Hepatitis Monthly

Published by: Kowsar

Impact of Hepatitis C Virus Infection on Cognitive Function in Patients With Covert Hepatic Encephalopathy

Farnaz Hashemi 1 , Ali Fathi Ashtiani 2 , Babak Mirminachi 1 , Maryam Sharafkhah 1 , Golnaz Ekhlasi 1 , Elham Jafari 1 and Hossein Poustchi 1 , *
Authors Information
1 Liver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, IR Iran
2 Behavioral Sciences Research Center, Baqiyatallah University of Medical Sciences, Tehran, IR Iran
Article information
  • Hepatitis Monthly: July 01, 2015, 15 (7); e30507
  • Published Online: July 22, 2015
  • Article Type: Research Article
  • Received: June 7, 2015
  • Accepted: June 16, 2015
  • DOI: 10.5812/hepatmon.30507v2

To Cite: Hashemi F, Fathi Ashtiani A, Mirminachi B, Sharafkhah M, Ekhlasi G, et al. Impact of Hepatitis C Virus Infection on Cognitive Function in Patients With Covert Hepatic Encephalopathy, Hepat Mon. 2015 ; 15(7):e30507. doi: 10.5812/hepatmon.30507v2.

Copyright © 2015, Kowsar Corp. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Bajaj JS, Wade JB, Sanyal AJ. Spectrum of neurocognitive impairment in cirrhosis: Implications for the assessment of hepatic encephalopathy. Hepatology. 2009; 50(6): 2014-21[DOI][PubMed]
  • 2. Bajaj JS, Cordoba J, Mullen KD, Amodio P, Shawcross DL, Butterworth RF, et al. Review article: the design of clinical trials in hepatic encephalopathy--an International Society for Hepatic Encephalopathy and Nitrogen Metabolism (ISHEN) consensus statement. Aliment Pharmacol Ther. 2011; 33(7): 739-47[DOI][PubMed]
  • 3. Das A, Dhiman RK, Saraswat VA, Verma M, Naik SR. Prevalence and natural history of subclinical hepatic encephalopathy in cirrhosis. J Gastroenterol Hepatol. 2001; 16(5): 531-5[PubMed]
  • 4. Hartmann IJ, Groeneweg M, Quero JC, Beijeman SJ, de Man RA, Hop WC, et al. The prognostic significance of subclinical hepatic encephalopathy. Am J Gastroenterol. 2000; 95(8): 2029-34[DOI][PubMed]
  • 5. Prasad S, Dhiman RK, Duseja A, Chawla YK, Sharma A, Agarwal R. Lactulose improves cognitive functions and health-related quality of life in patients with cirrhosis who have minimal hepatic encephalopathy. Hepatology. 2007; 45(3): 549-59[DOI][PubMed]
  • 6. Bajaj JS, Hafeezullah M, Hoffmann RG, Saeian K. Minimal hepatic encephalopathy: a vehicle for accidents and traffic violations. Am J Gastroenterol. 2007; 102(9): 1903-9[DOI][PubMed]
  • 7. Groeneweg M, Quero JC, De Bruijn I, Hartmann IJ, Essink-bot ML, Hop WC, et al. Subclinical hepatic encephalopathy impairs daily functioning. Hepatology. 1998; 28(1): 45-9[DOI][PubMed]
  • 8. Bajaj JS, Riggio O, Allampati S, Prakash R, Gioia S, Onori E, et al. Cognitive dysfunction is associated with poor socioeconomic status in patients with cirrhosis: an international multicenter study. Clin Gastroenterol Hepatol. 2013; 11(11): 1511-6[DOI][PubMed]
  • 9. Regev A, Berho M, Jeffers LJ, Milikowski C, Molina EG, Pyrsopoulos NT, et al. Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection. Am J Gastroenterol. 2002; 97(10): 2614-8[DOI][PubMed]
  • 10. Corpechot C, Carrat F, Poujol-Robert A, Gaouar F, Wendum D, Chazouilleres O, et al. Noninvasive elastography-based assessment of liver fibrosis progression and prognosis in primary biliary cirrhosis. Hepatology. 2012; 56(1): 198-208[DOI][PubMed]
  • 11. Kim SU, Lee JH, Kim do Y, Ahn SH, Jung KS, Choi EH, et al. Prediction of liver-related events using fibroscan in chronic hepatitis B patients showing advanced liver fibrosis. PLoS One. 2012; 7(5)[DOI][PubMed]
  • 12. Lemoine M, Katsahian S, Ziol M, Nahon P, Ganne-Carrie N, Kazemi F, et al. Liver stiffness measurement as a predictive tool of clinically significant portal hypertension in patients with compensated hepatitis C virus or alcohol-related cirrhosis. Aliment Pharmacol Ther. 2008; 28(9): 1102-10[DOI][PubMed]
