Hepatitis Monthly

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Analytical Assessment of Interleukin - 23 and -27 Cytokines in Healthy People and Patients With Hepatitis C Virus Infection (Genotypes 1 and 3a)

Asghar Ashrafi Hafez 1 , Abbas Ahmadi Vasmehjani 2 , Rasoul Baharlou 2 , Seyed Dawood Mousavi Nasab 3 , Mohammad Hasan Davami 2 , * , Ahmad Najafi 2 , Negar Joharinia 2 , Hasan Rezanezhad 2 , Nayeb Ali Ahmadi 4 and Masoumeh Imanzad 5 , 6
Authors Information
1 Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran
2 Department of Microbiology and Immunology, Jahrom University of Medical Sciences, Jahrom, IR Iran
3 Department of Virology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, IR Iran
4 Department of Medical Lab Technology and Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran
5 Department of Social Medicine, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, IR Iran
6 Young Researchers Club, Shahr-e-Qods branch, Islamic Azad University, Tehran, IR Iran
Article information
  • Hepatitis Monthly: September 01, 2014, 14 (9); e21000
  • Published Online: September 27, 2014
  • Article Type: Research Article
  • Received: June 7, 2014
  • Revised: July 20, 2014
  • Accepted: August 6, 2014
  • DOI: 10.5812/hepatmon.21000

To Cite: Ashrafi Hafez A, Ahmadi Vasmehjani A, Baharlou R, Mousavi Nasab S D, Davami M H, et al. Analytical Assessment of Interleukin - 23 and -27 Cytokines in Healthy People and Patients With Hepatitis C Virus Infection (Genotypes 1 and 3a), Hepat Mon. 2014 ; 14(9):e21000. doi: 10.5812/hepatmon.21000.

Copyright © 2014, Kowsar Corp. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Lauer GM, Walker BD. Hepatitis C virus infection. N Engl J Med. 2001; 345(1): 41-52[DOI][PubMed]
  • 2. Rehermann B. Hepatitis C virus versus innate and adaptive immune responses: a tale of coevolution and coexistence. J Clin Invest. 2009; 119(7): 1745-54[DOI][PubMed]
  • 3. Ksiaa Cheikhrouhou L, Sfar I, Aounallah-Skhiri H, Aouadi H, Jendoubi-Ayed S, Ben Abdallah T, et al. Cytokine and apoptosis gene polymorphisms influence the outcome of hepatitis C virus infection. Hepatobiliary Pancreat Dis Int. 2011; 10(3): 280-8[PubMed]
  • 4. Fainboim L, Chernavsky A, Paladino N, Flores AC, Arruvito L. Cytokines and chronic liver disease. Cytokine Growth Factor Rev. 2007; 18(1-2): 143-57[DOI][PubMed]
  • 5. Dharancy S, Conti F, Desreumaux P, Paris JC, Calmus Y. [Cytokine imbalance during hepatitis C virus infection. Consequences in hepatic pathophysiology]. Gastroenterol Clin Biol. 2001; 25(6-7): 595-604[PubMed]
  • 6. Jia HY, Du J, Zhu SH, Ma YJ, Chen HY, Yang BS, et al. The roles of serum IL-18, IL-10, TNF-alpha and sIL-2R in patients with chronic hepatitis C. Hepatobiliary Pancreat Dis Int. 2002; 1(3): 378-82[PubMed]
  • 7. Ryan EJ, O’Farrelly C. The affect of chronic hepatitis C infection on dendritic cell function: a summary of the experimental evidence. J Viral Hepat. 2011; 18(9): 601-7[DOI]
  • 8. Hunter CA. New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions. Nat Rev Immunol. 2005; 5(7): 521-31[DOI][PubMed]
  • 9. Xu M, Mizoguchi I, Morishima N, Chiba Y, Mizuguchi J, Yoshimoto T. Regulation of antitumor immune responses by the IL-12 family cytokines, IL-12, IL-23, and IL-27. Clin Dev Immunol. 2010; 2010[DOI][PubMed]
  • 10. Grakoui A, Shoukry NH, Woollard DJ, Han JH, Hanson HL, Ghrayeb J, et al. HCV persistence and immune evasion in the absence of memory T cell help. Science. 2003; 302(5645): 659-62[DOI][PubMed]
  • 11. Aggarwal S, Ghilardi N, Xie MH, de Sauvage FJ, Gurney AL. Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J Biol Chem. 2003; 278(3): 1910-4[DOI][PubMed]
  • 12. Hassoba H, Leheta O, Sayed A, Fahmy H, Fathy A, Abbas F, et al. IL-10 and IL-12p40 in Egyptian patients with HCV-related chronic liver disease. Egypt J Immunol. 2003; 10(1): 1-8[PubMed]
  • 13. Yoshimoto T, Yoshimoto T, Yasuda K, Mizuguchi J, Nakanishi K. IL-27 suppresses Th2 cell development and Th2 cytokines production from polarized Th2 cells: a novel therapeutic way for Th2-mediated allergic inflammation. J Immunol. 2007; 179(7): 4415-23[PubMed]
  • 14. Batten M, Li J, Yi S, Kljavin NM, Danilenko DM, Lucas S, et al. Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells. Nat Immunol. 2006; 7(9): 929-36[DOI][PubMed]
  • 15. Fitzgerald DC, Zhang GX, El-Behi M, Fonseca-Kelly Z, Li H, Yu S, et al. Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells. Nat Immunol. 2007; 8(12): 1372-9[DOI][PubMed]
  • 16. Greenwell-Wild T, Vazquez N, Jin W, Rangel Z, Munson PJ, Wahl SM. Interleukin-27 inhibition of HIV-1 involves an intermediate induction of type I interferon. Blood. 2009; 114(9): 1864-74[DOI][PubMed]
  • 17. Frank AC, Zhang X, Katsounas A, Bharucha JP, Kottilil S, Imamichi T. Interleukin-27, an anti-HIV-1 cytokine, inhibits replication of hepatitis C virus. J Interferon Cytokine Res. 2010; 30(6): 427-31[DOI][PubMed]
  • 18. Zhu C, Zhang R, Liu L, Rasool ST, Mu Y, Sun W, et al. Hepatitis B virus enhances interleukin-27 expression both in vivo and in vitro. Clin Immunol. 2009; 131(1): 92-7[DOI][PubMed]
  • 19. Schvoerer E, Navas MC, Thumann C, Fuchs A, Meyer N, Habersetzer F, et al. Production of interleukin-18 and interleukin-12 in patients suffering from chronic hepatitis C virus infection before antiviral therapy. J Med Virol. 2003; 70(4): 588-93[DOI][PubMed]
  • 20. El-Kady IM, Lotfy M, Badra G, El-Masry S, Waked I. Interleukin (IL)-4, IL-10, IL-18 and IFN-gamma cytokines pattern in patients with combined hepatitis C virus and Schistosoma mansoni infections. Scand J Immunol. 2005; 61(1): 87-91[DOI][PubMed]
  • 21. Zhang L, Miao L, Han F, Dou XG. [Cytokine levels in serum of patients with chronic hepatitis C and its significance]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2011; 27(3): 301-3[PubMed]
  • 22. Mona F, Schaalan WAM, Hesham H, Amin VD. Correlation to interleukin-17, interleukin-23 and PⅢNP in hepatitis C virus genotype 4. World J Gastroen. 2012; 18(28): 3738-44
  • 23. Takeda A, Hamano S, Yamanaka A, Hanada T, Ishibashi T, Mak TW, et al. Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment. J Immunol. 2003; 170(10): 4886-90[PubMed]
  • 24. Ruckerl D, Hessmann M, Yoshimoto T, Ehlers S, Holscher C. Alternatively activated macrophages express the IL-27 receptor alpha chain WSX-1. Immunobiology. 2006; 211(6-8): 427-36[DOI][PubMed]
  • 25. Lee CH, Choi YH, Yang SH, Lee CW, Ha SJ, Sung YC. Hepatitis C virus core protein inhibits interleukin 12 and nitric oxide production from activated macrophages. Virology. 2001; 279(1): 271-9[DOI][PubMed]
  • 26. Waggoner SN, Hall CH, Hahn YS. HCV core protein interaction with gC1q receptor inhibits Th1 differentiation of CD4+ T cells via suppression of dendritic cell IL-12 production. J Leukoc Biol. 2007; 82(6): 1407-19[DOI][PubMed]
  • 27. Tornero C, Alberola J, Tamarit A, Navarro D. Effect of highly active anti-retroviral therapy and hepatitis C virus co-infection on serum levels of pro-inflammatory and immunoregulatory cytokines in human immunodeficiency virus-1-infected individuals. Clin Microbiol Infect. 2006; 12(6): 555-60[DOI][PubMed]
  • 28. Guzzo C, Hopman WM, Che Mat NF, Wobeser W, Gee K. Impact of HIV infection, highly active antiretroviral therapy, and hepatitis C coinfection on serum interleukin-27. AIDS. 2010; 24(9): 1371-4[DOI][PubMed]
  • 29. Murakami S, Okubo K, Tsuji Y, Sakata H, Takahashi T, Kikuchi M, et al. Changes in liver enzymes after surgery in anti-hepatitis C virus-positive patients. World J Surg. 2004; 28(7): 671-4[DOI][PubMed]
  • 30. Green RM, Flamm S. AGA technical review on the evaluation of liver chemistry tests. Gastroenterology. 2002; 123(4): 1367-84[PubMed]
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