Severe Mononeuritis Multiplex Associated with Peginterferon-Ribavirin Therapy of Chronic Hepatitis C

AUTHORS

Darko Nozic 1 , * , Branislav Antic 2 , Vasna Begovic 2 , Gorana Stamenkovic 2

1 Clinic of Infectious and Tropical Diseases, Military Medical Academy, [email protected], Serbia

2 Clinic of Neurosurgery, Military Medical Academy, Serbia

How to Cite: Nozic D, Antic B, Begovic V, Stamenkovic G. Severe Mononeuritis Multiplex Associated with Peginterferon-Ribavirin Therapy of Chronic Hepatitis C, Hepat Mon. Online ahead of Print ; 9(1):70-72. doi: 10.5812/cardiovascmed.4498.

ARTICLE INFORMATION

Hepatitis Monthly: 9 (1); 70-72
Article Type: Case Report
Received: October 14, 2008
Accepted: January 3, 2009
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Abstract

Vasculitis is a common extrahepatic manifestation of chronic hepatitis C virus infection and could be either associatedwith cryoglobulinemia or not.

The mechanism of peripheral neuropathy seems to be vasculitic in both cryoglobulinemic and non-cryoglobulinemic patients. Antiviral therapy with peginterferon and ribavirin usually improves symptoms of virus-induced neuropathy. Herein, we reported on a rare case of hard mononeuritis multiplex triggered by antiviral therapy in a patient without neurological symptoms before the treatment.

Keywords

Hepatitis C Peginterferon Mononeuritis Multiplex Cryoglobulinemia

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