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Autoantibodies in Hepatitis C Virus-Related Chronic Liver Disease

AUTHORS

Takashi Himoto 1 , * , Mikio Nishioka 2

AUTHORS INFORMATION

1 Department of Gastroenterology and Neurology, Kagawa University School of Medicine, thimoto@med.kagawa-u.ac.jp, Japan

2 Department of Gastroenterology and Neurology, Kagawa University School of Medicine, Japan

How to Cite: Himoto T, Nishioka M. Autoantibodies in Hepatitis C Virus-Related Chronic Liver Disease, Hepat Mon. Online ahead of Print ; 8(4):295-303.

ARTICLE INFORMATION

Hepatitis Monthly: 8 (4); 295-303
Article Type: Review Article
Received: June 16, 2008
Accepted: September 28, 2008

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Abstract

Persistent hepatitis C virus (HCV) infection evokes autoimmune response including production of autoantibodies and concomitant autoimmune disorders. Numerous types of autoantibodies such as non-organ-specific autoantibodies and liver-specific autoantibodies have been identified in sera of patients with HCV-related chronic liver disease (CLD). The production of these autoantibodies in HCV-related CLD reflects "virus-induced autoimmunity."  Molecular mimicry between the HCV polyprotein and self-proteins, and polyclonal B cell activation by chronic HCV infection have been proposed as possible mechanisms for the occurrence of autoantibodies in HCV-related CLD. Some autoantibodies are tightly associated with concurrent autoimmune diseases, and others closely associated with peculiar human leukocyte antigen (HLA) haplotypes. Changes in the titers of autoantibodies during the antiviral treatment may predict the sustained virological response in individuals. In this article, we mainly focus on the interpretations of autoantibodies in HCV-related CLD.

Keywords

Antiviral Treatment Autoantibodies Hepatitis C Virus HLA Haplotype Molecular Mimicry

© 0, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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