Hepatitis Monthly

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Study of miR-29a-5p Expression in HIV Positive and HIV/HCV Co-Infected Patients in Sanandaj-Iran

Shoaib Advay 1 , Abbas Ahmadi 2 , Mohammad Abdi 2 , 3 , * and Ali Mohammad Arabzadeh 1
Authors Information
1 Department of Virology, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran
2 Cellular and Molecular Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran
3 Department of Clinical Biochemistry, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran
Article information
  • Hepatitis Monthly: January 01, 2017, 17 (1); e41594
  • Published Online: December 21, 2016
  • Article Type: Research Article
  • Received: August 18, 2016
  • Revised: October 1, 2016
  • Accepted: December 14, 2016
  • DOI: 10.5812/hepatmon.41594

To Cite: Advay S, Ahmadi A, Abdi M, Arabzadeh A M. Study of miR-29a-5p Expression in HIV Positive and HIV/HCV Co-Infected Patients in Sanandaj-Iran, Hepat Mon. 2017 ; 17(1):e41594. doi: 10.5812/hepatmon.41594.

Copyright © 2016, Kowsar Corp. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
  • 1. Shetty AK. Epidemiology of HIV infection in women and children: a global perspective. Curr HIV Res. 2013; 11(2): 81-92[DOI][PubMed]
  • 2. Jangra RK, Yi M, Lemon SM. Regulation of hepatitis C virus translation and infectious virus production by the microRNA miR-122. J Virol. 2010; 84(13): 6615-25[DOI][PubMed]
  • 3. Flores A, Quesada E. Entry inhibitors directed towards glycoprotein gp120: an overview on a promising target for HIV-1 therapy. Curr Med Chem. 2013; 20(6): 751-71[DOI][PubMed]
  • 4. Masgala A, Bonovas S, Nikolopoulos GK. Recent advances in the treatment of HIV/HBV and HIV/HCV co-infection. Mini Rev Med Chem. 2012; 12(9): 890-904[DOI][PubMed]
  • 5. Zhou YH, Liu FL, Yao ZH, Duo L, Li H, Sun Y, et al. Comparison of HIV-, HBV-, HCV- and co-infection prevalence between Chinese and Burmese intravenous drug users of the China-Myanmar border region. PLoS One. 2011; 6(1): 16349[DOI][PubMed]
  • 6. Zidan A, Scheuerlein H, Schule S, Settmacher U, Rauchfuss F. Epidemiological pattern of hepatitis B and hepatitis C as etiological agents for hepatocellular carcinoma in iran and worldwide. Hepat Mon. 2012; 12(10): 6894
  • 7. Gadalla SM, Preiss LR, Eyster ME, Goedert JJ. Correlates of high hepatitis C virus RNA load in a cohort of HIV-negative and HIV-positive individuals with haemophilia. J Viral Hepat. 2011; 18(3): 161-9[DOI][PubMed]
  • 8. Grzeszczuk A, Wandalowicz AD, Jaroszewicz J, Flisiak R. Prevalence and Risk Factors of HCV/HIV Co-Infection and HCV Genotype Distribution in North-Eastern Poland. Hepat Mon. 2015; 15(7): 27740[DOI][PubMed]
  • 9. Gupta A, Swaminathan G, Martin-Garcia J, Navas-Martin S. MicroRNAs, hepatitis C virus, and HCV/HIV-1 co-infection: new insights in pathogenesis and therapy. Viruses. 2012; 4(11): 2485-513[DOI][PubMed]
  • 10. Houzet L, Jeang KT. MicroRNAs and human retroviruses. Biochim Biophys Acta. 2011; 1809(11-12): 686-93[DOI][PubMed]
  • 11. Skalsky RL, Cullen BR. Viruses, microRNAs, and host interactions. Annu Rev Microbiol. 2010; 64: 123-41[DOI][PubMed]
  • 12. El-Guendy NM, Helwa R, El-Halawany MS, Abdel Rahman Ali S, Tantawy Aly M, Hasan Alieldin N. The Liver MicroRNA Expression Profiles Associated With Chronic Hepatitis C Virus (HCV) Genotype-4 Infection: A Preliminary Study. Hepat Mon. 2016; 16(4): 33881[DOI]
  • 13. Nathans R, Chu CY, Serquina AK, Lu CC, Cao H, Rana TM. Cellular microRNA and P bodies modulate host-HIV-1 interactions. Mol Cell. 2009; 34(6): 696-709[DOI][PubMed]
  • 14. Bandyopadhyay S, Friedman RC, Marquez RT, Keck K, Kong B, Icardi MS, et al. Hepatitis C virus infection and hepatic stellate cell activation downregulate miR-29: miR-29 overexpression reduces hepatitis C viral abundance in culture. J Infect Dis. 2011; 203(12): 1753-62[DOI][PubMed]
  • 15. Kaleji H, Tabaraei A, Abbasi A, Javeed N, Bazoori M, Golmohamadi R, et al. Expression Analysis of Cellular Mir-29a and mir-29b in HIV Positive Patients. Med Lab J. 2015; 9(5): 23-7
  • 16. Mott JL, Kobayashi S, Bronk SF, Gores GJ. mir-29 regulates Mcl-1 protein expression and apoptosis. Oncogene. 2007; 26(42): 6133-40[DOI][PubMed]
  • 17. Pekarsky Y, Santanam U, Cimmino A, Palamarchuk A, Efanov A, Maximov V, et al. Tcl1 expression in chronic lymphocytic leukemia is regulated by miR-29 and miR-181. Cancer Res. 2006; 66(24): 11590-3[DOI][PubMed]
  • 18. Fabbri M, Garzon R, Cimmino A, Liu Z, Zanesi N, Callegari E, et al. MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B. Proc Natl Acad Sci U S A. 2007; 104(40): 15805-10[DOI][PubMed]
  • 19. Gebeshuber CA, Zatloukal K, Martinez J. miR-29a suppresses tristetraprolin, which is a regulator of epithelial polarity and metastasis. EMBO Rep. 2009; 10(4): 400-5[DOI][PubMed]
  • 20. Abdi M, Ahmadi A, Roshany D, Khodadadi I, Javid S, Shahmohammad-Nezhad S, et al. Diagnostic value of serum adenosine deaminase activity in HIV infected patients of Kurdish population. Clin Lab. 2013; 59(7-8): 757-62[PubMed]
  • 21. Sterling RK, Lissen E, Clumeck N, Sola R, Correa MC, Montaner J, et al. Development of a simple noninvasive index to predict significant fibrosis in patients with HIV/HCV coinfection. Hepatology. 2006; 43(6): 1317-25[DOI][PubMed]
  • 22. Wai CT, Greenson JK, Fontana RJ, Kalbfleisch JD, Marrero JA, Conjeevaram HS, et al. A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C. Hepatology. 2003; 38(2): 518-26[DOI][PubMed]
  • 23. Abdi M, Rahbari R, Khatooni Z, Naseri N, Najafi A, Khodadadi I. Serum Adenosine Deaminase (ADA) Activity: A Novel Screening Test to Differentiate HIV Monoinfection From HIV-HBV and HIV-HCV Coinfections. J Clin Lab Anal. 2016; 30(3): 200-3[DOI][PubMed]
  • 24. Khodadadi I, Abdi M, Ahmadi A, Wahedi MS, Menbari S, Lahoorpour F, et al. Analysis of serum adenosine deaminase (ADA) and ADA1 and ADA2 isoenzyme activities in HIV positive and HIV-HBV co-infected patients. Clin Biochem. 2011; 44(12): 980-3[DOI][PubMed]
  • 25. Khodadadi I, Abdi M, Javid S, Ahmadi A, Roshani D, Rahbari R. Comparison of adenosine deaminase level in HIV positive patients co-infected with hepatitis B and C and healthy subjects. Sci J Kurdistan Uni Med Sci. 2013; 18(3): 93-103
  • 26. Shirzad H, Bagheri N, Azadegan-Dehkordi F, Zamanzad B, Izadpanah E, Abdi M, et al. New insight to IL-23/IL-17 axis in Iranian infected adult patients with gastritis: effects of genes polymorphisms on expression of cytokines. Acta Gastroenterol Belg. 2015; 78(2): 212-8[PubMed]
  • 27. Consolidated Guidelines on HIV Testing Services: 5Cs: Consent, Confidentiality, Counselling, Correct Results and Connection 2015. 2015; [PubMed]
  • 28. Benhamou Y, Bochet M, Di Martino V, Charlotte F, Azria F, Coutellier A, et al. Liver fibrosis progression in human immunodeficiency virus and hepatitis C virus coinfected patients. The Multivirc Group. Hepatology. 1999; 30(4): 1054-8[DOI][PubMed]
  • 29. Tovo CV, Becker SC, Almeida PR, Galperim B, Chaves S. Progression of liver fibrosis in monoinfected patients by hepatitis C virus and coinfected by HCV and human immunodeficiency virus. Arq Gastroenterol. 2013; 50(1): 19-22[DOI][PubMed]
  • 30. Lo Re V3, Kallan MJ, Tate JP, Localio AR, Lim JK, Goetz MB, et al. Hepatic decompensation in antiretroviral-treated patients co-infected with HIV and hepatitis C virus compared with hepatitis C virus-monoinfected patients: a cohort study. Ann Intern Med. 2014; 160(6): 369-79[DOI][PubMed]
  • 31. Anadol E, Schierwagen R, Elfimova N, Tack K, Schwarze-Zander C, Eischeid H, et al. Circulating microRNAs as a marker for liver injury in human immunodeficiency virus patients. Hepatology. 2015; 61(1): 46-55[DOI][PubMed]
  • 32. Ahluwalia JK, Khan SZ, Soni K, Rawat P, Gupta A, Hariharan M, et al. Human cellular microRNA hsa-miR-29a interferes with viral nef protein expression and HIV-1 replication. Retrovirology. 2008; 5: 117[DOI][PubMed]
  • 33. Patel P, Ansari MY, Bapat S, Thakar M, Gangakhedkar R, Jameel S. The microRNA miR-29a is associated with human immunodeficiency virus latency. Retrovirology. 2014; 11: 108[DOI][PubMed]
  • 34. Adoro S, Cubillos-Ruiz JR, Chen X, Deruaz M, Vrbanac VD, Song M, et al. IL-21 induces antiviral microRNA-29 in CD4 T cells to limit HIV-1 infection. Nat Commun. 2015; 6: 7562[DOI][PubMed]
  • 35. Rosca A, Anton G, Botezatu A, Temereanca A, Ene L, Achim C, et al. miR-29a associates with viro-immunological markers of HIV infection in treatment experienced patients. J Med Virol. 2016; 88(12): 2132-7[DOI][PubMed]
  • 36. Gupta P, Liu B, Wu JQ, Soriano V, Vispo E, Carroll AP, et al. Genome-wide mRNA and miRNA analysis of peripheral blood mononuclear cells (PBMC) reveals different miRNAs regulating HIV/HCV co-infection. Virology. 2014; 450-451: 336-49[DOI][PubMed]
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