Hepatitis Monthly

Published by: Kowsar

Impact of the IL-10 Promoter Gene Polymorphisms in the Severity of Chronic Hepatitis B Infection

Sahand Ghaleh Baghi 1 , 2 , * , Seyed Moayed Alavian 1 , 3 , Leila Mehrnoush 1 and Shima Salimi 1
Authors Information
1 Baqiyatallah Research Center for Gastroenterology and Liver Diseases (BRCGL), Tehran, IR Iran
2 Department of Otolaryngology and Head and Neck Surgery, Rasool Akram Hospital, Tehran, IR Iran
3 Middle East Liver Disease Center (MELD), Tehran, IR Iran
Article information
  • Hepatitis Monthly: July 01, 2015, 15 (7); e28287
  • Published Online: July 22, 2015
  • Article Type: Research Article
  • Received: March 6, 2015
  • Revised: May 22, 2015
  • Accepted: June 20, 2015
  • DOI: 10.5812/hepatmon.28287v2

To Cite: Ghaleh Baghi S, Alavian S M, Mehrnoush L, Salimi S. Impact of the IL-10 Promoter Gene Polymorphisms in the Severity of Chronic Hepatitis B Infection, Hepat Mon. 2015 ; 15(7):e28287. doi: 10.5812/hepatmon.28287v2.

Abstract
Copyright © 2015, Kowsar Corp. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
Acknowledgements
Footnote
References
  • 1. Lee WM. Hepatitis B virus infection. N Engl J Med. 1997; 337(24): 1733-45[DOI][PubMed]
  • 2. Zhang PA, Wu JM, Li Y, Yang XS. Association of polymorphisms of interleukin-18 gene promoter region with chronic hepatitis B in Chinese Han population. World J Gastroenterol. 2005; 11(11): 1594-8[PubMed]
  • 3. Gurevich I. Hepatitis Part II. Viral hepatitis B, C, and D. Heart Lung. 1993; 22(5): 450-6[PubMed]
  • 4. Rosario Pac M, Arnedo A, Montaner MD, Prieto P, Garcia J, Izuel M, et al. [Epidemic outbreak of hepatitis B from the tattoo in gypsy families]. Rev Esp Salud Publica. 1996; 70(1): 63-9[PubMed]
  • 5. Andre F. Hepatitis B epidemiology in Asia, the Middle East and Africa. Vaccine. 2000; 18-2
  • 6. Zali MR, Farhadi A, Masjedi M, Zargar A, Nowroozi A. Epidemiology of hepatitis B in the Islamic Republic of Iran. East Mediterr Health J. 1996; 2(2): 290-8
  • 7. Eftekhari Y, Kazemi Arababadi M, Hakimi H, Rezazadeh Zarandi E. Common HBV genotype in southeastern Iranian patients. Arch Iran Med. 2010; 13(2): 147-9[PubMed]
  • 8. Danis VA, Millington M, Hyland VJ, Grennan D. Cytokine production by normal human monocytes: inter-subject variation and relationship to an IL-1 receptor antagonist (IL-1Ra) gene polymorphism. Clin Exp Immunol. 1995; 99(2): 303-10[PubMed]
  • 9. Motavaf M, Safari S, Alavian SM. Interleukin 18 Gene Promoter Polymorphisms and Susceptibility to Chronic Hepatitis B Infection: A Review Study. Hepat Month. 2014; 14(5)[DOI]
  • 10. Sharafi H, Pouryasin A, Alavian SM, Behnava B, Keshvari M, Salimi S, et al. Distribution of IL28B Genotypes in Iranian Patients with Chronic Hepatitis C and Healthy Individuals. Hepat Mon. 2012; 12(12)[DOI][PubMed]
  • 11. Wu L, Chen L, Zhou L, Xie H, Wei B, Yin S, et al. Association of interleukin 18 gene promoter polymorphisms with HBV recurrence after liver transplantation in Han Chinese population. Hepat Mon. 2011; 11(6): 469-74[PubMed]
  • 12. Kusumoto K, Uto H, Hayashi K, Takahama Y, Nakao H, Suruki R, et al. Interleukin-10 or tumor necrosis factor-alpha polymorphisms and the natural course of hepatitis C virus infection in a hyperendemic area of Japan. Cytokine. 2006; 34(1-2): 24-31[DOI][PubMed]
  • 13. Oleksyk TK, Thio CL, Truelove AL, Goedert JJ, Donfield SM, Kirk GD, et al. Single nucleotide polymorphisms and haplotypes in the IL10 region associated with HCV clearance. Genes Immun. 2005; 6(4): 347-57[DOI][PubMed]
  • 14. Gao QJ, Liu DW, Zhang SY, Jia M, Wang LM, Wu LH, et al. Polymorphisms of some cytokines and chronic hepatitis B and C virus infection. World J Gastroenterol. 2009; 15(44): 5610-9[PubMed]
  • 15. Grove J, Daly AK, Bassendine MF, Gilvarry E, Day CP. Interleukin 10 promoter region polymorphisms and susceptibility to advanced alcoholic liver disease. Gut. 2000; 46(4): 540-5[PubMed]
  • 16. Ladero JM, Fernandez-Arquero M, Tudela JI, Agundez JA, Diaz-Rubio M, Benitez J, et al. Single nucleotide polymorphisms and microsatellite alleles of tumor necrosis factor alpha and interleukin-10 genes and the risk of advanced chronic alcoholic liver disease. Liver. 2002; 22(3): 245-51[PubMed]
  • 17. Ramos JA, Silva R, Hoffmann L, Ramos AL, Cabello PH, Urmenyi TP, et al. Association of IL-10, IL-4, and IL-28B gene polymorphisms with spontaneous clearance of hepatitis C virus in a population from Rio de Janeiro. BMC Res Notes. 2012; 5: 508[DOI][PubMed]
  • 18. Persico M, Capasso M, Persico E, Masarone M, Renzo A, Spano D, et al. Interleukin-10 - 1082 GG polymorphism influences the occurrence and the clinical characteristics of hepatitis C virus infection. J Hepatol. 2006; 45(6): 779-85[DOI][PubMed]
  • 19. Yee LJ, Tang J, Gibson AW, Kimberly R, Van Leeuwen DJ, Kaslow RA. Interleukin 10 polymorphisms as predictors of sustained response in antiviral therapy for chronic hepatitis C infection. Hepatology. 2001; 33(3): 708-12[DOI][PubMed]
  • 20. Moore KW, de Waal Malefyt R, Coffman RL, O'Garra A. Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol. 2001; 19: 683-765[DOI][PubMed]
  • 21. Ben-Ari Z, Mor E, Papo O, Kfir B, Sulkes J, Tambur AR, et al. Cytokine gene polymorphisms in patients infected with hepatitis B virus. Am J Gastroenterol. 2003; 98(1): 144-50[DOI][PubMed]
  • 22. Miyazoe S, Hamasaki K, Nakata K, Kajiya Y, Kitajima K, Nakao K, et al. Influence of interleukin-10 gene promoter polymorphisms on disease progression in patients chronically infected with hepatitis B virus. Am J Gastroenterol. 2002; 97(8): 2086-92[DOI][PubMed]
  • 23. Lio D, Caruso C, Di Stefano R, Colonna Romano G, Ferraro D, Scola L, et al. IL-10 and TNF-α polymorphisms and the recovery from HCV infection. Hum Immunol. 2003; 64(7): 674-80[DOI]
  • 24. Mangia A, Santoro R, Piattelli M, Pazienza V, Grifa G, Iacobellis A, et al. IL-10 haplotypes as possible predictors of spontaneous clearance of HCV infection. Cytokine. 2004; 25(3): 103-9[PubMed]
  • 25. Swiatek BJ. Is interleukin-10 gene polymorphism a predictive marker in HCV infection? Cytokine Growth Factor Rev. 2012; 23(1-2): 47-59[DOI][PubMed]
  • 26. Eskdale J, Keijsers V, Huizinga T, Gallagher G. Microsatellite alleles and single nucleotide polymorphisms (SNP) combine to form four major haplotype families at the human interleukin-10 (IL-10) locus. Genes Immun. 1999; 1(2): 151-5[DOI][PubMed]
  • 27. Knapp S, Hennig BJ, Frodsham AJ, Zhang L, Hellier S, Wright M, et al. Interleukin-10 promoter polymorphisms and the outcome of hepatitis C virus infection. Immunogenetics. 2003; 55(6): 362-9[DOI][PubMed]
  • 28. Turner DM, Williams DM, Sankaran D, Lazarus M, Sinnott PJ, Hutchinson IV. An investigation of polymorphism in the interleukin-10 gene promoter. Eur J Immunogenet. 1997; 24(1): 1-8[PubMed]
  • 29. Keshvari M, Alavian SM, Sharafi H. How Can We Make Decision for Patients With Chronic Hepatitis B According to Hepatitis B Virus (HBV) DNA Level? Hepat Mon. 2014; 14(1)[DOI]
  • 30. Cheong JY, Cho SW, Hwang IL, Yoon SK, Lee JH, Park CS, et al. Association between chronic hepatitis B virus infection and interleukin-10, tumor necrosis factor-alpha gene promoter polymorphisms. J Gastroenterol Hepatol. 2006; 21(7): 1163-9[DOI][PubMed]
  • 31. Sofian M, Kalantar E, Aghakhani A, Hosseini S, Banifazl M, Eslamifar A, et al. No correlation between interleukin-10 gene promoter polymorphisms and hepatitis B virus infection outcome. Hepat Mon. 2013; 13(5)[DOI][PubMed]
  • 32. Wang S, Huang D, Sun S, Ma W, Zhen Q. Interleukin-10 promoter polymorphism predicts initial response of chronic hepatitis B to interferon alfa. Virol J. 2011; 8: 28[DOI][PubMed]
  • 33. Peng XM, Huang YS, Ma HH, Gu L, Xie QF, Gao ZL. Interleukin-10 promoter polymorphisms are associated with the mode and sequel of HBeAg seroconversion in patients with chronic hepatitis B virus infection. Liver Int. 2006; 26(3): 326-33[DOI][PubMed]
  • 34. Xie HY, Wang WL, Yao MY, Yu SF, Feng XN, Jin J, et al. Polymorphisms in cytokine genes and their association with acute rejection and recurrence of hepatitis B in Chinese liver transplant recipients. Arch Med Res. 2008; 39(4): 420-8[DOI][PubMed]
  • 35. He XX, Chang Y, Jiang HJ, Tang F, Meng FY, Xie QH, et al. Persistent effect of IFNAR-1 genetic polymorphism on the long-term pathogenesis of chronic HBV infection. Viral Immunol. 2010; 23(3): 251-7[DOI][PubMed]
  • 36. Gong QM, Kong XF, Yang ZT, Xu J, Wang L, Li XH, et al. Association study of IFNAR2 and IL10RB genes with the susceptibility and interferon response in HBV infection. J Viral Hepat. 2009; 16(9): 674-80[PubMed]
  • 37. Pestka S, Krause CD, Sarkar D, Walter MR, Shi Y, Fisher PB. Interleukin-10 and related cytokines and receptors. Annu Rev Immunol. 2004; 22: 929-79[PubMed]
  • 38. Lu YL, Wu X, Huang HL, Dai LC. Allele polymorphisms of interleukin-10 and hepatitis B, C virus infection. Chin Med J (Engl). 2010; 123(10): 1338-44[PubMed]
  • 39. Shin HD, Park BL, Kim LH, Jung JH, Kim JY, Yoon JH, et al. Interleukin 10 haplotype associated with increased risk of hepatocellular carcinoma. Hum Mol Genet. 2003; 12(8): 901-6[PubMed]
  • 40. Wu JF, Ni YH, Lin YT, Lee TJ, Hsu SH, Chen HL, et al. Human interleukin-10 genotypes are associated with different precore/core gene mutation patterns in children with chronic hepatitis B virus infection. J Pediatr. 2011; 158(5): 808-13[DOI][PubMed]
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