Hepatitis Monthly

Published by: Kowsar

Association Between LYPLAL1 rs12137855 Polymorphism With Ultrasound-Defined Non-Alcoholic Fatty Liver Disease in a Chinese Han Population

Chen Yuan 1 , Linlin Lu 2 , 3 , Baiquan An 1 , 4 , Wenwen Jin 4 , Quanjiang Dong 3 , 4 , Yongning Xin 1 , 2 , 4 , * and Shiying Xuan 1 , *
Authors Information
1 Department of Gastroenterology, Qingdao Municipal Hospital, Nanjing Medical University, Qingdao, China
2 Digestive Disease Key Laboratory of Qingdao, Qingdao, China
3 Central Laboratories, Qingdao Municipal Hospital, Qingdao, China
4 Department of Gastroenterology, Qingdao Municipal Hospital, Qingdao, China
Corresponding Authors:
Article information
  • Hepatitis Monthly: December 01, 2015, 15 (12); e33155
  • Published Online: December 19, 2015
  • Article Type: Research Article
  • Received: September 14, 2015
  • Revised: October 9, 2015
  • Accepted: October 17, 2015
  • DOI: 10.5812/hepatmon.33155

To Cite: Yuan C, Lu L, An B, Jin W, Dong Q, et al. Association Between LYPLAL1 rs12137855 Polymorphism With Ultrasound-Defined Non-Alcoholic Fatty Liver Disease in a Chinese Han Population, Hepat Mon. 2015 ; 15(12):e33155. doi: 10.5812/hepatmon.33155.

Abstract
Copyright © 2015, Kowsar Corp. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
Footnotes
References
  • 1. Clark JM. The epidemiology of nonalcoholic fatty liver disease in adults. J Clin Gastroenterol. 2006; 40 Suppl 1-10[DOI][PubMed]
  • 2. Kleiner DE, Brunt EM, Van Natta M, Behling C, Contos MJ, Cummings OW, et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology. 2005; 41(6): 1313-21[DOI][PubMed]
  • 3. Oh MK, Winn J, Poordad F. Review article: Diagnosis and treatment of non-alcoholic fatty liver disease. Aliment Pharmacol Ther. 2008; 28(5): 503-22[DOI][PubMed]
  • 4. Milic S, Stimac D. Nonalcoholic fatty liver disease/steatohepatitis: Epidemiology, pathogenesis, clinical presentation and treatment. Dig Dis. 2012; 30(2): 158-62[DOI][PubMed]
  • 5. Fan JG, Farrell GC. Epidemiology of non-alcoholic fatty liver disease in China. J Hepatol. 2009; 50(1): 204-10[DOI][PubMed]
  • 6. Speliotes EK, Yerges-Armstrong LM, Wu J, Hernaez R, Kim LJ, Palmer CD, et al. Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits. PLoS Genet. 2011; 7(3)[DOI][PubMed]
  • 7. Fischer M, Pleiss J. The Lipase Engineering Database: A navigation and analysis tool for protein families. Nucleic Acids Res. 2003; 31(1): 319-21[PubMed]
  • 8. Lei X, Callaway M, Zhou H, Yang Y, Chen W. Obesity associated Lyplal1 gene is regulated in diet induced obesity but not required for adipocyte differentiation. Mol Cell Endocrinol. 2015; 411: 207-13[DOI][PubMed]
  • 9. Heid IM, Jackson AU, Randall JC, Winkler TW, Qi L, Steinthorsdottir V, et al. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet. 2010; 42(11): 949-60[DOI][PubMed]
  • 10. Jimenez MA, Akerblad P, Sigvardsson M, Rosen ED. Critical role for Ebf1 and Ebf2 in the adipogenic transcriptional cascade. Mol Cell Biol. 2007; 27(2): 743-57[DOI][PubMed]
  • 11. Randall JC, Winkler TW, Kutalik Z, Berndt SI, Jackson AU, Monda KL, et al. Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. PLoS Genet. 2013; 9(6)[DOI][PubMed]
  • 12. Fox CS, Liu Y, White CC, Feitosa M, Smith AV, Heard-Costa N, et al. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. PLoS Genet. 2012; 8(5)[DOI][PubMed]
  • 13. Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, Jackson AU, et al. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet. 2010; 42(11): 937-48[DOI][PubMed]
  • 14. Rickham PP. Human Experimentation. Code of Ethics of the World Medical Association. Declaration of Helsinki. Br Med J. 1964; 2(5402): 177[PubMed]
  • 15. Razavizade M, Jamali R, Arj A, Talari H. Serum parameters predict the severity of ultrasonographic findings in non-alcoholic fatty liver disease. Hepatobiliary Pancreatic Dis Int. 2012; 11(5): 513-20[DOI]
  • 16. Niu TH, Jiang M, Xin YN, Jiang XJ, Lin ZH, Xuan SY. Lack of association between apolipoprotein C3 gene polymorphisms and risk of nonalcoholic fatty liver disease in a Chinese Han population. World J Gastroenterol. 2014; 20(13): 3655-62[DOI][PubMed]
  • 17. Kotronen A, Westerbacka J, Bergholm R, Pietilainen KH, Yki-Jarvinen H. Liver fat in the metabolic syndrome. J Clin Endocrinol Metab. 2007; 92(9): 3490-7[DOI][PubMed]
  • 18. Kitamoto A, Kitamoto T, Nakamura T, Ogawa Y, Yoneda M, Hyogo H, et al. Association of polymorphisms in GCKR and TRIB1 with nonalcoholic fatty liver disease and metabolic syndrome traits. Endocr J. 2014; 61(7): 683-9[PubMed]
  • 19. Lin YC, Chang PF, Chang MH, Ni YH. Genetic variants in GCKR and PNPLA3 confer susceptibility to nonalcoholic fatty liver disease in obese individuals. Am J Clin Nutr. 2014; 99(4): 869-74[DOI][PubMed]
  • 20. Palmer ND, Musani SK, Yerges-Armstrong LM, Feitosa MF, Bielak LF, Hernaez R, et al. Characterization of European ancestry nonalcoholic fatty liver disease-associated variants in individuals of African and Hispanic descent. Hepatology. 2013; 58(3): 966-75[DOI][PubMed]
  • 21. Gorden A, Yang R, Yerges-Armstrong LM, Ryan KA, Speliotes E, Borecki IB, et al. Genetic variation at NCAN locus is associated with inflammation and fibrosis in non-alcoholic fatty liver disease in morbid obesity. Hum Hered. 2013; 75(1): 34-43[DOI][PubMed]
  • 22. Petta S, Valenti L, Marchesini G, Di Marco V, Licata A, Camma C, et al. PNPLA3 GG genotype and carotid atherosclerosis in patients with non-alcoholic fatty liver disease. PLoS One. 2013; 8(9)[DOI][PubMed]
  • 23. Kawaguchi T, Sumida Y, Umemura A, Matsuo K, Takahashi M, Takamura T, et al. Genetic polymorphisms of the human PNPLA3 gene are strongly associated with severity of non-alcoholic fatty liver disease in Japanese. PLoS One. 2012; 7(6)[DOI][PubMed]
  • 24. Malhi H, Gores GJ. Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease. Semin Liver Dis. 2008; 28(4): 360-9[DOI][PubMed]
  • 25. Schindhelm RK, Diamant M, Dekker JM, Tushuizen ME, Teerlink T, Heine RJ. Alanine aminotransferase as a marker of non-alcoholic fatty liver disease in relation to type 2 diabetes mellitus and cardiovascular disease. Diabetes Metab Res Rev. 2006; 22(6): 437-43[DOI][PubMed]
  • 26. Prati D, Taioli E, Zanella A, Della Torre E, Butelli S, Del Vecchio E, et al. Updated definitions of healthy ranges for serum alanine aminotransferase levels. Ann Intern Med. 2002; 137(1): 1-10[PubMed]
  • 27. Pratt DS, Kaplan MM. Evaluation of abnormal liver-enzyme results in asymptomatic patients. N Engl J Med. 2000; 342(17): 1266-71[DOI][PubMed]
  • 28. Marchesini G, Bugianesi E, Forlani G, Cerrelli F, Lenzi M, Manini R, et al. Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome. Hepatology. 2003; 37(4): 917-23[DOI][PubMed]
  • 29. Leon-Mimila P, Vega-Badillo J, Gutierrez-Vidal R, Villamil-Ramirez H, Villareal-Molina T, Larrieta-Carrasco E, et al. A genetic risk score is associated with hepatic triglyceride content and non-alcoholic steatohepatitis in Mexicans with morbid obesity. Exp Mol Pathol. 2015; 98(2): 178-83[DOI][PubMed]
  • 30. Burke JE, Dennis EA. Phospholipase A2 biochemistry. Cardiovasc Drugs Ther. 2009; 23(1): 49-59[DOI][PubMed]
  • 31. Burke JE, Dennis EA. Phospholipase A2 structure/function, mechanism, and signaling. J Lipid Res. 2009; 50 Suppl-42[DOI][PubMed]
  • 32. He S, McPhaul C, Li JZ, Garuti R, Kinch L, Grishin NV, et al. A sequence variation (I148M) in PNPLA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysis. J Biol Chem. 2010; 285(9): 6706-15[DOI][PubMed]
  • 33. Dixon JB, Bhathal PS, O'Brien PE. Nonalcoholic fatty liver disease: predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese. Gastroenterology. 2001; 121(1): 91-100[PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:

Author(s):

Article(s):

Create Citiation Alert
via Google Reader

Readers' Comments