Hepatitis Monthly

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Hepatitis E Virus Circulation in Italy: Phylogenetic and Evolutionary Analysis

Carla Montesano 1 , Marta Giovanetti 1 , Marco Ciotti 2 , Eleonora Cella 3 , 4 , Alessandra Lo Presti 3 , Alba Grifoni 5 , Gianguglielmo Zehender 6 , Silvia Angeletti 7 and Massimo Ciccozzi 3 , 7 , *
Authors Information
1 Department of Biology, University of Rome Tor Vergata, Rome, Italy
2 Laboratory of Molecular Virology, Polyclinic Tor Vergata Foundation, Rome, Italy
3 Molecular Epidemiology and Microbial Evolution (FEMEM)/Epidemiology Unit, Department of Infectious, Parasitic and Immune-Mediated Diseases, Institute Superiore di Sanita, Rome, Italy
4 Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy
5 ProxAgen Ltd, Sofia, Bulgaria
6 Laboratory of Infectious Diseases and Tropical Medicine, University of Milan, Milan, Italy
7 Clinical Pathology and Microbiology Laboratory, University Hospital Campus Bio-Medico, Rome, Italy
Article information
  • Hepatitis Monthly: 16 (3); e58760
  • Published Online: March 12, 2016
  • Article Type: Research Article
  • Received: July 31, 2015
  • Accepted: January 9, 2016
  • DOI: 10.5812/hepatmon.31951

To Cite: Montesano C, Giovanetti M, Ciotti M, Cella E, Lo Presti A, et al. Hepatitis E Virus Circulation in Italy: Phylogenetic and Evolutionary Analysis, Hepat Mon. Online ahead of Print ; 16(3):e58760. doi: 10.5812/hepatmon.31951.

Copyright © 2016, Kowsar Corp. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
  • 1. Labrique AB, Zaman K, Hossain Z, Saha P, Yunus M, Hossain A, et al. An exploratory case control study of risk factors for hepatitis E in rural Bangladesh. PLoS One. 2013; 8(5)[DOI][PubMed]
  • 2. Panda SK, Thakral D, Rehman S. Hepatitis E virus. Rev Med Virol. 2007; 17(3): 151-80[DOI][PubMed]
  • 3. Kamar N, Bendall R, Legrand-Abravanel F, Xia NS, Ijaz S, Izopet J, et al. Hepatitis E. The Lancet. 2012; 379(9835): 2477-88[DOI]
  • 4. Tam AW, Smith MM, Guerra ME, Huang CC, Bradley DW, Fry KE, et al. Hepatitis E virus (HEV): Molecular cloning and sequencing of the full-length viral genome. Virology. 1991; 185(1): 120-31[DOI]
  • 5. Lu L, Li C, Hagedorn CH. Phylogenetic analysis of global hepatitis E virus sequences: genetic diversity, subtypes and zoonosis. Rev Med Virol. 2006; 16(1): 5-36[DOI][PubMed]
  • 6. Johne R, Plenge-Bonig A, Hess M, Ulrich RG, Reetz J, Schielke A. Detection of a novel hepatitis E-like virus in faeces of wild rats using a nested broad-spectrum RT-PCR. J Gen Virol. 2010; 91: 750-8[DOI][PubMed]
  • 7. Takahashi M, Nishizawa T, Sato H, Sato Y, Jirintai S, Nagashima S, et al. Analysis of the full-length genome of a hepatitis E virus isolate obtained from a wild boar in Japan that is classifiable into a novel genotype. J Gen Virol. 2011; 92: 902-8[DOI][PubMed]
  • 8. Zhao C, Ma Z, Harrison TJ, Feng R, Zhang C, Qiao Z, et al. A novel genotype of hepatitis E virus prevalent among farmed rabbits in China. J Med Virol. 2009; 81(8): 1371-9[DOI][PubMed]
  • 9. Buisson Y, Grandadam M, Nicand E, Cheval P, van Cuyck-Gandre H, Innis B, et al. Identification of a novel hepatitis E virus in Nigeria. J Gen Virol. 2000; 81: 903-9[DOI][PubMed]
  • 10. van Cuyck-Gandre H, Zhang HY, Tsarev SA, Clements NJ, Cohen SJ, Caudill JD, et al. Characterization of hepatitis E virus (HEV) from Algeria and Chad by partial genome sequence. J Med Virol. 1997; 53(4): 340-7[DOI]
  • 11. Tam AW, White R, Reed E, Short M, Zhang Y, Fuerst TR, et al. In vitro propagation and production of hepatitis E virus from in vivo-infected primary macaque hepatocytes. Virology. 1996; 215(1): 1-9[DOI][PubMed]
  • 12. Garbuglia AR, Scognamiglio P, Petrosillo N, Mastroianni CM, Sordillo P, Gentile D, et al. Hepatitis E virus genotype 4 outbreak, Italy, 2011. Emerg Infect Dis. 2013; 19(1): 110-4[DOI][PubMed]
  • 13. Giordani MT, Fabris P, Brunetti E, Goblirsch S, Romano L. Hepatitis E and lymphocytic leukemia in Man, Italy. Emerg Infect Dis. 2013; 19(12): 2054-6[DOI][PubMed]
  • 14. Caruso C, Modesto P, Bertolini S, Peletto S, Acutis PL, Dondo A, et al. Serological and virological survey of hepatitis E virus in wild boar populations in northwestern Italy: detection of HEV subtypes 3e and 3f. Arch Virol. 2015; 160(1): 153-60[DOI][PubMed]
  • 15. Colson P, Borentain P, Queyriaux B, Kaba M, Moal V, Gallian P, et al. Pig liver sausage as a source of hepatitis E virus transmission to humans. J Infect Dis. 2010; 202(6): 825-34[DOI][PubMed]
  • 16. Hoofnagle JH, Nelson KE, Purcell RH. Hepatitis E. N Engl J Med. 2012; 367(13): 1237-44[DOI][PubMed]
  • 17. Wedemeyer H, Pischke S, Manns MP. Pathogenesis and treatment of hepatitis e virus infection. Gastroenterology. 2012; 142(6): 1388-97
  • 18. Martinelli N, Pavoni E, Filogari D, Ferrari N, Chiari M, Canelli E, et al. Hepatitis E virus in wild boar in the central northern part of Italy. Transbound Emerg Dis. 2015; 62(2): 217-22[DOI][PubMed]
  • 19. Romano L, Paladini S, Tagliacarne C, Canuti M, Bianchi S, Zanetti AR. Hepatitis E in Italy: a long-term prospective study. J Hepatol. 2011; 54(1): 34-40[DOI][PubMed]
  • 20. Martinelli N, Luppi A, Cordioli P, Lombardi G, Lavazza A. Prevalence of hepatitis E virus antibodies in pigs in Northern Italy. Infect Ecol Epidemiol. 2011; 1: 1-3[DOI]
  • 21. Martelli F, Caprioli A, Zengarini M, Marata A, Fiegna C, Di Bartolo I, et al. Detection of hepatitis E virus (HEV) in a demographic managed wild boar (Sus scrofa scrofa) population in Italy. Vet Microbiol. 2008; 126(1-3): 74-81[DOI][PubMed]
  • 22. Lo Presti A, Ciccozzi M, Cella E, Lai A, Simonetti FR, Galli M, et al. Origin, evolution, and phylogeography of recent epidemic CHIKV strains. Infect Genet Evol. 2012; 12(2): 392-8[DOI][PubMed]
  • 23. Ciccozzi M, Lo Presti A, Cella E, Giovanetti M, Lai A, El-Sawaf G, et al. Phylogeny of Dengue and Chikungunya viruses in Al Hudayda governorate, Yemen. Infect Genet Evol. 2014; 27: 395-401[DOI][PubMed]
  • 24. Lo Presti A, Ciccozzi M, Cella E, Giovanetti M, Zehender G, Valenti D, et al. Migration patterns of HIV-1 subtype B virus in Northern Italy. New Microbiol. 2013; 36(1): 75-9[PubMed]
  • 25. Posada D, Buckley TR. Model selection and model averaging in phylogenetics: advantages of akaike information criterion and bayesian approaches over likelihood ratio tests. Syst Biol. 2004; 53(5): 793-808[DOI][PubMed]
  • 26. Villano U, Lo Presti A, Equestre M, Cella E, Pisani G, Giovanetti M, et al. Molecular epidemiology and phylogenetic analysis of Hepatitis B virus in a group of migrants in Italy. BMC Infect Dis. 2015; 15: 531[DOI]
  • 27. Yang Z, Nielsen R, Goldman N, Pedersen AM. Codon-substitution models for heterogeneous selection pressure at amino acid sites. Genetics. 2000; 155(1): 431-49[PubMed]
  • 28. Yang Z, Wong WS, Nielsen R. Bayes empirical bayes inference of amino acid sites under positive selection. Mol Biol Evol. 2005; 22(4): 1107-18[DOI][PubMed]
  • 29. Anisimova M, Bielawski JP, Yang Z. Accuracy and power of the likelihood ratio test in detecting adaptive molecular evolution. Mol Biol Evol. 2001; 18(8): 1585-92[PubMed]
  • 30. Anisimova M, Bielawski JP, Yang Z. Accuracy and power of bayes prediction of amino acid sites under positive selection. Mol Biol Evol. 2002; 19(6): 950-8[PubMed]
  • 31. Pond SL, Frost SD, Muse SV. HyPhy: hypothesis testing using phylogenies. Bioinformatics. 2005; 21(5): 676-9[DOI][PubMed]
  • 32. Kosakovsky Pond SL, Frost SD. Not so different after all: a comparison of methods for detecting amino acid sites under selection. Mol Biol Evol. 2005; 22(5): 1208-22[DOI][PubMed]
  • 33. Perez-Gracia MT, Suay B, Mateos-Lindemann ML. Hepatitis E: an emerging disease. Infect Genet Evol. 2014; 22: 40-59[DOI][PubMed]
  • 34. Zehender G, Ebranati E, Lai A, Luzzago C, Paladini S, Tagliacarne C, et al. Phylogeography and phylodynamics of European genotype 3 hepatitis E virus. Infect Genet Evol. 2014; 25: 138-43[PubMed]
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