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Nutritional Status and Blood Trace Elements in Cirrhotic Patients

AUTHORS

Mohammad Hossein Somi 1 , * , Alireza Ostad Rahimi 2 , Behnaz Moshrefi 2 , Parisa Rezaeifar 3 , Jamal Ghaem Moghami 3

AUTHORS INFORMATION

1 Associate Professor of Gastroenterology, Liver and Gastrointestinal Disease Research Center, Tabriz University of Medical Sciences, mhosseinsina@yahoo.com, Tabriz, IR.IRAN

2 Assistant Professor of Nutrition, Liver and Gastrointestinal Disease Research Center, Tabriz University of Medical Sciences, Tabriz, IR.IRAN

3 General Practitioner, Liver and Gastrointestinal Disease Research Center, Tabriz University of Medical Sciences, IR.IRAN

How to Cite: Somi M, Rahimi A, Moshrefi B, Rezaeifar P, Moghami J. Nutritional Status and Blood Trace Elements in Cirrhotic Patients, Hepat Mon. Online ahead of Print ; 7(1):27-32.

ARTICLE INFORMATION

Hepatitis Monthly: 7 (1); 27-32
Article Type: Research Article
Received: March 20, 2006
Accepted: October 20, 2006

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Abstract

Background and Aims: In this study, the effect of infections and inflammation developed during hepatitis B vaccination program on antibody response in hemodialysis (HD) patients was evaluated.

Methods: In total, 94 patients who had hepatitis B surface antigen (HBsAg) (-), antibody to hepatitis B surface (antiHBs) (-), antibody against hepatitis B core immunoglobulin G (antiHBcIgG) (-) (Group A) and who were previously vaccinated but having antibody titer levels lower than 10 mIU/mL (Group B), on maintenance HD program were included in this study. In group A, 40 |μ|g intramuscular vaccine on 0, 1, 2 and 6 months and in group B, 40 μ|g of intramuscular booster dose vaccine were administered. Antibody titer of 10 mIU/mL was considered as positive. Group A was then divided into two subgroups with respect to antibody response (Group A1 and Group A2).

Results: Eighty-one patients completed the study (Group A; n=64, mean age=42.3±11.4 years; Group B: n=17, mean age=53.6±10.6 years). In Group A, antibody response was positive in 82.8% (Group A1), negative in 17.2% (Group A2) and it was positive in 100% of Group B. Inflammatory parameters, nutritional and demographic features were found similarly in all groups. Throughout the study, infections developed most frequently in Group A.

Conclusions: We concluded that acute infections and inflammations developed in patients vaccinated according to vaccination schedule recommended for HBV prophylaxis during HD treatment does not affect antibody response and acute phase reactants are not indicators for negative antibody response.

Keywords

Liver Cirrhosis Trace Elements Malnutrition

© 0, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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