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Serological Markers of Blood Borne Viruses among Persons with Combined Factor V and VIII Deficiency

AUTHORS

Hassan Mansouritorghabeh 1 , * , Reza Farid Hosseini 2 , Aliakbar Pourfathollah 3 , Azizollah Behjati 2

AUTHORS INFORMATION

1 Immunology Research Center, Ghaem Hospital, Mashhad University of Medical Sciences, mansouritorghabe@mums.ac.ir, Khorasan-e-Razavi, IR.Iran

2 Immunology Research Center, Ghaem Hospital, Mashhad University of Medical Sciences, Khorasan-e-Razavi, IR.Iran

3 Experimental Hematology and Blood Banking Group, Medical Sciences School, Tarbiat Modarres University (TMU), Tehran, IR.Iran

How to Cite: Mansouritorghabeh H, Hosseini R, Pourfathollah A, Behjati A. Serological Markers of Blood Borne Viruses among Persons with Combined Factor V and VIII Deficiency, Hepat Mon. Online ahead of Print ; 8(3):221-224.

ARTICLE INFORMATION

Hepatitis Monthly: 8 (3); 221-224
Article Type: Brief Report
Received: May 4, 2008
Accepted: July 13, 2008

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Abstract

Background and Aims: Combined factor V and VIII deficiency (CF5F8D) is a rare hemorrhagic disorder. Treatment of patients with blood products has been associated with infections with blood-borne viruses. Due to absence of any survey on status of blood borne viruses in individuals with CF5F8D, we tried to address this question.

Methods: Among 25 known cases, 24 individuals were assessed for hepatitis B and C viruses (HBV & HCV), human T lymphotropic virus type one (HTLV-I) and human immunodeficiency virus type1/2 (HIV1/2) using enzyme linked immunosorbent assay method.

Results: In the group under survey, 2 cases (8.3%) were positive for anti-HCV. There was no infection with HBV, HTLV-I and HIV.

Conclusions: Hepatitis C is a major health problem in CF5F8D, as in hemophiliacs, and may need more attention from manufacturers of blood products and more careful pre-transfusion screening of blood products for anti-HCV.

Keywords

CF5F8D Hemophilia HCV HBV HIV1/2 HTLV-I

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