Hepatitis Monthly

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Distinct Toll-like Receptor 3 and 7 Expression in Peripheral Blood Mononuclear Cells From Patients with Chronic Hepatitis C Infection

Mahsa Motavaf 1 , 2 , Fatemeh Noorbakhsh 1 , Seyed Moayed Alavian 2 and Zohreh Sharifi 1 , 3 , *
Authors Information
1 Department of Microbiology, Islamic Azad University of Varamin-Pishva, Varamin, IR Iran
2 Department of Molecular Hepatology, Middle East Liver Disease Center (MELD), Tehran, IR Iran
3 Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, IR Iran
Article information
  • Hepatitis Monthly: April 01, 2014, 14 (4); e16421
  • Published Online: April 7, 2014
  • Article Type: Research Article
  • Received: November 26, 2013
  • Revised: January 25, 2014
  • Accepted: February 8, 2014
  • DOI: 10.5812/hepatmon.16421

To Cite: Motavaf M, Noorbakhsh F, Alavian S M, Sharifi Z. Distinct Toll-like Receptor 3 and 7 Expression in Peripheral Blood Mononuclear Cells From Patients with Chronic Hepatitis C Infection, Hepat Mon. 2014 ; 14(4):e16421. doi: 10.5812/hepatmon.16421.

Abstract
Copyright © 2014, Kowsar Corp. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
Acknowledgements
Footnotes
References
  • 1. Alavian S, Asl M, Lankarani K, Shahbabaie M, Bahrami Ahmadi A, Kabir A. Hepatitis C Infection in the General Population of Iran: A Systematic Review. Hepat Mon. 2009; 9(3): 211-23
  • 2. Vaidya SA, Cheng G. Toll-like receptors and innate antiviral responses. Curr Opin Immunol. 2003; 15(4): 402-7[DOI][PubMed]
  • 3. Mozer-Lisewska I, Sikora J, Kowala-Piaskowska A, Kaczmarek M, Dworacki G, Żeromski J. The incidence and significance of pattern-recognition receptors in chronic viral hepatitis types B and C in man. 2010; 58(4): 295-302[PubMed]
  • 4. Akira S, Takeda K. Toll-like receptor signalling. Nature Rev Immunol. 2004; 4(7): 499-511[PubMed]
  • 5. Schulz O, Diebold SS, Chen M, Näslund TI, Nolte MA, Alexopoulou L, et al. Toll-like receptor 3 promotes cross-priming to virus-infected cells. Nature. 2005; 433(7028): 887-92[PubMed]
  • 6. Duong FHT, Filipowicz M, Tripodi M, La Monica N, Heim MH. Hepatitis C virus inhibits interferon signaling through up-regulation of protein phosphatase 2A. Gastroenterol. 2004; 126(1): 263-77[PubMed]
  • 7. Li K, Foy E, Ferreon JC, Nakamura M, Ferreon AC, Ikeda M, et al. Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF. Proc Natl Acad Sci U S A. 2005; 102(8): 2992-7[DOI][PubMed]
  • 8. Sumpter R, Jr., Loo YM, Foy E, Li K, Yoneyama M, Fujita T, et al. Regulating intracellular antiviral defense and permissiveness to hepatitis C virus RNA replication through a cellular RNA helicase, RIG-I. J Virol. 2005; 79(5): 2689-99[DOI][PubMed]
  • 9. Atencia R, Bustamante FJ, Valdivieso A, Arrieta A, Rinon M, Prada A, et al. Differential expression of viral PAMP receptors mRNA in peripheral blood of patients with chronic hepatitis C infection. BMC Infect Dis. 2007; 7: 136[DOI][PubMed]
  • 10. Chang S, Kodys K, Szabo G. Impaired expression and function of toll-like receptor 7 in hepatitis C virus infection in human hepatoma cells. Hepatology. 2010; 51(1): 35-42[DOI][PubMed]
  • 11. Vollmer J, Rankin R, Hartmann H, Jurk M, Samulowitz U, Wader T, et al. Immunopharmacology of CpG oligodeoxynucleotides and ribavirin. Antimicrob Agents Chemother. 2004; 48(6): 2314-7[DOI][PubMed]
  • 12. Dolganiuc A, Garcia C, Kodys K, Szabo G. Distinct Toll-like receptor expression in monocytes and T cells in chronic HCV infection. World J Gastroenterol. 2006; 12(8): 1198-204[PubMed]
  • 13. Lehmann MH, Weber J, Gastmann O, Sigusch HH. Pseudogene-free amplification of human GAPDH cDNA. Biotechniques. 2002; 33(4): 766-70[PubMed]
  • 14. Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 2001; 29(9)[PubMed]
  • 15. Pflugheber J, Fredericksen B, Sumpter R, Jr., Wang C, Ware F, Sodora DL, et al. Regulation of PKR and IRF-1 during hepatitis C virus RNA replication. Proc Natl Acad Sci U S A. 2002; 99(7): 4650-5[DOI][PubMed]
  • 16. Abe T, Kaname Y, Hamamoto I, Tsuda Y, Wen X, Taguwa S, et al. Hepatitis C virus nonstructural protein 5A modulates the toll-like receptor-MyD88-dependent signaling pathway in macrophage cell lines. J Virol. 2007; 81(17): 8953-66[DOI][PubMed]
  • 17. Thomas A, Laxton C, Rodman J, Myangar N, Horscroft N, Parkinson T. Investigating Toll-like receptor agonists for potential to treat hepatitis C virus infection. Antimicrob Agents Chemother. 2007; 51(8): 2969-78[DOI][PubMed]
  • 18. Imran M, Waheed Y, Manzoor S, Bilal M, Ashraf W, Ali M, et al. Interaction of Hepatitis C virus proteins with pattern recognition receptors. Virol J. 2012; 9: 126[DOI][PubMed]
  • 19. Mohammed KI, Adel LA, Ali-Eldin FA, Eladawy S. Expression of Toll like receptors 3 & 7 in peripheral blood from patients with chronic hepatitis C virus infection and their correlation with interferon-alpha. Egypt J Immunol. 2013; 20(1): 13-22[PubMed]
  • 20. Sato K, Ishikawa T, Okumura A, Yamauchi T, Sato S, Ayada M, et al. Expression of Toll-like receptors in chronic hepatitis C virus infection. J Gastroenterol Hepatol. 2007; 22(10): 1627-32[DOI][PubMed]
  • 21. Lee J, Wu CC, Lee KJ, Chuang TH, Katakura K, Liu YT, et al. Activation of anti-hepatitis C virus responses via Toll-like receptor 7. Proc Natl Acad Sci U S A. 2006; 103(6): 1828-33[DOI][PubMed]
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