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Hepatitis C Virus Infection and Chronic Obstructive Pulmonary Disease

AUTHORS

Serpil Erol 1 , * , Leyla saglam 2 , Ahmet Ozbek 2 , Ayten Kadanali 2

AUTHORS INFORMATION

1 Ataturk University Medical School, Aziziye Hospital, Department of Clinical Microbiology and Infectious Diseases, sererol@gmail.com, Turkey

2 Department of Chest Diseases, Ataturk University Medical School, Turkey

How to Cite: Erol S, saglam L, Ozbek A, Kadanali A. Hepatitis C Virus Infection and Chronic Obstructive Pulmonary Disease, Hepat Mon. Online ahead of Print ; 9(1):39-44.

ARTICLE INFORMATION

Hepatitis Monthly: 9 (1); 39-44
Article Type: Research Article
Received: November 16, 2008
Accepted: January 11, 2009

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Abstract

Background and Aims: A growing pile of evidence supports the notion that pulmonary involvement is one of the extrahepatic manifestations of chronic hepatitis C virus (HCV) infection. The objective of this study was to determine the prevalence of HCV infection in patients with chronic obstructive pulmonary disease (COPD), and vice versa.

Methods: Two cross-sectional studies were performed: 1. A prevalence study of HCV infection among patients with COPD; 2. A prevalence study of COPD among patients with chronic HCV infection. COPD was diagnosed according to ATS/ERS guidelines. The prevalence of HCV infection in COPD group was compared with the result of a previous study which determined the prevalence of HCV infection in general population. Prevalence of COPD in patients with chronic HCV infection was also compared to those with chronic hepatitis B virus (HBV) infection.

Results: The study included 108 patients with COPD, 68 patients with chronic HCV infection, and 60 patients with chronic HBV infection. HCV infection was observed in 8.3% of patients with COPD, and 1.2% of the control subjects (P= 0.000). The prevalence of COPD among patients with chronic HCV and HBV infection was 17.6%, and 5%, respectively (P=0.03). Comparing COPD-positive and -negative chronic HCV patients for risk factors for COPD revealed that only the mean age was higher in COPD-positive patients (60.8±9.1 years vs. 46.5±11.5 years, P=0.000). In multivariate analysis, age was found to be the only independent predictor of COPD in HCV group.

Conclusions: Patients with COPD have increased prevalence of HCV infection, and patients with HCV infection, have increased prevalence of COPD. COPD may be an extrahepatic disease associated with HCV infection.

Keywords

Hepatitis C Chronic Obstructive Pulmonary Disease Prevalence Extrahepatic Manifestation

© 0, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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