HCV dsRNA-Activated Macrophages Inhibit HCV Replication in Hepatocytes

Authors Information
Article Notes and Dates
To Cite : Wang Y, Li J, Wang X, Zhou Y, Zhang T, et al. HCV dsRNA-Activated Macrophages Inhibit HCV Replication in Hepatocytes, Hepat Mon. 2015 ;15(8):e29282. doi: 10.5812/hepatmon.29282.
Copyright: Copyright © 2015, Hepatitis Monthly. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited..
Abstract
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
Acknowledgements
Footnotes
References
  • 1. Alter MJ. Prevention of spread of hepatitis C. Hepatology. 2002; 36(5 Suppl 1)-8[DOI][PubMed]
  • 2. Kawai T, Akira S. Toll-like receptor and RIG-I-like receptor signaling. Ann N Y Acad Sci. 2008; 1143: 1-20[DOI][PubMed]
  • 3. Kawai T, Akira S. Innate immune recognition of viral infection. Nat Immunol. 2006; 7(2): 131-7[DOI][PubMed]
  • 4. Kumar A, Zhang J, Yu FS. Toll-like receptor 3 agonist poly(I:C)-induced antiviral response in human corneal epithelial cells. Immunology. 2006; 117(1): 11-21[DOI][PubMed]
  • 5. West J, Damania B. Upregulation of the TLR3 pathway by Kaposi's sarcoma-associated herpesvirus during primary infection. J Virol. 2008; 82(11): 5440-9[DOI][PubMed]
  • 6. Alexopoulou L, Holt AC, Medzhitov R, Flavell RA. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature. 2001; 413(6857): 732-8[DOI][PubMed]
  • 7. Wang N, Liang Y, Devaraj S, Wang J, Lemon SM, Li K. Toll-like receptor 3 mediates establishment of an antiviral state against hepatitis C virus in hepatoma cells. J Virol. 2009; 83(19): 9824-34[DOI][PubMed]
  • 8. Janeway CAJ, Medzhitov R. Innate immune recognition. Annu Rev Immunol. 2002; 20: 197-216[DOI][PubMed]
  • 9. Li J, Ye L, Wang X, Hu S, Ho W. Induction of interferon-gamma contributes to Toll-like receptor 3-mediated herpes simplex virus type 1 inhibition in astrocytes. J Neurosci Res. 2012; 90(2): 399-406[DOI][PubMed]
  • 10. Zhou Y, Wang X, Liu M, Hu Q, Song L, Ye L, et al. A critical function of toll-like receptor-3 in the induction of anti-human immunodeficiency virus activities in macrophages. Immunology. 2010; 131(1): 40-9[DOI][PubMed]
  • 11. Battaglia AM, Hagmeyer KO. Combination therapy with interferon and ribavirin in the treatment of chronic hepatitis C infection. Ann Pharmacother. 2000; 34(4): 487-94[PubMed]
  • 12. Gale MJ, Foy EM. Evasion of intracellular host defence by hepatitis C virus. Nature. 2005; 436(7053): 939-45[DOI][PubMed]
  • 13. Li K, Foy E, Ferreon JC, Nakamura M, Ferreon AC, Ikeda M, et al. Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF. Proc Natl Acad Sci U S A. 2005; 102(8): 2992-7[DOI][PubMed]
  • 14. Foy E, Li K, Sumpter RJ, Loo YM, Johnson CL, Wang C, et al. Control of antiviral defenses through hepatitis C virus disruption of retinoic acid-inducible gene-I signaling. Proc Natl Acad Sci U S A. 2005; 102(8): 2986-91[DOI][PubMed]
  • 15. Li XD, Sun L, Seth RB, Pineda G, Chen ZJ. Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity. Proc Natl Acad Sci U S A. 2005; 102(49): 17717-22[DOI][PubMed]
  • 16. Racanelli V, Rehermann B. The liver as an immunological organ. Hepatology. 2006; 43(2 Suppl 1)-62[DOI][PubMed]
  • 17. Khakoo SI, Soni PN, Savage K, Brown D, Dhillon AP, Poulter LW, et al. Lymphocyte and macrophage phenotypes in chronic hepatitis C infection. Correlation with disease activity. Am J Pathol. 1997; 150(3): 963-70[PubMed]
  • 18. Heydtmann M. Macrophages in hepatitis B and hepatitis C virus infections. J Virol. 2009; 83(7): 2796-802[DOI][PubMed]
  • 19. Hassan NF, Campbell DE, Douglas SD. Purification of human monocytes on gelatin-coated surfaces. J Immunol Methods. 1986; 95(2): 273-6[PubMed]
  • 20. Li K, Li NL, Wei D, Pfeffer SR, Fan M, Pfeffer LM. Activation of chemokine and inflammatory cytokine response in hepatitis C virus-infected hepatocytes depends on Toll-like receptor 3 sensing of hepatitis C virus double-stranded RNA intermediates. Hepatology. 2012; 55(3): 666-75[DOI][PubMed]
  • 21. Zhong J, Gastaminza P, Cheng G, Kapadia S, Kato T, Burton DR, et al. Robust hepatitis C virus infection in vitro. Proc Natl Acad Sci U S A. 2005; 102(26): 9294-9[DOI][PubMed]
  • 22. Yang JH, Lai JP, Douglas SD, Metzger D, Zhu XH, Ho WZ. Real-time RT-PCR for quantitation of hepatitis C virus RNA. J Virol Methods. 2002; 102(1-2): 119-28[PubMed]
  • 23. Katze MG, He Y, Gale MJ. Viruses and interferon: a fight for supremacy. Nat Rev Immunol. 2002; 2(9): 675-87[DOI][PubMed]
  • 24. Tuplin A, Wood J, Evans DJ, Patel AH, Simmonds P. Thermodynamic and phylogenetic prediction of RNA secondary structures in the coding region of hepatitis C virus. RNA. 2002; 8(6): 824-41[PubMed]
  • 25. Liu X, He N, Fu Z, Duan S, Gao M, Zhang ZF. Plasma Hepatitis C Virus Viral Load Among Hepatitis C Virus Mono-Infected and HCV/HIV Co-Infected Individuals in Yunnan Province,China. Hepat Mon. 2012; 12(7): 453-9[DOI][PubMed]
  • 26. Zhang S, Kodys K, Li K, Szabo G. Human type 2 myeloid dendritic cells produce interferon-lambda and amplify interferon-alpha in response to hepatitis C virus infection. Gastroenterology. 2013; 144(2): 414-425 e7[DOI][PubMed]
  • 27. Takeda K, Akira S. Toll-like receptors in innate immunity. Int Immunol. 2005; 17(1): 1-14[DOI][PubMed]
  • 28. Argentini C, Genovese D, Dettori S, Rapicetta M. HCV genetic variability: from quasispecies evolution to genotype classification. Future Microbiol. 2009; 4(3): 359-73[DOI][PubMed]
  • 29. Radkowski M, Bednarska A, Horban A, Stanczak J, Wilkinson J, Adair DM, et al. Infection of primary human macrophages with hepatitis C virus in vitro: induction of tumour necrosis factor-alpha and interleukin 8. J Gen Virol. 2004; 85: 47-59[PubMed]
  • 30. Revie D, Salahuddin SZ. Role of macrophages and monocytes in hepatitis C virus infections. World J Gastroenterol. 2014; 20(11): 2777-84[DOI][PubMed]
  • 31. Fletcher NF, Sutaria R, Jo J, Barnes A, Blahova M, Meredith LW, et al. Activated macrophages promote hepatitis C virus entry in a tumor necrosis factor-dependent manner. Hepatology. 2014; 59(4): 1320-30[DOI][PubMed]
  • 32. Negash AA, Ramos HJ, Crochet N, Lau DT, Doehle B, Papic N, et al. IL-1beta production through the NLRP3 inflammasome by hepatic macrophages links hepatitis C virus infection with liver inflammation and disease. PLoS Pathog. 2013; 9(4)[DOI][PubMed]
  • 33. Canbay A, Feldstein AE, Higuchi H, Werneburg N, Grambihler A, Bronk SF, et al. Kupffer cell engulfment of apoptotic bodies stimulates death ligand and cytokine expression. Hepatology. 2003; 38(5): 1188-98[DOI][PubMed]
  • 34. Dolganiuc A, Oak S, Kodys K, Golenbock DT, Finberg RW, Kurt-Jones E, et al. Hepatitis C core and nonstructural 3 proteins trigger toll-like receptor 2-mediated pathways and inflammatory activation. Gastroenterology. 2004; 127(5): 1513-24[PubMed]
  • 35. Chang S, Dolganiuc A, Szabo G. Toll-like receptors 1 and 6 are involved in TLR2-mediated macrophage activation by hepatitis C virus core and NS3 proteins. J Leukoc Biol. 2007; 82(3): 479-87[DOI][PubMed]
  • 36. Chattergoon MA, Latanich R, Quinn J, Winter ME, Buckheit R3, Blankson JN, et al. HIV and HCV activate the inflammasome in monocytes and macrophages via endosomal Toll-like receptors without induction of type 1 interferon. PLoS Pathog. 2014; 10(5)[DOI][PubMed]
  • 37. Alavian SM, Ande SR, Coombs KM, Yeganeh B, Davoodpour P, Hashemi M, et al. Virus-triggered autophagy in viral hepatitis - possible novel strategies for drug development. J Viral Hepat. 2011; 18(12): 821-30[DOI][PubMed]
  • 38. Khattab MA, Eslam M, Alavian SM. Hepatitis C virus as a multifaceted disease: a simple and updated approach for extrahepatic manifestations of hepatitis C virus infection. Hepat Mon. 2010; 10(4): 258-69[PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:

Author(s):

Article(s):

Create Citiaion Alert via Google Reader

Cited By:

Hepatitis Monthly accepts terms & conditions of:

International Committee of Medical Journal Editors (ICMJE) Citedby Linking DOI enabled Crossref iThenticate COPE Cross Check