Liver Histopathological Features of HBeAg-Negative Chronic Hepatitis B in Young Bangladeshis


Mamun Al Mahtab 1 , * , Salimur Rahman 2 , Mobin Khan 2 , Fazal Karim 2 , Md Kamal 2

1 Department of Hepatology, Bangabandhu Sheikh Mujib Medical University,, Bangladesh

2 Department of Hepatology, Bangabandhu Sheikh Mujib Medical University, Bangladesh

How to Cite: Mahtab M, Rahman S, Khan M, Karim F, Kamal M. Liver Histopathological Features of HBeAg-Negative Chronic Hepatitis B in Young Bangladeshis, Hepat Mon. Online ahead of Print ; 9(1):29-33.


Hepatitis Monthly: 9 (1); 29-33
Article Type: Research Article
Received: June 13, 2008
Accepted: August 18, 2008




Background & Aims: HBV infection is common in Bangladesh. However, the characteristics of young patients incidentally detected with HBeAg-negative chronic hepatitis B is yet to be studied in this country.

Methods: We did percutaneous liver biopsies in 36 patients with chronic hepatitis B (CHB) aged between 8 and 20 years. They were all HBeAg-negative with persistently normal or raised serum ALT values.

Results: 56% of patients had significant necro-inflammation. Significant fibrosis was seen in 17.6% of patients. Serum ALT was raised in 38.2%. A high HBV DNA load was observed only in 26.5% of patients. HBeAg-negative CHB is assumed not to be present in the age group studied, since this is the age group that represents immunotolerance to CHB. Immunotolerant CHB patients are positive for HBeAg, have normal ALT with high HBV DNA load. However, our study not only documented that HBeAg-negative CHB is common in our young population, but the data were also in contrary to what was expected in such age group of CHB patients.

Conclusions: HBeAg-negative CHB is an entity that can be seen in young population and a significant percentage of such patients may have considerable hepatic involvement.


Chronic Hepatitis B HBeAg Negative Liver Histology

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