Hepatitis Monthly

Published by: Kowsar

Volatile Anesthetics in Ischemic Liver Injury: Enemy or Friend?

Masood Mohseni 1 , Saeid Safari 1 , 2 and Seyed Moayed Alavian 2 , 3 , *
Authors Information
1 Department of Anesthesiology, Iran University of Medical Sciences, Tehran, IR Iran
2 Middle East Liver Diseases Center (MELD), Tehran, IR Iran
3 Baqiyatallah Research Center for Gastroenterology and Liver Diseases, Baqiyatallah University of Medical Sciences, Tehran, IR Iran
Article information
  • Hepatitis Monthly: June 01, 2014, 14 (6); e19880
  • Published Online: June 1, 2014
  • Article Type: Editorial
  • Received: April 30, 2014
  • Accepted: May 1, 2014
  • DOI: 10.5812/hepatmon.19880

To Cite: Mohseni M, Safari S, Alavian S M. Volatile Anesthetics in Ischemic Liver Injury: Enemy or Friend?, Hepat Mon. 2014 ; 14(6):e19880. doi: 10.5812/hepatmon.19880.

Copyright © 2014, Kowsar Corp. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
  • 1. Bahde R, Spiegel HU. Hepatic ischaemia-reperfusion injury from bench to bedside. Br J Surg. 2010; 97(10): 1461-75[DOI][PubMed]
  • 2. Fuhrmann V, Jager B, Zubkova A, Drolz A. Hypoxic hepatitis - epidemiology, pathophysiology and clinical management. Wien Klin Wochenschr. 2010; 122(5-6): 129-39[DOI][PubMed]
  • 3. Serracino-Inglott F, Habib NA, Mathie RT. Hepatic ischemia-reperfusion injury. Am J Surg. 2001; 181(2): 160-6[PubMed]
  • 4. Clavien PA, Selzner M, Rudiger HA, Graf R, Kadry Z, Rousson V, et al. A prospective randomized study in 100 consecutive patients undergoing major liver resection with versus without ischemic preconditioning. Ann Surg. 2003; 238(6): 843-50[DOI][PubMed]
  • 5. Heidenberg WJ, Torio IS, Cebula J. Halothane hepatitis. An American disease? Lancet. 1963; 1(7292): 85-6[PubMed]
  • 6. Lehmann K, Clavien PA. History of hepatic surgery. Surg Clin North Am. 2010; 90(4): 655-64[DOI][PubMed]
  • 7. Clavien PA, Petrowsky H, DeOliveira ML, Graf R. Strategies for safer liver surgery and partial liver transplantation. N Engl J Med. 2007; 356(15): 1545-59[DOI][PubMed]
  • 8. Khajavi M, Emami A, Etezadi F, Safari S, Sharifi A, Shariat Moharari R. Conscious Sedation and Analgesia in Colonoscopy: Ketamine/Propofol Combination has Superior Patient Satisfaction Versus Fentanyl/Propofol. Anesth Pain Med. 2013; 3(1): 208-13[DOI][PubMed]
  • 9. Yang LQ, Tao KM, Liu YT, Cheung CW, Irwin MG, Wong GT, et al. Remifentanil preconditioning reduces hepatic ischemia-reperfusion injury in rats via inducible nitric oxide synthase expression. Anesthesiology. 2011; 114(5): 1036-47[DOI][PubMed]
  • 10. Azmude A, Agha'amou S, Yousefshahi F, Berjis K, Mirmohammad'khani M, Sadaat'ahmadi F, et al. Pregnancy outcome using general anesthesia versus spinal anesthesia for in vitro fertilization. Anesth Pain Med. 2013; 3(2): 239-42[DOI][PubMed]
  • 11. Khan ZH. Pain management in intensive care unit patients: the role of ultra-short acting opioid: remifentanil. Anesth Pain Med. 2013; 3(1): 188-90[DOI][PubMed]
  • 12. Beck-Schimmer B, Breitenstein S, Urech S, De Conno E, Wittlinger M, Puhan M, et al. A randomized controlled trial on pharmacological preconditioning in liver surgery using a volatile anesthetic. Ann Surg. 2008; 248(6): 909-18[DOI][PubMed]
  • 13. Selzner N, Boehnert M, Selzner M. Preconditioning, postconditioning, and remote conditioning in solid organ transplantation: basic mechanisms and translational applications. Transplant Rev (Orlando). 2012; 26(2): 115-24[DOI][PubMed]
  • 14. Gurusamy KS, Kumar Y, Pamecha V, Sharma D, Davidson BR. Ischaemic pre-conditioning for elective liver resections performed under vascular occlusion. Cochrane Database Syst Rev. 2009; (1)[DOI][PubMed]
  • 15. Theodoraki K, Tympa A, Karmaniolou I, Tsaroucha A, Arkadopoulos N, Smyrniotis V. Ischemia/reperfusion injury in liver resection: a review of preconditioning methods. Surg Today. 2011; 41(5): 620-9[DOI][PubMed]
  • 16. Beck-Schimmer B, Breitenstein S, Bonvini JM, Lesurtel M, Ganter M, Weber A, et al. Protection of pharmacological postconditioning in liver surgery: results of a prospective randomized controlled trial. Ann Surg. 2012; 256(5): 837-44[DOI][PubMed]
  • 17. Maines MD. The heme oxygenase system: update 2005. Antioxid Redox Signal. 2005; 7(11-12): 1761-6[DOI][PubMed]
  • 18. Ryter SW, Alam J, Choi AM. Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications. Physiol Rev. 2006; 86(2): 583-650[DOI][PubMed]
  • 19. Barrier A, Olaya N, Chiappini F, Roser F, Scatton O, Artus C, et al. Ischemic preconditioning modulates the expression of several genes, leading to the overproduction of IL-1Ra, iNOS, and Bcl-2 in a human model of liver ischemia-reperfusion. FASEB J. 2005; 19(12): 1617-26[DOI][PubMed]
  • 20. Habibollahi P, Mahboobi N, Esmaeili S, Safari S, Dabbagh A, Alavian SM. Halothane-induced hepatitis: A forgotten issue in developing countries: Halothane-induced hepatitis. Hepat Mon. 2011; 11(1): 3-6[PubMed]
  • 21. Dabbagh A, Rajaei S. The Role of Anesthetic Drugs in Liver Apoptosis. Hepat Mon. 2013; 13(8)[DOI][PubMed]
  • 22. Mahboobi N, Esmaili S, Safari S, Habibollahi P, Dabbagh A, Alavian SM. Halothane: How should it be treated in a developing country? EMHJ. 2011;
  • 23. Gut J. Molecular basis of halothane hepatitis. Arch Toxicol Suppl. 1998; 20: 3-17[PubMed]
  • 24. Habibollahi P, Mahboobi N, Esmaeili S, Safari S, Dabbagh A, Alavian SM. Halothane-induced hepatitis: A forgotten issue in developing countries. Hepat Mon. 2011; 11(1): 3
  • 25. Eger EI, 2nd, Smuckler EA, Ferrell LD, Goldsmith CH, Johnson BH. Is enflurane hepatotoxic? Anesth Analg. 1986; 65(1): 21-30[PubMed]
  • 26. Elliott RH, Strunin L. Hepatotoxicity of volatile anaesthetics. Br J Anaesth. 1993; 70(3): 339-48[PubMed]
  • 27. Gelman S. General anesthesia and hepatic circulation. Can J Physiol Pharmacol. 1987; 65(8): 1762-79[PubMed]
  • 28. Holaday DA, Fiserova-Bergerova V, Latto IP, Zumbiel MA. Resistance of isoflurane to biotransformation in man. Anesthesiology. 1975; 43(3): 325-32[PubMed]
  • 29. Gunza JT, Pashayan AG. Postoperative elevation of serum transaminases following isoflurane anesthesia. J Clin Anesth. 1992; 4(4): 336-41[PubMed]
  • 30. Brunt EM, White H, Marsh JW, Holtmann B, Peters MG. Fulminant hepatic failure after repeated exposure to isoflurane anesthesia: a case report. Hepatology. 1991; 13(6): 1017-21[PubMed]
  • 31. Turner GB, O'Rourke D, Scott GO, Beringer TR. Fatal hepatotoxicity after re-exposure to isoflurane: a case report and review of the literature. Eur J Gastroenterol Hepatol. 2000; 12(8): 955-9[PubMed]
  • 32. Hoetzel A, Leitz D, Schmidt R, Tritschler E, Bauer I, Loop T, et al. Mechanism of hepatic heme oxygenase-1 induction by isoflurane. Anesthesiology. 2006; 104(1): 101-9[PubMed]
  • 33. Gatecel C, Losser MR, Payen D. The postoperative effects of halothane versus isoflurane on hepatic artery and portal vein blood flow in humans. Anesth Analg. 2003; 96(3): 740-5[PubMed]
  • 34. Kanaya N, Nakayama M, Fujita S, Namiki A. Comparison of the effects of sevoflurane, isoflurane and halothane on indocyanine green clearance. Br J Anaesth. 1995; 74(2): 164-7[PubMed]
  • 35. Bedirli N, Ofluoglu E, Kerem M, Utebey G, Alper M, Yilmazer D, et al. Hepatic energy metabolism and the differential protective effects of sevoflurane and isoflurane anesthesia in a rat hepatic ischemia-reperfusion injury model. Anesth Analg. 2008; 106(3): 830-7[DOI][PubMed]
  • 36. Sutton TS, Koblin DD, Gruenke LD, Weiskopf RB, Rampil IJ, Waskell L, et al. Fluoride metabolites after prolonged exposure of volunteers and patients to desflurane. Anesth Analg. 1991; 73(2): 180-5[PubMed]
  • 37. Malhotra P, Mychaskiw G, Rai A. Desflurane versus opioid anesthesia for cardiac shunt procedures in infants with cyantoic congential heart disease. Anesth Pain Med. 2013; 3(1): 191-7[DOI][PubMed]
  • 38. Hartman JC, Pagel PS, Proctor LT, Kampine JP, Schmeling WT, Warltier DC. Influence of desflurane, isoflurane and halothane on regional tissue perfusion in dogs. Can J Anaesth. 1992; 39(8): 877-87[DOI][PubMed]
  • 39. Weiskopf RB, Eger EI, 2nd, Ionescu P, Yasuda N, Cahalan MK, Freire B, et al. Desflurane does not produce hepatic or renal injury in human volunteers. Anesth Analg. 1992; 74(4): 570-4[PubMed]
  • 40. Ko JS, Gwak MS, Choi SJ, Kim GS, Kim JA, Yang M, et al. The effects of desflurane and propofol-remifentanil on postoperative hepatic and renal functions after right hepatectomy in liver donors. Liver Transpl. 2008; 14(8): 1150-8[DOI][PubMed]
  • 41. Kotake Y. [Anesthetic protection against hepatic injury]. Masui. 2006; 55(5): 570-8[PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments