Hepatitis Monthly

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Genetic Polymorphism of CYP27B1-1260 as Associated With Impaired Fasting Glucose in Patients With Chronic Hepatitis C Undergoing Antiviral Therapy

Derong Sun 1 , Wenqian Qi 1 , Song Wang 2 , Xu Wang 1 , Yonggui Zhang 1 and Jiangbin Wang 1 , *
Authors Information
1 Department of Gastroenterology, China-Japan Union Hospital, Jilin University, Changchun, PR China
2 Department of Urology, The Second Hospital, Jilin University, Changchun, PR China
Article information
  • Hepatitis Monthly: September 01, 2016, 16 (9); e35179
  • Published Online: May 28, 2016
  • Article Type: Research Article
  • Received: December 4, 2015
  • Revised: April 24, 2016
  • Accepted: May 8, 2016
  • DOI: 10.5812/hepatmon.35179

To Cite: Sun D, Qi W, Wang S, Wang X, Zhang Y, et al. Genetic Polymorphism of CYP27B1-1260 as Associated With Impaired Fasting Glucose in Patients With Chronic Hepatitis C Undergoing Antiviral Therapy, Hepat Mon. 2016 ; 16(9):e35179. doi: 10.5812/hepatmon.35179.

Copyright © 2016, Kowsar Corp. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Naing C, Mak JW, Ahmed SI, Maung M. Relationship between hepatitis C virus infection and type 2 diabetes mellitus: meta-analysis. World J Gastroenterol. 2012; 18(14): 1642-51[DOI][PubMed]
  • 2. Elkrief L, Chouinard P, Bendersky N, Hajage D, Larroque B, Babany G, et al. Diabetes mellitus is an independent prognostic factor for major liver-related outcomes in patients with cirrhosis and chronic hepatitis C. Hepatology. 2014; 60(3): 823-31[DOI][PubMed]
  • 3. Petit JM, Bour JB, Galland-Jos C, Minello A, Verges B, Guiguet M, et al. Risk factors for diabetes mellitus and early insulin resistance in chronic hepatitis C. J Hepatol. 2001; 35(2): 279-83[PubMed]
  • 4. Staiger H, Machicao F, Fritsche A, Haring HU. Pathomechanisms of type 2 diabetes genes. Endocr Rev. 2009; 30(6): 557-85[DOI][PubMed]
  • 5. Fabris P, Betterle C, Greggio NA, Zanchetta R, Bosi E, Biasin MR, et al. Insulin-dependent diabetes mellitus during alpha-interferon therapy for chronic viral hepatitis. J Hepatol. 1998; 28(3): 514-7[PubMed]
  • 6. Betterle C, Fabris P, Zanchetta R, Pedini B, Tositti G, Bosi E, et al. Autoimmunity against pancreatic islets and other tissues before and after interferon-alpha therapy in patients with hepatitis C virus chronic infection. Diabetes Care. 2000; 23(8): 1177-81[PubMed]
  • 7. Welch NM, Jensen DM. Pegylated interferon based therapy with second-wave direct-acting antivirals in genotype 1 chronic hepatitis C. Liver Int. 2015; 35 Suppl 1: 11-7[DOI][PubMed]
  • 8. Florez JC, Jablonski KA, Bayley N, Pollin TI, de Bakker PI, Shuldiner AR, et al. TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program. N Engl J Med. 2006; 355(3): 241-50[DOI][PubMed]
  • 9. Groves CJ, Zeggini E, Minton J, Frayling TM, Weedon MN, Rayner NW, et al. Association analysis of 6,736 U.K. subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk. Diabetes. 2006; 55(9): 2640-4[DOI][PubMed]
  • 10. Zhang C, Qi L, Hunter DJ, Meigs JB, Manson JE, van Dam RM, et al. Variant of transcription factor 7-like 2 (TCF7L2) gene and the risk of type 2 diabetes in large cohorts of U.S. women and men. Diabetes. 2006; 55(9): 2645-8[DOI][PubMed]
  • 11. McGrath JJ, Saha S, Burne TH, Eyles DW. A systematic review of the association between common single nucleotide polymorphisms and 25-hydroxyvitamin D concentrations. J Steroid Biochem Mol Biol. 2010; 121(1-2): 471-7[DOI][PubMed]
  • 12. Bourlon PM, Faure-Dussert A, Billaudel B. Modulatory role of 1,25 dihydroxyvitamin D3 on pancreatic islet insulin release via the cyclic AMP pathway in the rat. Br J Pharmacol. 1997; 121(4): 751-8[DOI][PubMed]
