Hepatitis Monthly

Published by: Kowsar

GB Virus C infection in Patients With HIV/Hepatitis C Virus Coinfection: Improvement of the Liver Function in Chronic Hepatitis C

Yue Feng 1 , Li Liu 1 , Yue-Mei Feng 2 , Wenhua Zhao 3 , Zheng Li 4 , A-Mei Zhang 1 , Yuzhu Song 1 and Xueshan Xia 1 , *
Authors Information
1 Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, China
2 Research Institute of Nutrition and Food Sciences, Kunming Medical University, Kunming, China
3 The Key Laboratory of Tropical and Subtropical Animal Disease, Kunming, China
4 Department of Clinical Laboratory, The First People’s Hospital of Yunnan Province, Kunming, China
Article information
  • Hepatitis Monthly: March 01, 2014, 14 (3); e14169
  • Published Online: March 3, 2014
  • Article Type: Brief Report
  • Received: August 20, 2013
  • Revised: December 11, 2013
  • Accepted: February 9, 2014
  • DOI: 10.5812/hepatmon.14169

To Cite: Feng Y, Liu L, Feng Y, Zhao W, Li Z, et al. GB Virus C infection in Patients With HIV/Hepatitis C Virus Coinfection: Improvement of the Liver Function in Chronic Hepatitis C, Hepat Mon. 2014 ; 14(3):e14169. doi: 10.5812/hepatmon.14169.

Copyright © 2014, Kowsar Corp. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Stapleton JT, Foung S, Muerhoff AS, Bukh J, Simmonds P. The GB viruses: a review and proposed classification of GBV-A, GBV-C (HGV), and GBV-D in genus Pegivirus within the family Flaviviridae. J Gen Virol. 2011; 92: 233-46[DOI][PubMed]
  • 2. Bhattarai N, Stapleton JT. GB virus C: the good boy virus? Trends Microbiol. 2012; 20(3): 124-30[DOI][PubMed]
  • 3. Petrik J, Guella L, Wight DG, Pearson GM, Hinton J, Parker H, et al. Hepatic histology in hepatitis C virus carriers coinfected with hepatitis G virus. Gut. 1998; 42(1): 103-6[PubMed]
  • 4. Hekmat S, Mohraz M, Vahabpour R, Jam S, Bahramali G, Banifazl M, et al. Frequency and genotype of GB virus C among Iranian patients infected with HIV. J Med Virol. 2008; 80(11): 1941-6[DOI][PubMed]
  • 5. Schwarze-Zander C, Blackard JT, Zheng H, Addo MM, Lin W, Robbins GK, et al. GB virus C (GBV-C) infection in hepatitis C virus (HCV)/HIV-coinfected patients receiving HCV treatment: importance of the GBV-C genotype. J Infect Dis. 2006; 194(4): 410-9[DOI][PubMed]
  • 6. Berzsenyi MD, Bowden DS, Kelly HA, Watson KM, Mijch AM, Hammond RA, et al. Reduction in hepatitis C-related liver disease associated with GB virus C in human immunodeficiency virus coinfection. Gastroenterology. 2007; 133(6): 1821-30[DOI][PubMed]
  • 7. Schwarze-Zander C, Blackard JT, Rockstroh JK. Role of GB virus C in modulating HIV disease. Expert Rev Anti Infect Ther. 2012; 10(5): 563-72[DOI][PubMed]
  • 8. Keyvani H, Mohammadi A, Sabouri Ghannad M, Hajabdolbaghi M. The Effect of GBV-C Infection on CD4 Count and Viral Loads in Patients Infected With HIV. Hepat Mon. 2012; 12(1): 39-42[PubMed]
  • 9. Xiang J, Wunschmann S, Diekema DJ, Klinzman D, Patrick KD, George SL, et al. Effect of coinfection with GB virus C on survival among patients with HIV infection. N Engl J Med. 2001; 345(10): 707-14[DOI][PubMed]
  • 10. Bjorkman P, Flamholc L, Naucler A, Molnegren V, Wallmark E, Widell A. GB virus C during the natural course of HIV-1 infection: viremia at diagnosis does not predict mortality. AIDS. 2004; 18(6): 877-86[PubMed]
  • 11. Kaye S, Howard M, Alabi A, Hansmann A, Whittle H, Schim van der Loeff M. No observed effect of GB virus C coinfection on disease progression in a cohort of African woman infected with HIV-1 or HIV-2. Clin Infect Dis. 2005; 40(6): 876-8[DOI][PubMed]
  • 12. Ghanbari R, Ravanshad M, Hosseini SY, Yaghobi R, Shahzamani K. Genotyping and infection rate of GBV-C among Iranian HCV- infected patients. Hepat Mon. 2010; 10(2): 80-7[PubMed]
  • 13. Lin W, Weinberg EM, Chung RT. Pathogenesis of accelerated fibrosis in HIV/HCV co-infection. J Infect Dis. 2013; 207 Suppl 1-8[DOI][PubMed]
  • 14. Feng Y, Zhao W, Feng Y, Dai J, Li Z, Zhang X, et al. A novel genotype of GB virus C: its identification and predominance among injecting drug users in Yunnan, China. PLoS One. 2011; 6(10)[DOI][PubMed]
  • 15. Xia X, Lu L, Tee KK, Zhao W, Wu J, Yu J, et al. The unique HCV genotype distribution and the discovery of a novel subtype 6u among IDUs co-infected with HIV-1 in Yunnan, China. J Med Virol. 2008; 80(7): 1142-52[DOI][PubMed]
  • 16. Hofer H, Aydin I, Neumueller-Guber S, Mueller C, Scherzer TM, Staufer K, et al. Prevalence and clinical significance of GB virus type C/hepatitis G virus coinfection in patients with chronic hepatitis C undergoing antiviral therapy. J Viral Hepat. 2011; 18(7): 513-7[DOI][PubMed]
  • 17. Berzsenyi MD, Bowden DS, Roberts SK. GB virus C: insights into co-infection. J Clin Virol. 2005; 33(4): 257-66[DOI][PubMed]
  • 18. Berzsenyi MD, Woollard DJ, McLean CA, Preiss S, Perreau VM, Beard MR, et al. Down-regulation of intra-hepatic T-cell signaling associated with GB virus C in a HCV/HIV co-infected group with reduced liver disease. J Hepatol. 2011; 55(3): 536-44[DOI][PubMed]
  • 19. Pereira LM, Spinelli V, Ximenes RA, Cavalcanti MS, Melo R, Juca N, et al. Chronic hepatitis C infection: influence of the viral load, genotypes, and GBV-C/HGV coinfection on the severity of the disease in a Brazilian population. J Med Virol. 2002; 67(1): 27-32[PubMed]
  • 20. Tan D, Matsumoto A, Conry-Cantilena C, Melpolder JC, Shih JW, Leuther M, et al. Analysis of hepatitis G virus (HGV) RNA, antibody to HGV envelope protein, and risk factors for blood donors coinfected with HGV and hepatitis C virus. J Infect Dis. 1999; 179(5): 1055-61[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments