Hepatitis Monthly

Published by: Kowsar

Tumor Suppressor DLEC1 can Stimulate the Proliferation of Cancer Cells When AP-2ɑ2 is Down-Regulated in HCT116

Guo-Hua Qiu 1 , 2 , * , Xiaojin Xie 2 , Linhong Deng 1 and Shing Chuan Hooi 2 , *
Authors Information
1 Institute of Biomedical Engineering and Health Sciences, Changzhou University, Changzhou, PR China
2 Department of Physiology, Faculty of Medicine, National University of Singapore, Singapore, Republic of Singapore
Corresponding Authors:
Article information
  • Hepatitis Monthly: November 01, 2015, 15 (11); e29829
  • Published Online: November 28, 2015
  • Article Type: Research Article
  • Received: May 18, 2015
  • Revised: July 28, 2015
  • Accepted: August 12, 2015
  • DOI: 10.5812/hepatmon.29829

To Cite: Qiu G, Xie X, Deng L, Hooi S C. Tumor Suppressor DLEC1 can Stimulate the Proliferation of Cancer Cells When AP-2ɑ2 is Down-Regulated in HCT116, Hepat Mon. 2015 ;15(11):e29829. doi: 10.5812/hepatmon.29829.

Abstract
Copyright © 2015, Kowsar Corp. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
Acknowledgements
Footnotes
References
  • 1. Daigo Y, Nishiwaki T, Kawasoe T, Tamari M, Tsuchiya E, Nakamura Y. Molecular cloning of a candidate tumor suppressor gene, DLC1, from chromosome 3p21.3. Cancer Res. 1999; 59(8): 1966-72[PubMed]
  • 2. Kwong J, Lee JY, Wong KK, Zhou X, Wong DT, Lo KW, et al. Candidate tumor-suppressor gene DLEC1 is frequently downregulated by promoter hypermethylation and histone hypoacetylation in human epithelial ovarian cancer. Neoplasia. 2006; 8(4): 268-78[DOI][PubMed]
  • 3. Seng TJ, Currey N, Cooper WA, Lee CS, Chan C, Horvath L, et al. DLEC1 and MLH1 promoter methylation are associated with poor prognosis in non-small cell lung carcinoma. Br J Cancer. 2008; 99(2): 375-82[DOI][PubMed]
  • 4. Ying J, Poon FF, Yu J, Geng H, Wong AH, Qiu GH, et al. DLEC1 is a functional 3p22.3 tumour suppressor silenced by promoter CpG methylation in colon and gastric cancers. Br J Cancer. 2009; 100(4): 663-9[DOI][PubMed]
  • 5. Park SY, Kwon HJ, Lee HE, Ryu HS, Kim SW, Kim JH, et al. Promoter CpG island hypermethylation during breast cancer progression. Virchows Arch. 2011; 458(1): 73-84[DOI][PubMed]
  • 6. Qiu GH, Salto-Tellez M, Ross JA, Yeo W, Cui Y, Wheelhouse N, et al. The tumor suppressor gene DLEC1 is frequently silenced by DNA methylation in hepatocellular carcinoma and induces G1 arrest in cell cycle. J Hepatol. 2008; 48(3): 433-41[DOI][PubMed]
  • 7. Zhang Q, Ying J, Li J, Fan Y, Poon FF, Ng KM, et al. Aberrant promoter methylation of DLEC1, a critical 3p22 tumor suppressor for renal cell carcinoma, is associated with more advanced tumor stage. J Urol. 2010; 184(2): 731-7[DOI][PubMed]
  • 8. Kwong J, Chow LS, Wong AY, Hung WK, Chung GT, To KF, et al. Epigenetic inactivation of the deleted in lung and esophageal cancer 1 gene in nasopharyngeal carcinoma. Genes Chromosomes Cancer. 2007; 46(2): 171-80[DOI][PubMed]
  • 9. Chan WH, Chang KP, Yang SW, Yao TC, Ko TY, Lee YS, et al. Transcriptional repression of DLEC1 associates with the depth of tumor invasion in oral squamous cell carcinoma. Oral Oncol. 2010; 46(12): 874-9[DOI][PubMed]
  • 10. Wang Z, Li L, Su X, Gao Z, Srivastava G, Murray PG, et al. Epigenetic silencing of the 3p22 tumor suppressor DLEC1 by promoter CpG methylation in non-Hodgkin and Hodgkin lymphomas. J Transl Med. 2012; 10: 209[DOI][PubMed]
  • 11. Eckert D, Buhl S, Weber S, Jager R, Schorle H. The AP-2 family of transcription factors. Genome Biol. 2005; 6(13): 246[DOI][PubMed]
  • 12. Stabach PR, Thiyagarajan MM, Woodfield GW, Weigel RJ. AP2alpha alters the transcriptional activity and stability of p53. Oncogene. 2006; 25(15): 2148-59[DOI][PubMed]
  • 13. Kuckenberg P, Kubaczka C, Schorle H. The role of transcription factor Tcfap2c/TFAP2C in trophectoderm development. Reprod Biomed Online. 2012; 25(1): 12-20[DOI][PubMed]
  • 14. Bar-Eli M. Gene regulation in melanoma progression by the AP-2 transcription factor. Pigment Cell Res. 2001; 14(2): 78-85[PubMed]
  • 15. Powe DG, Akhtar G, Habashy HO, Abdel-Fatah T, Rakha EA, Green AR, et al. Investigating AP-2 and YY1 protein expression as a cause of high HER2 gene transcription in breast cancers with discordant HER2 gene amplification. Breast Cancer Res. 2009; 11(6)[DOI][PubMed]
  • 16. Ropponen KM, Kellokoski JK, Pirinen RT, Moisio KI, Eskelinen MJ, Alhava EM, et al. Expression of transcription factor AP-2 in colorectal adenomas and adenocarcinomas; comparison of immunohistochemistry and in situ hybridisation. J Clin Pathol. 2001; 54(7): 533-8[PubMed]
  • 17. Zhang X, Leung YK, Ho SM. AP-2 regulates the transcription of estrogen receptor (ER)-beta by acting through a methylation hotspot of the 0N promoter in prostate cancer cells. Oncogene. 2007; 26(52): 7346-54[DOI][PubMed]
  • 18. Zeng YX, Somasundaram K, el-Deiry WS. AP2 inhibits cancer cell growth and activates p21WAF1/CIP1 expression. Nat Genet. 1997; 15(1): 78-82[DOI][PubMed]
  • 19. Yan F, He Q, Hu X, Li W, Wei K, Li L, et al. Direct regulation of caspase3 by the transcription factor AP2alpha is involved in aspirininduced apoptosis in MDAMB453 breast cancer cells. Mol Med Rep. 2013; 7(3): 909-14[DOI][PubMed]
  • 20. Li X, Glubrecht DD, Godbout R. AP2 transcription factor induces apoptosis in retinoblastoma cells. Genes Chromosomes Cancer. 2010; 49(9): 819-30[DOI][PubMed]
  • 21. Wajapeyee N, Britto R, Ravishankar HM, Somasundaram K. Apoptosis induction by activator protein 2alpha involves transcriptional repression of Bcl-2. J Biol Chem. 2006; 281(24): 16207-19[DOI][PubMed]
  • 22. Li Q, Lohr CV, Dashwood RH. Activator protein 2alpha suppresses intestinal tumorigenesis in the Apc(min) mouse. Cancer Lett. 2009; 283(1): 36-42[DOI][PubMed]
  • 23. Yu S, Asa SL, Weigel RJ, Ezzat S. Pituitary tumor AP-2alpha recognizes a cryptic promoter in intron 4 of fibroblast growth factor receptor 4. J Biol Chem. 2003; 278(22): 19597-602[DOI][PubMed]
  • 24. Zhu C, Huang Y, Weydert CJ, Oberley LW, Domann FE. Constitutive activation of transcription factor AP-2 is associated with decreased MnSOD expression in transformed human lung fibroblasts. Antioxid Redox Signal. 2001; 3(3): 387-95[DOI][PubMed]
  • 25. Yu L, Hitchler MJ, Sun W, Sarsour EH, Goswami PC, Klingelhutz AJ, et al. AP-2alpha Inhibits c-MYC Induced Oxidative Stress and Apoptosis in HaCaT Human Keratinocytes. J Oncol. 2009; 2009: 780874[DOI][PubMed]
  • 26. Pfisterer P, Ehlermann J, Hegen M, Schorle H. A subtractive gene expression screen suggests a role of transcription factor AP-2 alpha in control of proliferation and differentiation. J Biol Chem. 2002; 277(8): 6637-44[DOI][PubMed]
  • 27. Shi D, Xie F, Zhang Y, Tian Y, Chen W, Fu L, et al. TFAP2A regulates nasopharyngeal carcinoma growth and survival by targeting HIF-1alpha signaling pathway. Cancer Prev Res (Phila). 2014; 7(2): 266-77[DOI][PubMed]
  • 28. Qiu GH, Leung CH, Yun T, Xie X, Laban M, Hooi SC. Recognition and suppression of transfected plasmids by protein ZNF511-PRAP1, a potential molecular barrier to transgene expression. Mol Ther. 2011; 19(8): 1478-86[DOI][PubMed]
  • 29. Huang BH, Laban M, Leung CH, Lee L, Lee CK, Salto-Tellez M, et al. Inhibition of histone deacetylase 2 increases apoptosis and p21Cip1/WAF1 expression, independent of histone deacetylase 1. Cell Death Differ. 2005; 12(4): 395-404[DOI][PubMed]
  • 30. Fontes MR, Teh T, Jans D, Brinkworth RI, Kobe B. Structural basis for the specificity of bipartite nuclear localization sequence binding by importin-alpha. J Biol Chem. 2003; 278(30): 27981-7[DOI][PubMed]
  • 31. Sherr CJ, Roberts JM. Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev. 1995; 9(10): 1149-63[PubMed]
  • 32. Koinuma D, Tsutsumi S, Kamimura N, Taniguchi H, Miyazawa K, Sunamura M, et al. Chromatin immunoprecipitation on microarray analysis of Smad2/3 binding sites reveals roles of ETS1 and TFAP2A in transforming growth factor beta signaling. Mol Cell Biol. 2009; 29(1): 172-86[DOI][PubMed]
  • 33. Allouche A, Nolens G, Tancredi A, Delacroix L, Mardaga J, Fridman V, et al. The combined immunodetection of AP-2alpha and YY1 transcription factors is associated with ERBB2 gene overexpression in primary breast tumors. Breast Cancer Res. 2008; 10(1)[DOI][PubMed]
  • 34. Sun A, Bagella L, Tutton S, Romano G, Giordano A. From G0 to S phase: a view of the roles played by the retinoblastoma (Rb) family members in the Rb-E2F pathway. J Cell Biochem. 2007; 102(6): 1400-4[DOI][PubMed]
  • 35. Li H, Watts GS, Oshiro MM, Futscher BW, Domann FE. AP-2alpha and AP-2gamma are transcriptional targets of p53 in human breast carcinoma cells. Oncogene. 2006; 25(39): 5405-15[DOI][PubMed]
  • 36. Hasleton MD, Ibbitt JC, Hurst HC. Characterization of the human activator protein-2gamma (AP-2gamma) gene: control of expression by Sp1/Sp3 in breast tumour cells. Biochem J. 2003; 373: 925-32[DOI][PubMed]
  • 37. Schuierer M, Hilger-Eversheim K, Dobner T, Bosserhoff AK, Moser M, Turner J, et al. Induction of AP-2alpha expression by adenoviral infection involves inactivation of the AP-2rep transcriptional corepressor CtBP1. J Biol Chem. 2001; 276(30): 27944-9[DOI][PubMed]
  • 38. Cheng YH, Handwerger S. Identification of an enhancer of the human activating protein-2alpha gene that contains a critical Ets1 binding site. J Clin Endocrinol Metab. 2003; 88(7): 3305-11[DOI][PubMed]
  • 39. Nakayama M, Iida M, Koseki H, Ohara O. A gene-targeting approach for functional characterization of KIAA genes encoding extremely large proteins. FASEB J. 2006; 20(10): 1718-20[DOI][PubMed]
  • 40. Muller FU, Loser K, Kleideiter U, Neumann J, von Wallbrunn C, Dobner T, et al. Transcription factor AP-2alpha triggers apoptosis in cardiac myocytes. Cell Death Differ. 2004; 11(5): 485-93[DOI][PubMed]
  • 41. Orso F, Penna E, Cimino D, Astanina E, Maione F, Valdembri D, et al. AP-2alpha and AP-2gamma regulate tumor progression via specific genetic programs. FASEB J. 2008; 22(8): 2702-14[DOI][PubMed]
  • 42. Mo X, Kowenz-Leutz E, Xu H, Leutz A. Ras induces mediator complex exchange on C/EBP beta. Mol Cell. 2004; 13(2): 241-50[PubMed]
  • 43. Valin A, Gill G. Regulation of the dual-function transcription factor Sp3 by SUMO. Biochem Soc Trans. 2007; 35: 1393-6[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:

Author(s):

Article(s):

Create Citiation Alert
via Google Reader

Readers' Comments