Hepatitis Monthly

Published by: Kowsar

Detection of Telomerase Reverse Transcriptase mRNA in Peripheral Blood Mononuclear Cells of Patients With Liver Failure

Zhu Chuanwu 1 , * , Qian Feng 1 , Li Ming 1 , Wang Haiyan 2 , Fang Huan 1 , Luo Xiangrong 1 , Zhang Xuehua 1 , Zhu Xiang 1 , Shen Xiujuan 1 and Xu Ping 3
Authors Information
1 Department of Hepatology, The Affiliated Infectious Disease Hospital of Soochow University, Suzhou, China
2 Department of Infectious Diseases, The Second Affiliated Hospital of Bengbu Medical College, Bengbu, China
3 Key Laboratory of Infection and Immunity, The Affiliated Infectious Disease Hospital of Soochow University, Suzhou, China
Article information
  • Hepatitis Monthly: April 01, 2014, 14 (4); e17976
  • Published Online: April 14, 2014
  • Article Type: Research Article
  • Received: February 2, 2014
  • Revised: February 21, 2014
  • Accepted: March 12, 2014
  • DOI: 10.5812/hepatmon.17976

To Cite: Chuanwu Z, Feng Q, Ming L, Haiyan W, Huan F, et al. Detection of Telomerase Reverse Transcriptase mRNA in Peripheral Blood Mononuclear Cells of Patients With Liver Failure, Hepat Mon. 2014 ; 14(4):e17976. doi: 10.5812/hepatmon.17976.

Copyright © 2014, Kowsar Corp. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Dubrana K, Perrod S, Gasser SM. Turning telomeres off and on. Curr Opin Cell Biol. 2001; 13(3): 281-9[PubMed]
  • 2. Yan P, Coindre JM, Benhattar J, Bosman FT, Guillou L. Telomerase activity and human telomerase reverse transcriptase mRNA expression in soft tissue tumors: correlation with grade, histology, and proliferative activity. Cancer Res. 1999; 59(13): 3166-70[PubMed]
  • 3. Granger MP, Wright WE, Shay JW. Telomerase in cancer and aging. Crit Rev Oncol Hematol. 2002; 41(1): 29-40[PubMed]
  • 4. Harrington L, Zhou W, McPhail T, Oulton R, Yeung DS, Mar V, et al. Human telomerase contains evolutionarily conserved catalytic and structural subunits. Genes Dev. 1997; 11(23): 3109-15[PubMed]
  • 5. Matsumura-Arioka Y, Ohtani K, Hara T, Iwanaga R, Nakamura M. Identification of two distinct elements mediating activation of telomerase (hTERT) gene expression in association with cell growth in human T cells. Int Immunol. 2005; 17(2): 207-15[DOI][PubMed]
  • 6. Mizukoshi E, Nakamoto Y, Marukawa Y, Arai K, Yamashita T, Tsuji H, et al. Cytotoxic T cell responses to human telomerase reverse transcriptase in patients with hepatocellular carcinoma. Hepatology. 2006; 43(6): 1284-94[DOI][PubMed]
  • 7. Yao XX, Yin L, Sun ZC. The expression of hTERT mRNA and cellular immunity in gastric cancer and precancerosis. World J Gastroenterol. 2002; 8(4): 586-90[PubMed]
  • 8. Huang YK, Fan XG, Qiu F, Wang ZM. Combined detection of mRNA expression of Alpha-fetoprotein in peripheral blood and telomerase activity of monocytes in hepatocellular carcinoma patients. Hepatogastroenterology. 2013; 60(121): 1-5[DOI][PubMed]
  • 9. Wu W, Yao DF, Qiu LW, Wu XH, Yao M, Su XQ, et al. Abnormal expression of hepatomas and circulating telomerase and its clinical values. Hepatobiliary Pancreat Dis Int. 2005; 4(4): 544-9[PubMed]
  • 10. Wiemann SU, Satyanarayana A, Tsahuridu M, Tillmann HL, Zender L, Klempnauer J, et al. Hepatocyte telomere shortening and senescence are general markers of human liver cirrhosis. FASEB J. 2002; 16(9): 935-42[DOI][PubMed]
  • 11. Satra M, Dalekos GN, Kollia P, Vamvakopoulos N, Tsezou A. Telomerase reverse transcriptase mRNA expression in peripheral lymphocytes of patients with chronic HBV and HCV infections. J Viral Hepat. 2005; 12(5): 488-93[DOI][PubMed]
  • 12. Zhu CW, Chen M, Luo XR, Wang HY, Wang LH, Wu JH, et al. Interferon alpha on expression of hTERT mRNA in peripheral blood mononuclear cells of patients with chronic hepatitis B. Clin Dev Immunol. 2011; 2011: 920146[DOI][PubMed]
  • 13. Miura N, Kabashima H, Shimizu M, Sato R, Tsukamoto T, Harada T, et al. Clinical impact of serum transforming growth factor-alpha mRNA as a predictive biomarker for the prognosis of fulminant hepatitis. Hepatol Int. 2008; 2(2): 213-21[DOI][PubMed]
  • 14. Rudolph KL, Chang S, Millard M, Schreiber-Agus N, DePinho RA. Inhibition of experimental liver cirrhosis in mice by telomerase gene delivery. Science. 2000; 287(5456): 1253-8[PubMed]
  • 15. Sirma H, Kumar M, Meena JK, Witt B, Weise JM, Lechel A, et al. The promoter of human telomerase reverse transcriptase is activated during liver regeneration and hepatocyte proliferation. Gastroenterology. 2011; 141(1): 326-3[DOI][PubMed]
  • 16. Schiodt FV, Ostapowicz G, Murray N, Satyanarana R, Zaman A, Munoz S, et al. Alpha-fetoprotein and prognosis in acute liver failure. Liver Transpl. 2006; 12(12): 1776-81[DOI][PubMed]
  • 17. Li Q, Yuan GY, Tang KC, Liu GW, Wang R, Cao WK. Prognostic factors for chronic severe hepatitis and construction of a prognostic model. Hepatobiliary Pancreat Dis Int. 2008; 7(1): 40-4[PubMed]
  • 18. Du WB, Pan XP, Li LJ. Prognostic models for acute liver failure. Hepatobiliary Pancreat Dis Int. 2010; 9(2): 122-8[PubMed]
  • 19. Liver Failure, Severe Liver Diseases. [Diagnostic and treatment guidelines for liver failure]. Zhonghua Gan Zang Bing Za Zhi. 2006; 14(9): 643-6[PubMed]
  • 20. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001; 25(4): 402-8[DOI][PubMed]
  • 21. Batra Y, Acharya SK. Acute liver failure: prognostic markers. Indian J Gastroenterol. 2003; 22 Suppl 2-8[PubMed]
  • 22. Liu XY, Hu JH, Wang HF. [Analysis of prognostic factors for patients with acute-on-chronic liver failure]. Zhonghua Gan Zang Bing Za Zhi. 2009; 17(8): 607-10[PubMed]
  • 23. Wlodzimirow KA, Eslami S, Abu-Hanna A, Nieuwoudt M, Chamuleau RA. A systematic review on prognostic indicators of acute on chronic liver failure and their predictive value for mortality. Liver Int. 2013; 33(1): 40-52[DOI][PubMed]
  • 24. Bala L, Mehrotra M, Mohindra S, Saxena R, Khetrapal CL. Early prognostic markers for fatal fulminant hepatic failure cases with viral hepatitis: proton nuclear magnetic resonance spectroscopic studies of serum. Dig Liver Dis. 2013; 45(2): 155-63[DOI][PubMed]
  • 25. Widmann JJ, Fahimi HD. Proliferation of mononuclear phagocytes (Kupffer cells) and endothelial cells in regenerating rat liver. A light and electron microscopic cytochemical study. Am J Pathol. 1975; 80(3): 349-66[PubMed]
  • 26. Vujanovic NL, Polimeno L, Azzarone A, Francavilla A, Chambers WH, Starzl TE, et al. Changes of liver-resident NK cells during liver regeneration in rats. J Immunol. 1995; 154(12): 6324-38[PubMed]
  • 27. Lin XM, Liu YB, Zhou F, Wu YL, Chen L, Fang HQ. Expression of tumor necrosis factor-alpha converting enzyme in liver regeneration after partial hepatectomy. World J Gastroenterol. 2008; 14(9): 1353-7[PubMed]
  • 28. Batusic DS, von Bargen A, Blaschke S, Dudas J, Ramadori G. Different physiology of interferon-alpha/-gamma in models of liver regeneration in the rat. Histochem Cell Biol. 2011; 136(2): 131-44[DOI][PubMed]
  • 29. Naughton BA, Gamba-Vitalo C, Naughton GK, Liu P, Gordon AS. Granulopoiesis and colony stimulating factor production in regenerating liver. Exp Hematol. 1982; 10(5): 451-8[PubMed]
  • 30. Miura N, Maeda Y, Kanbe T, Yazama H, Takeda Y, Sato R, et al. Serum human telomerase reverse transcriptase messenger RNA as a novel tumor marker for hepatocellular carcinoma. Clin Cancer Res. 2005; 11(9): 3205-9[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments