Hepatitis Monthly

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Correlation Between Patatin-Like Phospholipase Domain-Containing Protein 3 Gene Polymorphisms and Liver Cirrhosis in a Chinese Han Population With Chronic Hepatitis B

Jin Tong 1 , Jinjun Guo 2 , Jun Hu 2 , Sihui Hou 2 , Yu Zhang 2 and Qingling Li 1 , *
Authors Information
1 Institute of Life Sciences, Chongqing Medical University, Chongqing, China
2 Department of Gastroenterology and Hepatology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
Article information
  • Hepatitis Monthly: August 01, 2014, 14 (8); e18943
  • Published Online: August 17, 2014
  • Article Type: Research Article
  • Received: March 14, 2014
  • Revised: May 15, 2014
  • Accepted: July 31, 2014
  • DOI: 10.5812/hepatmon.18943

To Cite: Tong J, Guo J, Hu J, Hou S, Zhang Y, et al. Correlation Between Patatin-Like Phospholipase Domain-Containing Protein 3 Gene Polymorphisms and Liver Cirrhosis in a Chinese Han Population With Chronic Hepatitis B, Hepat Mon. 2014 ; 14(8):e18943. doi: 10.5812/hepatmon.18943.

Copyright © 2014, Kowsar Corp. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Lai CL, Yuen MF. Chronic hepatitis B--new goals, new treatment. N Engl J Med. 2008; 359(23): 2488-91[DOI][PubMed]
  • 2. Guo XC, Wu YQ. A review: progress of prevention and control on viral hepatitis in China. Biomed Environ Sci. 1999; 12(3): 227-32[PubMed]
  • 3. Papatheodoridis G, Buti M, Cornberg M, Janssen HL, Mutimer D, Pol S. EASL clinical practice guidelines: Management of chronic hepatitis B virus infection. J Hepatol. 2012; 57(1): 167-85
  • 4. Tang B, Kruger WD, Chen G, Shen F, Lin WY, Mboup S, et al. Hepatitis B viremia is associated with increased risk of hepatocellular carcinoma in chronic carriers. J Med Virol. 2004; 72(1): 35-40[DOI][PubMed]
  • 5. Miyazoe S, Hamasaki K, Nakata K, Kajiya Y, Kitajima K, Nakao K, et al. Influence of interleukin-10 gene promoter polymorphisms on disease progression in patients chronically infected with hepatitis B virus. Am J Gastroenterol. 2002; 97(8): 2086-92[DOI][PubMed]
  • 6. Song QL, He XX, Yang H, Li J, Chen M, Wang MY, et al. Association of a TANK gene polymorphism with outcomes of hepatitis B virus infection in a Chinese Han population. Viral Immunol. 2012; 25(1): 73-8[DOI][PubMed]
  • 7. Wang H, Zhao YP, Gao CF, Ji Q, Gressner AM, Yang ZX, et al. Transforming growth factor beta 1 gene variants increase transcription and are associated with liver cirrhosis in Chinese. Cytokine. 2008; 43(1): 20-5[DOI][PubMed]
  • 8. Sanyal AJ. NASH: A global health problem. Hepatol Res. 2011; 41(7): 670-4[DOI][PubMed]
  • 9. Romeo S, Kozlitina J, Xing C, Pertsemlidis A, Cox D, Pennacchio LA, et al. Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nat Genet. 2008; 40(12): 1461-5[DOI][PubMed]
  • 10. Tian C, Stokowski RP, Kershenobich D, Ballinger DG, Hinds DA. Variant in PNPLA3 is associated with alcoholic liver disease. Nat Genet. 2010; 42(1): 21-3[DOI][PubMed]
  • 11. Rotman Y, Koh C, Zmuda JM, Kleiner DE, Liang TJ. The association of genetic variability in patatin-like phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver disease. Hepatology. 2010; 52(3): 894-903[DOI][PubMed]
  • 12. Trepo E, Gustot T, Degre D, Lemmers A, Verset L, Demetter P, et al. Common polymorphism in the PNPLA3/adiponutrin gene confers higher risk of cirrhosis and liver damage in alcoholic liver disease. J Hepatol. 2011; 55(4): 906-12[DOI][PubMed]
  • 13. Trepo E, Pradat P, Potthoff A, Momozawa Y, Quertinmont E, Gustot T, et al. Impact of patatin-like phospholipase-3 (rs738409 C>G) polymorphism on fibrosis progression and steatosis in chronic hepatitis C. Hepatology. 2011; 54(1): 60-9[DOI][PubMed]
