Hepatitis Monthly

Published by: Kowsar

Leptin Receptor Gene Polymorphisms and the Risk of Non-Alcoholic Fatty Liver Disease and Coronary Atherosclerosis in the Chinese Han Population

Bai-Quan An 1 , Lin-Lin Lu 2 , 3 , Chen Yuan 1 , Yong-Ning Xin 1 , 2 , 4 , * and Shi-Ying Xuan 1 , 2 , 4 , *
Authors Information
1 Department of Gastroenterology, Qingdao Municipal College, Nanjing Medical University, Qingdao, Shandong Province, China
2 Digestive Disease Key Laboratory of Qingdao, Qingdao, China
3 Central Laboratories, Qingdao Municipal Hospital, Qingdao, China
4 Department of Gastroenterology, Qingdao Municipal Hospital, Qingdao, China
Corresponding Authors:
Article information
  • Hepatitis Monthly: 16 (4); e58758
  • Published Online: April 27, 2016
  • Article Type: Research Article
  • Received: November 27, 2015
  • Revised: January 26, 2016
  • Accepted: February 5, 2016
  • DOI: 10.5812/hepatmon.35055

To Cite: An B, Lu L, Yuan C, Xin Y, Xuan S. Leptin Receptor Gene Polymorphisms and the Risk of Non-Alcoholic Fatty Liver Disease and Coronary Atherosclerosis in the Chinese Han Population, Hepat Mon. Online ahead of Print ; 16(4):e58758. doi: 10.5812/hepatmon.35055.

Copyright © 2016, Kowsar Corp. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Targher G, Day CP, Bonora E. Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease. N Engl J Med. 2010; 363(14): 1341-50[DOI][PubMed]
  • 2. Cheng Y, An B, Jiang M, Xin Y, Xuan S. Association of Tumor Necrosis Factor-alpha Polymorphisms and Risk of Coronary Artery Disease in Patients With Non-alcoholic Fatty Liver Disease. Hepat Mon. 2015; 15(3)[DOI][PubMed]
  • 3. Petta S, Valenti L, Marchesini G, Di Marco V, Licata A, Camma C, et al. PNPLA3 GG genotype and carotid atherosclerosis in patients with non-alcoholic fatty liver disease. PLoS One. 2013; 8(9)[DOI][PubMed]
  • 4. Aller R, De Luis DA, Izaola O, Gonzalez Sagrado M, Conde R, Pacheco D, et al. Lys656Asn polymorphism of leptin receptor, leptin levels and insulin resistance in patients with non alcoholic fatty liver disease. Eur Rev Med Pharmacol Sci. 2012; 16(3): 335-41[PubMed]
  • 5. Niu TH, Jiang M, Xin YN, Jiang XJ, Lin ZH, Xuan SY. Lack of association between apolipoprotein C3 gene polymorphisms and risk of nonalcoholic fatty liver disease in a Chinese Han population. World J Gastroenterol. 2014; 20(13): 3655-62[DOI][PubMed]
  • 6. Jian-gao F, Chinese Liver Disease A. Guidelines for management of nonalcoholic fatty liver disease: an updated and revised edition. Zhonghua Gan Zang Bing Za Zhi. 2010; 18(3): 163-6[PubMed]
  • 7. Kotronen A, Westerbacka J, Bergholm R, Pietilainen KH, Yki-Jarvinen H. Liver fat in the metabolic syndrome. J Clin Endocrinol Metab. 2007; 92(9): 3490-7[DOI][PubMed]
  • 8. Dias NF, Fernandes AE, Melo ME, Reinhardt HL, Cercato C, Villares SM, et al. Lack of mutations in the leptin receptor gene in severely obese children. Arq Bras Endocrinol Metabol. 2012; 56(3): 178-83[PubMed]
  • 9. Salopuro T, Pulkkinen L, Lindstrom J, Eriksson JG, Valle TT, Hamalainen H, et al. Genetic variation in leptin receptor gene is associated with type 2 diabetes and body weight: The Finnish Diabetes Prevention Study. Int J Obes (Lond). 2005; 29(10): 1245-51[DOI][PubMed]
  • 10. Mizuta E, Kokubo Y, Yamanaka I, Miyamoto Y, Okayama A, Yoshimasa Y, et al. Leptin gene and leptin receptor gene polymorphisms are associated with sweet preference and obesity. Hypertens Res. 2008; 31(6): 1069-77[DOI][PubMed]
  • 11. Ukkola O, Bouchard C. Role of candidate genes in the responses to long-term overfeeding: review of findings. Obes Rev. 2004; 5(1): 3-12[PubMed]
  • 12. Tabassum R, Mahendran Y, Dwivedi OP, Chauhan G, Ghosh S, Marwaha RK, et al. Common variants of IL6, LEPR, and PBEF1 are associated with obesity in Indian children. Diabetes. 2012; 61(3): 626-31[DOI][PubMed]
  • 13. Furusawa T, Naka I, Yamauchi T, Natsuhara K, Kimura R, Nakazawa M, et al. The Q223R polymorphism in LEPR is associated with obesity in Pacific Islanders. Hum Genet. 2010; 127(3): 287-94[DOI][PubMed]
  • 14. Okada T, Ohzeki T, Nakagawa Y, Sugihara S, Arisaka O, Study Group of Pediatric O, et al. Impact of leptin and leptin-receptor gene polymorphisms on serum lipids in Japanese obese children. Acta Paediatr. 2010; 99(8): 1213-7[DOI][PubMed]
  • 15. Zain SM, Mohamed Z, Mahadeva S, Cheah PL, Rampal S, Chin KF, et al. Impact of leptin receptor gene variants on risk of non-alcoholic fatty liver disease and its interaction with adiponutrin gene. J Gastroenterol Hepatol. 2013; 28(5): 873-9[DOI][PubMed]
  • 16. Zhang C, Guo L, Guo X. [Interaction of polymorphisms of Leptin receptor gene Gln223Arg, MnSOD9Ala/Val genes and smoking in nonalcoholic fatty liver disease]. Wei Sheng Yan Jiu. 2014; 43(5): 724-31[PubMed]
  • 17. Chen SH, Li YM, Jiang LL, Yu CH. [Evaluation of leptin receptor Lys109Arg polymorphism in patients with non-alcoholic fatty liver disease]. Zhonghua Gan Zang Bing Za Zhi. 2006; 14(6): 453-5[PubMed]
  • 18. Bienertova-Vasku JA, Spinarova L, Bienert P, Vasku A. Association between variants in the genes for leptin, leptin receptor, and proopiomelanocortin with chronic heart failure in the Czech population. Heart Vessels. 2009; 24(2): 131-7[DOI][PubMed]
  • 19. Saukko M, Kesaniemi YA, Ukkola O. Leptin receptor Lys109Arg and Gln223Arg polymorphisms are associated with early atherosclerosis. Metab Syndr Relat Disord. 2010; 8(5): 425-30[DOI][PubMed]
  • 20. Aijala M, Santaniemi M, Bloigu R, Kesaniemi YA, Ukkola O. Leptin receptor Arg109 homozygotes display decreased total mortality as well as lower incidence of cardiovascular disease and related death. Gene. 2014; 534(1): 88-92[DOI][PubMed]
  • 21. Gu P, Jiang W, Chen M, Lu B, Shao J, Du H, et al. Association of leptin receptor gene polymorphisms and essential hypertension in a Chinese population. J Endocrinol Invest. 2012; 35(9): 859-65[DOI][PubMed]
  • 22. Liu Y, Lou YQ, Liu K, Liu JL, Wang ZG, Wen J, et al. Role of leptin receptor gene polymorphisms in susceptibility to the development of essential hypertension: a case-control association study in a Northern Han Chinese population. J Hum Hypertens. 2014; 28(9): 551-6[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments