Hepatitis Monthly

Published by: Kowsar

Efficacy and Safety of Ferric Chloride in Controlling Hepatic Bleeding; An Animal Model Study

Saeed Nouri 1 and Mohammad Reza Sharif 2 , *
Authors Information
1 Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, IR Iran
2 Trauma Research Center, Kashan University of Medical Sciences, Kashan, IR Iran
Article information
  • Hepatitis Monthly: June 01, 2014, 14 (6); e18652
  • Published Online: June 9, 2014
  • Article Type: Research Article
  • Received: March 1, 2014
  • Revised: April 6, 2014
  • Accepted: May 15, 2014
  • DOI: 10.5812/hepatmon.18652

To Cite: Nouri S, Sharif M R. Efficacy and Safety of Ferric Chloride in Controlling Hepatic Bleeding; An Animal Model Study, Hepat Mon. 2014 ; 14(6):e18652. doi: 10.5812/hepatmon.18652.

Copyright © 2014, Kowsar Corp. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
  • 1. Sauaia A, Moore FA, Moore EE, Moser KS, Brennan R, Read RA, et al. Epidemiology of trauma deaths: a reassessment. J Trauma. 1995; 38(2): 185-93[PubMed]
  • 2. Baykul T, Alanoglu EG, Kocer G. Use of Ankaferd Blood Stopper as a hemostatic agent: a clinical experience. J Contemp Dent Pract. 2010; 11(1)-94[PubMed]
  • 3. McBee WL, Koerner KR. Review of hemostatic agents used in dentistry. Dent Today. 2005; 24(3): 62-5[PubMed]
  • 4. Lemon RR, Steele PJ, Jeansonne BG. Ferric sulfate hemostasis: effect on osseous wound healing. Left in situ for maximum exposure. J Endod. 1993; 19(4): 170-3[PubMed]
  • 5. Odabas ME, Erturk M, Cinar C, Tuzuner T, Tulunoglu O. Cytotoxicity of a new hemostatic agent on human pulp fibroblasts in vitro. Med Oral Patol Oral Cir Bucal. 2011; 16(4)-7[PubMed]
  • 6. Clark WR, Jr, Leather RP. Hemostasis during liver resections. Surgery. 1970; 67(3): 556-7[PubMed]
  • 7. Helewski K, Kowalczyk-Ziomek G, Czecior E, Wyrobiec G, Harabin-Slowinska M, Juszko-Piekut M, et al. Protective effect of intermittent clamping of the portal triad in the rat liver on liver ischemia-reperfusion injury. Hepat Mon. 2011; 11(6): 445-51[PubMed]
  • 8. Cogbill TH, Moore EE, Jurkovich GJ, Feliciano DV, Morris JA, Mucha P. Severe hepatic trauma: a multi-center experience with 1,335 liver injuries. J Trauma. 1988; 28(10): 1433-8[PubMed]
  • 9. Beal SL. Fatal hepatic hemorrhage: an unresolved problem in the management of complex liver injuries. J Trauma. 1990; 30(2): 163-9[PubMed]
  • 10. Saifi J, Fortune JB, Graca L, Shah DM. Benefits of intra-abdominal pack placement for the management of nonmechanical hemorrhage. Arch Surg. 1990; 125(1): 119-22[PubMed]
  • 11. Dodd GD, 3rd, Soulen MC, Kane RA, Livraghi T, Lees WR, Yamashita Y, et al. Minimally invasive treatment of malignant hepatic tumors: at the threshold of a major breakthrough. Radiographics. 2000; 20(1): 9-27[DOI][PubMed]
  • 12. Guidelines for drinking water quality. 1991; : 308-9
  • 13. Wu CC, Ho WM, Cheng SB, Yeh DC, Wen MC, Liu TJ, et al. Perioperative parenteral tranexamic acid in liver tumor resection: a prospective randomized trial toward a "blood transfusion"-free hepatectomy. Ann Surg. 2006; 243(2): 173-80[DOI][PubMed]
  • 14. Pereboom IT, de Boer MT, Porte RJ, Molenaar IQ. Aprotinin and nafamostat mesilate in liver surgery: effect on blood loss. Dig Surg. 2007; 24(4): 282-7[DOI][PubMed]
