To Cite:
Constantinescu
I, Dinu
A, Boscaiu
V, Niculescu
M. Hepatitis B Virus Core Promoter Mutations in Patients With Chronic Hepatitis B and Hepatocellular Carcinoma in Bucharest, Romania,
Hepat Mon.
2014
; 14(10):e22072.
doi: 10.5812/hepatmon.22072.
1.
Tacke F, Gehrke C, Luedde T, Heim A, Manns MP, Trautwein C. Basal core promoter and precore mutations in the hepatitis B virus genome enhance replication efficacy of Lamivudine-resistant mutants. J Virol. 2004; 78(16): 8524-35[DOI][PubMed]
2.
Voiculescu M,
Iliescu L,
Ionescu C,
Micu L,
Ismail G,
Zilisteanu D,
et al.
A cross-sectional epidemiological study of HBV, HCV, HDV and HEV prevalence in the SubCarpathian and South-Eastern regions of Romania. J Gastrointestin Liver Dis. 2010; 19(1): 43-8[PubMed]
3.
Tong MJ, Blatt LM, Kao JH, Cheng JT, Corey WG. Basal core promoter T1762/A1764 and precore A1896 gene mutations in hepatitis B surface antigen-positive hepatocellular carcinoma: a comparison with chronic carriers. Liver Int. 2007; 27(10): 1356-63[DOI][PubMed]
4.
Fang ZL, Ling R, Wang SS, Nong J, Huang CS, Harrison TJ. HBV core promoter mutations prevail in patients with hepatocellular carcinoma from Guangxi, China. J Med Virol. 1998; 56(1): 18-24[PubMed]
5.
Shi M, Zhang Y, Zhang J, Liu W, Xing L. Hepatitis B virus genotypes, precore mutations, and basal core promoter mutations in HBV-infected Chinese patients with persistently normal alanine aminotransferase and low serum HBV-DNA levels. Braz J Infect Dis. 2012; 16(1): 52-6[PubMed]
6.
Yang HC,
Chen CL,
Shen YC,
Peng CY,
Liu CJ,
Tseng TC,
et al.
Distinct evolution and predictive value of hepatitis B virus precore and basal core promoter mutations in interferon-induced hepatitis B e antigen seroconversion. Hepatology. 2013; 57(3): 934-43[DOI][PubMed]
7.
Yeh SH,
Tsai CY,
Kao JH,
Liu CJ,
Kuo TJ,
Lin MW,
et al.
Quantification and genotyping of hepatitis B virus in a single reaction by real-time PCR and melting curve analysis. J Hepatol. 2004; 41(4): 659-66[DOI][PubMed]
8.
Erhardt A,
Blondin D,
Hauck K,
Sagir A,
Kohnle T,
Heintges T,
et al.
Response to interferon alfa is hepatitis B virus genotype dependent: genotype A is more sensitive to interferon than genotype D. Gut. 2005; 54(7): 1009-13[DOI][PubMed]
9.
Enomoto M, Tamori A, Nishiguchi S. Hepatitis B virus genotypes and response to antiviral therapy. Clin Lab. 2006; 52(1-2): 43-7[PubMed]
10.
Ren X,
Xu Z,
Liu Y,
Li X,
Bai S,
Ding N,
et al.
Hepatitis B virus genotype and basal core promoter/precore mutations are associated with hepatitis B-related acute-on-chronic liver failure without pre-existing liver cirrhosis. J Viral Hepat. 2010; 17(12): 887-95[DOI][PubMed]
11.
Ghabeshi S, Sharifi Z, Hosseini SM, Mahmoodian Shooshtari M. Correlation between viral load of HBV in chronic hepatitis B patients and precore and Basal core promoter mutations. Hepat Mon. 2013; 13(2)[DOI][PubMed]
12.
Tong MJ, Blatt LM, Kao JH, Cheng JT, Corey WG. Precore/basal core promoter mutants and hepatitis B viral DNA levels as predictors for liver deaths and hepatocellular carcinoma. World J Gastroenterol. 2006; 12(41): 6620-6[PubMed]
13.
Ohata K, Hamasaki K, Toriyama K, Ishikawa H, Nakao K, Eguchi K. High viral load is a risk factor for hepatocellular carcinoma in patients with chronic hepatitis B virus infection. J Gastroenterol Hepatol. 2004; 19(6): 670-5[DOI][PubMed]
14.
Chen CJ,
Yang HI,
Su J,
Jen CL,
You SL,
Lu SN,
et al.
Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level. JAMA. 2006; 295(1): 65-73[DOI][PubMed]
15.
Chen BF, Liu CJ, Jow GM, Chen PJ, Kao JH, Chen DS. High prevalence and mapping of pre-S deletion in hepatitis B virus carriers with progressive liver diseases. Gastroenterology. 2006; 130(4): 1153-68[DOI][PubMed]
16.
Hunt CM, McGill JM, Allen MI, Condreay LD. Clinical relevance of hepatitis B viral mutations. Hepatology. 2000; 31(5): 1037-44[DOI][PubMed]
17.
Kao JH, Chen PJ, Lai MY, Chen DS. Basal core promoter mutations of hepatitis B virus increase the risk of hepatocellular carcinoma in hepatitis B carriers. Gastroenterology. 2003; 124(2): 327-34[DOI][PubMed]
18.
Yotsuyanagi H, Hino K, Tomita E, Toyoda J, Yasuda K, Iino S. Precore and core promoter mutations, hepatitis B virus DNA levels and progressive liver injury in chronic hepatitis B. J Hepatol. 2002; 37(3): 355-63[PubMed]
19.
Muroyama R,
Kato N,
Yoshida H,
Otsuka M,
Moriyama M,
Wang Y,
et al.
Nucleotide change of codon 38 in the X gene of hepatitis B virus genotype C is associated with an increased risk of hepatocellular carcinoma. J Hepatol. 2006; 45(6): 805-12[DOI][PubMed]
20.
Liu CJ,
Chen BF,
Chen PJ,
Lai MY,
Huang WL,
Kao JH,
et al.
Role of hepatitis B virus precore/core promoter mutations and serum viral load on noncirrhotic hepatocellular carcinoma: a case-control study. J Infect Dis. 2006; 194(5): 594-9[DOI][PubMed]
21.
Liu CJ,
Chen BF,
Chen PJ,
Lai MY,
Huang WL,
Kao JH,
et al.
Role of hepatitis B viral load and basal core promoter mutation in hepatocellular carcinoma in hepatitis B carriers. J Infect Dis. 2006; 193(9): 1258-65[DOI][PubMed]
22.
Zhang Q, Cao G. Genotypes, mutations, and viral load of hepatitis B virus and the risk of hepatocellular carcinoma: HBV properties and hepatocarcinogenesis. Hepat Mon. 2011; 11(2): 86-91[PubMed]
23.
Craxi A, Yurdaydin C. From viral pathobiology to the treatment of hepatitis B virus infection EASL Monothematic Conference (Istanbul, Turkey, October 6-8, 2005). J Hepatol. 2006; 44(6): 1186-95[DOI][PubMed]
24.
Papatheodoridis GV,
Manesis EK,
Manolakopoulos S,
Elefsiniotis IS,
Goulis J,
Giannousis J,
et al.
Is there a meaningful serum hepatitis B virus DNA cutoff level for therapeutic decisions in hepatitis B e antigen-negative chronic hepatitis B virus infection? Hepatology. 2008; 48(5): 1451-9[DOI][PubMed]
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