurent UB. Hyaluronan: its nature, distribution, functions and turnover. J Intern Med. 1997; 242(1): 27-33[PubMed]
  • 19. George J, Stern R. Serum hyaluronan and hyaluronidase: very early markers of toxic liver injury. Clin Chim Acta. 2004; 348(1-2): 189-97[DOI][PubMed]
  • 20. Murray RK, Granner DK, Mayes PA, Rodwell VW. Harperʼs illustrated biochemistry. 2003;
  • 21. Jiang D, Liang J, Noble PW. Hyaluronan as an immune regulator in human diseases. Physiol Rev. 2011; 91(1): 221-64[DOI][PubMed]
  • 22. Fraser JR, Appelgren LE, Laurent TC. Tissue uptake of circulating hyaluronic acid. A whole body autoradiographic study. Cell Tissue Res. 1983; 233(2): 285-93[PubMed]
  • 23. Idobe Y, Murawaki Y, Ikuta Y, Koda M, Kawasaki H. Post-prandial serum hyaluronan concentration in patients with chronic liver disease. Intern Med. 1998; 37(7): 568-75[PubMed]
  • 24. Tangkijvanich P, Kongtawelert P, Pothacharoen P, Mahachai V, Suwangool P, Poovorawan Y. Serum hyaluronan: a marker of liver fibrosis in patients with chronic liver disease. Asian Pac J Allergy Immunol. 2003; 21(2): 115-20[PubMed]
  • 25. Stern R, Jedrzejas MJ. Hyaluronidases: their genomics, structures, and mechanisms of action. Chem Rev. 2006; 106(3): 818-39[DOI][PubMed]
  • 26. Gressner OA, Weiskirchen R, Gressner AM. Biomarkers of liver fibrosis: clinical translation of molecular pathogenesis or based on liver-dependent malfunction tests. Clin Chim Acta. 2007; 381(2): 107-13[DOI][PubMed]
  • 27. Patel K, Lajoie A, Heaton S, Pianko S, Behling CA, Bylund D, et al. Clinical use of hyaluronic acid as a predictor of fibrosis change in hepatitis C. J Gastroenterol Hepatol. 2003; 18(3): 253-7[PubMed]
  • 28. Arain SA, Meo SA, Jamal Q. Serum hyaluronic acid level does not reliably differentiate minimal and significant liver disease in chronic hepatitis C. Saudi Med J. 2011; 32(12): 1241-5[PubMed]
  • 29. Montazeri G, Estakhri A, Mohamadnejad M, Nouri N, Montazeri F, Mohammadkani A, et al. Serum hyaluronate as a non-invasive marker of hepatic fibrosis and inflammation in HBeAg-negative chronic hepatitis B. BMC Gastroenterol. 2005; 5: 32[DOI][PubMed]
  • 30. Valva P, Casciato P, Diaz Carrasco JM, Gadano A, Galdame O, Galoppo MC, et al. The role of serum biomarkers in predicting fibrosis progression in pediatric and adult hepatitis C virus chronic infection. PLoS One. 2011; 6(8)[DOI][PubMed]
  • 31. Zhang YX, Wu WJ, Zhang YZ, Feng YL, Zhou XX, Pan Q. Noninvasive assessment of liver fibrosis with combined serum aminotransferase/platelet ratio index and hyaluronic acid in patients with chronic hepatitis B. World J Gastroenterol. 2008; 14(46): 7117-21[PubMed]
  • 32. Parsian H, Rahimipour A, Nouri M, Somi MH, Qujeq D. Assessment of liver fibrosis development in chronic hepatitis B patients by serum hyaluronic acid and laminin levels. Acta Clin Croat. 2010; 49(3): 257-65[PubMed]
  • 33. Nobili V, Alisi A, Torre G, De Vito R, Pietrobattista A, Morino G, et al. Hyaluronic acid predicts hepatic fibrosis in children with nonalcoholic fatty liver disease. Transl Res. 2010; 156(4): 229-34[DOI][PubMed]
  • 34. Pares A, Deulofeu R, Gimenez A, Caballeria L, Bruguera M, Caballeria J, et al. Serum hyaluronate reflects hepatic fibrogenesis in alcoholic liver disease and is useful as a marker of fibrosis. Hepatology. 1996; 24(6): 1399-403[DOI][PubMed]
  • 35. Sakugawa H, Nakayoshi T, Kobashigawa K, Yamashiro T, Maeshiro T, Miyagi S, et al. Clinical usefulness of biochemical markers of liver fibrosis in patients with nonalcoholic fatty liver disease. World J Gastroenterol. 2005; 11(2): 255-9[PubMed]
  • 36. Suzuki A, Angulo P, Lymp J, Li D, Satomura S, Lindor K. Hyaluronic acid, an accurate serum marker for severe hepatic fibrosis in patients with non-alcoholic fatty liver disease. Liver Int. 2005; 25(4): 779-86[DOI][PubMed]
  • 37. Naveau S, Raynard B, Ratziu V, Abella A, Imbert-Bismut F, Messous D, et al. Biomarkers for the prediction of liver fibrosis in patients with chronic alcoholic liver disease. Clin Gastroenterol Hepatol. 2005; 3(2): 167-74[PubMed]
  • 38. Lebensztejn DM, Wierzbicka A, Socha P, Pronicki M, Skiba E, Werpachowska I, et al. Cytokeratin-18 and hyaluronic acid levels predict liver fibrosis in children with non-alcoholic fatty liver disease. Acta Biochim Pol. 2011; 58(4): 563-6[PubMed]
  • 39. Nanashima A, Yamaguchi H, Shibasaki S, Sawai T, Yamaguchi E, Yasutake T, et al. Measurement of serum hyaluronic acid level during the perioperative period of liver resection for evaluation of functional liver reserve. J Gastroenterol Hepatol. 2001; 16(10): 1158-63[PubMed]
  • 40. Pungpapong S, Nunes DP, Krishna M, Nakhleh R, Chambers K, Ghabril M, et al. Serum fibrosis markers can predict rapid fibrosis progression after liver transplantation for hepatitis C. Liver Transpl. 2008; 14(9): 1294-302[DOI][PubMed]
  • 41. Peters L, Mocroft A, Soriano V, Rockstroh J, Rauch A, Karlsson A, et al. Hyaluronic acid levels predict risk of hepatic encephalopathy and liver-related death in HIV/viral hepatitis coinfected patients. PLoS One. 2013; 8(5)[DOI][PubMed]
  • 42. Crawford DH, Murphy TL, Ramm LE, Fletcher LM, Clouston AD, Anderson GJ, et al. Serum hyaluronic acid with serum ferritin accurately predicts cirrhosis and reduces the need for liver biopsy in C282Y hemochromatosis. Hepatology. 2009; 49(2): 418-25[DOI][PubMed]
  • 43. Isman FK, Kucur M, Baysal B, Ozkan F. Evaluation of serum hyaluronic acid level and hyaluronidase activity in acute and chronic hepatitis C. J Int Med Res. 2007; 35(3): 346-52[PubMed]
  • 44. Bramley PN, Rathbone BJ, Forbes MA, Cooper EH, Losowsky MS. Serum hyaluronate as a marker of hepatic derangement in acute liver damage. J Hepatol. 1991; 13(1): 8-13[PubMed]
  • 45. Sadik NA, Ahmed A, Ahmed S. The significance of serum levels of adiponectin, leptin, and hyaluronic acid in hepatocellular carcinoma of cirrhotic and noncirrhotic patients. Hum Exp Toxicol. 2012; 31(4): 311-21[DOI][PubMed]
  • 46. Aghcheli K, Parsian H, Qujeq D, Talebi M, Mosapour A, Khalilipour E, et al. Serum hyaluronic acid and laminin as potential tumor markers for upper gastrointestinal cancers. Eur J Intern Med. 2012; 23(1): 58-64[DOI][PubMed]
  • 47. Parsian H, Alizadeh M, Negahdar H. Would the physicians eventually obsolete the liver biopsy for the assessment of liver fibrosis? Hepat Mon. 2012; 12(5): 353-4[DOI][PubMed]
  • 48. Geramizadeh B, Janfeshan K, Saberfiroozi M. Serum hyaluronic acid as a noninvasive marker of hepatic fibrosis in chronic hepatitis B. Saudi J Gastroenterol. 2008; 14(4): 174-7[DOI][PubMed]
  • 49. Avila RE, Carmo RA, Farah Kde P, Teixeira AL, Coimbra LV, Antunes CM, et al. Hyaluronic acid in the evaluation of liver fibrosis in patients with hepatitis C on haemodialysis. Braz J Infect Dis. 2010; 14(4): 335-41[PubMed]
  • 50. Yilmaz S, Bayan K, Tuzun Y, Dursun M, Kaplan A, Ozmen S, et al. Replacement of hystological findings: serum hyaluronic acid for fibrosis, high-sensitive C-reactive protein for necroinflamation in chronic viral hepatitis. Int J Clin Pract. 2007; 61(3): 438-43[DOI][PubMed]
  • 51. Camacho VR, Silveira TR, Oliveira JR, Barros SG, Cerski CT. Relationship between serum concetrations of type III procollagen, hyluronic acid and histopathological findings in the liver of HCV-positive blood donors. Arq Gastroenterol. 2007; 44(2): 118-22[PubMed]
  • 52. Hartley JL, Brown RM, Tybulewicz A, Hayes P, Wilson DC, Gillett P, et al. Hyaluronic acid predicts hepatic fibrosis in children with hepatic disease. J Pediatr Gastroentrol Nutr. 2006; 43(2): 217-21
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .
Readers' Comments