Improvement in the Amino Acid Imbalance in Hepatitis C Virus Infected Patients After Viral Eradication by Interferon Treatment

Authors Information
Article Notes and Dates
To Cite : Enomoto H, Nishikawa H, Ikeda N, Aizawa N, Sakai Y, et al. Improvement in the Amino Acid Imbalance in Hepatitis C Virus Infected Patients After Viral Eradication by Interferon Treatment, Hepat Mon. 2016 ;16(6):e35824. doi: 10.5812/hepatmon.35824.
Copyright: Copyright © 2016, Hepatitis Monthly. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited..
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Fischer JE, Yoshimura N, Aguirre A, James JH, Cummings MG, Abel RM, et al. Plasma amino acids in patients with hepatic encephalopathy. Effects of amino acid infusions. Am J Surg. 1974; 127(1): 40-7[PubMed]
  • 2. James JH, Ziparo V, Jeppsson B, Fischer JE. Hyperammonæmia, plasma aminoacid imbalance, and blood-brain aminoacid transport: A unified theory of portal-systemic encephalopathy. Lancet. 1979; 2(8146): 772-5[DOI]
  • 3. Tada T, Kumada T, Toyoda H, Kiriyama S, Tanikawa M, Hisanaga Y, et al. Impact of the branched-chain amino acid to tyrosine ratio and branched-chain amino acid granule therapy in patients with hepatocellular carcinoma: A propensity score analysis. J Gastroenterol Hepatol. 2015; 30(9): 1412-9[DOI][PubMed]
  • 4. Suzuki K, Suzuki K, Koizumi K, Ichimura H, Oka S, Takada H, et al. Measurement of serum branched-chain amino acids to tyrosine ratio level is useful in a prediction of a change of serum albumin level in chronic liver disease. Hepatol Res. 2008; 38(3): 267-72[DOI][PubMed]
  • 5. Enomoto H, Sakai Y, Aizawa N, Iwata Y, Tanaka H, Ikeda N, et al. Association of amino acid imbalance with the severity of liver fibrosis and esophageal varices. Ann Hepatol. 2013; 12(3): 471-8[PubMed]
  • 6. Oono T, Yamasaki T, Zaitsu J, Saeki I, Iwamoto T, Harima Y, et al. Association of tyrosine with insulin resistance in hepatitis C virus-related chronic liver disease. Hepatol Res. 2014; 44(10)-62[DOI][PubMed]
  • 7. Enomoto H, Aizawa N, Nakamura H, Takata R, Sakai Y, Iwata Y, et al. A new metabolism-related index correlates with the degree of liver fibrosis in hepatitis C virus-positive patients. Gastroenterol Res Pract. 2015; 2015: 926169[DOI][PubMed]
  • 8. Mukherjee S, Gollan JL. Assessment of Liver Function Sherlock’s Diseases of the Liver and Biliary System. 2011; : 20-35
  • 9. Morgan MY, Marshall AW, Milsom JP, Sherlock S. Plasma amino-acid patterns in liver disease. Gut. 1982; 23(5): 362-70[PubMed]
  • 10. Nakamura Y, Mizuguchi T, Kawamoto M, Meguro M, Harada K, Ota S, et al. Cluster analysis of indicators of liver functional and preoperative low branched-chain amino acid tyrosine ration indicate a high risk of early recurrence in analysis of 165 hepatocellular carcinoma patients after initial hepatectomy. Surgery. 2011; 150(2): 250-62[DOI][PubMed]
  • 11. Ishikawa T. Early administration of branched-chain amino acid granules. World J Gastroenterol. 2012; 18(33): 4486-90[DOI][PubMed]
  • 12. Kawaguchi T, Ide T, Taniguchi E, Hirano E, Itou M, Sumie S, et al. Clearance of HCV improves insulin resistance, beta-cell function, and hepatic expression of insulin receptor substrate 1 and 2. Am J Gastroenterol. 2007; 102(3): 570-6[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiaion Alert via Google Reader

Cited By:

Hepatitis Monthly accepts terms & conditions of:

International Committee of Medical Journal Editors (ICMJE) Citedby Linking DOI enabled Crossref iThenticate COPE Cross Check