IF: 1.578
Cite Score:
1.45
THOMSON REUTERS - SCOPUS

Efficacy of Lamivudine Therapy on Decompensated Liver Cirrhosis Due to Chronic Hepatitis B

AUTHORS

Mahmood Yousefi Mashhour 1 , Fariborz Mansour Ghanaei 2 , * , Hosein Foroutan 3 , Hadi Ghofrani 4 , Zahra Purrasuli 1 , Farahnaz Joukar 5

AUTHORS INFORMATION

1 Gastrointestinal and Liver Diseases Research Center (GLDRC), Guilan University of Medical Sciences, IR.IRAN

2 Gastrointestinal and Liver Diseases Research Center (GLDRC), Guilan University of Medical Sciences, ghanaei@gums.ac.ir, IR.IRAN

3 Digestive Diseases Research Center, Imam Khomeini Hospital, Medical Sciences, University of Tehran, Teahran, IR.IRAN

4 Digestive Diseases Research Center, Imam Khomeini Hospital, Medical Sciences, University of Tehran, Tehran, IR.IRAN

5 Rasht, IR.IRAN

How to Cite: Mashhour M, Ghanaei F, Foroutan H, Ghofrani H, Purrasuli Z, et al. Efficacy of Lamivudine Therapy on Decompensated Liver Cirrhosis Due to Chronic Hepatitis B, Hepat Mon. Online ahead of Print ; 7(2):77-81.

ARTICLE INFORMATION

Hepatitis Monthly: 7 (2); 77-81
Article Type: Research Article
Received: November 8, 2006
Accepted: August 18, 2007

Crossmark

CHEKING

READ FULL TEXT
Abstract

Background and Aims: The aim of this study was to determine the effect of lamivudine on liver function and clinical status of the patients with decompensated cirrhosis arising from hepatitis B virus (HBV).
Methods: In a clinical trial on the basis of liver consideration in 55 patients with cirrhosis that had positive HBsAg and HBV DNA, Child-Pugh score more than 8 and some other criteria were treated with lamivudine. In these patients, serum
level of bilirubin, albumin, ALT, AST and also the PT-INR were controlled at the beginning of study and then at intervals of 2 to 6 months and finally 12 months after the start of treatment.
Results: Five patients died in the first 6 months of treatments. The following results are related to 50 patients being under treatment with lamivudine at least for a period of 6 months. In these patients mean Child-Pugh score was decreased from 11 ± 2 to 7 ± 1 (P < 0.0001). All of the patients tolerated this drug very well.
Conclusions: Lamivudine can be effective in improvement of liver function in patients with decompensated liver cirrhosis resulting from HBV, but for determination of proper period of treatment, further studies are necessary.

Keywords

Lamivudine Hepatitis B Hepatitis C Cirrhosis

© 0, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

Full Text

Full text is available in PDF

COMMENTS

LEAVE A COMMENT HERE: