Hepatitis Monthly

Published by: Kowsar

The Effect of Berberis Vulgaris Extract on Transaminase Activities in Non-Alcoholic Fatty Liver Disease

Raziye Iloon Kashkooli 1 , Seyed Saeed Najafi 1 , * , Farkhondeh Sharif 1 , Azadeh Hamedi 2 , Mohammad Kazem Hoseini Asl 3 , Majid Najafi Kalyani 4 and Mehdi Birjandi 5
Authors Information
1 Department of Medical Surgical, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, IR Iran
2 Department of Pharmaceutical Biotechnology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, IR Iran
3 Gastroenterohepatology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, IR Iran
4 Department of Medical Surgical, School of Nursing, Fasa University of Medical Sciences, Fasa, IR Iran
5 Department of Biostatistics, School of Public Health, Lorestan University of Medical Sciences, Khoramabad, IR Iran
Article information
  • Hepatitis Monthly: February 01, 2015, 15 (2); e25067
  • Published Online: February 5, 2015
  • Article Type: Research Article
  • Received: November 1, 2014
  • Revised: January 1, 2015
  • Accepted: January 11, 2015
  • DOI: 10.5812/hepatmon.25067

To Cite: Iloon Kashkooli R, Najafi S S, Sharif F, Hamedi A, Hoseini Asl M K, et al. The Effect of Berberis Vulgaris Extract on Transaminase Activities in Non-Alcoholic Fatty Liver Disease, Hepat Mon. 2015 ; 15(2):e25067. doi: 10.5812/hepatmon.25067.

Copyright © 2015, Kowsar Corp. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
  • 1. Harte AL, da Silva NF, Creely SJ, McGee KC, Billyard T, Youssef-Elabd EM, et al. Elevated endotoxin levels in non-alcoholic fatty liver disease. J Inflamm (Lond). 2010; 7(15): 1-10[DOI][PubMed]
  • 2. Light N. Epidemiology, clinical features, and diagnosis of nonalcoholic steatohepatitis. 2011; 2(19): 17-22
  • 3. Khoshbaten M, Aliasgarzadeh A, Masnadi K, Tarzamani MK, Farhang S, Babaei H, et al. N-acetylcysteine improves liver function in patients with non-alcoholic Fatty liver disease. Hepat Mon. 2010; 10(1): 12-6[PubMed]
  • 4. Jamali R, Khonsari M, Merat S, Khoshnia M, Jafari E, Bahram Kalhori A, et al. Persistent alanine aminotransferase elevation among the general Iranian population: prevalence and causes. World J Gastroenterol. 2008; 14(18): 2867-71[PubMed]
  • 5. Hajiaghamohammadi AA, Ziaee A, Samimi R. The efficacy of licorice root extract in decreasing transaminase activities in non-alcoholic fatty liver disease: a randomized controlled clinical trial. Phytother Res. 2012; 26(9): 1381-4[DOI][PubMed]
  • 6. Jamali R. Non-alcoholic fatty liver disease: Diagnosis and evaluation of disease severity. Thrita 2013; 2(4): 43-51
  • 7. Razavizade M, Jamali R, Arj A, Matini SM, Moraveji A, Taherkhani E. The effect of pioglitazone and metformin on liver function tests, insulin resistance, and liver fat content in nonalcoholic Fatty liver disease: a randomized double blinded clinical trial. Hepat Mon. 2013; 13(5)[DOI][PubMed]
  • 8. Kirovski G, Schacherer D, Wobser H, Huber H, Niessen C, Beer C, et al. Prevalence of ultrasound-diagnosed non-alcoholic fatty liver disease in a hospital cohort and its association with anthropometric, biochemical and sonographic characteristics. Int J Clin Exp Med. 2010; 3(3): 202-10[PubMed]
  • 9. Kotronen A, Yki-Jarvinen H, Mannisto S, Saarikoski L, Korpi-Hyovalti E, Oksa H, et al. Non-alcoholic and alcoholic fatty liver disease - two diseases of affluence associated with the metabolic syndrome and type 2 diabetes: the FIN-D2D survey. BMC Public Health. 2010; 10: 237[DOI][PubMed]
  • 10. Savadkoohi F, Hosseini-Tabatabaei MT, Shahabi Nezhad S. The frequency of fatty liver in sonography of patients withou liver diseases background and its correlation with blood cholesterol and triglycerid. Iranian J Tabibe Shargh. 2003; 5(3): 177-83
  • 11. Eslami L, Merat S, Nasseri-Moghaddam S. Treatment of non-alcoholic fatty liver disease (nafld): A systematic review. MEJDD. 2009; 1(2): 89-99
  • 12. Jamali R. Non-alcoholic fatty liver disease: Diagnosis and evaluation of disease severity. Thrita J Med Sci. 2013; 2(2): 43-51[DOI]
  • 13. Stickel F, Schuppan D. Herbal medicine in the treatment of liver diseases. Dig Liver Dis. 2007; 39(4): 293-304[DOI][PubMed]
  • 14. Chang X, Yan H, Fei J, Jiang M, Zhu H, Lu D, et al. Berberine reduces methylation of the MTTP promoter and alleviates fatty liver induced by a high-fat diet in rats. J Lipid Res. 2010; 51(9): 2504-15[DOI][PubMed]
  • 15. Murugesh K, Yeligar VC, Maiti CB, Maity TK. Hepato protective and antioxidant role of Berberis tinctoria Lesch leaves on paracetamol induced hepatic damage in rats. Iran J Pharmacol Ther 2005; 4(1): 64-9
  • 16. Das S, Das MK, Mazumder PM, Das S, Basu SP. Cytotoxic activity of methanolic extract of Berberis aristata DC on colon cancer. Global J Pharmacol. 2009; 3(3): 137-40
  • 17. Murugesh KS, Yeligar VC, Maiti CB, Maity TK. Hepato protective and antioxidant role of Berberis tinctoria Lesch leaves on paracetamol induced hepatic damage in rats. 2005; (4): 64-9
  • 18. Hanachi P, Golkho SH. Using HPLC to determination the composition and antioxidant activity of Berberis vulgaris. Europ J Sci Res. 2009; 29(1): 47-54
  • 19. Hanachi P, Kua SH, Asmah R, Motalleb G, Fauziah O. Cytotoxic Effect of Berberis vulgaris Fruit Extract on the Proliferation of Human Liver Cancer Cell Line (HepG2) and its Antioxidant Properties. Int J Canc Res. 2006; 2(1): 1-9[DOI]
  • 20. Lewis JR, Mohanty SR. Nonalcoholic fatty liver disease: a review and update. Dig Dis Sci. 2010; 55(3): 560-78[DOI][PubMed]
  • 21. Tavangar SM, Khadem Sameni F, Derakhshan MH, Merat SH, Mehrnami A, Malekzadeh R. Correlation Of The Serum Levels Of The Alt And Ast With The Degree Of Inflammation And Fibrosis In The Liver Of Patients With Non-Alcoholic Steatohepatitis: Validation Of The Revisions Applied On The Brunt Scoring System. HAKIM. 2006; 8(4): 1
  • 22. Federico A, Trappoliere M, Loguercio C. Treatment of patients with non-alcoholic fatty liver disease: current views and perspectives. Dig Liver Dis. 2006; 38(11): 789-801[DOI][PubMed]
  • 23. Motalleb G, Hanachi P, Kua SH, Fauziah O, Asmah R. Evaluation of Phenolic Content and Total Antioxidant Activity in Berberis vulgaris Fruit Extract. J Biol Sci. 2005; 5(5): 648-53[DOI]
  • 24. Wei J, Wu J, Jiag J. Clinical study on improvement of typeⅡdiabetes mellitus complicated with fatty liver treated by berberine. Chinese J Integ Tradition West Med Liver Dis. 2004; 6: 334-6
  • 25. Yang QH, Hu SP, Zhang YP, Xie WN, Li N, Ji GY, et al. Effect of berberine on expressions of uncoupling protein-2 mRNA and protein in hepatic tissue of non-alcoholic fatty liver disease in rats. Chin J Integr Med. 2011; 17(3): 205-11[DOI][PubMed]
  • 26. Zhang Y, Li X, Zou D, Liu W, Yang J, Zhu N, et al. Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. J Clin Endocrinol Metab. 2008; 93(7): 2559-65[DOI][PubMed]
  • 27. Taheri S, Zarei A, Changizi Ashtiyani S, Rezaei A, Zaheiri S. Evaluation of the effects of hydroalcoholic extract of Berberis vulgaris root on the activity of liver enzymes in male hypercholesterolemic rats. Avicenna J Phytomed. 2012; 2(3): 153-61[PubMed]
  • 28. Motalleb G, Hanachi P, Fauziah O, Asmah R. Effect of Berberis vulgaris fruit extract on alpha-fetoprotein gene expression and chemical carcinogen metabolizing enzymes activities in hepatocarcinogenesis rats. Iran J Cancer Prev. 2012; 1(1): 33-42
  • 29. Eidi A, Zarin-Ghalam J. Hepatoprotective effect of Berberis vulgaris L. extract on CCl4-induced toxicity in rats. 2011; 16(3): 169-73
  • 30. Ebrahimi-Mamaghani M, Arefhosseini SR, Golzarand M, Aliasgarzadeh A, Vahed-Jabbary M. Long-term effects of processed Berberis vulgaris on some metabolic syndrome components. Iran J Endocrinol Metabol. 2009; 11(1): 41-7
  • 31. Farhadi A, Gavadifar K. Effects of berberise vulgaris fruit extract on blood cholesterol and triglyceride in hyperlipidemic patients . J Semnan Univ Med Sci. 2008; 9(3): 211-6
  • 32. Yin J, Xing H, Ye J. Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism. 2008; 57(5): 712-7[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments