Hepatitis Monthly

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Prevalence of Hepatitis B Virus Seromarkers in Young Adults Vaccinated at Birth; Impact on the Epidemiology of Hepatitis B Infection in Iran

Hiva Saffar 1 , Abolghasem Ajami 2 , Mohammed Jafar Saffar 3 , * , Jalil Shojaei 4 , Maryam Sotudeh-Anvari 1 , Kiarash Shams-Esfandabad 1 and Ali Reza Khalilian 5
Authors Information
1 Department of Pathology, Shariaty Hospital, Tehran University of Medical Sciences, Tehran, IR Iran
2 Department of Immunology, Mazandaran University of Medical Sciences, Sari, IR Iran
3 Pediatric Infectious Diseases Ward, Boali-Cina Hospital, Mazandaran University of Medical Sciences, Sari, IR Iran
4 Provincial Center for Diseases Control and Prevention, Mazandaran University of Medical Sciences, Sari, IR Iran
5 Department of Statistics, Mazandaran University of Medical Sciences, Sari, IR Iran
Article information
  • Hepatitis Monthly: May 01, 2014, 14 (5); e17263
  • Published Online: May 1, 2014
  • Article Type: Research Article
  • Received: January 8, 2014
  • Revised: March 2, 2014
  • Accepted: March 8, 2014
  • DOI: 10.5812/hepatmon.17263

To Cite: Saffar H, Ajami A, Saffar M J, Shojaei J, Sotudeh-Anvari M, et al. Prevalence of Hepatitis B Virus Seromarkers in Young Adults Vaccinated at Birth; Impact on the Epidemiology of Hepatitis B Infection in Iran, Hepat Mon. 2014 ; 14(5):e17263. doi: 10.5812/hepatmon.17263.

Copyright © 2014, Kowsar Corp. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Hepatitis B vaccines. Wkly Epidemiol Rec. 2009; 48: 405-19
  • 2. Zanetti AR, Van Damme P, Shouval D. The global impact of vaccination against hepatitis B: a historical overview. Vaccine. 2008; 26(49): 6266-73[DOI][PubMed]
  • 3. Ranger-Rogez S, Denis F. Hepatitis B mother--to--child transmission. Expert Rev Anti Infect Ther. 2004; 2(1): 133-45[PubMed]
  • 4. Hyams KC. Risks of chronicity following acute hepatitis B virus infection: a review. Clin Infect Dis. 1995; 20(4): 992-1000[PubMed]
  • 5. Van Herck K, Van Damme P. Benefits of early hepatitis B immunization programs for newborns and infants. Pediatr Infect Dis J. 2008; 27(10): 861-9[DOI][PubMed]
  • 6. Chen DS. Hepatitis B vaccination: The key towards elimination and eradication of hepatitis B. J Hepatol. 2009; 50(4): 805-16[DOI][PubMed]
  • 7. Huang LM, Lu CY, Chen DS. Hepatitis B virus infection, its sequelae, and prevention by vaccination. Curr Opin Immunol. 2011; 23(2): 237-43[DOI][PubMed]
  • 8. Poovorawan Y, Chongsrisawat V, Theamboonlers A, Leroux-Roels G, Kuriyakose S, Leyssen M, et al. Evidence of protection against clinical and chronic hepatitis B infection 20 years after infant vaccination in a high endemicity region. J Viral Hepat. 2011; 18(5): 369-75[DOI][PubMed]
  • 9. Ni YH, Huang LM, Chang MH, Yen CJ, Lu CY, You SL, et al. Two decades of universal hepatitis B vaccination in taiwan: impact and implication for future strategies. Gastroenterology. 2007; 132(4): 1287-93[DOI][PubMed]
  • 10. But DY, Lai CL, Lim WL, Fung J, Wong DK, Yuen MF. Twenty-two years follow-up of a prospective randomized trial of hepatitis B vaccines without booster dose in children: final report. Vaccine. 2008; 26(51): 6587-91[DOI][PubMed]
  • 11. Roznovsky L, Orsagova I, Kloudova A, Tvrdik J, Kabieszova L, Lochman I, et al. Long-term protection against hepatitis B after newborn vaccination: 20-year follow-up. Infection. 2010; 38(5): 395-400[DOI][PubMed]
  • 12. Bialek SR, Bower WA, Novak R, Helgenberger L, Auerbach SB, Williams IT, et al. Persistence of protection against hepatitis B virus infection among adolescents vaccinated with recombinant hepatitis B vaccine beginning at birth: a 15-year follow-up study. Pediatr Infect Dis J. 2008; 27(10): 881-5[DOI][PubMed]
  • 13. Salleras L, Dominguez A, Bruguera M, Plans P, Costa J, Cardenosa N, et al. Declining prevalence of hepatitis B virus infection in Catalonia (Spain) 12 years after the introduction of universal vaccination. Vaccine. 2007; 25(52): 8726-31[DOI][PubMed]
  • 14. Campagna M, Siddu A, Meloni A, Murru C, Masia G, Coppola RC. Epidemiological impact of mandatory vaccination against hepatitis B in Italian young adults. Hepat Mon. 2011; 11(9): 750-2[DOI][PubMed]
  • 15. Coppola RC, Meloni A, Campagna M. Impact of universal vaccination against hepatitis B: the italian model. Hepat Mon. 2012; 12(7): 417-9[DOI][PubMed]
  • 16. Merat S, Malekzadeh R, Rezvan H, Khatibian M. Hepatyitis B in Iran. Arch Iranian Med. 2000; 3(192-201)
  • 17. Zali MR, Mohammad K, Farhadi A, Masjedi MR, Zargar A. Nowroozi A. Epidemiology of hepatitis B in Iran. East Mediterr Health J. 1996; 2(2): 290-8
  • 18. Alavian SM, Fallahian F, Lankarani KB. Comparison of seroepidemiology and transmission modes of viral hepatitis B in Iran and Pakistan. Hepat Mon. 2008; 8(1): 51-9
  • 19. Expanded Programme on Immunization Global Adisory Group. Wkly Epidemiol Rec. 1992; 3: 11-6
  • 20. Hassan S, Ziba F. Antibody titer in Iranian children 6 years after hepatitis B vaccine administration. Vaccine. 2007; 25(17): 3511-4[DOI][PubMed]
  • 21. Hadi N, Hadi N. Assessment of anti-HBs antigen in 6- to 9-year-old children routinely vaccinated via vaccination program in Iran. Med Princ Pract. 2007; 16(4): 306-9[DOI][PubMed]
  • 22. Adibi P, Ghassemian R, Alavian SM, Ranjbar M, Mohammadalizadeh AH, Nematizadeh F, et al. Effectiveness of hepatitis B vaccination in children of chronic hepatitis B mothers. Saudi Med J. 2004; 25(10): 1414-8[PubMed]
  • 23. Kabir A, Alavian SM, Ahanchi N, Malekzadeh R. Combined passive and active immunoprophylaxis for preventing perinatal transmission of the hepatitis B virus in infants born to HBsAg positive mothers in comparison with vaccine alone. Hepatol Res. 2006; 36(4): 265-71[DOI][PubMed]
  • 24. Saffar MJ, Rezai MS. Long-term antibody response and immunologic memory in children immunized with hepatitis B vaccine at birth. Indian Pediatr. 2004; 41(12): 1232-7[PubMed]
  • 25. Merat S, Rezvan H, Nouraie M, Jamali A, Assari S, Abolghasemi H, et al. The prevalence of hepatitis B surface antigen and anti-hepatitis B core antibody in Iran: a population-based study. Arch Iran Med. 2009; 12(3): 225-31[PubMed]
  • 26. Alavian SM, Hajarizadeh B, Ahmadzad-Asl M, Kabir A, Lankarani KB. Hepatitis B Virus Infection in Iran: A Systematic Review. Hepat Mon. 2008; 8(4): 281-94
  • 27. SeyedAlinaghi SA, Kheirandish P, Karami N, Salem S, Shirzad H, Jahani MR, et al. High prevalence of chronic hepatitis B infection among injection drug users in Iran: the need to increase vaccination of adults at risk. Acta Med Iran. 2010; 48(1): 58-60[PubMed]
  • 28. Asl SKH, Avijgan M, Mohamadnejad M. High prevalence of HBV, HCV, and HIV infections in Gypsy population residing in Shahr-E-Kord. Popul. 2004; 3: 4
  • 29. Zali MR, Mohammad K, Noorbala AA, Noorimayer B, Shahraz S. Rate of hepatitis B seropositivity following mass vaccination in the Islamic Republic of Iran. East Mediterr Health J. 2005; 11(1-2): 62-7[PubMed]
  • 30. Farhat A, Khademi G, Mazlouman SJ. The prevalence of hepatitis B carrier state in Khorassan province of Iran. Saudi Med J. 2003; 24(5): 549-51[PubMed]
  • 31. Fathimoghaddam F, Hedayati-Moghaddam MR, Bidkhori HR, Ahmadi S, Sima HR. The prevalence of hepatitis B antigen-positivity in the general population of Mashhad, Iran. Hepat Mon. 2011; 11(5): 346-50[PubMed]
  • 32. Khedmat H, Alavian SM, Miri SM, Amini M, Aboualghasemi H. Trends in seroprevalence of hepatitis b, hepatitis c, hiv, and syphilis infections in Iranian blood donors from 2003 to 2005. Hepat Mon. 2009; 9(1): 24-8
  • 33. Alavian SM, Fallahian F, Lankarani KB. The changing epidemiology of viral hepatitis B in Iran. J Gastrointestin Liver Dis. 2007; 16(4): 403-6[PubMed]
  • 34. Mohebbi SR, Sanati A, Cheraghipour K, Rostami Nejad M, Shalmani HM, Zali MR. Hepatitis C and hepatitis B virus infection: epidemiology and risk factors in a large cohort of pregnant women in Lorestan, West of Iran. Hepat Mon. 2011; 11(9): 736-9[DOI][PubMed]
  • 35. Poorolajal J, Majdzadeh R. Prevalence of chronic hepatitis B infection in Iran: a review article. J Res Med Sci. 2009; 14(4): 249-58[PubMed]
  • 36. Jafarzadeh A, Montazerifar SJ. Persistence of anti-HBs antibody and immunological memory in children vaccinated with hepatitis B vaccine at birth. J Ayub Med Coll Abbottabad. 2006; 18(4): 4-9[PubMed]
  • 37. Poorolajal J, Mahmoodi M, Majdzadeh R, Nasseri-Moghaddam S, Haghdoost A, Ghalichi L, et al. Seroprotection of Hepatitis B Vaccine and Need for Booster Dose: A Meta-Analysis. Hepat Mon. 2009; 9(4): 293-304
  • 38. Poorolajal J, Mahmoodi M, Majdzadeh R, Nasseri-Moghaddam S, Haghdoost A, Fotouhi A. Long-term protection provided by hepatitis B vaccine and need for booster dose: a meta-analysis. Vaccine. 2010; 28(3): 623-31[DOI][PubMed]
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