To Cite:
Dehghan-Manshadi
M, Hadinedoushan
H, Amirbaigy
M K, Zare
F, Eslami
G, et al. Relative Expression of Toll-Like Receptors 2 and 7 mRNA in Peripheral Blood of Patients With Hepatitis C,
Hepat Mon.
2015
;15(11):e30427.
doi: 10.5812/hepatmon.30427.
1.
Hajarizadeh B, Grebely J, Dore GJ. Epidemiology and natural history of HCV infection. Nat Rev Gastroenterol Hepatol. 2013; 10(9): 553-62[DOI][PubMed]
2.
Elahi E,
Pourmand N,
Chaung R,
Rofoogaran A,
Boisver J,
Samimi-Rad K,
et al.
Determination of hepatitis C virus genotype by Pyrosequencing. J Virol Methods. 2003; 109(2): 171-6[PubMed]
3.
Moradpour D, Penin F, Rice CM. Replication of hepatitis C virus. Nat Rev Microbiol. 2007; 5(6): 453-63[DOI][PubMed]
4.
Hadinedoushan H, Salmanroghani H, Amirbaigy MK, Akhondi-Meybodi M. Hepatitis C virus genotypes and association with viral load in yazd, central province of iran. Hepat Mon. 2014; 14(3)[DOI][PubMed]
5.
Heathcote J, Main J. Treatment of hepatitis C. J Viral Hepat. 2005; 12(3): 223-35[DOI][PubMed]
6.
Kawai T, Akira S. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol. 2010; 11(5): 373-84[DOI][PubMed]
7.
Medzhitov R. Toll-like receptors and innate immunity. Nat Rev Immunol. 2001; 1(2): 135-45[DOI][PubMed]
8.
Howell J, Angus P, Gow P, Visvanathan K. Toll-like receptors in hepatitis C infection: implications for pathogenesis and treatment. J Gastroenterol Hepatol. 2013; 28(5): 766-76[DOI][PubMed]
9.
Schnare M, Barton GM, Holt AC, Takeda K, Akira S, Medzhitov R. Toll-like receptors control activation of adaptive immune responses. Nat Immunol. 2001; 2(10): 947-50[DOI][PubMed]
10.
Rajalakshmy AR, Malathi J, Madhavan HN. HCV core and NS3 proteins mediate toll like receptor induced innate immune response in corneal epithelium. Exp Eye Res. 2014; 128: 117-28[DOI][PubMed]
11.
Motavaf M, Noorbakhsh F, Alavian SM, Sharifi Z. Distinct Toll-like Receptor 3 and 7 Expression in Peripheral Blood Mononuclear Cells From Patients with Chronic Hepatitis C Infection. Hepat Mon. 2014; 14(4)[DOI][PubMed]
12.
Wang JP,
Zhang Y,
Wei X,
Li J,
Nan XP,
Yu HT,
et al.
Circulating Toll-like receptor (TLR) 2, TLR4, and regulatory T cells in patients with chronic hepatitis C. APMIS. 2010; 118(4): 261-70[DOI][PubMed]
13.
Dolganiuc A, Garcia C, Kodys K, Szabo G. Distinct Toll-like receptor expression in monocytes and T cells in chronic HCV infection. World J Gastroenterol. 2006; 12(8): 1198-204[PubMed]
14.
Atencia R,
Bustamante FJ,
Valdivieso A,
Arrieta A,
Rinon M,
Prada A,
et al.
Differential expression of viral PAMP receptors mRNA in peripheral blood of patients with chronic hepatitis C infection. BMC Infect Dis. 2007; 7: 136[DOI][PubMed]
15.
Chang S, Dolganiuc A, Szabo G. Toll-like receptors 1 and 6 are involved in TLR2-mediated macrophage activation by hepatitis C virus core and NS3 proteins. J Leukoc Biol. 2007; 82(3): 479-87[DOI][PubMed]
16.
Dolganiuc A,
Oak S,
Kodys K,
Golenbock DT,
Finberg RW,
Kurt-Jones E,
et al.
Hepatitis C core and nonstructural 3 proteins trigger toll-like receptor 2-mediated pathways and inflammatory activation. Gastroenterology. 2004; 127(5): 1513-24[PubMed]
17.
Horsmans Y,
Berg T,
Desager JP,
Mueller T,
Schott E,
Fletcher SP,
et al.
Isatoribine, an agonist of TLR7, reduces plasma virus concentration in chronic hepatitis C infection. Hepatology. 2005; 42(3): 724-31[DOI][PubMed]
18.
Bedossa P, Poynard T. An algorithm for the grading of activity in chronic hepatitis C. The METAVIR Cooperative Study Group. Hepatology. 1996; 24(2): 289-93[DOI][PubMed]
19.
He Q, Graham CS, Durante Mangoni E, Koziel MJ. Differential expression of toll-like receptor mRNA in treatment non-responders and sustained virologic responders at baseline in patients with chronic hepatitis C. Liver Int. 2006; 26(9): 1100-10[DOI][PubMed]
20.
Sato K,
Ishikawa T,
Okumura A,
Yamauchi T,
Sato S,
Ayada M,
et al.
Expression of Toll-like receptors in chronic hepatitis C virus infection. J Gastroenterol Hepatol. 2007; 22(10): 1627-32[DOI][PubMed]
21.
Abdel-Raouf TA, Ahmed A, Zaki WK, Abdella HM, Zid MA. Study of toll-like receptor 7 expression and interferon α in Egyptian patients with chronic hepatitis C Infection and Hepatocellular Carcinoma. Egypt J Med Hum Genet. 2014; 15(4): 387-92[DOI]
22.
Kang JY,
Nan X,
Jin MS,
Youn SJ,
Ryu YH,
Mah S,
et al.
Recognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodimer. Immunity. 2009; 31(6): 873-84[DOI][PubMed]
23.
Firdaus R,
Biswas A,
Saha K,
Mukherjee A,
Pal F,
Chaudhuri S,
et al.
Modulation of TLR 3, 7 and 8 expressions in HCV genotype 3 infected individuals: potential correlations of pathogenesis and spontaneous clearance. Biomed Res Int. 2014; 2014: 491064[DOI][PubMed]
24.
Lee HJ, Kim KC, Han JA, Choi SS, Jung YJ. The early induction of suppressor of cytokine signaling 1 and the downregulation of toll-like receptors 7 and 9 induce tolerance in costimulated macrophages. Mol Cells. 2015; 38(1): 26-32[DOI][PubMed]
25.
Sagan SM, Sarnow P. Plasmacytoid dendritic cells as guardians in hepatitis C virus-infected liver. Proc Natl Acad Sci U S A. 2010; 107(17): 7625-6[DOI][PubMed]
26.
Swaminathan G, Pascual D, Rival G, Perales-Linares R, Martin-Garcia J, Navas-Martin S. Hepatitis C virus core protein enhances HIV-1 replication in human macrophages through TLR2, JNK, and MEK1/2-dependent upregulation of TNF-alpha and IL-6. FEBS Lett. 2014; 588(18): 3501-10[DOI][PubMed]
27.
Soares JB,
Pimentel-Nunes P,
Afonso L,
Rolanda C,
Lopes P,
Roncon-Albuquerque RJ,
et al.
Increased hepatic expression of TLR2 and TLR4 in the hepatic inflammation-fibrosis-carcinoma sequence. Innate Immun. 2012; 18(5): 700-8[DOI][PubMed]
28.
Shehata MA, Abou El-Enein A, El-Sharnouby GA. Significance of toll-like receptors 2 and 4 mRNA expression in chronic hepatitis C virus infection. Egypt J Immunol. 2006; 13(1): 141-52[PubMed]
29.
Hammond T,
Lee S,
Watson MW,
Flexman JP,
Cheng W,
Fernandez S,
et al.
Toll-like receptor (TLR) expression on CD4+ and CD8+ T-cells in patients chronically infected with hepatitis C virus. Cell Immunol. 2010; 264(2): 150-5[DOI][PubMed]
30.
Berzsenyi MD,
Roberts SK,
Preiss S,
Woollard DJ,
Beard MR,
Skinner NA,
et al.
Hepatic TLR2 & TLR4 expression correlates with hepatic inflammation and TNF-alpha in HCV & HCV/HIV infection. J Viral Hepat. 2011; 18(12): 852-60[DOI][PubMed]
31.
Jahanbakhsh Sefidi F, Keyvani H, Monavari SH, Alavian SM, Fakhim S, Bokharaei-Salim F. Distribution of hepatitis C virus genotypes in Iranian chronic infected patients. Hepat Mon. 2013; 13(1)[DOI][PubMed]
32.
Zarkesh-Esfahani SH, Kardi MT, Edalati M. Hepatitis C virus genotype frequency in Isfahan province of Iran: a descriptive cross-sectional study. Virol J. 2010; 7: 69[DOI][PubMed]
33.
Kabir A, Alavian SM, Keyvani H. Distribution of hepatitis C virus genotypes in patients infected by different sources and its correlation with clinical and virological parameters: a preliminary study. Comp Hepatol. 2006; 5: 4[DOI][PubMed]
34.
Raja NS, Janjua KA. Epidemiology of hepatitis C virus infection in Pakistan. J Microbiol Immunol Infect. 2008; 41(1): 4-8[PubMed]
35.
Chakravarti A, Dogra G, Verma V, Srivastava AP. Distribution pattern of HCV genotypes & its association with viral load. Indian J Med Res. 2011; 133: 326-31[PubMed]