  • 13. Carrion JA, Navasa M, Bosch J, Bruguera M, Gilabert R, Forns X. Transient elastography for diagnosis of advanced fibrosis and portal hypertension in patients with hepatitis C recurrence after liver transplantation. Liver Transpl. 2006; 12(12): 1791-8[DOI][PubMed]
  • 14. Valentine AD, Meyers CA. Neurobehavioral effects of interferon therapy. Curr Psychiatry Rep. 2005; 7(5): 391-5[PubMed]
  • 15. Bajaj JS, Schubert CM, Heuman DM, Wade JB, Gibson DP, Topaz A, et al. Persistence of cognitive impairment after resolution of overt hepatic encephalopathy. Gastroenterology. 2010; 138(7): 2332-40[DOI][PubMed]
  • 16. Orangi M, Atefvahid MK, Ashayeri H. Standardization of the revised Wechsler memory scale in Shiraz. Iran J Psychiatry Clin Psychol. 2002; 7(4): 56-66
  • 17. Yazdi SM, Sharifian A, Dehghani-Beshne M, Momeni VR, Aminian O. Effects of fluoride on psychomotor performance and memory of aluminum potroom workers. Fluoride. 2011; 44(3): 158-62
  • 18. Ciecko-Michalska I, Wojcik J, Senderecka M, Wyczesany M, Binder M, Szewczyk J, et al. Cognitive functions in patients with liver cirrhosis: a tendency to commit more memory errors. Med Sci Monit. 2013; 19: 283-8[DOI][PubMed]
  • 19. Torres DS, Abrantes J, Brandao-Mello CE. Cognitive assessment of patients with minimal hepatic encephalopathy in Brazil. Metab Brain Dis. 2013; 28(3): 473-83[DOI][PubMed]
  • 20. Amodio P, Schiff S, Del Piccolo F, Mapelli D, Gatta A, Umilta C. Attention dysfunction in cirrhotic patients: an inquiry on the role of executive control, attention orienting and focusing. Metab Brain Dis. 2005; 20(2): 115-27[PubMed]
  • 21. Amodio P, Ridola L, Schiff S, Montagnese S, Pasquale C, Nardelli S, et al. Improving the inhibitory control task to detect minimal hepatic encephalopathy. Gastroenterology. 2010; 139(2): 510-8[DOI][PubMed]
  • 22. Modabbernia A, Poustchi H, Malekzadeh R. Neuropsychiatric and psychosocial issues of patients with hepatitis C infection: a selective literature review. Hepat Mon. 2013; 13(1)[DOI][PubMed]
  • 23. Adinolfi LE, Nevola R, Lus G, Restivo L, Guerrera B, Romano C, et al. Chronic hepatitis C virus infection and neurological and psychiatric disorders: an overview. World J Gastroenterol. 2015; 21(8): 2269-80[DOI][PubMed]
  • 24. Forton DM, Thomas HC, Murphy CA, Allsop JM, Foster GR, Main J, et al. Hepatitis C and cognitive impairment in a cohort of patients with mild liver disease. Hepatology. 2002; 35(2): 433-9[DOI][PubMed]
  • 25. Foster GR. Quality of life considerations for patients with chronic hepatitis C. J Viral Hepat. 2009; 16(9): 605-11[DOI][PubMed]
  • 26. Foster GR, Goldin RD, Thomas HC. Chronic hepatitis C virus infection causes a significant reduction in quality of life in the absence of cirrhosis. Hepatology. 1998; 27(1): 209-12[DOI][PubMed]
  • 27. Forton DM, Allsop JM, Main J, Foster GR, Thomas HC, Taylor-Robinson SD. Evidence for a cerebral effect of the hepatitis C virus. Lancet. 2001; 358(9275): 38-9[DOI][PubMed]
  • 28. Modabbernia A, Ashrafi M, Keyvani H, Taslimi S, Poorkaveh A, Merat S, et al. Brain-derived neurotrophic factor predicts physical health in untreated patients with hepatitis C. Biol Psychiatry. 2011; 70(5)-2[DOI][PubMed]
  • 29. Binder DK, Scharfman HE. Brain-derived neurotrophic factor. Growth Factors. 2004; 22(3): 123-31[PubMed]
  • 30. Hashimoto K, Shimizu E, Iyo M. Critical role of brain-derived neurotrophic factor in mood disorders. Brain Res Brain Res Rev. 2004; 45(2): 104-14[DOI][PubMed]
  • 31. Chen R, Liang FX, Moriya J, Yamakawa J, Sumino H, Kanda T, et al. Chronic fatigue syndrome and the central nervous system. J Int Med Res. 2008; 36(5): 867-74[PubMed]
  • 32. Nguyen JC, Killcross AS, Jenkins TA. Obesity and cognitive decline: role of inflammation and vascular changes. Front Neurosci. 2014; 8: 375[DOI][PubMed]
  • 33. Cournot M, Marquie JC, Ansiau D, Martinaud C, Fonds H, Ferrieres J, et al. Relation between body mass index and cognitive function in healthy middle-aged men and women. Neurology. 2006; 67(7): 1208-14[DOI][PubMed]
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