Hepatitis Monthly

Published by: Kowsar

S Gene Mutants Occurrence Among Hepatitis B Carriers in Malaysia

Jeyanthi Suppiah 1 , * , Rozainanee Mohd Zain 1 , Norazlah Bahari 2 , Salbiah Haji Nawi 3 and Zainah Saat 1
Authors Information
1 Virology Unit, Institute for Medical Research, Kuala Lumpur, Malaysia
2 Pathology Unit, Selayang Hospital, Selangor, Malaysia
3 Microbiology Unit, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia
Article information
  • Hepatitis Monthly: December 2014, 14 (12); e22565
  • Published Online: November 30, 2014
  • Article Type: Research Article
  • Received: August 6, 2014
  • Revised: October 11, 2014
  • Accepted: November 22, 2014
  • DOI: 10.5812/hepatmon.22565

To Cite: Suppiah J, Mohd Zain R, Bahari N, Haji Nawi S, Saat Z. et al. S Gene Mutants Occurrence Among Hepatitis B Carriers in Malaysia, Hepat Mon. 2014 ;14(12):e22565. doi: 10.5812/hepatmon.22565.

Copyright: Copyright © 2014, Hepatitis Monthly. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited..
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
  • 1. Coleman PF. Detecting hepatitis B surface antigen mutants. Emerg Infect Dis. 2006; 12(2): 198-203[DOI][PubMed]
  • 2. Quer J, Martell M, Rodriguez FA, Bosch A, Jardi R, Buti M, et al. The Impact of Rapid Evolution of Hepatitis Viruses. 2008;
  • 3. Yousuf R, Rapiaah M, Ahmed SA, Rosline H, Salam A, Selamah S, et al. Trends in hepatitis B virus infection among blood donors in Kelantan, Malaysia: a retrospective study. Southeast Asian J Trop Med Public Health. 2007; 38(6): 1070-4[PubMed]
  • 4. Merican I, Guan R, Amarapuka D, Alexander M, Chutaputti A, Chien R, et al. Chronic hepatitis B virus infection in Asian countries. Journal of Gastroenterology and Hepatology. 2000; 15(12): 1356-61[DOI]
  • 5. Pourkarim MR, Amini-Bavil-Olyaee S, Kurbanov F, Van Ranst M, Tacke F. Molecular identification of hepatitis B virus genotypes/subgenotypes: revised classification hurdles and updated resolutions. World J Gastroenterol. 2014; 20(23): 7152-68[DOI][PubMed]
  • 6. Sugauchi F, Mizokami M, Orito E, Ohno T, Kato H, Suzuki S, et al. A novel variant genotype C of hepatitis B virus identified in isolates from Australian Aborigines: complete genome sequence and phylogenetic relatedness. J Gen Virol. 2001; 82: 883-92[PubMed]
  • 7. Kahila Bar-Gal G, Kim MJ, Klein A, Shin DH, Oh CS, Kim JW, et al. Tracing hepatitis B virus to the 16th century in a Korean mummy. Hepatology. 2012; 56(5): 1671-80[DOI][PubMed]
  • 8. Schultz AK, Bulla I, Abdou-Chekaraou M, Gordien E, Morgenstern B, Zoaulim F, et al. jpHMM: recombination analysis in viruses with circular genomes such as the hepatitis B virus. Nucleic Acids Res. 2012; 40-8[DOI][PubMed]
  • 9. Suppiah J, Mohd Zain R, Haji Nawi S, Bahari N, Saat Z. Drug-resistance associated mutations in polymerase (p) gene of hepatitis B virus isolated from malaysian HBV carriers. Hepat Mon. 2014; 14(1)[DOI][PubMed]
  • 10. Liu S, Zhang H, Gu C, Yin J, He Y, Xie J, et al. Associations between hepatitis B virus mutations and the risk of hepatocellular carcinoma: a meta-analysis. J Natl Cancer Inst. 2009; 101(15): 1066-82[DOI][PubMed]
  • 11. Weinberger KM, Zoulek G, Bauer T, Bohm S, Jilg W. A novel deletion mutant of hepatitis B virus surface antigen. J Med Virol. 1999; 58(2): 105-10[PubMed]
  • 12. Yeung P, Wong DK, Lai CL, Fung J, Seto WK, Yuen MF. Association of hepatitis B virus pre-S deletions with the development of hepatocellular carcinoma in chronic hepatitis B. J Infect Dis. 2011; 203(5): 646-54[DOI][PubMed]
  • 13. Cao GW. Clinical relevance and public health significance of hepatitis B virus genomic variations. World J Gastroenterol. 2009; 15(46): 5761-9[PubMed]
  • 14. Biswas A, Panigrahi R, Banerjee A, Pal M, De BK, Chakrabarti S, et al. Differential pattern of pre-S mutations/deletions and its association with hepatitis B virus genotypes in Eastern India. Infect Genet Evol. 2012; 12(2): 384-91[DOI][PubMed]
  • 15. Sengupta S, Panda SK, Acharya SK, Durgapal H. Role of hepatitis B virus genotype D & its mutants in occult hepatitis B infection. Indian J Med Res. 2013; 138(3): 329-39[PubMed]
  • 16. Schaefer S. Hepatitis B virus: significance of genotypes. J Viral Hepat. 2005; 12(2): 111-24[DOI][PubMed]
  • 17. Kay A, Zoulim F. Hepatitis B virus genetic variability and evolution. Virus Res. 2007; 127(2): 164-76[DOI][PubMed]
  • 18. Chen CH, Hung CH, Lee CM, Hu TH, Wang JH, Wang JC, et al. Pre-S deletion and complex mutations of hepatitis B virus related to advanced liver disease in HBeAg-negative patients. Gastroenterology. 2007; 133(5): 1466-74[DOI][PubMed]
  • 19. Chen BF, Liu CJ, Jow GM, Chen PJ, Kao JH, Chen DS. High prevalence and mapping of pre-S deletion in hepatitis B virus carriers with progressive liver diseases. Gastroenterology. 2006; 130(4): 1153-68[DOI][PubMed]
  • 20. Lee SA, Kim K, Kim H, Kim BJ. Nucleotide change of codon 182 in the surface gene of hepatitis B virus genotype C leading to truncated surface protein is associated with progression of liver diseases. J Hepatol. 2012; 56(1): 63-9[DOI][PubMed]
  • 21. Kim BJ. Hepatitis B virus mutations related to liver disease progression of Korean patients. World J Gastroenterol. 2014; 20(2): 460-7[DOI][PubMed]
  • 22. Shi Y, Wei F, Hu D, Li Q, Smith D, Li N, et al. Mutations in the major hydrophilic region (MHR) of hepatitis B virus genotype C in North China. J Med Virol. 2012; 84(12): 1901-6[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader