Hepatitis Monthly

Published by: Kowsar

Negative Association of Plasma Levels of Vitamin D and miR-378 With Viral Load in Patients With Chronic Hepatitis B Infection

Ashraf Mohamadkhani 1 , Faegh Bastani 1 , Samaneh Khorrami 1 , Reza Ghanbari 1 , Sareh Eghtesad 1 , Maryam Sharafkhah 1 , Ghodratollah Montazeri 1 and Hossein Poustchi 1 , *
Authors Information
1 Liver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, IR Iran
Article information
  • Hepatitis Monthly: June 01, 2015, 15 (6); e28315
  • Published Online: June 23, 2015
  • Article Type: Research Article
  • Received: February 28, 2015
  • Revised: April 25, 2015
  • Accepted: April 28, 2015
  • DOI: 10.5812/hepatmon.28315v2

To Cite: Mohamadkhani A, Bastani F, Khorrami S, Ghanbari R, Eghtesad S, et al. Negative Association of Plasma Levels of Vitamin D and miR-378 With Viral Load in Patients With Chronic Hepatitis B Infection, Hepat Mon. 2015 ; 15(6):e28315. doi: 10.5812/hepatmon.28315v2.

Copyright © 2015, Kowsar Corp. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Fattovich G, Bortolotti F, Donato F. Natural history of chronic hepatitis B: special emphasis on disease progression and prognostic factors. J Hepatol. 2008; 48(2): 335-52[DOI][PubMed]
  • 2. Shoaei SD, Sali S, Karamipour M, Riahi E. Non-invasive histologic markers of liver disease in patients with chronic hepatitis B. Hepat Mon. 2014; 14(2)[DOI][PubMed]
  • 3. Brunetto MR, Oliveri F, Colombatto P, Moriconi F, Ciccorossi P, Coco B, et al. Hepatitis B surface antigen serum levels help to distinguish active from inactive hepatitis B virus genotype D carriers. Gastroenterology. 2010; 139(2): 483-90[DOI][PubMed]
  • 4. Mohamadkhani A, Katoonizadeh A, Poustchi H. Immune-Regulatory Events in the Clearance of HBsAg in Chronic Hepatitis B: Focuses on HLA-DP. Middle East J Dig Dis. 2015; 7(1): 5-13[PubMed]
  • 5. Zare-Bidaki M, Tsukiyama-Kohara K, Arababadi MK. Toll-like receptor 4 and hepatitis B infection: molecular mechanisms and pathogenesis. Viral Immunol. 2014; 27(7): 321-6[DOI][PubMed]
  • 6. Moradzadeh M, Tayebi S, Poustchi H, Sayehmiri K, Shahnazari P, Naderi E, et al. The Possible Role of TLR2 in Chronic Hepatitis B Patients with Precore Mutation. Adv Virol. 2013; 2013: 780319[DOI][PubMed]
  • 7. Bocher WO, Galun E, Marcus H, Daudi N, Terkieltaub D, Shouval D, et al. Reduced hepatitis B virus surface antigen-specific Th1 helper cell frequency of chronic HBV carriers is associated with a failure to produce antigen-specific antibodies in the trimera mouse. Hepatology. 2000; 31(2): 480-7[DOI][PubMed]
  • 8. Li YC, Chen Y, Liu W, Thadhani R. MicroRNA-mediated mechanism of vitamin D regulation of innate immune response. J Steroid Biochem Mol Biol. 2014; 144 Pt A: 81-6[DOI][PubMed]
  • 9. Xiao C, Rajewsky K. MicroRNA control in the immune system: basic principles. Cell. 2009; 136(1): 26-36[DOI][PubMed]
  • 10. Li L, Guo Z, Wang J, Mao Y, Gao Q. Serum miR-18a: a potential marker for hepatitis B virus-related hepatocellular carcinoma screening. Dig Dis Sci. 2012; 57(11): 2910-6[DOI][PubMed]
  • 11. Zhang X, Hou J, Lu M. Regulation of hepatitis B virus replication by epigenetic mechanisms and microRNAs. Front Genet. 2013; 4: 202[DOI][PubMed]
  • 12. Mohamadkhani A. Long Noncoding RNAs in Interaction With RNA Binding Proteins in Hepatocellular Carcinoma. Hepat Mon. 2014; 14(5)[DOI][PubMed]