  • 14. Czaja AJ, Carpenter HA. Sensitivity, specificity, and predictability of biopsy interpretations in chronic hepatitis. Gastroenterology. 1993; 105(6): 1824-32[PubMed]
  • 15. Rozario R, Ramakrishna B. Histopathological study of chronic hepatitis B and C: a comparison of two scoring systems. J Hepatol. 2003; 38(2): 223-9[PubMed]
  • 16. Papatheodoridis GV, Chrysanthos N, Savvas S, Sevastianos V, Kafiri G, Petraki K, et al. Diabetes mellitus in chronic hepatitis B and C: prevalence and potential association with the extent of liver fibrosis. J Viral Hepat. 2006; 13(5): 303-10[DOI][PubMed]
  • 17. Wong GL, Wong VW, Choi PC, Chan AW, Chim AM, Yiu KK, et al. Metabolic syndrome increases the risk of liver cirrhosis in chronic hepatitis B. Gut. 2009; 58(1): 111-7[DOI][PubMed]
  • 18. Falleti E, Fabris C, Cmet S, Cussigh A, Bitetto D, Fontanini E, et al. PNPLA3 rs738409C/G polymorphism in cirrhosis: relationship with the aetiology of liver disease and hepatocellular carcinoma occurrence. Liver Int. 2011; 31(8): 1137-43[DOI][PubMed]
  • 19. Li Q, Qu HQ, Rentfro AR, Grove ML, Mirza S, Lu Y, et al. PNPLA3 polymorphisms and liver aminotransferase levels in a Mexican American population. Clin Invest Med. 2012; 35(4)-45[PubMed]
  • 20. Altlparmak E, Koklu S, Yalinkilic M, Yuksel O, Cicek B, Kayacetin E, et al. Viral and host causes of fatty liver in chronic hepatitis B. World J Gastroenterol. 2005; 11(20): 3056-9[PubMed]
  • 21. Liu YM, Moldes M, Bastard JP, Bruckert E, Viguerie N, Hainque B, et al. Adiponutrin: A new gene regulated by energy balance in human adipose tissue. J Clin Endocrinol Metab. 2004; 89(6): 2684-9[DOI][PubMed]
  • 22. Jenkins CM, Mancuso DJ, Yan W, Sims HF, Gibson B, Gross RW. Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities. J Biol Chem. 2004; 279(47): 48968-75[DOI][PubMed]
  • 23. Nakamura M, Kanda T, Nakamoto S, Miyamura T, Jiang X, Wu S, et al. No correlation between PNPLA3 rs738409 genotype and fatty liver and hepatic cirrhosis in Japanese patients with HCV. PLoS One. 2013; 8(12)[DOI][PubMed]
  • 24. D'Eon TM, Souza SC, Aronovitz M, Obin MS, Fried SK, Greenberg AS. Estrogen regulation of adiposity and fuel partitioning. Evidence of genomic and non-genomic regulation of lipogenic and oxidative pathways. J Biol Chem. 2005; 280(43): 35983-91[DOI][PubMed]
  • 25. Repa JJ, Liang G, Ou J, Bashmakov Y, Lobaccaro JM, Shimomura I, et al. Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta. Genes Dev. 2000; 14(22): 2819-30[PubMed]
  • 26. Thomopoulos KC, Arvaniti V, Tsamantas AC, Dimitropoulou D, Gogos CA, Siagris D, et al. Prevalence of liver steatosis in patients with chronic hepatitis B: a study of associated factors and of relationship with fibrosis. Eur J Gastroenterol Hepatol. 2006; 18(3): 233-7[PubMed]
  • 27. Petta S, Camma C, Di Marco V, Macaluso FS, Maida M, Pizzolanti G, et al. Hepatic steatosis and insulin resistance are associated with severe fibrosis in patients with chronic hepatitis caused by HBV or HCV infection. Liver Int. 2011; 31(4): 507-15[DOI][PubMed]
  • 28. Ieluzzi D, Covolo L, Donato F, Fattovich G. Progression to cirrhosis, hepatocellular carcinoma and liver-related mortality in chronic hepatitis B patients in Italy. Dig Liver Dis. 2014; 46(5): 427-32[DOI][PubMed]
  • 29. Huang Y, He S, Li JZ, Seo YK, Osborne TF, Cohen JC, et al. A feed-forward loop amplifies nutritional regulation of PNPLA3. Proc Natl Acad Sci U S A. 2010; 107(17): 7892-7[DOI][PubMed]
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