  • 13. Hoenderop JG, Dardenne O, Van Abel M, Van Der Kemp AW, Van Os CH, St -Arnaud R, et al. Modulation of renal Ca2+ transport protein genes by dietary Ca2+ and 1,25-dihydroxyvitamin D3 in 25-hydroxyvitamin D3-1alpha-hydroxylase knockout mice. FASEB J. 2002; 16(11): 1398-406[DOI][PubMed]
  • 14. Munshi HG, Burks DJ, Joyal JL, White MF, Sacks DB. Ca2+ regulates calmodulin binding to IQ motifs in IRS-1. Biochemistry. 1996; 35(49): 15883-9[DOI][PubMed]
  • 15. Li Z, Joyal JL, Sacks DB. Binding of IRS proteins to calmodulin is enhanced in insulin resistance. Biochemistry. 2000; 39(17): 5089-96[PubMed]
  • 16. Lange CM, Bojunga J, Ramos-Lopez E, von Wagner M, Hassler A, Vermehren J, et al. Vitamin D deficiency and a CYP27B1-1260 promoter polymorphism are associated with chronic hepatitis C and poor response to interferon-alfa based therapy. J Hepatol. 2011; 54(5): 887-93[DOI][PubMed]
  • 17. Strader DB, Wright T, Thomas DL, Seeff LB, American Association for the Study of Liver D. Diagnosis, management, and treatment of hepatitis C. Hepatology. 2004; 39(4): 1147-71[DOI][PubMed]
  • 18. American Diabetes A. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2009; 32 Suppl 1-7[DOI][PubMed]
  • 19. Arase Y, Kobayashi M, Suzuki F, Suzuki Y, Kawamura Y, Akuta N, et al. Effect of type 2 diabetes on risk for malignancies includes hepatocellular carcinoma in chronic hepatitis C. Hepatology. 2013; 57(3): 964-73[DOI][PubMed]
  • 20. Elhawary EI, Mahmoud GF, El-Daly MA, Mekky FA, Esmat GG, Abdel-Hamid M. Association of HCV with diabetes mellitus: an Egyptian case-control study. Virol J. 2011; 8: 367[DOI][PubMed]
  • 21. Sciacqua A, Perticone M, Tassone EJ, Cimellaro A, Caroleo B, Miceli S, et al. Renal function is impaired in normotensive chronic HCV patients: role of insulin resistance. Intern Emerg Med. 2016; 11(4): 553-9[DOI][PubMed]
  • 22. Kaur H, Singh P, Pannu HS, Sood A, Jain NP, Bhoday HS. To study the prevalence of impaired glucose tolerance in patients with hepatitis C virus related chronic liver disease. J Clin Diagn Res. 2015; 9(3)-20[DOI][PubMed]
  • 23. Chen S, Villalta SA, Agrawal DK. FOXO1 Mediates Vitamin D Deficiency-Induced Insulin Resistance in Skeletal Muscle. J Bone Miner Res. 2016; 31(3): 585-95[DOI][PubMed]
  • 24. Johnson JA, Grande JP, Roche PC, Kumar R. Immunohistochemical localization of the 1,25(OH)2D3 receptor and calbindin D28k in human and rat pancreas. Am J Physiol. 1994; 267(3 Pt 1)-60[PubMed]
  • 25. Bland R, Markovic D, Hills CE, Hughes SV, Chan SL, Squires PE, et al. Expression of 25-hydroxyvitamin D3-1alpha-hydroxylase in pancreatic islets. J Steroid Biochem Mol Biol. 2004; 89-90(1-5): 121-5[DOI][PubMed]
  • 26. Zhu Q, Li N, Han Q, Li Z, Zhang G, Li F, et al. Single-nucleotide polymorphism at CYP27B1-1260, but not VDR Taq I, is possibly associated with persistent hepatitis B virus infection. Genet Test Mol Biomarkers. 2012; 16(9): 1115-21[DOI][PubMed]
  • 27. Bailey R, Cooper JD, Zeitels L, Smyth DJ, Yang JH, Walker NM, et al. Association of the vitamin D metabolism gene CYP27B1 with type 1 diabetes. Diabetes. 2007; 56(10): 2616-21[DOI][PubMed]
  • 28. Ramos-Lopez E, Kahles H, Weber S, Kukic A, Penna-Martinez M, Badenhoop K, et al. Gestational diabetes mellitus and vitamin D deficiency: genetic contribution of CYP27B1 and CYP2R1 polymorphisms. Diabetes Obes Metab. 2008; 10(8): 683-5[DOI][PubMed]
  • 29. Lopez ER, Zwermann O, Segni M, Meyer G, Reincke M, Seissler J, et al. A promoter polymorphism of the CYP27B1 gene is associated with Addison's disease, Hashimoto's thyroiditis, Graves' disease and type 1 diabetes mellitus in Germans. Eur J Endocrinol. 2004; 151(2): 193-7[PubMed]
  • 30. Jensen CJ, Stankovich J, Van der Walt A, Bahlo M, Taylor BV, van der Mei IA, et al. Multiple sclerosis susceptibility-associated SNPs do not influence disease severity measures in a cohort of Australian MS patients. PLoS One. 2010; 5(4)[DOI][PubMed]
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