  • 15. Cue JI, Cryer HG, Miller FB, Richardson JD, Polk HC, Jr. Packing and planned reexploration for hepatic and retroperitoneal hemorrhage: critical refinements of a useful technique. J Trauma. 1990; 30(8): 1007-11[PubMed]
  • 16. Denis C, Methia N, Frenette PS, Rayburn H, Ullman-Cullere M, Hynes RO, et al. A mouse model of severe von Willebrand disease: defects in hemostasis and thrombosis. Proc Natl Acad Sci U S A. 1998; 95(16): 9524-9[PubMed]
  • 17. Wadia Y, Xie H, Kajitani M. Liver repair and hemorrhage control by using laser soldering of liquid albumin in a porcine model. Lasers Surg Med. 2000; 27(4): 319-28[PubMed]
  • 18. David Richardson J, Franklin GA, Lukan JK, Carrillo EH, Spain DA, Miller FB, et al. Evolution in the management of hepatic trauma: a 25-year perspective. Ann Surg. 2000; 232(3): 324-30[PubMed]
  • 19. Pachter HL, Hofstetter SR. The current status of nonoperative management of adult blunt hepatic injuries. Am J Surg. 1995; 169(4): 442-54[PubMed]
  • 20. Carrillo EH, Richardson JD. The current management of hepatic trauma. Adv Surg. 2001; 35: 39-59[PubMed]
  • 21. Selzner N, Rudiger H, Graf R, Clavien PA. Protective strategies against ischemic injury of the liver. Gastroenterology. 2003; 125(3): 917-36[PubMed]
  • 22. Leonardi S, Vitaliti G. Liver fibrosis in patients with chronic liver diseases: are laboratory tests useful to diagnosis? Hepat Mon. 2011; 11(5): 382-3[PubMed]
  • 23. Figueras J, Llado L, Miro M, Ramos E, Torras J, Fabregat J, et al. Application of fibrin glue sealant after hepatectomy does not seem justified: results of a randomized study in 300 patients. Ann Surg. 2007; 245(4): 536-42[DOI][PubMed]
  • 24. Molenaar IQ, Warnaar N, Groen H, Tenvergert EM, Slooff MJ, Porte RJ. Efficacy and safety of antifibrinolytic drugs in liver transplantation: a systematic review and meta-analysis. Am J Transplant. 2007; 7(1): 185-94[DOI][PubMed]
  • 25. Berrevoet F, de Hemptinne B. Use of topical hemostatic agents during liver resection. Dig Surg. 2007; 24(4): 288-93[DOI][PubMed]
  • 26. Heaton N. Advances and methods in liver surgery: haemostasis. Eur J Gastroenterol Hepatol. 2005; 17 Suppl 1-12[PubMed]
  • 27. Chapman WC, Clavien PA, Fung J, Khanna A, Bonham A. Effective control of hepatic bleeding with a novel collagen-based composite combined with autologous plasma: results of a randomized controlled trial. Arch Surg. 2000; 135(10): 1200-4[PubMed]
  • 28. Schwartz M, Madariaga J, Hirose R, Shaver TR, Sher L, Chari R, et al. Comparison of a new fibrin sealant with standard topical hemostatic agents. Arch Surg. 2004; 139(11): 1148-54[DOI][PubMed]
  • 29. Jackson MR. Fibrin sealants in surgical practice: An overview. Am J Surg. 2001; 182(2 Suppl): 1S-7S[PubMed]
  • 30. Barr JD, Chauhan AK, Schaeffer GV, Hansen JK, Motto DG. Red blood cells mediate the onset of thrombosis in the ferric chloride murine model. Blood. 2013; 121(18): 3733-41[DOI][PubMed]
  • 31. Nouri S, Amirbeigy M, Hosseinpour M, Abdorrahim K, Sharif MR, Amirbeigy MK. [Evaluation of the Hemostatic Effect of Ferric Sulphate in Controlling External Bleeding in Mouse at Kashan University of Medical Sciences, 2012]. Iran J Surg. 2013; 21: 21-9
  • 32. Kim S, Rethnam S. Hemostasis in endodontic microsurgery. Dent Clin North Am. 1997; 41(3): 499-511[PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .
Readers' Comments