Hepatitis Monthly

Published by: Kowsar

Long Noncoding RNAs in Interaction With RNA Binding Proteins in Hepatocellular Carcinoma

Ashraf Mohamadkhani 1 , *
Author Information
1 Liver and Pancreatobiliary Disease Research Center, Digestive Disease Research institute, Shartati Hospital, Tehran University of Medical Sciences, Tehran, IR Iran
Article information
  • Hepatitis Monthly: May 01, 2014, 14 (5); e18794
  • Published Online: May 5, 2014
  • Article Type: Research Article
  • Received: March 6, 2014
  • Accepted: March 7, 2014
  • DOI: 10.5812/hepatmon.18794

To Cite: Mohamadkhani A. Long Noncoding RNAs in Interaction With RNA Binding Proteins in Hepatocellular Carcinoma, Hepat Mon. 2014 ; 14(5):e18794. doi: 10.5812/hepatmon.18794.

Copyright © 2014, Kowsar Corp. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
  • 1. Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, et al. The transcriptional landscape of the mammalian genome. Science. 2005; 309(5740): 1559-63[DOI][PubMed]
  • 2. Ponting CP, Oliver PL, Reik W. Evolution and functions of long noncoding RNAs. Cell. 2009; 136(4): 629-41[DOI][PubMed]
  • 3. Mercer TR, Mattick JS. Structure and function of long noncoding RNAs in epigenetic regulation. Nat Struct Mol Biol. 2013; 20(3): 300-7[DOI][PubMed]
  • 4. Qiu MT, Hu JW, Yin R, Xu L. Long noncoding RNA: an emerging paradigm of cancer research. Tumour Biol. 2013; 34(2): 613-20[DOI][PubMed]
  • 5. Du Z, Fei T, Verhaak RG, Su Z, Zhang Y, Brown M, et al. Integrative genomic analyses reveal clinically relevant long noncoding RNAs in human cancer. Nat Struct Mol Biol. 2013; 20(7): 908-13[DOI][PubMed]
  • 6. Enfield KS, Pikor LA, Martinez VD, Lam WL. Mechanistic Roles of Noncoding RNAs in Lung Cancer Biology and Their Clinical Implications. Genet Res Int. 2012; 2012: 737416[DOI][PubMed]
  • 7. Quagliata L, Matter MS, Piscuoglio S, Arabi L, Ruiz C, Procino A, et al. lncRNA HOTTIP / HOXA13 expression is associated with disease progression and predicts outcome in hepatocellular carcinoma patients. Hepatology. 2013; [DOI][PubMed]
  • 8. Xie H, Ma H, Zhou D. Plasma HULC as a promising novel biomarker for the detection of hepatocellular carcinoma. Biomed Res Int. 2013; 2013: 136106[DOI][PubMed]
  • 9. He Y, Meng XM, Huang C, Wu BM, Zhang L, Lv XW, et al. Long noncoding RNAs: Novel insights into hepatocelluar carcinoma. Cancer Lett. 2013; [DOI][PubMed]
  • 10. Pan YF, Qin T, Feng L, Yu ZJ. Expression profile of altered long non-coding RNAs in patients with HBV-associated hepatocellular carcinoma. J Huazhong Univ Sci Technolog Med Sci. 2013; 33(1): 96-101[DOI][PubMed]
  • 11. Yeganeh B, Hashemi M, de Serres FJ, Los MJ, Ghavami S. Different faces of hepatocellular carcinoma as a health threat in 21st century. Hepat Mon. 2013; 13(2)[DOI][PubMed]
  • 12. Zidan A, Scheuerlein H, Schule S, Settmacher U, Rauchfuss F. Epidemiological pattern of hepatitis B and hepatitis C as etiological agents for hepatocellular carcinoma in iran and worldwide. Hepat Mon. 2012; 12(10 HCC)[DOI][PubMed]
  • 13. Mohamadkhani A, Montazeri G, Poustchi H. The Importance of Hepatitis B Virus Genome Diversity in Basal Core Promoter Region. Middle East Journal of Dig Dis. 2011; 3: 13-9
  • 14. Alswat KA, Sanai FM, Altuwaijri M, Albenmousa A, Almadi M, Al-Hamoudi WK, et al. Clinical characteristics of patients with hepatocellular carcinoma in a middle eastern population. Hepat Mon. 2013; 13(5)[DOI][PubMed]
  • 15. Gupta RA, Shah N, Wang KC, Kim J, Horlings HM, Wong DJ, et al. Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature. 2010; 464(7291): 1071-6[DOI][PubMed]
  • 16. Semrad K. Proteins with RNA chaperone activity: a world of diverse proteins with a common task-impediment of RNA misfolding. Biochem Res Int. 2011; 2011: 532908[DOI][PubMed]
  • 17. Li JH, Liu S, Zhou H, Qu LH, Yang JH. starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data. Nucleic Acids Res. 2014; 42(1)-7[DOI][PubMed]
  • 18. Amaral PP, Clark MB, Gascoigne DK, Dinger ME, Mattick JS. lncRNAdb: a reference database for long noncoding RNAs. Nucleic Acids Res. 2011; 39-51[DOI][PubMed]
