Hepatitis Monthly

Published by: Kowsar

HLA-DPB1 Variant Effect on Hepatitis B Virus Clearance and Liver Cirrhosis Development Among Southwest Chinese Population

Zhangyong Hu 1 , * , Jun Yang 1 , Guolian Xiong 1 , Han Shi 1 , Yuan Yuan 1 , Lin Fan 1 and Yali Wang 1
Authors Information
1 Department of Infection Diseases, First Affiliated Hospital, Chengdu Medical College, Chengdu, China
Article information
  • Hepatitis Monthly: August 01, 2014, 14 (8); e19747
  • Published Online: August 18, 2014
  • Article Type: Research Article
  • Received: April 30, 2014
  • Revised: June 26, 2014
  • Accepted: August 3, 2014
  • DOI: 10.5812/hepatmon.19747

To Cite: Hu Z, Yang J, Xiong G, Shi H, Yuan Y, et al. HLA-DPB1 Variant Effect on Hepatitis B Virus Clearance and Liver Cirrhosis Development Among Southwest Chinese Population, Hepat Mon. 2014 ; 14(8):e19747. doi: 10.5812/hepatmon.19747.

Copyright © 2014, Kowsar Corp. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
  • 1. Iino S. Natural history of hepatitis B and C virus infections. Oncology. 2002; 62 Suppl 1: 18-23[PubMed]
  • 2. Wright TL. Introduction to chronic hepatitis B infection. Am J Gastroenterol. 2006; 101 Suppl 1-6[DOI][PubMed]
  • 3. Ganem D, Prince AM. Hepatitis B virus infection--natural history and clinical consequences. N Engl J Med. 2004; 350(11): 1118-29[DOI][PubMed]
  • 4. Kamatani Y, Wattanapokayakit S, Ochi H, Kawaguchi T, Takahashi A, Hosono N, et al. A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians. Nat Genet. 2009; 41(5): 591-5[DOI][PubMed]
  • 5. Nishida N, Sawai H, Matsuura K, Sugiyama M, Ahn SH, Park JY, et al. Genome-wide association study confirming association of HLA-DP with protection against chronic hepatitis B and viral clearance in Japanese and Korean. PLoS One. 2012; 7(6)[DOI][PubMed]
  • 6. Mbarek H, Ochi H, Urabe Y, Kumar V, Kubo M, Hosono N, et al. A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese population. Hum Mol Genet. 2011; 20(19): 3884-92[DOI][PubMed]
  • 7. Al-Qahtani AA, Al-Anazi MR, Abdo AA, Sanai FM, Al-Hamoudi W, Alswat KA, et al. Association between HLA variations and chronic hepatitis B virus infection in Saudi Arabian patients. PLoS One. 2014; 9(1)[DOI][PubMed]
  • 8. Kim YJ, Kim HY, Lee JH, Yu SJ, Yoon JH, Lee HS, et al. A genome-wide association study identified new variants associated with the risk of chronic hepatitis B. Hum Mol Genet. 2013; 22(20): 4233-8[DOI][PubMed]
  • 9. Posuwan N, Payungporn S, Tangkijvanich P, Ogawa S, Murakami S, Iijima S, et al. Genetic association of human leukocyte antigens with chronicity or resolution of hepatitis B infection in thai population. PLoS One. 2014; 9(1)[DOI][PubMed]
  • 10. Wang L, Wu XP, Zhang W, Zhu DH, Wang Y, Li YP, et al. Evaluation of genetic susceptibility loci for chronic hepatitis B in Chinese: two independent case-control studies. PLoS One. 2011; 6(3)[DOI][PubMed]
  • 11. Thomas R, Thio CL, Apps R, Qi Y, Gao X, Marti D, et al. A novel variant marking HLA-DP expression levels predicts recovery from hepatitis B virus infection. J Virol. 2012; 86(12): 6979-85[DOI][PubMed]
  • 12. Vermehren J, Lotsch J, Susser S, Wicker S, Berger A, Zeuzem S, et al. A common HLA-DPA1 variant is associated with hepatitis B virus infection but fails to distinguish active from inactive Caucasian carriers. PLoS One. 2012; 7(3)[DOI][PubMed]
  • 13. Hu L, Zhai X, Liu J, Chu M, Pan S, Jiang J, et al. Genetic variants in human leukocyte antigen/DP-DQ influence both hepatitis B virus clearance and hepatocellular carcinoma development. Hepatology. 2012; 55(5): 1426-31[DOI][PubMed]
  • 14. Li J, Yang D, He Y, Wang M, Wen Z, Liu L, et al. Associations of HLA-DP variants with hepatitis B virus infection in southern and northern Han Chinese populations: a multicenter case-control study. PLoS One. 2011; 6(8)[DOI][PubMed]
  • 15. Di Cristofaro J, Silvy M, Chiaroni J, Bailly P. Single PCR multiplex SNaPshot reaction for detection of eleven blood group nucleotide polymorphisms: optimization, validation, and one year of routine clinical use. J Mol Diagn. 2010; 12(4): 453-60[DOI][PubMed]
  • 16. Pieters J. MHC class II-restricted antigen processing and presentation. Adv Immunol. 2000; 75: 159-208[PubMed]
  • 17. Handunnetthi L, Ramagopalan SV, Ebers GC, Knight JC. Regulation of major histocompatibility complex class II gene expression, genetic variation and disease. Genes Immun. 2010; 11(2): 99-112[DOI][PubMed]
  • 18. Hirayama K, Chen H, Kikuchi M, Yin T, Gu X, Liu J, et al. HLA-DR-DQ alleles and HLA-DP alleles are independently associated with susceptibility to different stages of post-schistosomal hepatic fibrosis in the Chinese population. Tissue Antigens. 1999; 53(3): 269-74[PubMed]
  • 19. Zhang Q, Yin J, Zhang Y, Deng Y, Ji X, Du Y, et al. HLA-DP polymorphisms affect the outcomes of chronic hepatitis B virus infections, possibly through interacting with viral mutations. J Virol. 2013; 87(22): 12176-86[DOI][PubMed]
  • 20. Guo X, Zhang Y, Li J, Ma J, Wei Z, Tan W, et al. Strong influence of human leukocyte antigen (HLA)-DP gene variants on development of persistent chronic hepatitis B virus carriers in the Han Chinese population. Hepatology. 2011; 53(2): 422-8[DOI][PubMed]
  • 21. Wong DK, Watanabe T, Tanaka Y, Seto WK, Lee CK, Fung J, et al. Role of HLA-DP polymorphisms on chronicity and disease activity of hepatitis B infection in Southern Chinese. PLoS One. 2013; 8(6)[DOI][PubMed]
  • 22. O'Brien TR, Kohaar I, Pfeiffer RM, Maeder D, Yeager M, Schadt EE, et al. Risk alleles for chronic hepatitis B are associated with decreased mRNA expression of HLA-DPA1 and HLA-DPB1 in normal human liver. Genes Immun. 2011; 12(6): 428-33[DOI][PubMed]
  • 23. Webster GJ, Reignat S, Maini MK, Whalley SA, Ogg GS, King A, et al. Incubation phase of acute hepatitis B in man: dynamic of cellular immune mechanisms. Hepatology. 2000; 32(5): 1117-24[DOI][PubMed]
  • 24. Cheng HR, Liu CJ, Tseng TC, Su TH, Yang HI, Chen CJ, et al. Host genetic factors affecting spontaneous HBsAg seroclearance in chronic hepatitis B patients. PLoS One. 2013; 8(1)[DOI][PubMed]
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