Hepatitis Monthly

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Tumor Necrosis Factor-α-308 G/A Polymorphisms and Risk of Hepatocellular Carcinoma: A Meta-Analysis

Soheil Tavakolpour 1 , 2 and Shahnaz Sali 2 , *
Authors Information
1 Iran University of Medical Sciences, Tehran, IR Iran
2 Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran
Article information
  • Hepatitis Monthly: April 01, 2016, 16 (4); e33537
  • Published Online: April 12, 2016
  • Article Type: Review Article
  • Received: October 2, 2015
  • Accepted: March 14, 2016
  • DOI: 10.5812/hepatmon.33537

To Cite: Tavakolpour S, Sali S. Tumor Necrosis Factor-α-308 G/A Polymorphisms and Risk of Hepatocellular Carcinoma: A Meta-Analysis, Hepat Mon. 2016 ; 16(4):e33537. doi: 10.5812/hepatmon.33537.

Copyright © 2016, Kowsar Corp. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Context
2. Evidence Acquisition
3. Results
4. Conclusions
  • 1. Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 2010; 127(12): 2893-917[DOI][PubMed]
  • 2. Perz JF, Armstrong GL, Farrington LA, Hutin YJ, Bell BP. The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide. J Hepatol. 2006; 45(4): 529-38[DOI][PubMed]
  • 3. Jang MK, Su Kim H, Chung YH. Clinical aspects of tumor necrosis factor-α signaling in hepatocellular carcinoma. Curr Pharm Des. 2014; 20(17): 2799-808[DOI]
  • 4. Wang X, Lin Y. Tumor necrosis factor and cancer, buddies or foes? Acta Pharmacol Sin. 2008; 29(11): 1275-88[DOI][PubMed]
  • 5. Balkwill F. TNF-alpha in promotion and progression of cancer. Cancer Metastasis Rev. 2006; 25(3): 409-16[DOI][PubMed]
  • 6. Huang YS, Hwang SJ, Chan CY, Wu JC, Chao Y, Chang FY, et al. Serum levels of cytokines in hepatitis C-related liver disease: a longitudinal study. Zhonghua Yi Xue Za Zhi (Taipei). 1999; 62(6): 327-33[PubMed]
  • 7. Nakazaki H. Preoperative and postoperative cytokines in patients with cancer. Cancer. 1992; 70(3): 709-13[DOI]
  • 8. Bortolami M, Venturi C, Giacomelli L, Scalerta R, Bacchetti S, Marino F, et al. Cytokine, infiltrating macrophage and T cell-mediated response to development of primary and secondary human liver cancer. Dig Liver Dis. 2002; 34(11): 794-801[DOI]
  • 9. Zekri AR, Ashour MS, Hassan A, Alam El-Din HM, El-Shehaby AM, Abu-Shady MA. Cytokine profile in Egyptian hepatitis C virus genotype-4 in relation to liver disease progression. World J Gastroenterol. 2005; 11(42): 6624-30[PubMed]
  • 10. Tavakolpour S, Alavian SM, Sali S. Hepatitis B Reactivation During Immunosuppressive Therapy or Cancer Chemotherapy, Management, and Prevention: A Comprehensive Review. Hepat Mon. [DOI]
  • 11. Wilson AG, di Giovine FS, Blakemore AI, Duff GW. Single base polymorphism in the human tumour necrosis factor alpha (TNF alpha) gene detectable by NcoI restriction of PCR product. Hum Mol Genet. 1992; 1(5): 353[PubMed]
  • 12. Abraham LJ, Kroeger KM. Impact of the -308 TNF promoter polymorphism on the transcriptional regulation of the TNF gene: relevance to disease. J Leukoc Biol. 1999; 66(4): 562-6[PubMed]
  • 13. Wilson AG, Symons JA, McDowell TL, McDevitt HO, Duff GW. Effects of a polymorphism in the human tumor necrosis factor α promoter on transcriptional activation. Proc Natl Acad Sci. 1997; 94(7): 3195-9[DOI]
  • 14. Talaat RM, Esmail AA, Elwakil R, Gurgis AA, Nasr MI. Tumor necrosis factor-alpha-308G/A polymorphism and risk of hepatocellular carcinoma in hepatitis C virus-infected patients. Chin J Cancer. 2012; 31(1): 29-35
  • 15. Wang Y, Kato N, Hoshida Y, Yoshida H, Taniguchi H, Goto T, et al. Interleukin-1beta gene polymorphisms associated with hepatocellular carcinoma in hepatitis C virus infection. Hepatology. 2003; 37(1): 65-71[DOI][PubMed]
  • 16. Ben-Ari Z, Mor E, Papo O, Kfir B, Sulkes J, Tambur AR, et al. Cytokine gene polymorphisms in patients infected with hepatitis B virus. Am J Gastroenterol. 2003; 98(1): 144-50[DOI][PubMed]
  • 17. Heneghan MA, Johnson PJ, Clare M, Ho S, Harrison PM, Donaldson PT. Frequency and nature of cytokine gene polymorphisms in hepatocellular carcinoma in Hong Kong Chinese. Int J Gastrointest Cancer. 2003; 34(1): 19-26[DOI]
  • 18. Ho SY, Wang YJ, Chen HL, Chen CH, Chang CJ, Wang PJ, et al. Increased risk of developing hepatocellular carcinoma associated with carriage of the TNF2 allele of the -308 tumor necrosis factor-alpha promoter gene. Cancer Causes Control. 2004; 15(7): 657-63[DOI][PubMed]
  • 19. Niro GA, Fontana R, Gioffreda D, Valvano MR, Lacobellis A, Facciorusso D, et al. Tumor necrosis factor gene polymorphisms and clearance or progression of hepatitis B virus infection. Liver Int. 2005; 25(6): 1175-81[DOI][PubMed]
  • 20. Migita K, Miyazoe S, Maeda Y, Daikoku M, Abiru S, Ueki T, et al. Cytokine gene polymorphisms in Japanese patients with hepatitis B virus infection--association between TGF-beta1 polymorphisms and hepatocellular carcinoma. J Hepatol. 2005; 42(4): 505-10[DOI][PubMed]
  • 21. Chen CC, Yang SY, Liu CJ, Lin CL, Liaw YF, Lin SM, et al. Association of cytokine and DNA repair gene polymorphisms with hepatitis B-related hepatocellular carcinoma. Int J Epidemiol. 2005; 34(6): 1310-8[DOI][PubMed]
  • 22. Kummee P, Tangkijvanich P, Poovorawan Y, Hirankarn N. Association of HLA-DRB1*13 and TNF-alpha gene polymorphisms with clearance of chronic hepatitis B infection and risk of hepatocellular carcinoma in Thai population. J Viral Hepat. 2007; 14(12): 841-8[DOI][PubMed]
  • 23. Jeng JS, Tsai JF, Chuang LY, Ho MS, Lin ZY, Hsieh MY, et al. Tumor necrosis factor-α 308.2 polymorphism is associated with advanced hepatic fibrosis and higher risk for hepatocellular carcinoma. Neoplasia. 2007; 9(11): 987-92[DOI]
  • 24. Sakamoto T, Higaki Y, Hara M, Ichiba M, Horita M, Mizuta T, et al. Interaction between interleukin-1beta -31T/C gene polymorphism and drinking and smoking habits on the risk of hepatocellular carcinoma among Japanese. Cancer Lett. 2008; 271(1): 98-104[DOI][PubMed]
  • 25. Jeng JE, Tsai HR, Chuang LY, Tsai JF, Lin ZY, Hsieh MY, et al. Independent and additive interactive effects among tumor necrosis factor-alpha polymorphisms, substance use habits, and chronic hepatitis B and hepatitis C virus infection on risk for hepatocellular carcinoma. Medicine (Baltimore). 2009; 88(6): 349-57[DOI][PubMed]
  • 26. Ognjanovic S, Yuan JM, Chaptman AK, Fan Y, Yu MC. Genetic polymorphisms in the cytokine genes and risk of hepatocellular carcinoma in low-risk non-Asians of USA. Carcinogenesis. 2009; 30(5): 758-62[DOI][PubMed]
  • 27. Akkiz H, Bayram S, Bekar A, Ozdil B, Akgollu E, Sumbul AT, et al. G-308A TNF-alpha polymorphism is associated with an increased risk of hepatocellular carcinoma in the Turkish population: case-control study. Cancer Epidemiol. 2009; 33(3-4): 261-4[DOI][PubMed]
  • 28. Wang B, Wang J, Zheng Y, Zhou S, Zheng J, Wang F, et al. A study of TNF-alpha-238 and -308 polymorphisms with different outcomes of persistent hepatitis B virus infection in China. Pathology. 2010; 42(7): 674-80[DOI][PubMed]
  • 29. Shi Z, Du C. Tumor necrosis factor alpha 308 G/A polymorphism and hepatocellular carcinoma risk in a Chinese population. Genet Test Mol Biomarkers. 2011; 15(7-8): 569-72[DOI][PubMed]
  • 30. Shi HZ, Ren P, Lu QJ, Niedrgethmnn M, Wu GY. Association between EGF, TGF-beta1 and TNF-alpha gene polymorphisms and hepatocellular carcinoma. Asian Pac J Cancer Prev. 2012; 13(12): 6217-20[PubMed]
  • 31. Radwan MI, Pasha HF, Mohamed RH, Hussien HI, El-Khshab MN. Influence of transforming growth factor-beta1 and tumor necrosis factor-alpha genes polymorphisms on the development of cirrhosis and hepatocellular carcinoma in chronic hepatitis C patients. Cytokine. 2012; 60(1): 271-6[DOI][PubMed]
  • 32. Teixeira AC, Mendes CJ, Marano LA, Deghaide NH, Secaf M, Elias JJ, et al. Alleles and genotypes of polymorphisms of IL-18, TNF-alpha and IFN-gamma are associated with a higher risk and severity of hepatocellular carcinoma (HCC) in Brazil. Hum Immunol. 2013; 74(8): 1024-9[DOI][PubMed]
  • 33. Saxena R, Chawla YK, Verma I, Kaur J. IFN-gamma (+874) and not TNF-alpha (-308) is associated with HBV-HCC risk in India. Mol Cell Biochem. 2014; 385(1-2): 297-307[DOI][PubMed]
  • 34. Feng H, Kuai JH, Zhang MY, Wang GC, Shi YJ, Zhang JY. Tumor necrosis factor-alpha gene -308G > A polymorphism alters the risk of hepatocellular carcinoma in a Han Chinese population. Diagn Pathol. 2014; 9: 199[DOI][PubMed]
  • 35. Rizk EB, Amr ER, Mohamed Abd EM, Ghada A. Interleukin-1Beta and Tumor Necrosis Factor-Alpha Genes Polymorphism and Hepatocellular Carcinoma in Patients with Hepatitis C Virus in Egyptian Population. Indian J Appl Res. 2014; 4(2)
  • 36. Sghaier I, Zidi S, Mouelhi L, Dabbech R, Ghazouani E, Brochot E, et al. The relationship between TNF alpha gene polymorphisms (-238/-308), TNF RII VNTR (p75) and outcomes of hepatitis B virus infection in Tunisian population. Gene. 2015; 568(2): 140-5[DOI][PubMed]
  • 37. Gao J, Xie L, Yang WS, Zhang W, Gao S, Wang J, et al. Risk factors of hepatocellular carcinoma--current status and perspectives. Asian Pac J Cancer Prev. 2012; 13(3): 743-52[PubMed]
  • 38. Sali S, Alavian SM, Foster GR, Keyvani H, Mehrnoosh L, Mohammadi N. Influencing Factors on the Outcome and Prognosis of Patients With HBV Infction: Seven Years Follow-up. Hepat Mon. 2013; 13(7)[DOI]
  • 39. Civan J, Hann HW. Hepatitis C virus mediated hepatocellular carcinoma: a focused review for a time of changing therapeutic options. N Am J Med Sci. 2014; 7(1): 37[DOI]
  • 40. Tavakolpour S. The new insight into management of hepatitis B virus patients with flare. Immunology letters. 2016; : 173-77
  • 41. Tavakolpour S. Inhibition of regulatory cells as a possible cure of chronically hepatitis B virus infected patients. Immunology letters. 2016; 171: 70-1
  • 42. Seitz HK, Stickel F. Molecular mechanisms of alcohol-mediated carcinogenesis. Nat Rev Cancer. 2007; 7(8): 599-612[DOI][PubMed]
  • 43. Wullaert A, van Loo G, Heyninck K, Beyaert R. Hepatic tumor necrosis factor signaling and nuclear factor-kappaB: effects on liver homeostasis and beyond. Endocr Rev. 2007; 28(4): 365-86[DOI][PubMed]
  • 44. Yang Y, Luo C, Feng R, Bi S. The TNF-alpha, IL-1B and IL-10 polymorphisms and risk for hepatocellular carcinoma: a meta-analysis. J Cancer Res Clin Oncol. 2011; 137(6): 947-52[DOI][PubMed]
  • 45. Wei Y, Liu F, Li B, Chen X, Ma Y, Yan L, et al. Polymorphisms of tumor necrosis factor-alpha and hepatocellular carcinoma risk: a HuGE systematic review and meta-analysis. Dig Dis Sci. 2011; 56(8): 2227-36[DOI][PubMed]
  • 46. Hu Q, Lou GG, Liu YC, Qian L, Lv BD. The Tumor Necrosis Factor-alpha-308 and -238 Polymorphisms and Risk of Hepatocellular Carcinoma for Asian Populations: A Meta-Analysis. Curr Ther Res Clin Exp. 2014; 76: 70-5[DOI][PubMed]
  • 47. Wang F, Chen S, Xu R. WITHDRAWN: Association of TNF-α-308G> A polymorphisms with hepatocellular carcinoma in Han Chinese population: A systematic review and meta-analysis. Clin Res Hepatol Gastroenterol. 2014; [DOI]
  • 48. Cheng K, Zhao YJ, Liu L, Wan JJ. Tumor necrosis factor-alpha 238 G/A polymorphism and risk of hepatocellular carcinoma: evidence from a meta-analysis. Asian Pac J Cancer Prev. 2013; 14(5): 3275-9[PubMed]
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