  • 19. Kim KS, Lee YI. Biallelic expression of the H19 and IGF2 genes in hepatocellular carcinoma. Cancer Lett. 1997; 119(2): 143-8[PubMed]
  • 20. Sohda T, Iwata K, Soejima H, Kamimura S, Shijo H, Yun K. In situ detection of insulin-like growth factor II (IGF2) and H19 gene expression in hepatocellular carcinoma. J Hum Genet. 1998; 43(1): 49-53[DOI][PubMed]
  • 21. Zhang L, Yang F, Yuan JH, Yuan SX, Zhou WP, Huo XS, et al. Epigenetic activation of the MiR-200 family contributes to H19-mediated metastasis suppression in hepatocellular carcinoma. Carcinogenesis. 2013; 34(3): 577-86[DOI][PubMed]
  • 22. Wu J, Qin Y, Li B, He WZ, Sun ZL. Hypomethylated and hypermethylated profiles of H19DMR are associated with the aberrant imprinting of IGF2 and H19 in human hepatocellular carcinoma. Genomics. 2008; 91(5): 443-50[DOI][PubMed]
  • 23. Morford LA, Davis C, Jin L, Dobierzewska A, Peterson ML, Spear BT. The oncofetal gene glypican 3 is regulated in the postnatal liver by zinc fingers and homeoboxes 2 and in the regenerating liver by alpha-fetoprotein regulator 2. Hepatology. 2007; 46(5): 1541-7[DOI][PubMed]
  • 24. Iizuka N, Oka M, Tamesa T, Hamamoto Y, Yamada-Okabe H. Imbalance in expression levels of insulin-like growth factor 2 and H19 transcripts linked to progression of hepatocellular carcinoma. Anticancer Res. 2004; 24(6): 4085-9[PubMed]
  • 25. Ishibashi M, Kogo R, Shibata K, Sawada G, Takahashi Y, Kurashige J, et al. Clinical significance of the expression of long non-coding RNA HOTAIR in primary hepatocellular carcinoma. Oncol Rep. 2013; 29(3): 946-50[DOI][PubMed]
  • 26. Geng YJ, Xie SL, Li Q, Ma J, Wang GY. Large intervening non-coding RNA HOTAIR is associated with hepatocellular carcinoma progression. J Int Med Res. 2011; 39(6): 2119-28[PubMed]
  • 27. Yang Z, Zhou L, Wu LM, Lai MC, Xie HY, Zhang F, et al. Overexpression of long non-coding RNA HOTAIR predicts tumor recurrence in hepatocellular carcinoma patients following liver transplantation. Ann Surg Oncol. 2011; 18(5): 1243-50[DOI][PubMed]
  • 28. Du Y, Kong G, You X, Zhang S, Zhang T, Gao Y, et al. Elevation of highly up-regulated in liver cancer (HULC) by hepatitis B virus X protein promotes hepatoma cell proliferation via down-regulating p18. J Biol Chem. 2012; 287(31): 26302-11[DOI][PubMed]
  • 29. Lai MC, Yang Z, Zhou L, Zhu QQ, Xie HY, Zhang F, et al. Long non-coding RNA MALAT-1 overexpression predicts tumor recurrence of hepatocellular carcinoma after liver transplantation. Med Oncol. 2012; 29(3): 1810-6[DOI][PubMed]
  • 30. Oliva J, Bardag-Gorce F, French BA, Li J, French SW. The regulation of non-coding RNA expression in the liver of mice fed DDC. Exp Mol Pathol. 2009; 87(1): 12-9[DOI][PubMed]
  • 31. Ripoche MA, Kress C, Poirier F, Dandolo L. Deletion of the H19 transcription unit reveals the existence of a putative imprinting control element. Genes Dev. 1997; 11(12): 1596-604[PubMed]
  • 32. Teschke K, Kelly SJ, Wiens M, Hertzman C, Dimich-Ward H, Ward JE, et al. Concentrations of organochlorine pesticides in the adipose tissue of British Columbia residents. Can J Public Health. 1993; 84(3): 192-6[PubMed]
  • 33. Yang F, Zhang L, Huo XS, Yuan JH, Xu D, Yuan SX, et al. Long noncoding RNA high expression in hepatocellular carcinoma facilitates tumor growth through enhancer of zeste homolog 2 in humans. Hepatology. 2011; 54(5): 1679-89[DOI][PubMed]
  • 34. Hou W, Bonkovsky HL. Non-coding RNAs in hepatitis C-induced hepatocellular carcinoma: Dysregulation and implications for early detection, diagnosis and therapy. World J Gastroenterol. 2013; 19(44): 7836-45[DOI][PubMed]
  • 35. Wang KC, Yang YW, Liu B, Sanyal A, Corces-Zimmerman R, Chen Y, et al. A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression. Nature. 2011; 472(7341): 120-4[DOI][PubMed]
  • 36. Brannan K, Bentley DL. Control of Transcriptional Elongation by RNA Polymerase II: A Retrospective. Genet Res Int. 2012; 2012: 170173[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .
Readers' Comments