Hepatitis Monthly

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Occult Hepatitis B Virus Infection in a Previously Vaccinated Injection Drug User

Eleanor A. Powell 1 , Sanam Razeghi 1 , Stephen Zucker 1 and Jason T. Blackard 1 , *
Authors Information
1 Division of Digestive Disease, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA
Article information
  • Hepatitis Monthly: February 01, 2016, 16 (2); e34758
  • Published Online: February 20, 2016
  • Article Type: Case Report
  • Received: November 16, 2015
  • Accepted: December 13, 2015
  • DOI: 10.5812/hepatmon.34758

To Cite: Powell E A, Razeghi S, Zucker S, Blackard J T. Occult Hepatitis B Virus Infection in a Previously Vaccinated Injection Drug User, Hepat Mon. 2016 ; 16(2):e34758. doi: 10.5812/hepatmon.34758.

Copyright © 2016, Kowsar Corp. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Introduction
2. Case Presentation
3. Discussion
  • 1. WHO | Hepatitis B [Internet]. Fact Sheet N204: Hepatitis B. World Health Organization; 2013;
  • 2. Pande C, Sarin SK, Patra S, Kumar A, Mishra S, Srivastava S, et al. Hepatitis B vaccination with or without hepatitis B immunoglobulin at birth to babies born of HBsAg‐positive mothers prevents overt HBV transmission but may not prevent occult HBV infection in babies: a randomized controlled trial. J Viral Hepatitis. 2013; 20(11): 801-10
  • 3. Xu L, Wei Y, Chen T, Lu J, Zhu C, Ni Z, et al. Occult HBV infection in anti-HBs-positive young adults after neonatal HB vaccination. Vaccine. 2010; 28(37): 5986-92
  • 4. Shahmoradi S, Yahyapour Y, Mahmoodi M, Alavian SM, Fazeli Z, Jazayeri SM. High prevalence of occult hepatitis B virus infection in children born to HBsAg-positive mothers despite prophylaxis with hepatitis B vaccination and HBIG. Int J Hepatol. 2012; 57(3): 515-21
  • 5. Su H, Zhang Y, Xu D, Wang B, Zhang L, Li D, et al. Occult hepatitis B virus infection in anti-HBs-positive infants born to HBsAg-positive mothers in China. PLoS One. 2013; 8(8)
  • 6. Weber B, Melchior W, Gehrke R, Doerr HW, Berger A, Rabenau H. Hepatitis B virus markers in anti-HBc only positive individuals. J Med Virol. 2001; 64(3): 312-9[PubMed]
  • 7. Martel N, Gomes SA, Chemin I, Trépo C, Kay A. Improved rolling circle amplification (RCA) of hepatitis B virus (HBV) relaxed-circular serum DNA (RC-DNA). J Virol Methods. 2013; 193(2): 653-9
  • 8. Gunther S, Li BC, Miska S, Kruger DH, Meisel H, Will H. A novel method for efficient amplification of whole hepatitis B virus genomes permits rapid functional analysis and reveals deletion mutants in immunosuppressed patients. J Virol. 1995; 69(9): 5437-44[PubMed]
  • 9. Drummond AJ, Rambaut A. BEAST: Bayesian evolutionary analysis by sampling trees. BMC Evol Biol. 2007; 7(1): 214
  • 10. Vivekanandan P, Kannangai R, Ray SC, Thomas DL, Torbenson M. Comprehensive genetic and epigenetic analysis of occult hepatitis B from liver tissue samples. Arch Clin Infect Dis. 2008; 46(8): 1227-36
  • 11. Hsu HY, Chang MH, Ni YH, Chiang CL, Wu JF, Chen HL. Universal infant immunization and occult hepatitis B virus infection in children and adolescents: a population-based study. Hepatology. 2015; 61(4): 1183-91[DOI][PubMed]
  • 12. Amponsah-Dacosta E, Lebelo RL, Rakgole JN, Selabe SG, Gededzha MP, Mayaphi SH, et al. Hepatitis B virus infection in post-vaccination South Africa: Occult HBV infection and circulating surface gene variants. J Clin Virol. 2015; 63: 12-7[DOI]
  • 13. van Dommelen L, Verbon A, van Doorn HR, Goossens VJ. Acute hepatitis B virus infection with simultaneous high HBsAg and high anti-HBs signals in a previously HBV vaccinated HIV-1 positive patient. J Clin Virol. 2010; 47(3): 293-6
  • 14. Manzini P, Abate ML, Valpreda C, Milanesi P, Curti F, Rizzetto M, et al. Evidence of acute primary occult hepatitis B virus infection in an Italian repeat blood donor. Transfusion. 2009; 49(4): 757-64
  • 15. Weber B, Muhlbacher A, Melchior W. Detection of an acute asymptomatic HBsAg negative hepatitis B virus infection in a blood donor by HBV DNA testing. J Clin Virol. 2005; 32(1): 67-70
  • 16. Martin CM, Welge JA, Shire NJ, Rouster SD, Shata MT, Sherman KE, et al. Genomic variability associated with the presence of occult hepatitis B virus in HIV co-infected individuals. J Viral Hepat. 2010; 17(8): 588-97[DOI][PubMed]
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