The Association of Maternal HBsAg Carrier Status and Perinatal Outcome


Soraya Saleh Gargari 1 , * , Sediegh Hantoushzadeh 2 , Nasrin Zendehdel 2 , Ashraf Jamal 2 , Hamed Aghdam 2

1 Feto-Maternal Unit, Mahdieh Hospital, Shahid Beheshti University, M.C., [email protected], Tehran, IR.Iran

2 Reproductive Health Research Center, Tehran University of Medical Sciences, Tehran, IR.Iran

How to Cite: Gargari S, Hantoushzadeh S, Zendehdel N, Jamal A, Aghdam H. The Association of Maternal HBsAg Carrier Status and Perinatal Outcome, Hepat Mon. Online ahead of Print ; 9(3):180-184.


Hepatitis Monthly: 9 (3); 180-184
Article Type: Research Article
Received: December 4, 2008
Accepted: January 10, 2009




Background and Aims: Hepatitis B virus infection is still a major public health concern all over the world, and much research must be carried out on the various aspects of this issue. Since infection with hepatitis B virus in pregnant mothers is a threat for both mother and her fetus, this study was performed to determine the relationship between maternal HBsAg carrier status and perinatal outcome.

Methods: A retrospective case-control study was performed on 450 carriers of hepatitis B surface antigen (HBsAg) pregnant women and compared to 450 controls. Both groups were matched for age, parity, and body mass index (BMI).

Results: When compared to the control group, patients with HBsAg displayed significantly higher incidence of gestational diabetes mellitus (GDM) (7.7% vs. 2% P=0.001), increased hospitalization period after delivery (22.9% vs. 3.33%, P<0.0001), preterm labor at less than 37 weeks (10.9% vs. 2.67%, P<0.0001), pregnancy induced hypertension (13% vs. 2.89%, P<0.0001), and preterm premature rupture of membranes (3.55% vs. 1.1%, P=0.03). Also, the incidence of macrosomy (6.67% vs. 2.22%, P=0.02), intrauterine fetal death (5.56% vs. 0.44%, P=0.001), still birth (2.89% vs. 0.44%, P=0.005), and NICU admission (25.78% vs. 2.22%, P<0.0001) in the carrier mothers were higher.

Conclusions: HBsAg carriers have increased risk of hospitalization period after delivery, preterm labor, gestational hypertension, preterm premature rupture of membranes. In addition higher incidence of macrosomy, intrauterine fetal death, still birth, and NICU admission were observed. Therefore our results showed HBsAg carrier mothers have increased maternal and neonatal complications.


Pregnancy Outcomes Hepatitis B Virus Carrier State HBsAg

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