  • 13. Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 2004; 116(2): 281-97[PubMed]
  • 14. Murakami Y, Yasuda T, Saigo K, Urashima T, Toyoda H, Okanoue T, et al. Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues. Oncogene. 2006; 25(17): 2537-45[DOI][PubMed]
  • 15. Mohri T, Nakajima M, Takagi S, Komagata S, Yokoi T. MicroRNA regulates human vitamin D receptor. Int J Cancer. 2009; 125(6): 1328-33[DOI][PubMed]
  • 16. Gregori S, Giarratana N, Smiroldo S, Uskokovic M, Adorini L. A 1alpha,25-dihydroxyvitamin D(3) analog enhances regulatory T-cells and arrests autoimmune diabetes in NOD mice. Diabetes. 2002; 51(5): 1367-74[PubMed]
  • 17. Hewison M. Vitamin D and immune function: autocrine, paracrine or endocrine? Scand J Clin Lab Invest Suppl. 2012; 243: 92-102[DOI][PubMed]
  • 18. Carlberg C, Campbell MJ. Vitamin D receptor signaling mechanisms: integrated actions of a well-defined transcription factor. Steroids. 2013; 78(2): 127-36[DOI][PubMed]
  • 19. Pedersen AW, Holmstrom K, Jensen SS, Fuchs D, Rasmussen S, Kvistborg P, et al. Phenotypic and functional markers for 1alpha,25-dihydroxyvitamin D(3)-modified regulatory dendritic cells. Clin Exp Immunol. 2009; 157(1): 48-59[PubMed]
  • 20. Farnik H, Bojunga J, Berger A, Allwinn R, Waidmann O, Kronenberger B, et al. Low vitamin D serum concentration is associated with high levels of hepatitis B virus replication in chronically infected patients. Hepatology. 2013; 58(4): 1270-6[PubMed]
  • 21. Fedirko V, Duarte-Salles T, Bamia C, Trichopoulou A, Aleksandrova K, Trichopoulos D, et al. Prediagnostic circulating vitamin D levels and risk of hepatocellular carcinoma in European populations: a nested case-control study. Hepatology. 2014; 60(4): 1222-30[DOI][PubMed]
  • 22. Ishak K, Baptista A, Bianchi L, Callea F, De Groote J, Gudat F, et al. Histological grading and staging of chronic hepatitis. J Hepatol. 1995; 22(6): 696-9
  • 23. Werle-Lapostolle B, Bowden S, Locarnini S, Wursthorn K, Petersen J, Lau G, et al. Persistence of cccDNA during the natural history of chronic hepatitis B and decline during adefovir dipivoxil therapy. Gastroenterology. 2004; 126(7): 1750-8[PubMed]
  • 24. Kozomara A, Griffiths-Jones S. miRBase: annotating high confidence microRNAs using deep sequencing data. Nucleic Acids Res. 2014; 42-73[DOI][PubMed]
  • 25. Hu J, Wang Z, Liao BY, Yu L, Gao X, Lu S, et al. Human miR-1228 as a stable endogenous control for the quantification of circulating microRNAs in cancer patients. Int J Cancer. 2014; 135(5): 1187-94[DOI][PubMed]
  • 26. Kitson MT, Roberts SK. D-livering the message: the importance of vitamin D status in chronic liver disease. J Hepatol. 2012; 57(4): 897-909[DOI][PubMed]
  • 27. Poustchi H, Mohamadkhani A, Bowden S, Montazeri G, Ayres A, Revill P, et al. Clinical significance of precore and core promoter mutations in genotype D hepatitis B-related chronic liver disease. J Viral Hepat. 2008; 15(10): 753-60[PubMed]
  • 28. Lee DY, Deng Z, Wang CH, Yang BB. MicroRNA-378 promotes cell survival, tumor growth, and angiogenesis by targeting SuFu and Fus-1 expression. Proc Natl Acad Sci U S A. 2007; 104(51): 20350-5[DOI][PubMed]
  • 29. Maldonado RA, von Andrian UH. How tolerogenic dendritic cells induce regulatory T cells. Adv Immunol. 2010; 108: 111-65[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments