Hepatitis Monthly

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Serological Patterns and Molecular Characterization of Occult Hepatitis B Virus Infection among Blood Donors

Hong Lin 1 , Hong Zhao 2 , Xinyi Tang 1 , Wenjia Hu 1 , Nizheng Jiang 1 , Shaowen Zhu 1 and Chengyin Huang 1 , *
Authors Information
1 Jiangsu Province Blood Center, Nanjing, China
2 The Second Hospital of Nanjing, Nanjing, China
Article information
  • Hepatitis Monthly: October 01, 2016, 16 (10); e40492
  • Published Online: October 2, 2016
  • Article Type: Research Article
  • Received: July 4, 2016
  • Revised: August 25, 2016
  • Accepted: September 5, 2016
  • DOI: 10.5812/hepatmon.40492

To Cite: Lin H, Zhao H, Tang X, Hu W, Jiang N, et al. Serological Patterns and Molecular Characterization of Occult Hepatitis B Virus Infection among Blood Donors, Hepat Mon. 2016 ; 16(10):e40492. doi: 10.5812/hepatmon.40492.

Copyright © 2016, Kowsar Corp. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
  • 1. Hepatitis B (Fact Sheet No 204). 2014;
  • 2. Gerlich WH. Prophylactic vaccination against hepatitis B: achievements, challenges and perspectives. Med Microbiol Immunol. 2015; 204(1): 39-55[DOI][PubMed]
  • 3. Liang X, Bi S, Yang W, Wang L, Cui G, Cui F, et al. Epidemiological serosurvey of hepatitis B in China--declining HBV prevalence due to hepatitis B vaccination. Vaccine. 2009; 27(47): 6550-7[DOI][PubMed]
  • 4. Wang J, Lu FM, Zhuang H. [The analysis on the epidemic trend of viral hepatitis in China during recent 10 years (2002-2011)]. Zhonghua Gan Zang Bing Za Zhi. 2013; 21(8): 561-4[PubMed]
  • 5. Ma L, Alla NR, Li X, Mynbaev OA, Shi Z. Mother-to-child transmission of HBV: review of current clinical management and prevention strategies. Rev Med Virol. 2014; 24(6): 396-406[DOI][PubMed]
  • 6. Raimondo G, Allain JP, Brunetto MR, Buendia MA, Chen DS, Colombo M, et al. Statements from the Taormina expert meeting on occult hepatitis B virus infection. J Hepatol. 2008; 49(4): 652-7[DOI][PubMed]
  • 7. El Ekiaby M, Lelie N, Allain JP. Nucleic acid testing (NAT) in high prevalence-low resource settings. Biologicals. 2010; 38(1): 59-64[DOI][PubMed]
  • 8. Hollinger FB. Hepatitis B virus infection and transfusion medicine: science and the occult. Transfusion. 2008; 48(5): 1001-26[DOI][PubMed]
  • 9. Allain JP, Cox L. Challenges in hepatitis B detection among blood donors. Curr Opin Hematol. 2011; 18(6): 461-6[DOI][PubMed]
  • 10. Liu Y, Li P, Li C, Zhou J, Wu C, Zhou YH. Detection of hepatitis B virus DNA among accepted blood donors in Nanjing, China. Virol J. 2010; 7: 193[DOI][PubMed]
  • 11. Zheng X, Ye X, Zhang L, Wang W, Shuai L, Wang A, et al. Characterization of occult hepatitis B virus infection from blood donors in China. J Clin Microbiol. 2011; 49(5): 1730-7[DOI][PubMed]
  • 12. Li L, Chen PJ, Chen MH, Chak KF, Lin KS, Tsai SJ. A pilot study for screening blood donors in Taiwan by nucleic acid amplification technology: detecting occult hepatitis B virus infections and closing the serologic window period for hepatitis C virus. Transfusion. 2008; 48(6): 1198-206[DOI][PubMed]
  • 13. Yuen MF, Lee CK, Wong DK, Fung J, Hung I, Hsu A, et al. Prevalence of occult hepatitis B infection in a highly endemic area for chronic hepatitis B: a study of a large blood donor population. Gut. 2010; 59(10): 1389-93[DOI][PubMed]
  • 14. Tsoi WC, Lelie N, Lin CK. Enhanced detection of hepatitis B virus in Hong Kong blood donors after introduction of a more sensitive transcription-mediated amplification assay. Transfusion. 2013; 53(10 Pt 2): 2477-88[DOI][PubMed]
  • 15. Jutavijittum P, Andernach IE, Yousukh A, Samountry B, Samountry K, Thammavong T, et al. Occult hepatitis B infections among blood donors in Lao PDR. Vox Sang. 2014; 106(1): 31-7[DOI][PubMed]
  • 16. Findik D, Arslan U, Baykan M. Determination of hepatitis B virus DNA incidence, viral load, and mutations in blood donors with HBsAg and anti-HBs-negative serology and antibodies to hepatitis B core antigen. Eur J Intern Med. 2007; 18(8): 571-5[DOI][PubMed]
  • 17. Yotsuyanagi H, Yasuda K, Moriya K, Shintani Y, Fujie H, Tsutsumi T, et al. Frequent presence of HBV in the sera of HBsAg-negative, anti-HBc-positive blood donors. Transfusion. 2001; 41(9): 1093-9[PubMed]
  • 18. Said ZN, Sayed MH, Aboel-Magd EK, Mahmoud MH, Setouhy ME, Mouftah F, et al. Occult hepatitis B virus infection among Egyptian blood donors. World J Hepatol. 2013; 5(2): 64-73[DOI][PubMed]
  • 19. Cui Y, Jia J. Update on epidemiology of hepatitis B and C in China. J Gastroenterol Hepatol. 2013; 28 Suppl 1: 7-10[DOI][PubMed]
  • 20. Yong-Lin Y, Qiang F, Ming-Shun Z, Jie C, Gui-Ming M, Zu-Hu H, et al. Hepatitis B surface antigen variants in voluntary blood donors in Nanjing, China. Virol J. 2012; 9: 82[DOI][PubMed]
  • 21. Yuan Q, Ou SH, Chen CR, Ge SX, Pei B, Chen QR, et al. Molecular characteristics of occult hepatitis B virus from blood donors in southeast China. J Clin Microbiol. 2010; 48(2): 357-62[DOI][PubMed]
  • 22. Sanchez-Tapias JM, Costa J, Mas A, Bruguera M, Rodes J. Influence of hepatitis B virus genotype on the long-term outcome of chronic hepatitis B in western patients. Gastroenterology. 2002; 123(6): 1848-56[DOI][PubMed]
  • 23. Mu SC, Lin YM, Jow GM, Chen BF. Occult hepatitis B virus infection in hepatitis B vaccinated children in Taiwan. J Hepatol. 2009; 50(2): 264-72[DOI][PubMed]
  • 24. Singh H, Pradhan M, Singh RL, Phadke S, Naik SR, Aggarwal R, et al. High frequency of hepatitis B virus infection in patients with beta-thalassemia receiving multiple transfusions. Vox Sang. 2003; 84(4): 292-9[PubMed]
  • 25. Xu L, Wei Y, Chen T, Lu J, Zhu CL, Ni Z, et al. Occult HBV infection in anti-HBs-positive young adults after neonatal HB vaccination. Vaccine. 2010; 28(37): 5986-92[DOI][PubMed]
  • 26. Zheng X, Ye X, Du P, Zeng J, Zhu W, Yang B, et al. High prevalence of anti-hepatitis B core antigen in hepatitis B virus-vaccinated Chinese blood donors suggests insufficient protection but little threat to the blood supply. Transfusion. 2015; 55(4): 890-7[DOI][PubMed]
  • 27. Levicnik-Stezinar S, Rahne-Potokar U, Candotti D, Lelie N, Allain JP. Anti-HBs positive occult hepatitis B virus carrier blood infectious in two transfusion recipients. J Hepatol. 2008; 48(6): 1022-5[DOI][PubMed]
  • 28. Poovorawan Y, Chongsrisawat V, Theamboonlers A, Leroux-Roels G, Kuriyakose S, Leyssen M, et al. Evidence of protection against clinical and chronic hepatitis B infection 20 years after infant vaccination in a high endemicity region. J Viral Hepat. 2011; 18(5): 369-75[DOI][PubMed]
  • 29. Ren FR, Wang JX, Huang Y, Yao FZ, Lv YL, Li JL, et al. Hepatitis B virus nucleic acid testing in Chinese blood donors with normal and elevated alanine aminotransferase. Transfusion. 2011; 51(12): 2588-95[DOI][PubMed]
  • 30. Spreafico M, Berzuini A, Foglieni B, Candotti D, Raffaele L, Guarnori I, et al. Poor efficacy of nucleic acid testing in identifying occult HBV infection and consequences for safety of blood supply in Italy. J Hepatol. 2015; 63(5): 1068-76[DOI][PubMed]
  • 31. Wang L, Chang L, Xie Y, Huang C, Xu L, Qian R, et al. What is the meaning of a nonresolved viral nucleic acid test-reactive minipool? Transfusion. 2015; 55(2): 395-404[DOI][PubMed]
  • 32. Gou H, Pan Y, Ge H, Zheng Y, Wu Y, Zeng J, et al. Evaluation of an individual-donation nucleic acid amplification testing algorithm for detecting hepatitis B virus infection in Chinese blood donors. Transfusion. 2015; 55(9): 2272-81[DOI][PubMed]
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