Hepatitis Monthly

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Hepatitis D Virus Infection Among Hepatitis B Surface Antigen Carriers and in “Isolated anti-HBc” Antibodies Profile in Central Tunisia

Salma Mhalla 1 , 2 , * , Yosr Kadri 2 , Sana Alibi 1 , Amel Letaief 3 , Jalel Boukadida 1 and Naila Hannachi 1
Authors Information
1 Laboratory of Microbiology and Immunology, F. Hached Teaching Hospital, (UR12SP34) University of Sousse, Sousse, Tunisia
2 Department of Microbiology, Fattouma Bourguiba Teaching Hospital, University of Monastir, Monastir, Tunisia
3 Department of Infectious Disease, F. Hached Teaching Hospital, University of Sousse, Sousse, Tunisia
Article information
  • Hepatitis Monthly: January 2016, 16 (1); e58769
  • Published Online: January 16, 2016
  • Article Type: Research Article
  • Received: September 3, 2015
  • Revised: October 31, 2015
  • Accepted: December 4, 2015
  • DOI: 10.5812/hepatmon.32354

To Cite: Mhalla S, Kadri Y, Alibi S, Letaief A, Boukadida J, et al. Hepatitis D Virus Infection Among Hepatitis B Surface Antigen Carriers and in “Isolated anti-HBc” Antibodies Profile in Central Tunisia, Hepat Mon. 2016 ; 16(1):e58769. doi: 10.5812/hepatmon.32354.

Copyright © 2016, Kowsar Corp.This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Rizzetto M. Hepatitis D: thirty years after. J Hepatol. 2009; 50(5): 1043-50[DOI][PubMed]
  • 2. Saravanan S, Velu V, Kumarasamy N, Shankar EM, Nandakumar S, Murugavel KG, et al. Seroprevalence of hepatitis delta virus infection among subjects with underlying hepatic diseases in Chennai, southern India. Trans R Soc Trop Med Hyg. 2008; 102(8): 793-6[DOI][PubMed]
  • 3. Rizzetto M, Purcell RH, Gerin JL. Epidemiology of HBV-associated delta agent: geographical distribution of anti-delta and prevalence in polytransfused HBsAg carriers. Lancet. 1980; 1(8180): 1215-8[PubMed]
  • 4. Lunel-Fabiani F, Mansour W, Amar AO, Aye M, Le Gal F, Malick FZ, et al. Impact of hepatitis B and delta virus co-infection on liver disease in Mauritania: a cross sectional study. J Infect. 2013; 67(5): 448-57[DOI][PubMed]
  • 5. Amini N, Alavian SM, Kabir A, Aalaei-Andabili SH, Saiedi Hosseini SY, Rizzetto M. Prevalence of hepatitis d in the eastern mediterranean region: systematic review and meta analysis. Hepat Mon. 2013; 13(1)[DOI][PubMed]
  • 6. Govindarajan S, Chin KP, Redeker AG, Peters RL. Fulminant B viral hepatitis: role of delta agent. Gastroenterology. 1984; 86(6): 1417-20[PubMed]
  • 7. Fattovich G, Giustina G, Christensen E, Pantalena M, Zagni I, Realdi G, et al. Influence of hepatitis delta virus infection on morbidity and mortality in compensated cirrhosis type B. The European Concerted Action on Viral Hepatitis (Eurohep). Gut. 2000; 46(3): 420-6[PubMed]
  • 8. Schaper M, Rodriguez-Frias F, Jardi R, Tabernero D, Homs M, Ruiz G, et al. Quantitative longitudinal evaluations of hepatitis delta virus RNA and hepatitis B virus DNA shows a dynamic, complex replicative profile in chronic hepatitis B and D. J Hepatol. 2010; 52(5): 658-64[DOI][PubMed]
  • 9. Wedemeyer H. Re-emerging interest in hepatitis delta: new insights into the dynamic interplay between HBV and HDV. J Hepatol. 2010; 52(5): 627-9[DOI][PubMed]
  • 10. Triki H. [Epidemiology of hepatitis B virus, hepatitis C virus and Delta virus in the general population and in liver cirrhosis in Tunisia]. Arch Inst Pasteur Tunis. 1994; 71(3-4): 403-6[PubMed]
  • 11. Triki H, Said N, Ben Salah A, Arrouji A, Ben Ahmed F, Bouguerra A, et al. Seroepidemiology of hepatitis B, C and delta viruses in Tunisia. Trans R Soc Trop Med Hyg. 1997; 91(1): 11-4[PubMed]
  • 12. Hannachi N, Bahri O, Mhalla S, Marzouk M, Sadraoui A, Belguith A, et al. [Hepatitis B virus infection in Tunisian pregnant women: risk factors and viral DNA levels in HBe antigen negative women]. Pathol Biol (Paris). 2009; 57(3)-7[DOI][PubMed]
  • 13. Lindh M, Andersson AS, Gusdal A. Genotypes, nt 1858 variants, and geographic origin of hepatitis B virus--large-scale analysis using a new genotyping method. J Infect Dis. 1997; 175(6): 1285-93[PubMed]
  • 14. Alhababi F, Sallam TA, Tong CY. The significance of 'anti-HBc only' in the clinical virology laboratory. J Clin Virol. 2003; 27(2): 162-9[PubMed]
  • 15. Rizzetto M. Hepatitis delta: the virus and the disease. J Hepatol. 1990; 11 Suppl 1-8[PubMed]
  • 16. Djebbi A, Rebai WK, Bahri O, Hogga N, Sadraoui A, Triki H. [Serological markers, viral RNA and genotype of hepatitis delta virus in HBs antigen positive Tunisian patients]. Pathol Biol (Paris). 2009; 57(7-8): 518-23[DOI][PubMed]
  • 17. Jenhani F, Ayed K, Gorgi Y, Zoulim F, Pichoud C, Trepo C. Delta infection in chronic HBs Ag carriers in Tunisia: high prevalence in chronic asymptomatic HBs Ag carriers and in HBs Ag positive cirrhosis. Ann Trop Med Parasitol. 1990; 84(4): 349-53[PubMed]
  • 18. Gaeta GB, Stroffolini T, Chiaramonte M, Ascione T, Stornaiuolo G, Lobello S, et al. Chronic hepatitis D: a vanishing Disease? An Italian multicenter study. Hepatology. 2000; 32(4 Pt 1): 824-7[DOI][PubMed]
  • 19. Degertekin H, Yalcin K, Yakut M. The prevalence of hepatitis delta virus infection in acute and chronic liver diseases in Turkey: an analysis of clinical studies. Turk J Gastroenterol. 2006; 17(1): 25-34[PubMed]
  • 20. Huo TI, Wu JC, Lin RY, Sheng WY, Chang FY, Lee SD. Decreasing hepatitis D virus infection in Taiwan: an analysis of contributory factors. J Gastroenterol Hepatol. 1997; 12(11): 747-51[PubMed]
  • 21. Acharya SK, Madan K, Dattagupta S, Panda SK. Viral hepatitis in India. Natl Med J India. 2006; 19(4): 203-17[PubMed]
  • 22. Makuwa M, Caron M, Souquiere S, Malonga-Mouelet G, Mahe A, Kazanji M. Prevalence and genetic diversity of hepatitis B and delta viruses in pregnant women in Gabon: molecular evidence that hepatitis delta virus clade 8 originates from and is endemic in central Africa. J Clin Microbiol. 2008; 46(2): 754-6[DOI][PubMed]
  • 23. Mele A, Mariano A, Tosti ME, Stroffolini T, Pizzuti R, Gallo G, et al. Acute hepatitis delta virus infection in Italy: incidence and risk factors after the introduction of the universal anti-hepatitis B vaccination campaign. Clin Infect Dis. 2007; 44(3)-24[DOI][PubMed]
  • 24. Bialek SR, Bower WA, Mottram K, Purchase D, Nakano T, Nainan O, et al. Risk factors for hepatitis B in an outbreak of hepatitis B and D among injection drug users. J Urban Health. 2005; 82(3): 468-78[DOI][PubMed]
  • 25. Seetlani NK, Abbas Z, Raza S, Yakoob J, Jafris W. Prevalence of hepatitis D in HBsAg positive patients visiting liver clinics. J Pak Med Assoc. 2009; 59(7): 434-7[PubMed]
  • 26. Ben-Alaya-Bouafif N, Bahri O, Chlif S, Bettaieb J, Toumi A, Bel Haj HN, et al. Heterogeneity of hepatitis B transmission in Tunisia: risk factors for infection and chronic carriage before the introduction of a universal vaccine program. Vaccine. 2010; 28(19): 3301-7[DOI][PubMed]
  • 27. Abe K, Hayakawa E, Sminov AV, Rossina AL, Ding X, Huy TT, et al. Molecular epidemiology of hepatitis B, C, D and E viruses among children in Moscow, Russia. J Clin Virol. 2004; 30(1): 57-61[DOI][PubMed]
  • 28. Heidrich B, Deterding K, Tillmann HL, Raupach R, Manns MP, Wedemeyer H. Virological and clinical characteristics of delta hepatitis in Central Europe. J Viral Hepat. 2009; 16(12): 883-94[DOI][PubMed]
  • 29. Ataei B, Yazdani MR, Kalantari H, Yaran M, Nokhodian Z, Javadi AA, et al. Hepatitis D virus infection in Isfahan, central Iran: Prevalence and risk factors among chronic HBV infection cases. Hepat Mon. 2011; 11(4): 269-72[PubMed]
  • 30. Triki H, Ben Slimane S, Ben Mami N, Sakka T, Ben Ammar A, Dellagi K. High circulation of hepatitis B virus (HBV) precore mutants in Tunisia, North Africa. Epidemiol Infect. 2000; 125(1): 169-74[PubMed]
  • 31. Bahri O, Cheikh I, Hajji N, Djebbi A, Maamouri N, Sadraoui A, et al. Hepatitis B genotypes, precore and core promoter mutants circulating in Tunisia. J Med Virol. 2006; 78(3): 353-7[DOI][PubMed]
  • 32. Ouneissa R, Bahri O, Alaya-Bouafif NB, Chouaieb S, Ben Yahia A, Sadraoui A, et al. Frequency and clinical significance of core promoter and precore region mutations in Tunisian patients infected chronically with hepatitis B. J Med Virol. 2012; 84(11): 1719-26[DOI][PubMed]
  • 33. Wang CX, Lu YQ, Qi P, Chen LH, Han JX. Efficient inhibition of hepatitis B virus replication by hepatitis delta virus ribozymes delivered by targeting retrovirus. Virol J. 2010; 7: 61[DOI][PubMed]
  • 34. Kushner T, Serper M, Kaplan DE. Delta hepatitis within the Veterans Affairs medical system in the United States: Prevalence, risk factors, and outcomes. J Hepatol. 2015; 63(3): 586-92[DOI][PubMed]
  • 35. Celen MK, Ayaz C, Hosoglu S, Geyik MF, Ulug M. Anti-hepatitis delta virus seroprevalence and risk factors in patients with hepatitis B in Southeast Turkey. Saudi Med J. 2006; 27(5): 617-20[PubMed]
  • 36. Ghamari S, Alavian SM, Rizzetto M, Olivero A, Smedile A, Khedive A, et al. Prevalence of hepatitis delta virus (HDV) infection in chronic hepatitis B patients with unusual clinical pictures. Hepat Mon. 2013; 13(8)[DOI][PubMed]
  • 37. Huang YH, Wu JC, Lu SN, Chiang TY, Chang FY, Lee SD. Phylogenetic analysis to document a common source of hepatitis D virus infection in a mother and her child. Zhonghua Yi Xue Za Zhi (Taipei). 1999; 62(1): 28-32[PubMed]
  • 38. Romeo R. [Role of the hepatitis Delta virus on the pathogenesis of hepatic cirrhosis and hepatocellular carcinoma. Recent advances]. Recenti Prog Med. 2010; 101(2): 52-6[PubMed]
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