Hepatitis Monthly

Published by: Kowsar

Comparing HBV Viral Load in Serum, Cerumen, and Saliva and Correlation With HBeAg Serum Status in Patients With Chronic Hepatitis B Infection

Elaheh Gholami Parizad 1 , Eskandar Gholami Parizad 2 , * , Afra Khosravi 1 , Mansour Amraei 3 , Azar Valizadeh 1 and Abdoullah Davoudian 4
Authors Information
1 Clinical Microbiology Research Centre, Ilam University of Medical Sciences, Ilam, IR Iran
2 Public Health Department, Psychosocial Injuries Prevention Research Centre, Ilam University of Medical Sciences, Ilam, IR Iran
3 Department of Clinical Physiology, Research Centre, Ilam University of Medical Sciences, Ilam, IR Iran
4 Department of Clinical Immunology, Ilam University of Medical Sciences, Ilam, IR Iran
Article information
  • Hepatitis Monthly: May 01, 2016, 16 (5); e30385
  • Published Online: April 27, 2016
  • Article Type: Research Article
  • Received: May 30, 2015
  • Revised: February 17, 2016
  • Accepted: April 6, 2016
  • DOI: 10.5812/hepatmon.30385

To Cite: Gholami Parizad E, Gholami Parizad E, Khosravi A, Amraei M, Valizadeh A, et al. Comparing HBV Viral Load in Serum, Cerumen, and Saliva and Correlation With HBeAg Serum Status in Patients With Chronic Hepatitis B Infection, Hepat Mon. 2016 ; 16(5):e30385. doi: 10.5812/hepatmon.30385.

Copyright © 2016, Kowsar Corp. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Merican I, Guan R, Amarapuka D, Alexander MJ, Chutaputti A, Chien RN, et al. Chronic hepatitis B virus infection in Asian countries. J Gastroenterol Hepatol. 2000; 15(12): 1356-61
  • 2. Trepo C, Chan HLY, Lok A. Hepatitis B virus infection. Lancet. 2014; 384(9959): 2053-63[DOI]
  • 3. Brechot C. Pathogenesis of hepatitis B virus-related hepatocellular carcinoma: old and new paradigms. Gastroenterology. 2004; 127(5 Suppl 1)-61[PubMed]
  • 4. Tang B, Kruger WD, Chen G, Shen F, Lin WY, Mboup S, et al. Hepatitis B viremia is associated with increased risk of hepatocellular carcinoma in chronic carriers. J Med Virol. 2004; 72(1): 35-40[DOI][PubMed]
  • 5. Lavanchy D. Worldwide epidemiology of HBV infection, disease burden, and vaccine prevention. J Clin Virol. 2005; 34-3
  • 6. Azizi F, Hatami H, Janghorbani M. Epidemiology and control of common diseases in Iran. 2000;
  • 7. Ni YH, Chang MH, Wu JF, Hsu HY, Chen HL, Chen DS. Minimization of hepatitis B infection by a 25-year universal vaccination program. J Hepatol. 2012; 57(4): 730-5[DOI][PubMed]
  • 8. Tang CM, Yau TO, Yu J. Management of chronic hepatitis B infection: current treatment guidelines, challenges, and new developments. World J Gastroenterol. 2014; 20(20): 6262-78[DOI][PubMed]
  • 9. Liaw YF, Kao JH, Piratvisuth T, Chan HL, Chien RN, Liu CJ, et al. Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2012 update. Hepatol Int. 2012; 6(3): 531-61[DOI][PubMed]
  • 10. Gholami-Parizad E, Taherikalani M, Mozaffar-Sabet NA, Asmar M, Gholami-Parizad S, Khosravi A, et al. Cerumen as a potential risk for transmission of Hepatitis B virus. Acta Microbiol Immunol Hung. 2011; 58(2): 105-12[DOI][PubMed]
  • 11. Mahboobi N, Agha-Hosseini F, Mahboobi N, Safari S, Lavanchy D, Alavian SM. Hepatitis B virus infection in dentistry: a forgotten topic. J Viral Hepat. 2010; 17(5): 307-16[DOI][PubMed]
  • 12. Noppornpanth S, Sathirapongsasuti N, Chongsrisawat V, Poovorawan Y. Detection of HbsAg and HBV DNA in serum and saliva of HBV carriers. Southeast Asian J Trop Med Public Health. 2000; 31(2): 419-21[PubMed]
  • 13. FitzSimons D, Hendrickx G, Vorsters A, Van Damme P. Hepatitis B vaccination: a completed schedule enough to control HBV lifelong? Milan, Italy, 17-18 November 2011. Vaccine. 2013; 31(4): 584-90[DOI][PubMed]
  • 14. Tong CY, Robson C, Wu Y, Issa R, Watts T, Wilkinson M, et al. Post-vaccination serological test results of infants at risk of perinatal transmission of hepatitis B using an intensified follow-up programme in a London centre. Vaccine. 2013; 31(31): 3174-8
  • 15. Zhang Q, Cao G. Genotypes, mutations, and viral load of hepatitis B virus and the risk of hepatocellular carcinoma: HBV properties and hepatocarcinogenesis. Hepat Mon. 2011; 11(2): 86-91[PubMed]
  • 16. Caccamo G, Saffioti F, Raimondo G. Hepatitis B virus and hepatitis C virus dual infection. World J Gastroenterol. 2014; 20(40): 14559-67[DOI][PubMed]
  • 17. Inoue J, Ueno Y, Shimosegawa T. Management of chronic hepatitis B patients: efficacy & limitation of nucleos(t)ide analogues. Indian J Med Res. 2011; 133: 11-3[PubMed]
  • 18. Martinot-Peignoux M, Lapalus M, Laouenan C, Lada O, Netto-Cardoso AC, Boyer N, et al. Prediction of disease reactivation in asymptomatic hepatitis B e antigen-negative chronic hepatitis B patients using baseline serum measurements of HBsAg and HBV-DNA. J Clin Virol. 2013; 58(2): 401-7[DOI][PubMed]
  • 19. Wood AJJ, Gerberding JL. Management of occupational exposures to blood-borne viruses. N England J Med. 1995; 332(7): 444-51
  • 20. Levy P, Marcellin P, Martinot-Peignoux M, Degott C, Nataf J, Benhamou JP. Clinical course of spontaneous reactivation of hepatitis B virus infection in patients with chronic hepatitis B. Hepatology. 1990; 12(3): 570-4[DOI]
  • 21. Chan HL, Thompson A, Martinot-Peignoux M, Piratvisuth T, Cornberg M, Brunetto MR, et al. Hepatitis B surface antigen quantification: why and how to use it in 2011 - a core group report. J Hepatol. 2011; 55(5): 1121-31[DOI][PubMed]
  • 22. Keshvari M, Alavian SM, Sharafi H. Comparison of Serum Hepatitis B Virus DNA and HBsAg Levels Between HBeAg-Negative and HBeAg-Positive Chronic Hepatitis B Patients. Jundishapur J Microbiol. 2015; 8(3)[DOI][PubMed]
  • 23. Jia W, Qi X, Ji YY, Xun YH, Wang H, Zhang WH, et al. Low Serum Hepatitis B Surface Antigen Level Predicts Compensated Cirrhosis Caused by Chronic Hepatitis B in HBeAg Positive Patients in East China. Hepat Mon. 2015; 15(8)[DOI][PubMed]
  • 24. Zhevachevsky NG, Nomokonova NY, Beklemishev AB, Belov GF. Dynamic study of HBsAg and HBeAg in saliva samples from patients with hepatitis B infection: diagnostic and epidemiological significance. J Med Virol. 2000; 61(4): 433-8[PubMed]
  • 25. Kalcioglu MT, Durmaz R, Ozturan O, Bayindir Y, Direkel S. Does cerumen have a risk for transmission of hepatitis B? Laryngoscope. 2004; 114(3): 577-80[DOI][PubMed]
  • 26. Zhang YL, Pan HY, Chen CR, Lou GQ, Ye RX, Lu DR. [The roles of saliva testing for preventing hepatitis B virus spreading]. Zhonghua Yu Fang Yi Xue Za Zhi. 2008; 42(8): 596-8[PubMed]
  • 27. Krasteva A, Panov VE, Jelev D, Antonov K, Ivanova A, Krastev Z. Evaluation of HBV DNA levels in saliva in subjects with different viremia as well as during peginterferon α-2a therapy. JIMAB. 2013; 19(4): 355-8
  • 28. Goh EK, Son BH, Kong SK, Chon KM, Cho KS. Analysis of hepatitis B virus in the cerumen and otorrhea of chronic HBV-infected patients: is there a hepatitis B virus infectivity? Otol Neurotol. 2008; 29(7): 929-32[DOI][PubMed]
  • 29. Krasteval A, Panov V, Jelev D, Antonov K, Ivanova A, Krastev Z. Evaluation Of HBV DNA Levels In Saliva In subjects With Different Viremia As Well as During Peg interferon -2a Therapy. J of IMAB. 2013; 19(4): 355-58
  • 30. Estakhri R, Dolatkhah H, Ghazanchaei A, Pourasgari B, Nourazarian M. Saliva or serum, which is better for the diagnosis of gastric Helicobacter pylori infection? Arch Clin Infect Dis. 2008; 3(3)
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments