Hepatitis Monthly

Published by: Kowsar

The Impact of Fragility Fractures on Health-Related Quality of Life in Patients With Primary Sclerosing Cholangitis

Joanna Raszeja-Wyszomirska 1 , Robert Kucharski 2 , Marta Zygmunt 1 , Krzysztof Safranow 3 and Tomasz Miazgowski 4 , *
Authors Information
1 Hepatology and Internal Medicine Unit, Department of General Transplant and Liver Surgery, Medical University of Warsaw, Warsaw, Poland
2 Liver Research Laboratories, Pomeranian Medical University, Szczecin, Poland
3 Department of Biochemistry and Chemistry, Pomeranian Medical University, Szczecin, Poland
4 Department of Hypertension and Internal Medicine, Pomeranian Medical University, Szczecin, Poland
Article information
  • Hepatitis Monthly: April 01, 2015, 15 (4); e25539
  • Published Online: April 25, 2015
  • Article Type: Research Article
  • Received: November 22, 2014
  • Revised: January 23, 2015
  • Accepted: February 4, 2015
  • DOI: 10.5812/hepatmon.25539

To Cite: Raszeja-Wyszomirska J, Kucharski R, Zygmunt M, Safranow K, Miazgowski T. The Impact of Fragility Fractures on Health-Related Quality of Life in Patients With Primary Sclerosing Cholangitis, Hepat Mon. 2015 ; 15(4):e25539. doi: 10.5812/hepatmon.25539.

Copyright © 2015, Kowsar Corp. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Hirschfield GM, Karlsen TH, Lindor KD, Adams DH. Primary sclerosing cholangitis. Lancet. 2013; 382(9904): 1587-99[DOI][PubMed]
  • 2. Targownik LE, Bernstein CN, Leslie WD. Risk factors and management of osteoporosis in inflammatory bowel disease. Curr Opin Gastroenterol. 2014; 30(2): 168-74[DOI][PubMed]
  • 3. Jacoby A, Rannard A, Buck D, Bhala N, Newton JL, James OF, et al. Development, validation, and evaluation of the PBC-40, a disease specific health related quality of life measure for primary biliary cirrhosis. Gut. 2005; 54(11): 1622-9[DOI][PubMed]
  • 4. Montali L, Tanaka A, Riva P, Takahashi H, Cocchi C, Ueno Y, et al. A short version of a HRQoL questionnaire for Italian and Japanese patients with Primary Biliary Cirrhosis. Dig Liver Dis. 2010; 42(10): 718-23[DOI][PubMed]
  • 5. Lips P, van Schoor NM. Quality of life in patients with osteoporosis. Osteoporos Int. 2005; 16(5): 447-55[DOI][PubMed]
  • 6. European Association for the Study of the L. EASL Clinical Practice Guidelines: management of cholestatic liver diseases. J Hepatol. 2009; 51(2): 237-67[DOI][PubMed]
  • 7. Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. Report of a WHO Study Group. World Health Organ Tech Rep Ser. 1994; 843: 1-129[PubMed]
  • 8. Ghasemi A, Rahimi Foroshani A, Kheibar N, Latifi M, Khanjani N, Eshagh Afkari M, et al. Effects of family-centered empowerment model based education program on quality of life in methamphetamine users and their families. Iran Red Crescent Med J. 2014; 16(3)[DOI][PubMed]
  • 9. Younossi ZM, Kiwi ML, Boparai N, Price LL, Guyatt G. Cholestatic liver diseases and health-related quality of life. Am J Gastroenterol. 2000; 95(2): 497-502[DOI][PubMed]
  • 10. Al-Harthy N, Kumagi T, Coltescu C, Hirschfield GM. The specificity of fatigue in primary biliary cirrhosis: evaluation of a large clinic practice. Hepatology. 2010; 52(2): 562-70[DOI][PubMed]
  • 11. Al-Harthy N, Kumagi T, Parasar S, Coltescu C, Heathcote EJ, Hirschfield GM. High prevalence of fatigue in patients with sclerosing cholangitis. Hepatology J. 2009; 50
  • 12. Craig CL, Marshall AL, Sjostrom M, Bauman AE, Booth ML, Ainsworth BE, et al. International physical activity questionnaire: 12-country reliability and validity. Med Sci Sports Exerc. 2003; 35(8): 1381-95[DOI][PubMed]
  • 13. Campbell MS, Lichtenstein GR, Rhim AD, Pazianas M, Faust T. Severity of liver disease does not predict osteopenia or low bone mineral density in primary sclerosing cholangitis. Liver Int. 2005; 25(2): 311-6[DOI][PubMed]
  • 14. Angulo P, Grandison GA, Fong DG, Keach JC, Lindor KD, Bjornsson E, et al. Bone disease in patients with primary sclerosing cholangitis. Gastroenterology. 2011; 140(1): 180-8[DOI][PubMed]
  • 15. Hay JE, Lindor KD, Wiesner RH, Dickson ER, Krom RA, LaRusso NF. The metabolic bone disease of primary sclerosing cholangitis. Hepatology. 1991; 14(2): 257-61[PubMed]
  • 16. Guichelaar MM, Kendall R, Malinchoc M, Hay JE. Bone mineral density before and after OLT: long-term follow-up and predictive factors. Liver Transpl. 2006; 12(9): 1390-402[DOI][PubMed]
  • 17. Alcalde Vargas A, Pascasio Acevedo JM, Gutierrez Domingo I, Garcia Jimenez R, Sousa Martin JM, Ferrer Rios MT, et al. Prevalence and characteristics of bone disease in cirrhotic patients under evaluation for liver transplantation. Transplant Proc. 2012; 44(6): 1496-8[DOI][PubMed]
  • 18. Loftus EJ, Harewood GC, Loftus CG, Tremaine WJ, Harmsen WS, Zinsmeister AR, et al. PSC-IBD: a unique form of inflammatory bowel disease associated with primary sclerosing cholangitis. Gut. 2005; 54(1): 91-6[DOI][PubMed]
  • 19. Lundqvist K, Broome U. Differences in colonic disease activity in patients with ulcerative colitis with and without primary sclerosing cholangitis: a case control study. Dis Colon Rectum. 1997; 40(4): 451-6[PubMed]
  • 20. Sokol H, Cosnes J, Chazouilleres O, Beaugerie L, Tiret E, Poupon R, et al. Disease activity and cancer risk in inflammatory bowel disease associated with primary sclerosing cholangitis. World J Gastroenterol. 2008; 14(22): 3497-503[PubMed]
  • 21. Leslie WD, Orwoll ES, Nielson CM, Morin SN, Majumdar SR, Johansson H, et al. Estimated lean mass and fat mass differentially affect femoral bone density and strength index but are not FRAX independent risk factors for fracture. J Bone Miner Res. 2014; 29(11): 2511-9[DOI][PubMed]
  • 22. Shin D, Kim S, Kim KH, Park SM. Importance of fat mass and lean mass on bone health in men: the Fourth Korean National Health and Nutrition Examination Survey (KNHANES IV). Osteoporos Int. 2014; 25(2): 467-74[DOI][PubMed]
  • 23. Hinriksdottir G, Arngrimsson SA, Misic MM, Evans EM. Lean soft tissue contributes more to bone health than fat mass independent of physical activity in women across the lifespan. Maturitas. 2013; 74(3): 264-9[DOI][PubMed]
  • 24. Borer KT. Physical activity in the prevention and amelioration of osteoporosis in women : interaction of mechanical, hormonal and dietary factors. Sports Med. 2005; 35(9): 779-830[PubMed]
  • 25. Guanabens N, Cerda D, Monegal A, Pons F, Caballeria L, Peris P, et al. Low bone mass and severity of cholestasis affect fracture risk in patients with primary biliary cirrhosis. Gastroenterology. 2010; 138(7): 2348-56[DOI][PubMed]
  • 26. Benito de Valle M, Rahman M, Lindkvist B, Bjornsson E, Chapman R, Kalaitzakis E. Factors that reduce health-related quality of life in patients with primary sclerosing cholangitis. Clin Gastroenterol Hepatol. 2012; 10(7): 769-775 e2[DOI][PubMed]
  • 27. Raszeja-Wyszomirska J, Wunsch E, Krawczyk M, Rigopoulou EI, Bogdanos D, Milkiewicz P. Prospective evaluation of PBC-specific health-related quality of life questionnaires in patients with primary sclerosing cholangitis. Liver Int. 2014; [DOI][PubMed]
  • 28. Milkiewicz P, Heathcote EJ. Fatigue in chronic cholestasis. Gut. 2004; 53(4): 475-7[PubMed]
  • 29. Fatigue in PSC patients with and without inflammatory bowel disease. Hepatology. : 1004A-5A
  • 30. Chen P, Krege JH, Adachi JD, Prior JC, Tenenhouse A, Brown JP, et al. Vertebral fracture status and the World Health Organization risk factors for predicting osteoporotic fracture risk. J Bone Miner Res. 2009; 24(3): 495-502[DOI][PubMed]
  • 31. Kim N, Rowe BH, Raymond G, Jen H, Colman I, Jackson SA, et al. Underreporting of vertebral fractures on routine chest radiography. AJR Am J Roentgenol. 2004; 182(2): 297-300[DOI][PubMed]
  • 32. Lopes JB, Fung LK, Cha CC, Gabriel GM, Takayama L, Figueiredo CP, et al. The impact of asymptomatic vertebral fractures on quality of life in older community-dwelling women: the Sao Paulo Ageing & Health Study. Clinics (Sao Paulo). 2012; 67(12): 1401-6[PubMed]
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