Hepatitis Monthly

Published by: Kowsar

Transarterial Ethanol Ablation Combined with Transarterial Chemoembolization for Hepatocellular Carcinoma with Portal Vein Tumor Thrombus

Biao Yang 1 , Xin You 1 , Min lan Yuan 2 , Tian Qiang Qin 4 , Lin Jia Duan 3 , Jiao He 3 , Ze Jun Fei 3 , Xuan Zhou 3 , Rui Yu Zan 1 and Zheng Yin Liao 1 , *
Authors Information
1 Department of Abdominal Oncology, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, China
2 Psychiatry Centre, West China Hospital, West China Medical School, Sichuan University, Chengdu, China
3 Department of Radiology, West China Hospital, West China Medical School, Sichuan University, Chengdu, China
4 Chinese Evidence-Based Medicine Centre, West China Hospital, West China Medical School, Sichuan University, Chengdu, China
Article information
  • Hepatitis Monthly: August 01, 2016, 16 (8); e37584
  • Published Online: July 23, 2016
  • Article Type: Research Article
  • Received: March 4, 2016
  • Revised: May 23, 2016
  • Accepted: June 19, 2016
  • DOI: 10.5812/hepatmon.37584

To Cite: Yang B, You X, Yuan M L, Qin T Q, Duan L J, et al. Transarterial Ethanol Ablation Combined with Transarterial Chemoembolization for Hepatocellular Carcinoma with Portal Vein Tumor Thrombus, Hepat Mon. 2016 ; 16(8):e37584. doi: 10.5812/hepatmon.37584.

Copyright © 2016, Kowsar Corp. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
  • 1. El-Serag HB, Rudolph KL. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology. 2007; 132(7): 2557-76[DOI][PubMed]
  • 2. Llovet JM, Bustamante J, Castells A, Vilana R, Ayuso Mdel C, Sala M, et al. Natural history of untreated nonsurgical hepatocellular carcinoma: rationale for the design and evaluation of therapeutic trials. Hepatology. 1999; 29(1): 62-7[DOI][PubMed]
  • 3. Esnaola NF, Mirza N, Lauwers GY, Ikai I, Regimbeau JM, Belghiti J, et al. Comparison of clinicopathologic characteristics and outcomes after resection in patients with hepatocellular carcinoma treated in the United States, France, and Japan. Ann Surg. 2003; 238(5): 711-9[DOI][PubMed]
  • 4. Kondo K, Chijiiwa K, Kai M, Otani K, Nagaike K, Ohuchida J, et al. Surgical strategy for hepatocellular carcinoma patients with portal vein tumor thrombus based on prognostic factors. J Gastrointest Surg. 2009; 13(6): 1078-83[DOI][PubMed]
  • 5. Ban D, Shimada K, Yamamoto Y, Nara S, Esaki M, Sakamoto Y, et al. Efficacy of a hepatectomy and a tumor thrombectomy for hepatocellular carcinoma with tumor thrombus extending to the main portal vein. J Gastrointest Surg. 2009; 13(11): 1921-8[DOI][PubMed]
  • 6. Chen JS, Wang Q, Chen XL, Huang XH, Liang LJ, Lei J, et al. Clinicopathologic characteristics and surgical outcomes of hepatocellular carcinoma with portal vein tumor thrombosis. J Surg Res. 2012; 175(2): 243-50[DOI][PubMed]
  • 7. Takayasu K, Arii S, Ikai I, Omata M, Okita K, Ichida T, et al. Prospective cohort study of transarterial chemoembolization for unresectable hepatocellular carcinoma in 8510 patients. Gastroenterology. 2006; 131(2): 461-9[DOI][PubMed]
  • 8. Ohkubo T, Yamamoto J, Sugawara Y, Shimada K, Yamasaki S, Makuuchi M, et al. Surgical results for hepatocellular carcinoma with macroscopic portal vein tumor thrombosis. J Am Coll Surg. 2000; 191(6): 657-60[PubMed]
  • 9. Tanaka A, Morimoto T, Yamaoka Y. Implications of surgical treatment for advanced hepatocellular carcinoma with tumor thrombi in the portal vein. Hepatogastroenterology. 1996; 43(9): 637-43[PubMed]
  • 10. Pawarode A, Voravud N, Sriuranpong V, Kullavanijaya P, Patt YZ. Natural history of untreated primary hepatocellular carcinoma: a retrospective study of 157 patients. Am J Clin Oncol. 1998; 21(4): 386-91[PubMed]
  • 11. Park JH, Han JK, Chung JW, Choi BI, Han MC, Kim YI. Superselective transcatheter arterial embolization with ethanol and iodized oil for hepatocellular carcinoma. J Vasc Interv Radiol. 1993; 4(3): 333-9
  • 12. Yu SC, Hui JW, Hui EP, Mo F, Lee PS, Wong J, et al. Embolization efficacy and treatment effectiveness of transarterial therapy for unresectable hepatocellular carcinoma: a case-controlled comparison of transarterial ethanol ablation with lipiodol-ethanol mixture versus transcatheter arterial chemoembolization. J Vasc Interv Radiol. 2009; 20(3): 352-9[DOI][PubMed]
  • 13. Gu YK, Luo RG, Huang JH, Si Tu QJ, Li XX, Gao F. Transarterial embolization ablation of hepatocellular carcinoma with a lipiodol-ethanol mixture. World J Gastroenterol. 2010; 16(45): 5766-72[PubMed]
  • 14. Si Q,, Huang SX, TONG W, Qian XL, Lv XP, Huang YL. Clinical study of blood perfusion characteristics in liver cancer and portal vein tumor thrombosis by CEUS and CDUS. Military Med J Southeast China. 2011; 13(1): 20-2
  • 15. U SC, Hui JW, Hui EP, Chan SL, Lee KF, Mo F. Unresectable hepatocellular carcinoma: randomized controlled trial of transarterial ethanol ablation versus transcatheter arterial chemoembolization. Radiol. 2014; 270(2): 607-20
  • 16. Miyayama S, Yamashiro M, Hashimoto M, Hashimoto N, Ikuno M, Okumura K, et al. Comparison of local control in transcatheter arterial chemoembolization of hepatocellular carcinoma </=6 cm with or without intraprocedural monitoring of the embolized area using cone-beam computed tomography. Cardiovasc Intervent Radiol. 2014; 37(2): 388-95[DOI][PubMed]
  • 17. Eisenhauer EA, Therasse P, Bogaerts J, Schwartz LH, Sargent D, Ford R, et al. New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur J Cancer. 2009; 45(2): 228-47[DOI][PubMed]
  • 18. Luo J, Guo RP, Lai EC, Zhang YJ, Lau WY, Chen MS, et al. Transarterial chemoembolization for unresectable hepatocellular carcinoma with portal vein tumor thrombosis: a prospective comparative study. Ann Surg Oncol. 2011; 18(2): 413-20[DOI][PubMed]
  • 19. Yoon JH, Kim HC, Chung JW, Yoon JH, Jae HJ, Park JH. CT findings of completely regressed hepatocellular carcinoma with main portal vein tumor thrombosis after transcatheter arterial chemoembolization. Korean J Radiol. 2010; 11(1): 69-74[DOI][PubMed]
  • 20. Kan Z, Wallace S. Transcatheter liver lobar ablation: an experimental trial in an animal model. Eur Radiol. 1997; 7(7): 1071-5[DOI][PubMed]
  • 21. Wallace MJ, Murthy R, Kamat PP, Moore T, Rao SH, Ensor J, et al. Impact of C-arm CT on hepatic arterial interventions for hepatic malignancies. J Vasc Interv Radiol. 2007; 18(12): 1500-7[DOI][PubMed]
  • 22. Mathupala SP, Rempel A, Pedersen PL. Glucose catabolism in cancer cells: identification and characterization of a marked activation response of the type II hexokinase gene to hypoxic conditions. J Biol Chem. 2001; 276(46): 43407-12[DOI][PubMed]
  • 23. Tanaka K, Okazaki H, Nakamura S, Endo O, Inoue S, Takamura Y, et al. Hepatocellular carcinoma: treatment with a combination therapy of transcatheter arterial embolization and percutaneous ethanol injection. Radiology. 1991; 179(3): 713-7[DOI][PubMed]
  • 24. Yamaoka Y, Kumada K, Ino K, Takayasu T, Shimahara Y, Mori K, et al. Liver resection for hepatocellular carcinoma (HCC) with direct removal of tumor thrombi in the main portal vein. World J Surg. 1992; 16(6): 1172-6[PubMed]
  • 25. Le Treut YP, Hardwigsen J, Ananian P, Saisse J, Gregoire E, Richa H, et al. Resection of hepatocellular carcinoma with tumor thrombus in the major vasculature. A European case-control series. J Gastrointest Surg. 2006; 10(6): 855-62[DOI][PubMed]
  • 26. Mazzaferro V, Regalia E, Doci R, Andreola S, Pulvirenti A, Bozzetti F, et al. Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. N Engl J Med. 1996; 334(11): 693-9[DOI][PubMed]
  • 27. Okada S, Okazaki N, Nose H, Yoshimori M, Aoki K. Prognostic factors in patients with hepatocellular carcinoma receiving systemic chemotherapy. Hepatology. 1992; 16(1): 112-7[PubMed]
  • 28. Minagawa M, Makuuchi M, Takayama T, Ohtomo K. Selection criteria for hepatectomy in patients with hepatocellular carcinoma and portal vein tumor thrombus. Ann Surg. 2001; 233(3): 379-84[PubMed]
  • 29. Prunoiu V, Cirimbei C, Marincas M, Cirimbei S, Bratucu E. Extending indication for radiofrequency ablation (585-9RFA) in cancer surgery. Chirurgia (Bucur). 2011; 106(5): 585-9
  • 30. Chan MK, Kwok PC, Chan SC, Lam TW, Lo KK, Lam CL. Percutaneous ethanol injection as a possible curative treatment for malignant portal vein thrombosis in hepatocellular carcinoma. Cardiovasc Intervent Radiol. 1999; 22(4): 326-8[PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments